{"title":"[Pouchitis].","authors":"Louise Thomsen, Sine Jacobsen, Anders Tøttrup","doi":"10.61409/V01250033","DOIUrl":"https://doi.org/10.61409/V01250033","url":null,"abstract":"<p><p>Pouchitis is the most common complication following ileal pouch-anal anastomosis. It is characterized by pouch inflammation and symptoms resembling ulcerative colitis. The aetiology is thought to involve a combination of genetic factors, a dysregulated immune response, and alterations in the gut microbiome. Pouchitis is classified as acute if symptoms less-than 4 weeks or chronic if symptoms > 4 weeks. Acute pouchitis is typically treated with antibiotics, while chronic pouchitis may require cyclic antibiotics or immunomodulatory therapy. This review indicates that more research is needed to improve understanding and treatment.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Intracranial hypotension and secondary Chiaris malformation caused by spontaneous spinal fluid leakage].","authors":"Jeppe Damgren Vesterager, Svetlana Rudnicka, Carsten Reidies Bjarkam","doi":"10.61409/V01250064","DOIUrl":"https://doi.org/10.61409/V01250064","url":null,"abstract":"<p><p>Charis Malformation type 1 (CM1) is a common incidental radiological finding, most often asymptomatic. Congenital CM1 is often due to a small fossa posterior, while acquired CM1 may be due to a change in pressure gradient over the foramen magnum. We present a case of a previously healthy patient with a several yearlong story of occipital headache, dizziness and nausea. MRI of cerebrum showed CM1, and repeated CT-myelography showed a CSF leak in relation to the right TH7 nerve root. The leak was operatively closed. After two months, the patient had no symptoms of CM1 or intracranial hypotension.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Steen Antonsen, Jesper Farup Revsholm, Lars Koch Hansen, Eva Rabing Brix Petersen
{"title":"[Evaluation of biochemical results].","authors":"Steen Antonsen, Jesper Farup Revsholm, Lars Koch Hansen, Eva Rabing Brix Petersen","doi":"10.61409/V09240597","DOIUrl":"https://doi.org/10.61409/V09240597","url":null,"abstract":"<p><p>Reference intervals (RI) are used to evaluate biochemical results in diagnosis. In monitoring the critical difference (KF) should be preferred, as the biological within-person variation divided by the between-person variation for biochemical quantities often is less-than 0,6, meaning that results may change without exceeding the limits of RI. The personal RI is a variant of KF. It uses the same terminology as conventional RI, but is less flexible than KF. This review finds that IT systems for evaluating analytical results should consider the shortcomings of RI and offer the availability of KF.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Myasthenic crisis with respiratory failure caused by COVID-19].","authors":"Troels Ulrik Eliasen, Troels Bek Jensen, Steffen Leth, Nilanjan Dey","doi":"10.61409/V12240851","DOIUrl":"https://doi.org/10.61409/V12240851","url":null,"abstract":"<p><p>Myasthenic crisis is a severe complication of myasthenia gravis (MG) characterized by respiratory failure. This case report presents a 24-year-old woman admitted with respiratory distress, eventually diagnosed with myasthenic crisis triggered by COVID-19. Initial symptoms included throat pain and dysphagia with no evident pathology. Elevated acetylcholine receptor antibodies confirmed MG. The case underscores the importance of considering neuromuscular diseases in unexplained respiratory failure, highlighting early diagnosis and treatment as key to reducing the need for invasive ventilation.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Martin Havmose, Katrine Karmisholt, Anders Klit, Simon Francis Thomsen
{"title":"[Rhinoplasty with late-onset side effect to silicone implant].","authors":"Martin Havmose, Katrine Karmisholt, Anders Klit, Simon Francis Thomsen","doi":"10.61409/V01250031","DOIUrl":"https://doi.org/10.61409/V01250031","url":null,"abstract":"<p><p>This is a case report of a 75-year-old woman who simultaneously developed a firm tumour on the dorsum and apex of the nose. Swap for culture was negative. Punch biopsy from the dorsum and apex showed inflammation, but no foreign body reaction or malignancy. Four months after onset of the tumour, the patient developed an inflammatory reaction with pus formation and subsequent extrusion of a piece of silicone from the apex. She revealed that she 43 years prior to this incident had a rhinoplasty with a silicone implant performed. This illustrates a potential side effect to silicone implant with very late onset, manifesting as a foreign body reaction.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christina Damsted Petersen, Susanne Neergaard Poll
