Veterinary journal最新文献

{"title":"Haemoglobin concentration measurement agreement obtained from three different devices in anaesthetised horses","authors":"Luiz Cesar Pereira Santos ,&nbsp;Kate Werfel ,&nbsp;Gustavo Ferlini-Agne","doi":"10.1016/j.tvjl.2025.106394","DOIUrl":"10.1016/j.tvjl.2025.106394","url":null,"abstract":"<div><div>Accurate measurement of haemoglobin concentration is crucial for monitoring the oxygen-carrying capacity in anaesthetised horses. This prospective study aimed to determine the agreement in haemoglobin concentration in anaesthetised horses using the SpHb pulse co-oximeter, an Epoc® blood gas analyser, and values derived from packed cell volume (PCV), which served as the reference method in this study. The study included 34 horses undergoing elective surgeries. Blood samples were collected from each horse and divided for analysis using the microhaematocrit method to estimate haemoglobin concentration ([Hb]PCV_est) and the Epoc®. Haemoglobin concentrations were compared to SpHb readings using Lin’s concordance correlation coefficient (CCC) and Bland-Altman analysis, with a predefined acceptable clinical limit of agreement set at a 7 % variance from the reference. The mean [Hb]PCV_est was 14.6 ± 1.8 g/dL, the Epoc® [Hb] was 11.0 ± 1.8 g/dL, and the SpHb® [Hb] was 9.6 ± 1.5 g/dL. Analysis revealed poor agreement between the SpHb and Epoc® devices compared to [Hb]PCV_est. Both SpHb and Epoc® methods underestimated haemoglobin concentrations by an average of 4.96 g/dL and 3.6 g/dL, respectively. Lin’s CCC indicated weak concordance (0.08 for SpHb and 0.14 for Epoc®). Bland-Altman analysis demonstrated significant biases, exceeding the acceptable 7 % threshold, with wide limits of agreement. In conclusion, both the SpHb pulse co-oximeter and the Epoc® showed poor agreement with the [Hb]PCV_est method, underestimating haemoglobin levels in anaesthetised horses. Further research with larger sample sizes and species-specific device calibration is necessary to establish the true accuracy and clinical utility of the SpHb Radical-7® device in horses.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"313 ","pages":"Article 106394"},"PeriodicalIF":2.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bayesian latent class analyses show that serological testing outperforms conventional diagnostic methods for the detection of Ascaris in (individual) pigs","authors":"Ghazanfar Abbas ,&nbsp;Hannah Mitchell ,&nbsp;Mark Stevenson ,&nbsp;Yuet On Lee ,&nbsp;Abdul Ghafar ,&nbsp;Charles Gauci ,&nbsp;Hagan Brodziak ,&nbsp;Leah G. Starick ,&nbsp;Regina M. Fogarty ,&nbsp;Bernie Gleeson ,&nbsp;Dianne Phillips ,&nbsp;Tao Wang ,&nbsp;Robin B. Gasser ,&nbsp;Abdul Jabbar","doi":"10.1016/j.tvjl.2025.106396","DOIUrl":"10.1016/j.tvjl.2025.106396","url":null,"abstract":"<div><div>This study employed Bayesian latent class analyses to estimate the diagnostic accuracy of faecal egg count (FEC), milk spot detection and the ELISA for detection of <em>Ascaris suum</em> using matched samples from individual pigs in Australia. A total of 251 blood, faecal and liver samples were collected from finisher pigs from four Victorian pig farms. Matched samples (<em>n</em> = 189) were used to compare the three diagnostic tests. The ELISA detected a higher proportion of positive samples (56 %; 95 % CI 48–62 %) compared to milk spot detection (42 %; 95 % CI 35–49 %) and FEC (17 %; 95 % CI 12–23 %). Only the ELISA detected <em>A. suum</em> infections on two of the four farms, with 14 % and 41 % within-farm prevalence estimates. Agreement between diagnostic tests was moderate for FEC and milk spot detection (Cohen’s kappa 0.42; 95 % CI 0.30–0.53) and ELISA and milk spot detection (0.52; 0.41–0.64), while fair agreement was observed between FEC and ELISA (0.28; 0.19–0.37). Our latent class analyses identified a higher diagnostic sensitivity for the ELISA (0.92; 95 % CrI [credible interval] 0.86–0.96) than FEC (0.43; 0.34–0.53) and milk spot detection (0.86; 0.79–0.92). A strong association was observed between ELISA outcomes (optical density [OD] and OD ratio [ODr]) and milk spot grades (low, medium, high), with higher OD and ODr values corresponding to an increased number of milk spots on the liver. This study highlights the limitations of conventional <em>A. suum</em> detection methods. Quantitative estimates of the diagnostic sensitivity of the ELISA facilitate its use as a tool for assessing <em>A. suum</em> exposure in pig herds.