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[Opioid insensitivity associated with genetic variants in the μ-opioid receptor]. [与μ-阿片受体基因变异相关的阿片不敏感]。
Ugeskrift for laeger Pub Date : 2026-05-04 DOI: 10.61409/V11250924
Anton Lund, Malene Djursby, Pia Jæger, Jakob Højlund
{"title":"[Opioid insensitivity associated with genetic variants in the μ-opioid receptor].","authors":"Anton Lund, Malene Djursby, Pia Jæger, Jakob Højlund","doi":"10.61409/V11250924","DOIUrl":"https://doi.org/10.61409/V11250924","url":null,"abstract":"<p><p>Interindividual variation in opioid response is well described, but complete insensitivity is exceedingly rare. In this case report, a healthy 32-year-old female demonstrated no clinical effect of large doses of opioids. Exome sequencing revealed two variants in the OPRM1 encoding the μ-opioid receptor, offering a plausible genetic explanation. The patient was anaesthetised for two laparoscopic procedures, and successful management relied on a multimodal strategy including esketamine and epidural analgesia.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The treatment of adults with intellectual disabilities]. [成人智障的治疗]。
Ugeskrift for laeger Pub Date : 2026-05-04 DOI: 10.61409/V10250857
Magnus Roland Balleby, Jeppe Feigenberg Johansen, Berit Shönewolf-Greulich, Anne Sabers, Lise Cronberg Salem, Jimmi Nielsen
{"title":"[The treatment of adults with intellectual disabilities].","authors":"Magnus Roland Balleby, Jeppe Feigenberg Johansen, Berit Shönewolf-Greulich, Anne Sabers, Lise Cronberg Salem, Jimmi Nielsen","doi":"10.61409/V10250857","DOIUrl":"https://doi.org/10.61409/V10250857","url":null,"abstract":"<p><p>Life expectancy is significantly reduced in people with intellectual disabilities (ID) compared to those without ID, especially in severe cases. The diagnosis is made using validated IQ tests or through clinical assessment. The aetiology of ID is diverse and unknown in half of the cases. Several risk factors increase the likelihood of ID. Patients are often multimorbid and simultaneously underdiagnosed. This review finds that the lack of adaptive functioning is important for understanding people with ID. Informed consent may depend on the complexity of the treatment decision.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Anesthesia for obese patients]. 【肥胖患者的麻醉】。
Ugeskrift for laeger Pub Date : 2026-05-04 DOI: 10.61409/V07250595
Lærke Dam Dengsøe Petersen, Jannie Tanderup Sørensen, Marie Vestergaard Vad
{"title":"[Anesthesia for obese patients].","authors":"Lærke Dam Dengsøe Petersen, Jannie Tanderup Sørensen, Marie Vestergaard Vad","doi":"10.61409/V07250595","DOIUrl":"https://doi.org/10.61409/V07250595","url":null,"abstract":"<p><p>This review focuses on the perioperative anaesthesiological perspectives to be considered for general anesthesia in obese patients and is based on primary literature, international guidelines, and enhanced recovery after surgery recommendations. Obese patients have an altered respiratory, circulatory, and metabolic physiology. These changes cause anaesthesiological challenges during general anesthesia, but also postoperatively. Due to the increasing incidence of obese patients, anaesthesiologists and other relevant personnel should have common knowledge of how to handle these challenges.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bulløs scabies. 牛ø疥疮。
Ugeskrift for laeger Pub Date : 2026-05-04 DOI: 10.61409/V74007
Jakob Lillemoen Drivenes, Kåre Steinar Tveit
{"title":"Bulløs scabies.","authors":"Jakob Lillemoen Drivenes, Kåre Steinar Tveit","doi":"10.61409/V74007","DOIUrl":"https://doi.org/10.61409/V74007","url":null,"abstract":"","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Penetrating neck trauma]. [穿透性颈部创伤]。
Ugeskrift for laeger Pub Date : 2026-05-04 DOI: 10.61409/V09250725
Mohamed Adel El-Refaii, Kasper Daugaard Larsen, Søren Steemann Rudolph, Preben Homøe, Jacob Melchiors
{"title":"[Penetrating neck trauma].","authors":"Mohamed Adel El-Refaii, Kasper Daugaard Larsen, Søren Steemann Rudolph, Preben Homøe, Jacob Melchiors","doi":"10.61409/V09250725","DOIUrl":"https://doi.org/10.61409/V09250725","url":null,"abstract":"<p><p>Penetrating injuries to the neck are severe and complex, representing a significant challenge in the emergency department and surgical management. Historically, management was based on anatomical zone classification, often leading to unnecessary surgical explorations. Advances in imaging have led to the »no-zone approach«, which relies on clinical findings and CT angiography. This strategy reduces unnecessary interventions while ensuring rapid treatment for patients requiring urgent surgery. This review aims to standardise the management of such injuries nationwide.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Arthrofibrosis of the knee]. [膝关节关节纤维化]。
Ugeskrift for laeger Pub Date : 2026-04-27 DOI: 10.61409/V10250891