{"title":"[Complications for Ballerine pearl spiral].","authors":"Christina Damsted Petersen, Susanne Neergaard Poll","doi":"10.61409/V01250026","DOIUrl":"10.61409/V01250026","url":null,"abstract":"<p><p>The Ballerine copper intrauterine device (IUD) has been used worldwide since 2014 and in Denmark since 2020. There is limited documentation for its effectiveness and possible risks and complications. In this case report, two women, one 22-year-old (multipara) and the other 24-year-old (nullipara), both experienced extrauterine displacement and perforation. In both cases, the IUD needed removal surgically. Clinical experience with the insertion of an IUD as well as the need for detailed information on possible complications is advised. Further studies on the Ballerine cobber IUD are warranted.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trygve Ulvund Solstad, Claudia Schröder, Michael Festersen Nielsen, Kim Agerholm Brogaard
{"title":"[Scrotal pain as the presenting symptom of metastatic sigmoid cancer].","authors":"Trygve Ulvund Solstad, Claudia Schröder, Michael Festersen Nielsen, Kim Agerholm Brogaard","doi":"10.61409/V12240896","DOIUrl":"10.61409/V12240896","url":null,"abstract":"<p><p>Colorectal cancer is one of the most common malignancies globally, and typical sites of metastasis include the liver and lungs; however, metastasis to the testes is exceedingly rare. We report a case where a 54-year-old male presented with acute scrotal pain and swelling. Scrotal ultrasound revealed a solid mass, and further investigations identified metastatic adenocarcinoma originating from the sigmoid colon. This case highlights the importance of considering malignancy in older patients with scrotal symptoms, especially when common causes have been ruled out.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Local administration of tranexamic acid for prevention and treatment of bleeding].","authors":"Jeppe Hjembæk-Brandt, Mathias Maagaard, Christine Nygaard Svendsen, Preben Homø, Jakob Felbo Paulsen","doi":"10.61409/V11240825","DOIUrl":"10.61409/V11240825","url":null,"abstract":"<p><p>Tranexamic acid (TXA) is an antifibrinolytic drug found on WHO's list of \"essential medicines\". TXA is effective in reducing bleeding by 30-40% in a wide range of clinical scenarios and is most often administered systemically. Concerns regarding increased risk of thromboembolic events have prompted research into local administration of TXA. Local administration of TXA has therefore been investigated in a wide range of clinical scenarios with most studies showing an effect approximately equal to systemically administrated TXA and with minimal risk of systemic side effects, as argued in this review.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristoffer N Skaastrup, Carolina C Graffe, Siska Frahm-Falkenberg, Christian Krarup, Johannes K Jakobsen
{"title":"[Neuralgic amyotrophy].","authors":"Kristoffer N Skaastrup, Carolina C Graffe, Siska Frahm-Falkenberg, Christian Krarup, Johannes K Jakobsen","doi":"10.61409/V09240628","DOIUrl":"10.61409/V09240628","url":null,"abstract":"<p><p>This review provides an overview of neuralgic amyotrophy (NA) to improve treatment and collaboration. The disorder is a neuropathy characterized by acute onset of asymmetric severe pain, paresis, atrophy, and sensory deficits followed by prolonged remission. The incidence of NA is likely higher than previously assumed. Initial treatment includes a combination of long-lasting NSAIDs and slow-release opioids, while corticosteroids may be considered in severe cases. Physical therapy is reserved for chronic phase treatment. Electrophysiological tests and ultrasound may aid the clinical diagnosis.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}