Virus research最新文献_第7页

High-throughput screening for respiratory pathogens within pigs in Denmark; analysis of circulating porcine respiratory coronaviruses and their association with other pathogens 高通量筛查丹麦猪体内的呼吸道病原体；分析循环猪呼吸道冠状病毒及其与其他病原体的关联。

IF 2.5 4区医学

Virus research Pub Date : 2024-11-26 DOI: 10.1016/j.virusres.2024.199501

Amalie Ehlers Bedsted , Nicole B. Goecke , Charlotte K. Hjulsager , Pia Ryt-Hansen , Kasama Chusang Larsen , Thomas Bruun Rasmussen , Anette Bøtner , Lars E. Larsen , Graham J. Belsham

{"title":"High-throughput screening for respiratory pathogens within pigs in Denmark; analysis of circulating porcine respiratory coronaviruses and their association with other pathogens","authors":"Amalie Ehlers Bedsted , Nicole B. Goecke , Charlotte K. Hjulsager , Pia Ryt-Hansen , Kasama Chusang Larsen , Thomas Bruun Rasmussen , Anette Bøtner , Lars E. Larsen , Graham J. Belsham","doi":"10.1016/j.virusres.2024.199501","DOIUrl":"10.1016/j.virusres.2024.199501","url":null,"abstract":"<div><div>Porcine respiratory coronavirus (PRCV) typically causes subclinical or mild respiratory infections in pigs, but may lead to more severe disease with other factors. PRCV infection in Denmark was initially detected in 1984, but data are lacking about its current prevalence and diversity. Antibodies against PRCV were detected in about 75 % of recent pig sera from Denmark. In addition, pig nasal swab samples were screened for PRCV and 12 other respiratory pathogens using a high-throughput RT-qPCR system. All targeted pathogens were detected but at different prevalences. Significant associations were found between the presence of PRCV and certain other pathogens. From PRCV positive samples, partial spike gene sequences and complete nucleocapsid coding sequences were determined. In phylogenetic analyses, these PRCVs clustered with earlier European PRCVs and were distinct from transmissible gastroenteritis virus. We conclude that PRCV is widespread within the pig population in Denmark. Further studies on the significance of PRCV are warranted.</div></div>","PeriodicalId":23483,"journal":{"name":"Virus research","volume":"350 ","pages":"Article 199501"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dominance of dengue virus serotype-2 in Pakistan (2023–2024): Molecular characterization of the envelope gene and exploration of antiviral targets 巴基斯坦登革热病毒血清型-2 的优势（2023-2024 年）：包膜基因的分子特征和抗病毒目标的探索。

IF 2.5 4区医学

Virus research Pub Date : 2024-11-23 DOI: 10.1016/j.virusres.2024.199497

Haidar Ali , Iffat Saleem , Muhammad Saad Ahmed , Deeba Amraiz , Imran Shahid , Eman A. Al-Shahari , Jing Yang , Liaqat Ali

{"title":"Dominance of dengue virus serotype-2 in Pakistan (2023–2024): Molecular characterization of the envelope gene and exploration of antiviral targets","authors":"Haidar Ali , Iffat Saleem , Muhammad Saad Ahmed , Deeba Amraiz , Imran Shahid , Eman A. Al-Shahari , Jing Yang , Liaqat Ali","doi":"10.1016/j.virusres.2024.199497","DOIUrl":"10.1016/j.virusres.2024.199497","url":null,"abstract":"<div><div>Dengue virus infection, caused by a single positive-stranded RNA virus from the <em>Flaviviridae</em> family, represents a significant public health challenge in tropical and subtropical regions. This virus has four serotypes (DENV-1, 2, 3, and 4), primarily transmitted by Aedes mosquitoes. Despite extensive research, effective antiviral treatments and vaccines remain elusive due to the viral diversity and the complex mechanisms such as antibody-dependent enhancement (ADE). In the current study, NS1-positive serum samples from dengue cases in Pakistan (2023–2024), were analyzed to determine the predominant serotype and characterize the envelope (E) gene for further exploration of antiviral targets. Out of 100 samples, 63 (63%) tested positive for DENV-2, indicating its predominance during this period, while two samples showed mixed infections with DENV-2 and DENV-3. The envelope gene was successfully amplified using nested PCR, validated through gel electrophoresis and sanger sequencing. Phylogenetic analysis revealed high similarity of the DENV-2 isolates to strains from China and India. Computational modeling of the envelope protein structure identified potential antiviral binding sites and further molecular docking studies suggested that specific antiviral compounds like Arbidol and Quercetin can inhibit early steps in viral infection. Additionally, BepiPred-3.0 predicted several B-cell epitopes, which could be useful for vaccine development. These findings enhance our understanding of dengue epidemiology in Pakistan and contribute to the development of targeted antiviral therapies, potentially informing future vaccination strategies and outbreak management.</div></div>","PeriodicalId":23483,"journal":{"name":"Virus research","volume":"350 ","pages":"Article 199497"},"PeriodicalIF":2.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive transcriptomic analysis identifies cholesterol transport pathway as a therapeutic target of porcine epidemic diarrhea coronavirus 综合转录组分析发现胆固醇转运途径是猪流行性腹泻冠状病毒的治疗靶点