Gustav Holm Schæbel, Jonathan Jetsmark Bjerre-Bastos, Kristoffer Weisskirchner Barfod
{"title":"[Arthrofibrosis of the knee].","authors":"Gustav Holm Schæbel, Jonathan Jetsmark Bjerre-Bastos, Kristoffer Weisskirchner Barfod","doi":"10.61409/V10250891","DOIUrl":"https://doi.org/10.61409/V10250891","url":null,"abstract":"<p><p>Arthrofibrosis is a complex complication following surgery or trauma, leading to reduced mobility, pain, and decreased quality of life. The condition results from an excessive inflammatory response and the formation of scar tissue. Diagnosis is clinical, excluding mechanical and infectious causes. Treatment includes exercise, patient education, and, in select cases, surgery. This review finds that prognosis depends on early treatment and an individualised approach, while further research is needed for better diagnostics and management.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prevention of incisional and parastomal hernias]. 【切口疝和造口旁疝的预防】。
Ugeskrift for laeger Pub Date : 2026-04-27 DOI: 10.61409/V10250888
Amjed Safaa Abdulrasool, Mehmet Öztoprak, Per Helligsø, Ayat Allah Alnabhan, Muthanna Al-Jumaili, Michael Festersen Nielsen
{"title":"[Prevention of incisional and parastomal hernias].","authors":"Amjed Safaa Abdulrasool, Mehmet Öztoprak, Per Helligsø, Ayat Allah Alnabhan, Muthanna Al-Jumaili, Michael Festersen Nielsen","doi":"10.61409/V10250888","DOIUrl":"https://doi.org/10.61409/V10250888","url":null,"abstract":"<p><p>Incisional and parastomal hernias are frequent and significant complications following abdominal surgery, leading to reduced quality of life and substantial healthcare costs. This review provides a comprehensive review of the latest international guidelines, including the 2022 EHS/AHS guideline on abdominal wall closure and the 2023 EHS Rapid Guideline on parastomal hernia prevention. Key recommendations include risk stratification of patients, the superiority of the small-bites fascial closure technique for midline closure, and the selective use of prophylactic mesh.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pædiatrisk staphylococcal scalded skin syndromei. 葡萄球菌性烫伤皮肤综合征。
Ugeskrift for laeger Pub Date : 2026-04-27 DOI: 10.61409/V74004
Eva Guldberg, Rasmus Kolind
{"title":"Pædiatrisk staphylococcal scalded skin syndromei.","authors":"Eva Guldberg, Rasmus Kolind","doi":"10.61409/V74004","DOIUrl":"https://doi.org/10.61409/V74004","url":null,"abstract":"","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Burkitt's lymphoma in a girl with peripheral facial palsy and breast involvement]. [一例伴有周围性面瘫和乳房受累的女孩的伯基特淋巴瘤]。
Ugeskrift for laeger Pub Date : 2026-04-27 DOI: 10.61409/V10250787
Emil Kudahl Christensen, Christina Friis Jensen
{"title":"[Burkitt's lymphoma in a girl with peripheral facial palsy and breast involvement].","authors":"Emil Kudahl Christensen, Christina Friis Jensen","doi":"10.61409/V10250787","DOIUrl":"https://doi.org/10.61409/V10250787","url":null,"abstract":"<p><p>Burkitt lymphoma (BL) is a rare, aggressive B-cell non-Hodgkin lymphoma with rapid proliferation. Typical manifestations include abdominal disease, B-symptoms and bone marrow infiltration, while rare presentations may include nodal disease, facial palsy and breast involvement. This case report presents a 17-year-old girl with sporadic BL who developed peripheral facial palsy and rapid bilateral breast enlargement. This case highlights the importance of systematic follow-up after facial palsy in young patients and attention to associated symptoms and biochemical abnormalities suggestive of malignancy.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Leptin treatment of multiple symmetric lipomatosis due to a mitochondrial defect]. [瘦素治疗线粒体缺陷引起的多重对称脂肪瘤病]。
Ugeskrift for laeger Pub Date : 2026-04-27 DOI: 10.61409/V12251037
Sigrid B Gribsholt, Jens M Bruun, Steen B Pedersen, Bjørn Richelsen
{"title":"[Leptin treatment of multiple symmetric lipomatosis due to a mitochondrial defect].","authors":"Sigrid B Gribsholt, Jens M Bruun, Steen B Pedersen, Bjørn Richelsen","doi":"10.61409/V12251037","DOIUrl":"https://doi.org/10.61409/V12251037","url":null,"abstract":"<p><p>Multiple symmetric lipomatosis, or Madelung's disease, is a rare condition with symmetrical fat deposits on the upper body, increasingly associated with genetic mutations. In this case report, we present a patient with an mitofusin 2 mutation causing mitochondrial dysfunction and extremely low leptin. Treatment with metreleptin led to reduced appetite, 17% weight loss, improved triglyceride levels, insulin sensitivity, and reduced liver fat. This is the first published Danish case; metreleptin shows promising results in the treatment of rare leptin-deficient lipodystrophic disorders.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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