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"313 ","pages":"Article 106396"},"PeriodicalIF":2.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conserved domains of flagellin as adjuvants for an inactivated vaccine against porcine epidemic diarrhea virus","authors":"Haroon Afzal ,&nbsp;Nguyen-Thanh Hoa ,&nbsp;Asad Murtaza ,&nbsp;Thu-Dung Doan ,&nbsp;Yao-Chi Chung ,&nbsp;Guan-Ming Ke ,&nbsp;Li-Ting Cheng","doi":"10.1016/j.tvjl.2025.106393","DOIUrl":"10.1016/j.tvjl.2025.106393","url":null,"abstract":"<div><div>Flagellin activates immune response through Toll-like Receptor 5 (TLR5) and can serve as a vaccine adjuvant. In this study, we evaluated the adjuvancy of the conserved domains of flagellins from three different bacteria: <em>Salmonella typhimurium</em>, <em>Bacillus subtilis</em>, and <em>Bacillus cereus</em>. The conserved domains were recombinantly expressed, and all three recombinant proteins demonstrated robust TLR5 activation <em>in vitro</em>. The recombinant proteins were formulated with inactivated porcine epidemic diarrhea virus (PEDV) as vaccines and mice were vaccinated for immune evaluation. Results showed that all three recombinant proteins enhanced proinflammatory response (IL-6 and TNF-α), cellular immunity, and PEDV-specific antibody response, when compared to the PEDV-alone group. In a virus neutralization test, all three recombinant proteins significantly enhanced the neutralization titer elicited by the PEDV vaccine. We conclude that despite differences in their sequences, conserved domains of flagellins from the three bacteria can activate TLR5 and may serve as vaccine adjuvants.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"313 ","pages":"Article 106393"},"PeriodicalIF":2.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro antibacterial activity of hemp (Cannabis sativa L.) extract seed oil against multidrug resistant bacterial pathogens in small animal veterinary dermatology","authors":"Valeria Toppi ,&nbsp;Mattia Pirolo ,&nbsp;Elisa Rampacci ,&nbsp;Gabriele Scattini ,&nbsp;Laura Musa ,&nbsp;Giorgia della Rocca ,&nbsp;Alessandra Di Salvo ,&nbsp;Marina De Benedetti ,&nbsp;Luca Guardabassi ,&nbsp;Patrizia Casagrande Proietti","doi":"10.1016/j.tvjl.2025.106392","DOIUrl":"10.1016/j.tvjl.2025.106392","url":null,"abstract":"<div><div>There is an urgent need for alternative antimicrobial therapies in veterinary small animal dermatology due to the limited therapeutic options available for treatment of infections caused by multidrug-resistant bacteria. This study aimed to evaluate the potential of hemp (<em>Cannabis sativa</em> L.) seed oil for topical treatment of localized infections of the skin, such as otitis externa. Antimicrobial activity was determined by broth microdilution using a strain collection of bacterial pathogens associated with skin infections, including <em>Staphylococcus pseudintermedius</em> (n = 120), <em>Staphylococcus aureus</em> (n = 48), and <em>Pseudomonas aeruginosa</em> (n = 26). Checkerboard dilution tests were used to assess the interaction of hemp seed oil with two antimicrobials used for management of otitis externa, gentamicin and enrofloxacin, while <em>in vitro</em> cytotoxicity was evaluated by the cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assay on mouse fibroblast cell line L929. Minimum inhibitory concentrations (MICs) in staphylococci (0.025–0.2 % v/v) were markedly lower than in <em>P. aeruginosa</em> (&gt;0.4 % v/v). Within <em>S. pseudintermedius</em>, methicillin-resistant strains displayed lower susceptibility compared to susceptible strains. Hemp seed oil showed synergy with gentamicin (Fractional Inhibitory Concentration Index &lt; 0.5), reducing the MIC of gentamicin-resistant <em>S. pseudintermedius</em> strains (≥16 µg/ml) below the clinical susceptibility breakpoint (≤4 µg/ml). No changes in cell viability were observed at concentrations below 2 % v/v. These findings suggest that hemp seed oil could be an effective and safe alternative or adjuvant to conventional antimicrobials for managing otitis externa and other skin focal infections caused by staphylococci, including methicillin-resistant strains.