Veterinary journal最新文献

{"title":"Antimicrobial dispensing for common conditions in dogs and cats at a large veterinary practice network, 2023","authors":"J.Scott Weese ,&nbsp;Morgan E. Taylor-Rakocevic ,&nbsp;Kseniya Topdjian ,&nbsp;Ian Battersby","doi":"10.1016/j.tvjl.2025.106374","DOIUrl":"10.1016/j.tvjl.2025.106374","url":null,"abstract":"<div><div>Understanding antimicrobial use is a core component of antimicrobial stewardship. This study aimed to assess antimicrobial dispensing for common clinical conditions in dogs and cats presented to veterinary clinics belonging to a large clinic network in the USA. Antimicrobials were prescribed for 831,017 patient visits, to 702,576 (85 %) dogs and 128,441 (15 %) cats. Cefpodoxime (n = 203,145, 29 %), amoxicillin-clavulanate (154,779, 22 %) and metronidazole (150,830, 21 %) were the most commonly dispensed antimicrobials in dogs, while cefovecin (55,579, 43 %) and amoxicillin-clavulanate (44,857, 35 %) predominated in cats. In dogs, drugs classified by the WHO MIA List as highest priority critically important (HPCIA) accounted for 39 % of drugs dispensed, while those classified as highly important (HIA) accounted for 61 %. In cats, HPCIA drugs accounted for 46 % of drugs dispensed while HIA drugs accounted for 54 %. Consistency of drug selection with selected treatment guidelines was 76 % (30,562/40,375) for dogs and 57 % (12,810/22,644) for cats. There were regional differences in drug selection patterns for all of the 10 most common diseases, for both dogs and cats. While no single metric or data source provides a full understanding of antimicrobial use, these data provide the foundation for assessment of antimicrobial use practices and provide insight and baseline data for development of interventions to improve antimicrobial use practices.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"312 ","pages":"Article 106374"},"PeriodicalIF":2.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective evaluation of the diagnosis of acetabular fracture in cattle and the outcome after conservative treatment","authors":"Robin Näf ,&nbsp;David Devaux ,&nbsp;Andrea Bischofberger ,&nbsp;Karl Nuss","doi":"10.1016/j.tvjl.2025.106375","DOIUrl":"10.1016/j.tvjl.2025.106375","url":null,"abstract":"<div><div>Acetabular fractures are rare in cattle, and their prognosis has generally been considered unfavourable. The goal of this retrospective study was to determine the diagnosis, treatment, and outcome in 36 cattle with 37 acetabular fractures presented to the Unit of Ruminant Surgery, University of Zurich Veterinary Hospital, from January 2016 to November 2024. All cattle were female and mostly young (13 months, median age; range, 9 – 92 months). The median lameness score was 3/5 (range 1 – 5/5), and all cattle could stand. A diagnosis of acetabular fracture was based on clinical and radiographic findings. Adjunctive ultrasonography was used in 21 cases. Simple fractures were the most common and occurred in 25 cattle; one heifer had bilateral simple acetabular fractures with ischial involvement. Fractures with 1–2 additional fragments occurred in four cattle, and seven animals had comminuted fractures. Treatment consisted of stall rest for 3 months. Based on owner information, most cattle (31/36, 86.0 %) were sound after 3 months, and 34/36 (94.4 %) were free of lameness 6 months after admission. By the end of November 2024, most cattle (27/36) had calved at least once since admission to our clinic, and 24/25 cows (available information) had unassisted calvings. Twenty-one of the 36 cows were still productive at the end of the study. Based on our findings, the prognosis of acetabular fractures in cattle is favourable. Conservative treatment consisting of stall rest and pain management is straightforward, providing a good long-term outcome.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"313 ","pages":"Article 106375"},"PeriodicalIF":2.