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Antiphospholipid antibodies and antiphospholipid syndrome. 抗磷脂抗体和抗磷脂综合征。
Ugeskrift for laeger Pub Date : 2024-05-20 DOI: 10.61409/V11230715
Rasmus Søgaard Hansen, Julie Brogaard Larsen, Pernille Just Vinholt, Anne Voss, Anders Abildgaard
{"title":"Antiphospholipid antibodies and antiphospholipid syndrome.","authors":"Rasmus Søgaard Hansen, Julie Brogaard Larsen, Pernille Just Vinholt, Anne Voss, Anders Abildgaard","doi":"10.61409/V11230715","DOIUrl":"10.61409/V11230715","url":null,"abstract":"<p><p>Individuals with antiphospholipid syndrome (APS) have antibodies directed against phospholipid-binding proteins (aPL). The condition is most associated with an increased risk of thromboembolism and obstetric complications. The 2023 classification criteria for APS include six clinical domains (venous thromboembolism, arterial thrombosis, microvascular events, obstetric events, cardiac valve, thrombocytopaenia) and two laboratory domains (lupus anticoagulant, and anti-cardiolipin or anti-β2-glycoprotein-I antibodies). Diagnosis and treatment of APS are specialist tasks and are summarised in this review.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A practical guide for writing a PhD thesis. 博士论文写作实用指南。
Ugeskrift for laeger Pub Date : 2024-05-20 DOI: 10.61409/V12230804
Siv Fonnes, Jacob Rosenberg
{"title":"A practical guide for writing a PhD thesis.","authors":"Siv Fonnes, Jacob Rosenberg","doi":"10.61409/V12230804","DOIUrl":"10.61409/V12230804","url":null,"abstract":"<p><p>There is an increasing number of PhD students in health sciences, but no formal reporting guideline for writing a thesis exists. This review provides a practical guide with an overview of the article-based/synopsis PhD thesis that consists of eight parts: 1) initial formalities, 2) introduction, 3) methodological considerations, 4) study presentations, 5) discussion, 6) conclusion, 7) perspectives, and 8) concluding formalities. It is elaborated with detailed information, practical advice, and a template, so the thesis complies with the demands of the Danish Graduate Schools of Health Sciences.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prophylactic progesterone and preterm birth. 预防性黄体酮与早产。
Ugeskrift for laeger Pub Date : 2024-05-20 DOI: 10.61409/V10230636
Caroline Madsen, Andreas Overby Ørsted, Maria Birkvad Rasmussen, Mette Hykkelbjerg Christensen, Line Engelbrechtsen, Malene Mie Canning, Mette Hansen Viuff, Lone Storgaard, Jeannet Lauenborg
{"title":"Prophylactic progesterone and preterm birth.","authors":"Caroline Madsen, Andreas Overby Ørsted, Maria Birkvad Rasmussen, Mette Hykkelbjerg Christensen, Line Engelbrechtsen, Malene Mie Canning, Mette Hansen Viuff, Lone Storgaard, Jeannet Lauenborg","doi":"10.61409/V10230636","DOIUrl":"10.61409/V10230636","url":null,"abstract":"<p><p>This review summarises the present knowledge of prophylactic progesterone and preterm birth. Preterm birth (less-than 37 weeks) is a leading cause of neonatal mortality and morbidity worldwide. The incidence varies globally but remains low in the Nordic countries (5-6%). Prediction and prevention are complicated due to diverse aetiology, but obstetric history and cervical length can improve prediction. Prophylactic vaginal progesterone initiated between 12 and 24 weeks of gestation is recommended to reduce preterm birth less-than 33-35 weeks in singleton pregnancies with a history of preterm birth or with a short cervix (less-than 25 mm) and can be considered for twin pregnancies with the same risk factors.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe hepatic cholestasis after treatment with amoxicillin/clavulanic acid. 使用阿莫西林/克拉维酸治疗后出现严重肝性胆汁淤积。
Ugeskrift for laeger Pub Date : 2024-05-20 DOI: 10.61409/V02240094
Michelle Meier, Peter Lykke Eriksen
{"title":"Severe hepatic cholestasis after treatment with amoxicillin/clavulanic acid.","authors":"Michelle Meier, Peter Lykke Eriksen","doi":"10.61409/V02240094","DOIUrl":"10.61409/V02240094","url":null,"abstract":"<p><p>Amoxicillin/clavulanate is a commonly used antibiotic. Though relatively rare, amoxicillin/clavulanate carries the highest incidence of idiosyncratic drug-induced liver disease. This case report presents an 80-year-old woman treated for simple respiratory tract infection with amoxicillin/clavulanate who was subsequently hospitalized with malaise and icterus and a biochemical cholestatic pattern with high alkaline phosphatase and bilirubin. Diagnostically challenging, ultimately, liver biopsy revealed drug-induced liver injury with a fatal course after attempt of supportive, symptomatic treatment.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical considerations and pitfalls in the use of depot antipsychotics 使用去势抗精神病药物的临床注意事项和误区
Ugeskrift for laeger Pub Date : 2024-05-13 DOI: 10.61409/v12230776
Niels August Willer Strand, Mette Ødegaard Nielsen, Jimmi Nielsen