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"313 ","pages":"Article 106392"},"PeriodicalIF":2.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liraglutide as a novel therapeutic for overweight in canines: A clinical study","authors":"Burak Dik ,&nbsp;Durmuş Hatipoglu ,&nbsp;Oguzhan Kahraman ,&nbsp;Tugba Melike Parlak ,&nbsp;Zekeriya Safa Inanc ,&nbsp;Metin Celik ,&nbsp;Samed Damar","doi":"10.1016/j.tvjl.2025.106376","DOIUrl":"10.1016/j.tvjl.2025.106376","url":null,"abstract":"<div><h3>Background</h3><div>The overweight/obesity in dogs is defined as a condition of abnormal fat accumulation or, beyond that, a multifactorial condition involving excessive fat accumulation along with different factors (insufficient physical activity, genetics (breed), metabolism, the microbiome, etc.). Preclinical obesity conditions increases the risk of progressing to clinical obesity and developing obesity-associated diseases such as type 2 diabetes, cardiovascular disease, certain cancers, and mental disorders.</div></div><div><h3>Objectives</h3><div>This study aimed to determine the weight-loss effects of liraglutide in dogs that do not engage in sufficient exercise, are fed table scraps, and develop obesity owing to aging.</div></div><div><h3>Animals</h3><div>In this study, 21 senior Golden Retriever dogs were divided into three equal groups.</div></div><div><h3>Methods</h3><div>Group 1 was considered healthy and consisted of dogs within the range of ideal body live weight and body condition scores, and fed dry commercial dog food at the amount of their daily metabolizable energy requirements. Group 2 included seven senior dogs with obesity fed commercial dry food adjusted for their daily metabolizable energy requirements. Group 3 comprised seven senior dogs with obesity fed commercial dry food adjusted for their daily energy requirements and concurrently treated with subcutaneous liraglutide at a dose of 1.2 mg/dog. The trial lasted for 40 days.</div></div><div><h3>Results</h3><div>Liraglutide treatment resulted in a decrease in body condition score (BCS) and body weight by day 40, although the reduction in body weight (13.27 %) did not reach statistical significance. Liraglutide significantly lowered cholesterol and triglyceride levels, and appetite tests revealed a marked suppression of food intake over consecutive days in treated dogs.</div></div><div><h3>Conclusions and clinical importance</h3><div>Liraglutide treatment may offer a viable option for treating obesity in dogs, and could potentially be used as a new anti-obesity drug in canines. Future long-term and detailed trials of liraglutide in dogs with obesity could facilitate its effective use in the field.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"313 ","pages":"Article 106376"},"PeriodicalIF":2.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence and epidemiology of bovine coronavirus in cattle in Kazakhstan.","authors":"Yuliya V Perfilyeva, Andrey V Zhigailov, Angelina A Malysheva, Alena S Cherusheva, Karina R Ivanova, Zhanna A Berdygulova, Akerke O Bissenbay, Saltanat A Kuatbekova, Zhaniya M Dosmagambet, Anzhelika V Lushova, Sofiya A Kan, Artyom V Kuligin, Moldir M Kuatbek, Akzhigit S Mashzhan, Nurshat Abdolla, Dinara A Naizabayeva, Anna S Nizkorodova, Perizat B Akshalova, Kirpichenko V Vladimir, Aida M Abdybekova, Aralbek S Rsaliyev, Yergali O Abduraimov, Seidigapbar M Mamadaliyev, Yuriy A Skiba, Yekaterina O Ostapchuk","doi":"10.1016/j.tvjl.2025.106371","DOIUrl":"10.1016/j.tvjl.2025.106371","url":null,"abstract":"<p><p>Bovine coronavirus (BCoV) causes gastrointestinal and respiratory diseases in cattle, but its prevalence in Kazakhstan remains unknown. This nationwide cross-sectional study aimed to assess BCoV prevalence in cattle and to investigate its epidemiological characteristics. Between April and August 2024, serum, nasal and rectal swab samples were collected from 2237 clinically healthy cattle across 390 farms in 17 oblasts of Kazakhstan. None of the farm owners reported vaccinating against BCoV. Serum samples were tested for BCoV-specific antibodies using a commercially available ELISA, while nested RT-PCR assays were performed on pooled nasal and rectal swabs to detect