IF 2.5 4区医学

Virus research Pub Date : 2024-11-23 DOI: 10.1016/j.virusres.2024.199502

Lilei Lv , Huaye Luo , Min Zhang , Chuntao Wu , Yifeng Jiang , Wu Tong , Guoxin Li , Yanjun Zhou , Yanhua Li , Zhao Wang , Changlong Liu

{"title":"Comprehensive transcriptomic analysis identifies cholesterol transport pathway as a therapeutic target of porcine epidemic diarrhea coronavirus","authors":"Lilei Lv , Huaye Luo , Min Zhang , Chuntao Wu , Yifeng Jiang , Wu Tong , Guoxin Li , Yanjun Zhou , Yanhua Li , Zhao Wang , Changlong Liu","doi":"10.1016/j.virusres.2024.199502","DOIUrl":"10.1016/j.virusres.2024.199502","url":null,"abstract":"<div><div>Porcine epidemic diarrhea virus (PEDV) is a highly contagious virus that poses a serious threat to the global pig industry. Despite extensive efforts, the mechanism underlying virus entry for PEDV remains elusive. In this study, we first identified PEDV-susceptible and non-susceptible cell lines by using PEDV spike pseudotyped vesicular stomatitis virus. Subsequently, we conducted a comprehensive transcriptomic analysis on these cell lines. Through integrating differential expression gene analysis with weighted gene co-expression network analysis, we identified the key pathways that are correlated with the PEDV entry. Our analysis revealed a strong correlation between cholesterol, sterols, and lipid transport with PEDV entry, suggesting a potential role for cholesterol transport in the PEDV entry. For further investigation, we treated Huh7, Vero and LLC-PK1 cells with a cholesterol transport inhibitor, ezetimibe, and observed a significant inhibition of PEDV entry and subsequent viral replication in these cells. Interestingly, pre-treating Huh7 cells with ezetimibe resulted in an increase in the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome coronavirus (MERS-CoV) pseudoviruses. Moreover, we found that cholesterol could facilitate the entry of PEDV into Huh7 and Vero cells, and this promoting effect can be blocked by ezetimibe. These findings suggest that targeting cholesterol transport specifically inhibits PEDV entry into susceptible cells. Our study offers novel insights into the mechanism of PEDV entry and the development of new therapeutic strategies against this economically important virus.</div></div>","PeriodicalId":23483,"journal":{"name":"Virus research","volume":"350 ","pages":"Article 199502"},"PeriodicalIF":2.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence of Zika virus circulation in human and livestock in Chad 寨卡病毒在乍得人和牲畜中传播的证据。

IF 2.5 4区医学

Virus research Pub Date : 2024-11-20 DOI: 10.1016/j.virusres.2024.199492

François Chable de la Héronnière , Jonathan Barthelemy , Guy R Takoudjou Dzomo , Fatima Abdelrazakh , Oumaima Djarma , Lucas Auguste , Abderrazzack A Fouda , Chatté Adawaye , Laurent Andreoletti , Mahamat Fayiz Abakar , Yannick Simonin , Sara Salinas , Franck JD Mennechet