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Static respiratory compliance in anaesthetised and intubated brachycephalic dogs with and without brachycephalic obstructive airway syndrome","authors":"Matilda Fitzmaurice ,&nbsp;Chiara Adami ,&nbsp;Jane Ladlow ,&nbsp;Francesca Tomlinson ,&nbsp;Claudia Gittel","doi":"10.1016/j.tvjl.2025.106372","DOIUrl":"10.1016/j.tvjl.2025.106372","url":null,"abstract":"<div><div>The impact of brachycephalic obstructive airway syndrome in dogs (BOAS) on respiratory mechanics is unclear and may affect the choice of ventilation strategies during anaesthesia. This prospective study included 56 client-owned brachycephalic dogs, allocated to be BOAS (<em>n</em> = 26) or non-BOAS dogs (<em>n</em> = 30) based on functional grading. All dogs were anaesthetised using a standardised anaesthetic protocol. Pressure-controlled ventilation was initiated around 30 min post-induction, maintaining peak inspiratory pressure at 7–12 cm H₂O. Static respiratory compliance (Cstat) was recorded at predetermined time points in sternal, right and left lateral recumbency. Thorax dimensions were assessed with a tape measure. Body surface area (BSA) was calculated and the ratio Cstat/BSA used as the main outcome variable. Comparison of means/medians, analysis of proportions, the Spearman correlation coefficient and both logistic and linear regression were used for data analysis. P &lt; 0.05 was considered statistically significant. Non-BOAS dogs showed significantly higher Cstat/BSA compared to BOAS dogs in sternal (41.6 (31.1–51.8) vs. 32.9 (24.4 – 39.2), respectively, P = 0.028), right lateral (36.2 (25.7 – 46.4) vs. 27.0 (22.7 – 35.6); P = 0.026) and left lateral (33.6 (22.6 – 45.5) vs. 24.6 (18.4 – 32.2); P = 0.020) recumbencies. For all dogs, the Cstat/BSA ratio was higher in sternal compared to lateral recumbencies. BOAS dogs had a significantly shorter distance between thoracic inlet and last rib compared to non-BOAS dogs (20 ± 4 vs. 23 ± 6 cm, respectively; P = 0.043). Reduced respiratory compliance in BOAS-affected dogs should be considered during mechanical ventilation.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"312 ","pages":"Article 106372"},"PeriodicalIF":2.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and classification of tooth resorption in small-breed dogs: A retrospective study using full-mouth intraoral radiographs","authors":"Jinhee Bae,&nbsp;Se Eun Kim,&nbsp;Kangmoon Seo","doi":"10.1016/j.tvjl.2025.106377","DOIUrl":"10.1016/j.tvjl.2025.106377","url":null,"abstract":"<div><div>Tooth resorption (TR) is a clinically significant dental condition in dogs; however, its classification and prevalence, particularly in small breeds, remain understudied despite its impact on quality of life. This retrospective study aimed to assess and classify the types of TR in small-breed dogs and investigate associations between TR and factors such as sex, skull type, body weight, number of missing teeth, TR type, breed, and age. Dental radiographs of 248 dogs weighing less than 15 kg, examined over a three-year period, were included in this study. Statistical analyses were performed to investigate the associations between the examined variables and TR. The most common type of resorption was external replacement resorption (ERR), followed by external inflammatory resorption (EIR). Significant associations were found among age, number of missing teeth, and total TR (<em>p</em> &lt; 0.01). In addition, the prevalence of ERR and EIR increased with age (<em>p</em> &lt; 0.01). The rate of TR was significantly higher in premolars than in incisors, canines, and molars (<em>p</em> &lt; 0.001). Maltese dogs showed a significantly higher prevalence of TR (<em>p</em> &lt; 0.05), particularly ERR (<em>p</em> &lt; 0.05), than other breeds. The TR rate increased significantly in dogs aged 9–11 years, 12–15 years, and over 15 years. Given the high prevalence of TR in older small-breed dogs, particularly in premolars and breeds such as Maltese, clinicians should exercise caution during tooth extraction. Thorough radiographic evaluation is recommended to accurately assess the extent of resorption, especially in older dogs and predisposed breeds.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"313 ","pages":"Article 106377"},"PeriodicalIF":2.