BCoV RNA. Sequencing and phylogenetic analysis were performed following RT-PCR testing. A univariate GEE model was used to assess the risk factors and a multivariate model was employed to refine the discovered associations. The animal-level seroprevalence of BCoV was 88.2 % (95 % CI: 84.3 %-92.0 %), while the herd-level seroprevalence was 89.6 % (95 % CI: 85.4 %-92.9 %). The eastern region of Kazakhstan had the lowest seroprevalence compared to other regions. Seropositivity was not associated with age, sex or breed, but correlated with the proportion of cattle in backyards, cattle density and farm size. BCoV shedding was detected in 2.4 % (95 % CI: 1.4 5 % - 3.4 %) of sampled animals and in 7.8 % (95 %CI: 5.3 % - 11.0 %) of cattle operations across 12 oblasts. Phylogenetic analysis of the complete hemagglutinin/esterase and spike genes revealed that the Kazakhstani BCoV strains belonged to the GIIa group. This first report on BCoV in Kazakhstan confirms its endemic presence, highlighting the need for a national control program.</p>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":" ","pages":"106371"},"PeriodicalIF":2.3,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiotherapy treatment of musculo-tendinous disorders of the canine shoulder: A clinical study","authors":"Ilaria Arena ,&nbsp;Simona Valentini ,&nbsp;Linda Nundini ,&nbsp;Thomas Dalmonte ,&nbsp;Giuseppe Spinella","doi":"10.1016/j.tvjl.2025.106379","DOIUrl":"10.1016/j.tvjl.2025.106379","url":null,"abstract":"<div><div>In veterinary literature, pathologies affecting the shoulder region in dogs are increasingly described, particularly in dogs that practice high-impact sporting activities. Physiotherapy may represent a complementary and supportive treatment to surgery and conservative therapy; however, the supporting scientific evidence is still limited. This study aims to evaluate a multimodal physiotherapy protocol in 25 dogs suffering from shoulder pathologies, examining time and number of sessions required to gain lameness recovery and trying to identify which variables (age, sex, weight, degree of lameness, presence of osteoarthritis, modalities) are able to positively or negatively influence recovery times. Patients received treatment consisting mainly of laser therapy and ultrasound combined with muscle strengthening exercises, hydrotherapy and manual techniques. Data were submitted to a descriptive and statistical analysis to highlight the recovery times and the most important variables. The results showed a mean clinical recovery time of 50 ± 35 days (median: 35 days) with a number of sessions equal to 10 ± 3 sessions (median: 10 sessions). Age, the presence of osteoarthritis, association between Laser and ultrasound therapy and the initial severity of the lameness significantly influenced recovery times. The study highlights the importance of a multimodal physiotherapeutic approach and underlines the need to carry out further large-scale research to standardize treatments and evaluate the impact on return to sporting activity.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"313 ","pages":"Article 106379"},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-based analysis for the identification of candidate genes associated with skin-photosensitization tolerance in sheep","authors":"Slim Ben Jemaa ,&nbsp;Alberto Cesarani ,&nbsp;Elena Ciani ,&nbsp;Salvatore Mastrangelo","doi":"10.1016/j.tvjl.2025.106380","DOIUrl":"10.1016/j.tvjl.2025.106380","url":null,"abstract":"<div><div>In ruminant livestock, skin photosensitization, caused by the ingestion of toxic plants, is relatively common and affects animal production. In this study, genotyping data from the Illumina OvineSNP50 BeadChip from two Italian local sheep breeds (Leccese and Altamurana) were used to identify putative genomic regions associated with response to skin photosensitization. We identified four genomic regions harbouring several candidate genes related to dermatitis, immune response, and coat color, that could be potentially involved in modulating photosensitization in sheep. These findings enhance our understanding of the genetic mechanisms underlying skin photosensitization in sheep and provide valuable insights into livestock adaptation to local environmental pressure.