Ultrastructural Pathology最新文献_第7页

Unveiling renal pathology's potential: exploring a rare subtype of amyloid - apolipoprotein CII amyloidosis in the youngest patient: a case report and literature review. 揭示肾脏病理学的潜力：探索一种罕见的淀粉样蛋白亚型--最年轻患者的载脂蛋白CII淀粉样变性：病例报告和文献综述。

IF 1.1 4区医学

Ultrastructural Pathology Pub Date : 2024-07-03 Epub Date: 2024-05-20 DOI: 10.1080/01913123.2024.2353397

Yiqin Zuo, Fiona Hanly, Duo Li, Efren Chavez, Omar Aljuboori, Gabriel Contreras, Guillermo A Herrera

引用次数: 0

Effect of peripheral blood mononuclear cells on ischemia-reperfusion injury of sciatic nerve of adult male albino rat: histological, immunohistochemical, and ultrastructural study. 外周血单核细胞对成年雄性白化大鼠坐骨神经缺血再灌注损伤的影响：组织学、免疫组织化学和超微结构研究。

IF 1 4区医学

Ultrastructural Pathology Pub Date : 2024-05-03 Epub Date: 2024-02-29 DOI: 10.1080/01913123.2024.2321144

Shaimaa Mostafa Kashef, Suzan Elsayed Abo Elnasr

{"title":"Effect of peripheral blood mononuclear cells on ischemia-reperfusion injury of sciatic nerve of adult male albino rat: histological, immunohistochemical, and ultrastructural study.","authors":"Shaimaa Mostafa Kashef, Suzan Elsayed Abo Elnasr","doi":"10.1080/01913123.2024.2321144","DOIUrl":"10.1080/01913123.2024.2321144","url":null,"abstract":"Ischemia/reperfusion (I/R) injury of sciatic nerve is a serious condition that results in nerve fiber degeneration, and reperfusion causes oxidative injury. Peripheral blood mononuclear cells (PBMNCs) have neuroregenerative power. This study was carried out to evaluate the potential ameliorative effect of PBMNCs on changes induced by I/R injury of the sciatic nerve. Fifty adult male albino rats were divided into donor and experimental groups that were subdivided into four groups: group I (control group), group II received 50 µL PBNMCs once intravenously via the tail vein, group III rubber tourniquet was placed around their Rt hind limb root for 2 hours to cause ischemia, group IV was subjected to limb ischemia as group III, then they were injected with 50 ul PBMNCs as group II before reperfusion. I/R injury showed disorganization of nerve fascicles with wide spaces in between nerve fibers. The mean area of collagen fibers, iNOS immunoexpression, and number of GFAP-positive Schwann cells of myelinated fibers showed a highly significant increase, while a highly significant reduction in the G-ratio and neurofilament immunoexpression was observed. Myelin splitting, invagination, evagination, and myelin figures were detected. PBMNC-treated group showed a marked improvement that was confirmed by histological, immunohistochemical, and ultrastructural findings.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"172-191"},"PeriodicalIF":1.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrastructural differences between synovial sarcoma and solitary fibrous tumor: comparative study in adult patients from the National Cancer Institute of Mexico. 滑膜肉瘤与单发纤维瘤的超微结构差异：墨西哥国家癌症研究所成年患者的比较研究。

IF 1 4区医学

Ultrastructural Pathology Pub Date : 2024-05-03 Epub Date: 2024-02-13 DOI: 10.1080/01913123.2024.2313742

Guillermo Ernesto Corredor-Alonso, Leonardo Saúl Lino-Silva, Erika Yazmin López-Flores, Tatiana Velásquez-Tovar, Hugo Ricardo Domínguez-Malagón

{"title":"Ultrastructural differences between synovial sarcoma and solitary fibrous tumor: comparative study in adult patients from the National Cancer Institute of Mexico.","authors":"Guillermo Ernesto Corredor-Alonso, Leonardo Saúl Lino-Silva, Erika Yazmin López-Flores, Tatiana Velásquez-Tovar, Hugo Ricardo Domínguez-Malagón","doi":"10.1080/01913123.2024.2313742","DOIUrl":"10.1080/01913123.2024.2313742","url":null,"abstract":"Synovial sarcoma (SS) and solitary fibrous tumor (SFT) are entities with considerable morphological and immunohistochemical similarities that sometimes show a non-confirmatory profile (TLE1 negative, CD34 and focal or negative STAT6 and lack of specific fusion IHC markers), in which the utility ultrastructure is unknown. A cross-sectional, retrospective, analytical, nonexperimental study was carried out by the Department of Pathology of the National Cancer Institute of Mexico (INCan) e from January 1, 2009 to December 31, 2018. With 17 SFT cases with diffuse or focal CD34 and STAT6 positivity and 18 cases of SS with positive FISH molecular test t(X:18) breakapart were studied by electron microscopy of fresh glutaraldehyde fixed or paraffin-embedded tissue. The ultrastructural findings with a significant difference present in the SS were tandem tight junctions, desmosomes and abundance of dilated rough endoplasmic reticulum (RER) cisternae (p < 0.001, 0.003, and 0.001, respectively); while in the (SFT) the presence of abundant glycogen, basal lamina, long and slender cytoplasmic processes, pinocytic vesicles, hemidesmosomes, and/or dense plaques, collagen skein, and microvilli-like buds (p = 0.028, 0.005, and <0.001 for the last five). We then infer that the five distinctive markers of the SFT are the collagen skeins intermingled with cellular processes in a shape of \"squid can,\" and the pinocytic vesicles as they were not observed in any case of SS. Conversely, tandem junctions were not found in any SFT case. Although the presence of multivesicular buds in the SFT was not significant, it had not been previously described.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"213-220"},"PeriodicalIF":1.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139724194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robert Erlandson obituary (September 4, 1937-February 4, 2024): a true giant and great champion of ultrastructural pathology. 罗伯特-厄兰森（Robert Erlandson）（1937 年 9 月 4 日-2024 年 2 月 4 日）：超微结构病理学的真正巨人和伟大倡导者。