{"title":"Clinical considerations and pitfalls in the use of depot antipsychotics","authors":"Niels August Willer Strand, Mette Ødegaard Nielsen, Jimmi Nielsen","doi":"10.61409/v12230776","DOIUrl":"https://doi.org/10.61409/v12230776","url":null,"abstract":"Long-acting injectable antipsychotics (LAI) is a frequently used treatment modality which has advantages over oral antipsychotics regarding hospitalization or relapse prevention. However, the pharmacokinetic properties of LAI greatly differ from oral antipsychotics. This necessitates an increased knowledge about LAI among clinicians, especially when commencing treatment, changing doses and discontinuing treatment. In this review, we summarize an array of clinically important characteristics of LAI and give a conceptual framework for understanding the pharmacokinetics of LAI.","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140985710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Depression medfører større handicap end mange tror. 抑郁症造成的残疾比许多人意识到的要多。
Ugeskrift for laeger Pub Date : 2024-05-13 DOI: 10.61409/V205168
Poul Videbech
{"title":"Depression medfører større handicap end mange tror.","authors":"Poul Videbech","doi":"10.61409/V205168","DOIUrl":"10.61409/V205168","url":null,"abstract":"","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperglycaemia in people with diabetes and chronic kidney disease 糖尿病和慢性肾病患者的高血糖症
Ugeskrift for laeger Pub Date : 2024-05-13 DOI: 10.61409/v01240051
J. M. Brøsen, Tobias Bomholt, Rikke Borg, Frederik Persson, U. Pedersen-Bjergaard
{"title":"Hyperglycaemia in people with diabetes and chronic kidney disease","authors":"J. M. Brøsen, Tobias Bomholt, Rikke Borg, Frederik Persson, U. Pedersen-Bjergaard","doi":"10.61409/v01240051","DOIUrl":"https://doi.org/10.61409/v01240051","url":null,"abstract":"Assessment and treatment of hyperglycaemia in people with diabetes and chronic kidney disease (CKD) are challenging. In advanced CKD HbA1c can be unreliable, and treatment adjustments should be supported by other glucose measurements (e.g., continuous glucose monitoring (CGM) or blood glucose measurements). Glucose-lowering treatments should be evaluated based on CKD and an individualised assessment of risk factors especially hypoglycaemia. This review aims at providing an overview of the options for glycaemic monitoring and glucose-lowering treatments in people with diabetes and CKD.","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140984444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testikulær schistosomiasis 睾丸血吸虫病
Ugeskrift for laeger Pub Date : 2024-05-13 DOI: 10.61409/v72026
Frederikke Anine Prætorius, Thomas Wagner
{"title":"Testikulær schistosomiasis","authors":"Frederikke Anine Prætorius, Thomas Wagner","doi":"10.61409/v72026","DOIUrl":"https://doi.org/10.61409/v72026","url":null,"abstract":"","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140982925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidental findings in MRI of the brain 脑部 MRI 意外发现
Ugeskrift for laeger Pub Date : 2024-05-13 DOI: 10.61409/v12230770
M. B. Skotting, Anders Vedel Holst, Tina Nørgaard Munch
{"title":"Incidental findings in MRI of the brain","authors":"M. B. Skotting, Anders Vedel Holst, Tina Nørgaard Munch","doi":"10.61409/v12230770","DOIUrl":"https://doi.org/10.61409/v12230770","url":null,"abstract":"This review investigates that there has been an increase in incidental brain MRI findings due to better technology and more scans. These unexpected, asymptomatic anomalies range from harmless to serious, requiring careful clinical and ethical handling. The prevalence of incidental findings with brain MRI is 6.3% and even higher when including white matter hyperintensities. There is a significant variation in this number dependent on the age of the person being scanned and the MRI quality.","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140983455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-reported systemic symptoms among women with breast implants 隆胸妇女自述的全身症状
Ugeskrift for laeger Pub Date : 2024-05-06 DOI: 10.61409/v12230801
Kaveh Borhani-Khomani, J. Kalstrup, Hannah Trøstrup, Trine Foged Henriksen, L. Hölmich, Anne Kristine Larsen Stellander
{"title":"Self-reported systemic symptoms among women with breast implants","authors":"Kaveh Borhani-Khomani, J. Kalstrup, Hannah Trøstrup, Trine Foged Henriksen, L. Hölmich, Anne Kristine Larsen Stellander","doi":"10.61409/v12230801","DOIUrl":"https://doi.org/10.61409/v12230801","url":null,"abstract":"Around 2,500 women receive a breast augmentation with silicone-based implants yearly in Denmark. A number of these women report various uncharacteristic systemic symptoms, which they attribute to the breast implants, including impaired cognition, joint pain, etc. This condition has been termed “breast implant illness” and is currently not a recognised diagnosis. The correlation between the patient’s self-reported symptoms and breast implants has not been established and there is limited evidence that surgery has any effect. In this review, the current literature on the topic has been reviewed.","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141006985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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