{"title":"Evidence of Zika virus circulation in human and livestock in Chad","authors":"François Chable de la Héronnière , Jonathan Barthelemy , Guy R Takoudjou Dzomo , Fatima Abdelrazakh , Oumaima Djarma , Lucas Auguste , Abderrazzack A Fouda , Chatté Adawaye , Laurent Andreoletti , Mahamat Fayiz Abakar , Yannick Simonin , Sara Salinas , Franck JD Mennechet","doi":"10.1016/j.virusres.2024.199492","DOIUrl":"10.1016/j.virusres.2024.199492","url":null,"abstract":"<div><div>Zika virus (ZIKV) is a major public health problem worldwide. After several reported outbreaks, the current extent of infections caused by this orthoflavivirus in the Sahel remains to be explored. We investigated the prevalence of neutralizing antibodies against ZIKV in the general population, in HIV-infected individuals and in livestock in Chad using a seroneutralization assay that ensures high specificity level. In this retrospective serological serosurveillance investigation, we estimated the neutralizing seroprevalence to be approximately 26 % (18/69) in healthy Chadian participants and 17 % (16/94) in HIV-infected individuals, with no statistical difference between these two subgroups or genders. In addition, we found an overall ZIKV prevalence of 14 % (8/59) in small ruminants (sheep and goats) living in the Lake Chad Basin area, demonstrating virus circulation in animals. Our pilot study shows for the first-time evidence of ZIKV circulation in humans and in livestock in Chad in close interaction with humans, and highlights the main challenges associated with this virus in Sahelian areas.</div></div>","PeriodicalId":23483,"journal":{"name":"Virus research","volume":"350 ","pages":"Article 199492"},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Replication and adaptation of avian infectious bronchitis viruses in pheasants (Phasianus colchicus) 雉鸡（Phasianus colchicus）中禽传染性支气管炎病毒的复制和适应。

IF 2.5 4区医学

Virus research Pub Date : 2024-11-20 DOI: 10.1016/j.virusres.2024.199495

Zongxi Han, Xiaochen Xu, Huixin Li, Shengwang Liu

{"title":"Replication and adaptation of avian infectious bronchitis viruses in pheasants (Phasianus colchicus)","authors":"Zongxi Han, Xiaochen Xu, Huixin Li, Shengwang Liu","doi":"10.1016/j.virusres.2024.199495","DOIUrl":"10.1016/j.virusres.2024.199495","url":null,"abstract":"<div><div>Infectious bronchitis virus (IBV) does not only cause disease in millions of chickens worldwide, but IBV-like viruses have also been detected or isolated from other domestic birds. We propose that the pheasant coronavirus (PhCoV) originates from IBV. Indeed, the IBV strains H120 and M41 can replicate but do not cause disease in pheasants. In this study, we found that three chicken nephropathogenic IBV strains, including ck/CH/LDL/091,021, ck/CH/LDL/140,520, and I0305/19, and the viruses recovered from the tissues of pheasants challenged with each IBV strain could replicate in some challenged pheasants with different capacities but could not cause disease. Overall, these viruses showed different capacities of replication and adaptation in pheasants, and the neutralizing antibody against each IBV strain could be detected in different numbers of pheasants challenged with each of the viruses, although the titers were generally low with large variation. Comparatively, ck/CH/LDL/140,520 and 20/P1-D5/Tr1 showed higher adaptation capacities in pheasants. Furthermore, the three IBV strains gained an increased capacity for adaptation when they passed in pheasants once, especially strain ck/CH/LDL/140,520, which gained an increased capacity for adaptation and extended tissue tropism when it was passaged in pheasants. Similar to IBV in chicken, the subpopulations within the virus were selected when the virus replicated and was passaged in pheasants, and the accumulation of mutations and deletions in the genome of each virus subpopulation accounted for the independent evolution of the virus in different tissues of pheasants. Taken together, we suggest that the phCoVs might originate from IBV through interspecies transmission from chickens to pheasants, before gaining increased tissue tropism, adaptation capacities, and disease-causing behaviors in pheasants during intraspecies transmission.</div></div>","PeriodicalId":23483,"journal":{"name":"Virus research","volume":"350 ","pages":"Article 199495"},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ZFP36 Facilitates Senecavirus A (SVA) replication by inhibiting the production of type I interferon ZFP36 通过抑制 I 型干扰素的产生促进塞内卡病毒 A (SVA) 的复制。

