Protective effects of Urtica dioica on the cerebral cortex damage induced by Potassium bromate in adult male albino rats.

IF 1.1 4区 医学 Q4 MICROSCOPY
Ultrastructural Pathology Pub Date : 2024-03-03 Epub Date: 2024-02-07 DOI:10.1080/01913123.2023.2287664
Abeer A Mahmoud, Maha Zayed Mohamed, Ebtehal Z Hassen
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引用次数: 0

Abstract

Potassium bromate is used in cheese production, beer making and is also used in pharmaceutical and cosmetic. It is a proven carcinogen as it is a strong oxidizing agent that generates free radicals during xenobiotic metabolism. Urtica dioica (Ud) (from the plants' family of Urticaceae) is a plant that has long been used as a medicinal plant in many parts of the world. It has been shown to have anti-inflammatory, antioxidant and immunosuppressive properties. So, this study aimed to clarify the effect of Potassium bromate on the histological structure of cerebral cortex of adult male albino rats, evaluate the possible protective role of Urtica dioica. Thirty adult healthy male albino rats were divided into three groups; group I (Control group), group II (KBrO3 treated group). Group III (KBrO3 and Urtica dioica treated group).At the end of the experiment, rats in all groups were anesthetized and specimens were processed for light and electron microscope. Morphometric and statistical analyses were also performed. Nerve cells of the treated group showed irregular contours, dark nuclei, irregular nuclear envelopes, dilated RER cisternae, and mitochondria with ruptured cristae. Vacuolated neuropil was also observed. Immunohistochemically, stained sections for GFAP showed strong positive reaction in the processes of astrocytes. Recovery group showed revealed nearly the same as the histological picture as the control group. In conclusion, potassium bromate induces degenerative effects on neurons of cerebral cortex and urtica dioica provide an important neuroprotective effects against these damaging impacts through their antioxidant properties.

杜鹃花对溴酸钾致成年雄性白化大鼠脑皮质损伤的保护作用。
溴酸钾用于奶酪生产,啤酒酿造,也用于制药和化妆品。它是一种被证实的致癌物,因为它是一种强氧化剂,在异种代谢过程中产生自由基。菊科荨麻(Urtica dioica, Ud)是一种在世界许多地方长期被用作药用植物的植物。它已被证明具有抗炎、抗氧化和免疫抑制的特性。因此,本研究旨在阐明溴酸钾对成年雄性白化大鼠大脑皮层组织结构的影响,并探讨白化荨麻疹可能的保护作用。将30只健康成年雄性白化大鼠分为3组;ⅰ组(对照组)、ⅱ组(KBrO3治疗组)。第三组(KBrO3和荨麻疹治疗组)。实验结束时,各组大鼠均麻醉,并对标本进行光镜和电镜观察。形态计量学和统计学分析也进行了。治疗组神经细胞轮廓不规则,核暗,核包膜不规则,内质网池扩张,线粒体嵴破裂。还观察到空泡化的神经膜。免疫组织化学染色显示GFAP在星形胶质细胞过程中呈强烈阳性反应。恢复组所显示的组织学图与对照组几乎相同。综上所述,溴酸钾对大鼠大脑皮层神经元的退行性损伤具有重要的神经保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Ultrastructural Pathology
Ultrastructural Pathology 医学-病理学
CiteScore
2.00
自引率
10.00%
发文量
40
审稿时长
6-12 weeks
期刊介绍: Ultrastructural Pathology is the official journal of the Society for Ultrastructural Pathology. Published bimonthly, we are the only journal to be devoted entirely to diagnostic ultrastructural pathology. Ultrastructural Pathology is the ideal journal to publish high-quality research on the following topics: Advances in the uses of electron microscopic and immunohistochemical techniques Correlations of ultrastructural data with light microscopy, histochemistry, immunohistochemistry, biochemistry, cell and tissue culturing, and electron probe analysis Important new, investigative, clinical, and diagnostic EM methods.
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