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"313 ","pages":"Article 106380"},"PeriodicalIF":2.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative and postoperative joint motion in chihuahuas with Grade III medial patellar luxation: A kinematic and goniometric analysis","authors":"Kannika Chayatup ,&nbsp;Chalika Wangdee ,&nbsp;Kumpanart Soontornvipart","doi":"10.1016/j.tvjl.2025.106369","DOIUrl":"10.1016/j.tvjl.2025.106369","url":null,"abstract":"<div><div>Medial patellar luxation (MPL) is a common orthopaedic disorder in dogs, resulting in stifle instability and altered pelvic limb biomechanics. While its effects on stifle function have been extensively documented, the influence on adjacent joints and the course of biomechanical recovery following surgical correction remain poorly characterized. This study aimed to evaluate active (AROM) and passive (PROM) range of motion in the stifle, hip, and tarsal joints of Chihuahuas with Grade III MPL using two-dimensional kinematic and goniometric analyses. Seventeen client-owned Chihuahuas were enrolled, comprising ten MPL-affected dogs and seven clinically healthy controls. MPL dogs underwent surgical correction, and joint motion assessments were performed preoperatively and at 2, 4, 6, and 8 weeks postoperatively. Significant reductions in stifle AROM and PROM, particularly in extension, were observed in the MPL group compared to controls, indicating functional impairment. Compensatory increases in hip and tarsal AROM were also detected preoperatively, suggesting biomechanical adaptation. Following surgery, stifle AROM progressively improved and approached control values by week 8, whereas stifle PROM remained consistently reduced. Temporal changes in hip and tarsal AROM suggested early compensatory adaptations, which gradually resolved as stifle function improved. However, persistent stifle PROM limitations underscore the need for early, targeted rehabilitation. A multimodal strategy addressing both primary joint dysfunction and compensatory changes is essential to optimize recovery. Baseline joint motion data may serve as valuable benchmarks for evaluating surgical outcomes and guiding individualized postoperative care.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"313 ","pages":"Article 106369"},"PeriodicalIF":2.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial dispensing for common conditions in dogs and cats at a large veterinary practice network, 2023","authors":"J.Scott Weese ,&nbsp;Morgan E. Taylor-Rakocevic ,&nbsp;Kseniya Topdjian ,&nbsp;Ian Battersby","doi":"10.1016/j.tvjl.2025.106374","DOIUrl":"10.1016/j.tvjl.2025.106374","url":null,"abstract":"<div><div>Understanding antimicrobial use is a core component of antimicrobial stewardship. This study aimed to assess antimicrobial dispensing for common clinical conditions in dogs and cats presented to veterinary clinics belonging to a large clinic network in the USA. Antimicrobials were prescribed for 831,017 patient visits, to 702,576 (85 %) dogs and 128,441 (15 %) cats. Cefpodoxime (n = 203,145, 29 %), amoxicillin-clavulanate (154,779, 22 %) and metronidazole (150,830, 21 %) were the most commonly dispensed antimicrobials in dogs, while cefovecin (55,579, 43 %) and amoxicillin-clavulanate (44,857, 35 %) predominated in cats. In dogs, drugs classified by the WHO MIA List as highest priority critically important (HPCIA) accounted for 39 % of drugs dispensed, while those classified as highly important (HIA) accounted for 61 %. In cats, HPCIA drugs accounted for 46 % of drugs dispensed while HIA drugs accounted for 54 %. Consistency of drug selection with selected treatment guidelines was 76 % (30,562/40,375) for dogs and 57 % (12,810/22,644) for cats. There were regional differences in drug selection patterns for all of the 10 most common diseases, for both dogs and cats. While no single metric or data source provides a full understanding of antimicrobial use, these data provide the foundation for assessment of antimicrobial use practices and provide insight and baseline data for development of interventions to improve antimicrobial use practices.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"312 ","pages":"Article 106374"},"PeriodicalIF":2.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}