IF 2.5 4区医学

Virus research Pub Date : 2024-11-18 DOI: 10.1016/j.virusres.2024.199498

Mengge Yin , Lingyu Guan , Min Zhang , Xiangmin Li , Ping Qian

引用次数: 0

Molecular epidemiology and pathogenicity of Wesselsbron virus circulating in Africa 在非洲流行的韦塞尔斯布隆病毒的分子流行病学和致病性。

IF 2.5 4区医学

Virus research Pub Date : 2024-11-17 DOI: 10.1016/j.virusres.2024.199499

Martin Faye , Nicholas Di Paola , Moussa Dia , Amadou Alpha Sall , Ousmane Faye

{"title":"Molecular epidemiology and pathogenicity of Wesselsbron virus circulating in Africa","authors":"Martin Faye , Nicholas Di Paola , Moussa Dia , Amadou Alpha Sall , Ousmane Faye","doi":"10.1016/j.virusres.2024.199499","DOIUrl":"10.1016/j.virusres.2024.199499","url":null,"abstract":"<div><div>Wesselsbron is a neglected, mosquito-borne zoonotic disease transmitted by several species of virus-infected <em>Aedes</em> mosquitoes endemic to tropical regions in Africa. It affects primarily domestic livestock species with teratogenic effects, but can jump to humans. Herein, we investigated the molecular epidemiology of Wesselsbron virus in Africa using whole genome sequencing and structural analysis, and assessed its pathogenicity and tropism through <em>in vivo</em> experiments. A total of twenty-five isolates collected from three countries were successfully characterized. Our study is noteworthy by identifying, for the first time, inter-clade recombination events on the genome of Wesselsbron virus. However, more investigations on the precise molecular mechanisms conducting the occurrence of recombination on the genome of Wesselsbron virus, are warranted. The identification of polymorphisms on motifs of virulence and selection pressures on major proteins showed evidence of genetic evolution for Wesselsbron virus. The clade 1 was more pathogenic and neurotropic in suckling mice and the intramuscular route was found to be the best transmission mode. Our findings also provide new insights in the pathogenicity and tropism of Wesselsbron virus, which could be useful for prevention, preparedness and future outbreak response. Considering its high prevalence in mosquito populations and the increasing number of sporadic human cases, Wesselsbron virus merits more attention in terms of prevention and preparedness, as its mosquito vectors continue to globally expand and there is no vaccine.</div></div>","PeriodicalId":23483,"journal":{"name":"Virus research","volume":"350 ","pages":"Article 199499"},"PeriodicalIF":2.5,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiviral activity of cathelicidins against porcine epidemic diarrhea virus (PEDV): Mechanisms, and efficacy 白头翁素对猪流行性腹泻病毒（PEDV）的抗病毒活性：机制和功效。

IF 2.5 4区医学

Virus research Pub Date : 2024-11-15 DOI: 10.1016/j.virusres.2024.199496

Fatemeh Pashaie , Tabitha E. Hoornweg , Floris J. Bikker , Tineke Veenendaal , Femke Broere , Edwin J.A. Veldhuizen

{"title":"Antiviral activity of cathelicidins against porcine epidemic diarrhea virus (PEDV): Mechanisms, and efficacy","authors":"Fatemeh Pashaie , Tabitha E. Hoornweg , Floris J. Bikker , Tineke Veenendaal , Femke Broere , Edwin J.A. Veldhuizen","doi":"10.1016/j.virusres.2024.199496","DOIUrl":"10.1016/j.virusres.2024.199496","url":null,"abstract":"<div><div>Porcine epidemic diarrhea virus (PEDV) is a harmful coronavirus infecting pigs, which is resulting in substantial financial losses in the global pig industry. The lack of effective vaccines or treatments underscores the pressing need for new antiviral strategies. Antimicrobial peptides (AMPs), specifically cathelicidins such as LL-37, have demonstrated promising activity against a range of viruses. This study aims to elucidate the antiviral mechanisms of cathelicidins by examining their inhibitory capabilities against PEDV <em>in vitro</em>. Four pig-derived antimicrobial peptides (PMAP-36, PMAP-23, PR-39, and PG-1), together with chicken-derived CATH-B1 and human-derived LL-37 were analyzed for their anti-PEDV activity. Flow cytometry and fluorescent microscopy confirmed that LL-37 and CATH-B1 had strong inhibitory effects at non-toxic concentrations of 5 and 10 µM, significantly reducing GFP-PEDV infection of Vero cells both in co- and pre-incubation setups. In contrast, none of the porcine peptides exhibited any inhibitory effects, even at higher doses. Fluorogenic LL-37 was shown to enter VERO cells, indicative of a possible immunomodulatory antiviral mode of action. However, transmission electron microscopy clearly indicated that both LL-37 and CATH-B1 affected virus morphology and caused aggregation of viral particles, showing that peptide-virus interaction caused reduced virus infectivity. In conclusion, this analysis highlights the potential of LL-37 and CATH-B1 as inhibitors against PEDV, suggesting promising directions for innovative therapeutic antiviral strategies.</div></div>","PeriodicalId":23483,"journal":{"name":"Virus research","volume":"350 ","pages":"Article 199496"},"PeriodicalIF":2.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First description of a mobatvirus (Hantaviridae) in the Amazon region 首次描述亚马逊地区的一种暴风病毒（Hantaviridae）。