IF 1 4区医学

Ultrastructural Pathology Pub Date : 2024-05-03 Epub Date: 2024-03-31 DOI: 10.1080/01913123.2024.2334996

David M Parham

引用次数: 0

Effect of platelet rich plasma versus melatonin on testicular injury induced by Busulfan in adult albino rats: a histological and immunohistochemical study. 富血小板血浆和褪黑素对成年白化大鼠布舒凡所致睾丸损伤的影响：组织学和免疫组化研究。

IF 1 4区医学

Ultrastructural Pathology Pub Date : 2024-05-03 Epub Date: 2024-02-29 DOI: 10.1080/01913123.2024.2322567

Eman M Askar, Amira M Abdelmegid, Laila M Elshal, Mohamed A Shaheen

{"title":"Effect of platelet rich plasma versus melatonin on testicular injury induced by Busulfan in adult albino rats: a histological and immunohistochemical study.","authors":"Eman M Askar, Amira M Abdelmegid, Laila M Elshal, Mohamed A Shaheen","doi":"10.1080/01913123.2024.2322567","DOIUrl":"10.1080/01913123.2024.2322567","url":null,"abstract":"This study was done to estimate the testicular histological alterations induced by Busulfan (BUS) and compare the possible protective effects of melatonin (MT) and platelet rich plasma (PRP) in a rat model. Sixty-four male rats were dispersed into: control group, BUS group, melatonin group, and PRP group. Blood samples were processed for biochemical analysis. Tissue specimens were managed for light and electron microscopic studies. Immunohistochemical expression of vimentin and proliferating cell nuclear antigen (PCNA) was performed. Busulfan induced severe testicular damage in all studied methodologies. It showed a statistically significant decrease in serum testosterone and elevation of MDA when compared to the control group. Abnormal testicular cytostructures suggesting defective spermatogenesis were observed: distorted seminiferous tubules, deformed spermatogenic cells, low germinal epithelium height, few mature spermatozoa, and also deformed barrier. Vimentin and PCNA expressions were reduced. Ultrastructurally, Sertoli cells and the blood testis barrier were deformed, spermatogenic cells were affected, and mature spermatozoa were few and showed abnormal structure. Both melatonin and PRP induced improvement in all the previous parameters and restoration of spermatogenesis as confirmed by improvement of Johnsen's score from 2.6 ± .74 to 7.6 ± .92. In conclusion, melatonin and PRP have equal potential to ameliorate the testicular toxicity of BUS. Melatonin can provide a better noninvasive way to combat BUS induced testicular injury.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"192-212"},"PeriodicalIF":1.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

“Ultrastructural changes of platelets in COVID-19 and chronic viral hepatitis patients “ "COVID-19 和慢性病毒性肝炎患者血小板的超微结构变化"

IF 1 4区医学

Ultrastructural Pathology Pub Date : 2024-04-15 DOI: 10.1080/01913123.2024.2342437

Ayat SalahEldin Mohamed Hassan, Sahar Samir Abdelmaksoud Abo Gaziah, Hieba Gamal Ezzelregal Awad, Salma Mohammed Hegab Abdelhady, Nagwa Abbdelkhalek Talaat Elkhafif, Noha Bassiouny Hassan Mostafa

引用次数: 0

Malformation of the endoplasmic reticulum system evolving into giant inclusions and Auer bodies in acute promyelocytic leukemia: an ultrastructural study of 6 cases 急性早幼粒细胞白血病中内质网系统畸形演变为巨内含体和奥尔体：对 6 个病例的超微结构研究

IF 1 4区医学

Ultrastructural Pathology Pub Date : 2024-04-15 DOI: 10.1080/01913123.2024.2340965