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of circulating microRNAs in plasma from horses with non-strangulating intestinal infarction and idiopathic peritonitis","authors":"Katrine Toft ,&nbsp;Maibritt Mardahl ,&nbsp;Ylva Hedberg-Alm ,&nbsp;Karin Anlén ,&nbsp;Eva Tydén ,&nbsp;Martin K. Nielsen ,&nbsp;Marie Louise Honoré ,&nbsp;Bastian Fromm ,&nbsp;Lise N. Nielsen ,&nbsp;Peter Nejsum ,&nbsp;Stig Milan Thamsborg ,&nbsp;Susanna Cirera ,&nbsp;Tina Holberg Pihl","doi":"10.1016/j.tvjl.2025.106378","DOIUrl":"10.1016/j.tvjl.2025.106378","url":null,"abstract":"<div><div>Non-strangulating intestinal infarctions (NSII) associated with <em>Strongylus vulgaris</em> infection and idiopathic peritonitis (IP) share similar clinical presentation but require different treatment approaches. Horses with NSII need surgical intervention, while idiopathic peritonitis cases can be successfully treated with antimicrobials. A correct diagnosis is thus crucial, but because the two diseases overlap in clinicopathological features, differentiation is difficult in clinical practice. MicroRNAs (miRNAs) are non-coding RNAs that exhibit measurable changes in abundance in tissues and circulation during disease. This study aimed to explore differences in plasma miRNA abundance between patients with NSII and IP. Plasma samples were collected from 43 horses, consisting of 21 with NSII and 22 with IP. A subset (n = 12) was submitted for deep small RNA sequencing to identify miRNAs differing between the groups. Next, a panel of nine miRNAs (two were potential normalizers) were selected for evaluation and confirmation by reverse transcription quantitative real-time PCR (RT-qPCR). Small RNA sequencing detected 628 miRNAs in the blood samples, but no miRNAs were differentially abundant between the disease groups. This finding was confirmed by qPCR. In agreement with previous studies, the top abundant miRNAs in both groups included Eca-Mir-122–5p and Eca-Mir-486–5p, as well as Eca-Mir-223–3p, which has previously been associated with inflammation. Target prediction for the most abundant miRNAs additionally predicted targets in inflammatory pathways. Evaluation of clinicopathological parameters revealed differences between the groups in two measures (white blood cell count and blood neutrophil count), which aligns with findings from previous studies. The results demonstrate that NSII and IP elicit similar miRNA profiles in plasma and are characterized by systemic inflammation.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"313 ","pages":"Article 106378"},"PeriodicalIF":2.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary lipid production in dogs with urothelial carcinoma","authors":"Akane Hayashi ,&nbsp;Shingo Maeda ,&nbsp;Arisa Yamazaki ,&nbsp;Tatsuro Nakamura ,&nbsp;Yuko Goto-Koshino ,&nbsp;Tomohiro Yonezawa ,&nbsp;Koji Kobayashi ,&nbsp;Takahisa Murata","doi":"10.1016/j.tvjl.2025.106373","DOIUrl":"10.1016/j.tvjl.2025.106373","url":null,"abstract":"<div><div>Canine urothelial carcinoma (cUC) is a prevalent and aggressive malignancy in dogs. Current treatments have limited effectiveness, and delays in diagnosis are often a concern. cUC is unique in that it shows high responsiveness to cyclooxygenase (COX) inhibitors and has a high frequency of a single nucleotide mutation in <em>BRAF</em>, known as <em>BRAF</em>^{<em>V595E</em>}. COX is one of the key enzymes involved in the production of lipid mediators, which regulate the progression of various diseases. Although studies have revealed the roles of COX in cUC, the production profiles of lipid mediators remain unknown. In this study, we comprehensively measured the urinary lipid mediator levels of cUC dogs using liquid chromatography-tandem mass spectrometry. We found that lipid production was altered in cUC, with increased amounts of several COX-catalyzed lipids, including prostaglandin E₂ and thromboxane B₂, and several lipoxygenase-catalyzed lipids, including leukotriene E₄. Additionally, we found that the <em>BRAF</em>^{<em>V595E</em>} mutation tended to increase the levels of most enzymatically produced lipids. Our results provide insights into novel therapeutic and diagnostic strategies for cUC and cancers with <em>BRAF</em> mutations.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"313 ","pages":"Article 106373"},"PeriodicalIF":2.3,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of prepartum clostridial vaccine administration with mitigation of respiratory and gastrointestinal disorders in calves","authors":"Shin Nakayama ,&nbsp;Daiki Aomori ,&nbsp;Fumika Mune ,&nbsp;Hiroaki Sato ,&nbsp;Osamu Nishino ,&nbsp;Shinichi Tose","doi":"10.1016/j.tvjl.2025.106368","DOIUrl":"10.1016/j.tvjl.2025.106368","url":null,"abstract":"<div><div>Pathogenic clostridial infections, particularly those involving <em>Clostridium perfringens</em> type A (CpA)-derived alpha-toxin (CpA-α), are a recognized cause of gastrointestinal disorders in young ruminants. However, the potential role of anti-clostridial antibodies in mitigating not only