IF 2.5 4区医学

Virus research Pub Date : 2024-11-13 DOI: 10.1016/j.virusres.2024.199494

Leonardo Henrique Almeida Hernández , Thito Yan Bezerra da Paz , Sandro Patroca da Silva , Bruno de Cássio Veloso de Barros , Taciana Fernandes Sousa Barbosa Coelho , Ana Cecília Ribeiro Cruz

引用次数: 0

Characterization of two lytic bacteriophages infecting carbapenem-resistant clinical Klebsiella pneumoniae in Dhaka, Bangladesh 孟加拉国达卡感染耐碳青霉烯类临床肺炎克雷伯氏菌的两种致死性噬菌体的特征。

IF 2.5 4区医学

Virus research Pub Date : 2024-11-09 DOI: 10.1016/j.virusres.2024.199491

Nishat Tasnim Ananna , Tushar Ahmed Shishir , Akash Ahmed , Syed Muktadir Al Sium , Md Salman Shakil , Fahim Kabir Monjurul Haque , Md Hasanuzzaman

{"title":"Characterization of two lytic bacteriophages infecting carbapenem-resistant clinical Klebsiella pneumoniae in Dhaka, Bangladesh","authors":"Nishat Tasnim Ananna , Tushar Ahmed Shishir , Akash Ahmed , Syed Muktadir Al Sium , Md Salman Shakil , Fahim Kabir Monjurul Haque , Md Hasanuzzaman","doi":"10.1016/j.virusres.2024.199491","DOIUrl":"10.1016/j.virusres.2024.199491","url":null,"abstract":"<div><div>Bacteriophages or bacteria infecting viruses are genetically diverse. Due to the emergence of antimicrobial-resistant bacteria, lytic bacteriophages are gaining enormous attention for treating superbug infections. <em>Klebsiella pneumoniae</em> is one of the eight most significant nosocomial pathogens and is addressed as a critical priority pathogen by WHO, requiring alternative treatment options. We reported two highly lytic bacteriophages, <em>Klebsiella</em> phage Kpn BM7 and the novel <em>Klebsiella</em> phage Kpn BU9, isolated from hospital wastewater and exhibiting lytic activity against different clinical isolates. Whole-genome analysis revealed that phages BM7 and BU9 belong to class Caudoviricetes. Phage BM7, with a genome length of 170,558 bp, is a member of the genus <em>Marfavirus</em> and the species <em>Marfavirus F48</em>. While phage BU9, with a genome length of 60,450 bp, remains unclassified. Neither phage harbors any lysogenic, toxin, or antimicrobial resistance genes. Both phages can steadily survive up to 40 °C and at pH 5–7. The optimal MOI was 0.1 for BM7 and 1 for BU9, with short latent periods of 10 and 25 min and burst sizes of 85 PFU/cell and 12 PFU/cell, respectively. This is the first carbapenem-resistant <em>K. pneumoniae</em> targeting lytic phages to be reported from Bangladesh. This study suggests that BM7 and BU9 are potential candidates for targeting carbapenem-resistant <em>K. pneumoniae.</em></div></div>","PeriodicalId":23483,"journal":{"name":"Virus research","volume":"350 ","pages":"Article 199491"},"PeriodicalIF":2.5,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0