Yong-Xin Ru, Shu-Xu Dong, Jing Liu, Jin-Hua Liu, Yuan Zhou, Brian Eyden

引用次数: 0

Correction. 更正。

IF 1 4区医学

Ultrastructural Pathology Pub Date : 2024-03-03 Epub Date: 2024-02-07 DOI: 10.1080/01913123.2024.2306049

引用次数: 0

Protective effects of Urtica dioica on the cerebral cortex damage induced by Potassium bromate in adult male albino rats. 杜鹃花对溴酸钾致成年雄性白化大鼠脑皮质损伤的保护作用。

IF 1 4区医学

Ultrastructural Pathology Pub Date : 2024-03-03 Epub Date: 2024-02-07 DOI: 10.1080/01913123.2023.2287664

Abeer A Mahmoud, Maha Zayed Mohamed, Ebtehal Z Hassen

{"title":"Protective effects of Urtica dioica on the cerebral cortex damage induced by Potassium bromate in adult male albino rats.","authors":"Abeer A Mahmoud, Maha Zayed Mohamed, Ebtehal Z Hassen","doi":"10.1080/01913123.2023.2287664","DOIUrl":"10.1080/01913123.2023.2287664","url":null,"abstract":"Potassium bromate is used in cheese production, beer making and is also used in pharmaceutical and cosmetic. It is a proven carcinogen as it is a strong oxidizing agent that generates free radicals during xenobiotic metabolism. Urtica dioica (Ud) (from the plants' family of Urticaceae) is a plant that has long been used as a medicinal plant in many parts of the world. It has been shown to have anti-inflammatory, antioxidant and immunosuppressive properties. So, this study aimed to clarify the effect of Potassium bromate on the histological structure of cerebral cortex of adult male albino rats, evaluate the possible protective role of Urtica dioica. Thirty adult healthy male albino rats were divided into three groups; group I (Control group), group II (KBrO3 treated group). Group III (KBrO3 and Urtica dioica treated group).At the end of the experiment, rats in all groups were anesthetized and specimens were processed for light and electron microscope. Morphometric and statistical analyses were also performed. Nerve cells of the treated group showed irregular contours, dark nuclei, irregular nuclear envelopes, dilated RER cisternae, and mitochondria with ruptured cristae. Vacuolated neuropil was also observed. Immunohistochemically, stained sections for GFAP showed strong positive reaction in the processes of astrocytes. Recovery group showed revealed nearly the same as the histological picture as the control group. In conclusion, potassium bromate induces degenerative effects on neurons of cerebral cortex and urtica dioica provide an important neuroprotective effects against these damaging impacts through their antioxidant properties.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"81-93"},"PeriodicalIF":1.0,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138452598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The diagnosis of asbestosis in the 21^st century: a clinicopathological correlation of 102 cases. 21 世纪石棉沉滞症的诊断：102 个病例的临床病理学相关性。

IF 1 4区医学

Ultrastructural Pathology Pub Date : 2024-03-03 Epub Date: 2024-02-07 DOI: 10.1080/01913123.2023.2299874

John M Carney, Thomas A Sporn, Victor L Roggli, Elizabeth N Pavlisko

{"title":"The diagnosis of asbestosis in the 21st century: a clinicopathological correlation of 102 cases.","authors":"John M Carney, Thomas A Sporn, Victor L Roggli, Elizabeth N Pavlisko","doi":"10.1080/01913123.2023.2299874","DOIUrl":"10.1080/01913123.2023.2299874","url":null,"abstract":"Asbestosis, defined as diffuse pulmonary fibrosis caused by inhalation of asbestos fibers, occurs after heavy exposures to asbestos dust over several decades. Because workplace exposures have been significantly curtailed since the banning of asbestos in insulation products, we were interested in examining the clinicopathological characteristics of cases diagnosed in the 21st century. The consultation files of one of the authors (VLR) were reviewed for cases of asbestosis diagnosed since 1/1/2001. 102 cases were identified, with a median age of 75 years (range: 45-89). There were 100 men and 2 women. The women were from Turkey and Brazil (none from the United States). Malignancies were present in 78 cases, including 38 lung cancers, 29 pleural mesotheliomas, and 8 peritoneal mesotheliomas. The grade of asbestosis was available in 88 cases (median severity of 2; scale: 1-4). Pleural plaque was present in 94% of cases. The most common exposure categories were insulators (39), shipyard workers (16), asbestos manufacturing (9), boiler workers (8) and pipefitter/welders (6). The median duration of exposure was 33 years (range: 2-49 years). Lung fiber burden analysis was performed in 34 cases, with amosite being the predominant fiber type. Results were compared with similar information for 475 cases diagnosed prior to 1/1/2001.","PeriodicalId":23430,"journal":{"name":"Ultrastructural Pathology","volume":" ","pages":"137-148"},"PeriodicalIF":1.0,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139404550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0