gastrointestinal but also respiratory disorders in calves remains poorly investigated under field conditions. This study evaluated the effects of anti-clostridial antibodies passively transferred from cows vaccinated with a clostridial vaccine (CV) during the prepartum period on gastrointestinal and respiratory disorders in nursing calves. Cows in the CV group were vaccinated at 8 and 4 weeks before parturition, whereas control cows were not. Colostrum intake was verified in calves from both groups. Serum antibody titers against clostridial and bovine respiratory disease (BRD) pathogens were measured. Treatment frequency and fecal consistency were also recorded. Anti-clostridial antibody titers were higher in CV cows and their calves compared to the control group. In the CV group, the number of respiratory treatments in calves showed a decreasing trend from 5 to 8 weeks of age and was significantly lower from 9 to 12 weeks of age. Fecal consistency at 1 week of age was also significantly improved in the CV group. The number of respiratory treatments was negatively correlated with anti-CpA-α antibody titers in calves, but not with anti-BRD titers. These findings suggest that prepartum CV vaccination may help mitigate both respiratory and gastrointestinal disorders in nursing calves, potentially reducing antibiotic use and lowering the risk of antimicrobial resistance in livestock industry.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"313 ","pages":"Article 106368"},"PeriodicalIF":2.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inducing and measuring positive affective state in domesticated equines: A Delphi consultation","authors":"Loni Loftus ,&nbsp;Lucy Asher ,&nbsp;Matthew Leach","doi":"10.1016/j.tvjl.2025.106370","DOIUrl":"10.1016/j.tvjl.2025.106370","url":null,"abstract":"<div><div>Over the last twenty years the definition of good animal welfare has advanced from the ‘absence of negative welfare states’ to the aim of identifying the presence of positive welfare states; however, research on positive animal welfare is relatively new. Consequently, through expert consultation, this study aimed to synthesise knowledge regarding domesticated equine emotional state, specifically methods to induce and measure positive affective states, which could be of significant benefit to equine welfare across sectors. A Delphi consultation of experts in the field of equine behaviour, welfare and affective state was undertaken to derive consensus agreement on definitions used when considering positive affective state in equines and methods suitable for inducing and measuring these states within experimental investigations. Ninety-three international experts participated in a robust three-round Delphi consultation with data gathered analysed qualitatively (thematic analysis) and quantitatively (ranking data, consensus benchmarks and Content Validity Index (CVI) / Content Validity Ratio (CVR) analyses). Retention rates were high (78 %), and consensus (minimum 70 % agreement) was reached within Round three of the consultation. Nineteen methods for inducing positive affect reached consensus (provision of high value food, an affiliative companion and a substrate to roll in where the highest ranked), and twelve behavioural (assessment of body language, facial actions and horse-horse interactions were ranked highest) and three physiological (evaluation of heart rate, heart rate variability and respiratory rate) variables for measuring positive affect also reached consensus. This consultation highlights several important considerations surrounding the induction and measurement of positive affective state in equines, including consideration of the individual’s personality and individual preference within any measures of affective state. We therefore recommend that establishing individual preference should be a prerequisite of research into positive affective states. It is anticipated that the results of this study can be used to provide new direction for research on positive affective states by providing expert agreed methods and measures for policy and practice through expert agreed approaches to induce positive affect in horses.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"312 ","pages":"Article 106370"},"PeriodicalIF":2.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra and postoperative effects of adding detomidine to a lidocaine paravertebral anaesthesia in cows undergoing standing abomasum displacement surgery","authors":"O. d’Anselme ,&nbsp;A. Hartnack ,&nbsp;O. Bühlmann ,&nbsp;P.R. Torgerson ,&nbsp;E. Kolp ,&nbsp;S.K. Ringer","doi":"10.1016/j.tvjl.2025.106364","DOIUrl":"10.1016/j.tvjl.2025.106364","url":null,"abstract":"<div><div>This study investigated the benefits of adding detomidine to a lidocaine proximal paravertebral nerve block (PPNB) for standing laparotomy in cattle. Forty adult cows undergoing surgery for abomasal displacement were randomly assigned to receive a PPNB with lidocaine (LIDO: 40 ml 2 % lidocaine per injection site) or lidocaine-detomidine (LIDO-DETO: lidocaine + 5 μg/kg detomidine equally distributed to the lidocaine syringes). The PPNB was done at T13, L1 and L2 vertebra, always by the same investigator using a blind technique. Intraoperative sedation score, pain score, heart (HR) and respiratory rate (RR) were recorded before PPNB and repeatedly after (5, 10, 15 min, then every 15 min) by a blinded observer (ODA). Rescue analgesia (local lidocaine infiltration) was applied based on the blinded surgeon’s decision. Quality of anaesthesia was also assessed by the surgeons using a visual analogue scale (VAS) at the end of the intervention. Postoperative pain was evaluated (ODA) using the Zürich Composite Measure Pain Scale (ZCMPS) and mechanical nociceptive threshold (MNT) testing at 0, 2, 6, 12, and 24 hours. Surgery was completed in all cows, though two (LIDO-DETO) went into sternal recumbency. LIDO-DETO resulted in superior VAS (P &lt; 0.001), higher sedation (P &lt; 0.001), lower pain scores (P = 0.001), and reduced RR (P = 0.015). Postoperatively, LIDO-DETO cows showed significantly lower ZCMPS (P = 0.048) and higher MNT on the wound's left side (P = 0.026). Adding detomidine to lidocaine PPNB improved intraoperative anaesthesia quality with potential postoperative analgesic benefits.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"311 ","pages":"Article 106364"},"PeriodicalIF":2.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, diagnosis, treatment outcomes and immunohistochemical characterization of neoplastic disorders in reptiles presented at a veterinary teaching hospital: A cross-sectional study (2010–2023)","authors":"F. Solanes-Vilanova,&nbsp;T. Hellebuyck,&nbsp;K. Chiers","doi":"10.1016/j.tvjl.2025.106366","DOIUrl":"10.1016/j.tvjl.2025.106366","url":null,"abstract":"<div><div>Neoplasms seem to be increasingly encountered in reptile medicine. The present study investigated the prevalence, diagnosis, treatment outcome and immunohistochemical characterization of neoplasms diagnosed in reptile patients presented at a veterinary teaching hospital between 2010 and 2023. In this cross-sectional study, we analyzed the clinical records of 12383 reptiles (2549 snakes, 3386 lizards, and 6448 chelonians). Within the study population, 7261 reptiles showed clinical signs and in 130 of these cases, a histological diagnosis of neoplasm was made. A total of 134 neoplasms were identified in 27 out of 3270 chelonians (0.83 %), 63 out of 2395 lizards (2.63 %), and 40 out of 1596 snakes (2.51 %). While dermal neoplasms (n = 59; 44 %) such as squamous and basal cell carcinoma, were the most common neoplasms in lizards and chelonians, snakes were most frequently diagnosed with alimentary tract neoplasms (n = 35; 26.1 %), particularly tubular adenocarcinomas. Integumentary, reproductive and oral neoplasms carried a good prognosis following complete surgical removal, in contrast to most other neoplasms, particularly those with malignant, multicentric, or metastatic features. The results of this study elucidate the diversity of neoplastic disorders that can be encountered in reptiles within a clinical setting. In addition, similarities and differences with previously published retrospective studies originating from specialty diagnostic services and species-specific predispositions were investigated. Although histological evaluation allowed the characterization and classification of a large number of the observed neoplasms, the application of appropriate immunohistochemical protocols was indispensable towards accurate identification of several neoplasms, particularly neoplasms originating from the hematopoietic system and soft tissue sarcomas.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"312 ","pages":"Article 106366"},"PeriodicalIF":2.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}