Nanna Wittrup Sodemann, Peter Kolind Brask-Thomsen, Peter Buur van Kooten Niekerk
{"title":"[Hemichorea caused by polycythemia vera].","authors":"Nanna Wittrup Sodemann, Peter Kolind Brask-Thomsen, Peter Buur van Kooten Niekerk","doi":"10.61409/V04250261","DOIUrl":"https://doi.org/10.61409/V04250261","url":null,"abstract":"<p><p>Polycythaemia vera (PV) is a chronic myeloproliferative disorder. PV should be suspected with hemoglobin >10.2/9.9 mmol/L (m/f) and/or PV-related features (aquagenic pruritus, erythromelalgia, atypical thrombosis, splenomegaly, thrombocytosis or leukocytosis). This case report highlights the connection between PV and neurological manifestations, including rare symptoms like chorea. An 82-year-old woman presented with sudden choreiform movements, dysarthria, and behavioral changes. Investigations ruled out primary neurological disease and confirmed PV. With treatment, the neurological symptoms resolved.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kirstine Hermann Jørgensen, Michael Perch, Kåre Hornbech, Thomas Decker Christensen, Ole Dan Jørgensen, Elisabeth Bendstrup
{"title":"[Lung volume reduction for the treatment of emphysema].","authors":"Kirstine Hermann Jørgensen, Michael Perch, Kåre Hornbech, Thomas Decker Christensen, Ole Dan Jørgensen, Elisabeth Bendstrup","doi":"10.61409/V04250263","DOIUrl":"https://doi.org/10.61409/V04250263","url":null,"abstract":"<p><p>Patients suffering from severe chronic obstructive pulmonary disease with emphysema on X-ray can be eligible for lung volume reduction, and these patients can therefore be referred to a department of respiratory diseases for further evaluation. Lung volume reduction can be performed either through surgery or endobronchial valve treatment. Both treatment options are effective in carefully selected patients. This review presents an updated status on the indications, effects, and complications of both types of lung volume reduction. It helps identify eligible patients in both the primary and secondary sectors.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Triogenome sequencing in neonatal epilepsy].","authors":"Seher Yücelbas, Simon Frost, Jesper Fenger-Grøn","doi":"10.61409/V04250330","DOIUrl":"https://doi.org/10.61409/V04250330","url":null,"abstract":"<p><p>Severely sick newborns with unexplained symptoms are clinically challenging, and acute triogenome sequencing is now an option. We describe a newborn girl who developed drug-resistant severe seizures of unknown origin. Genetic testing revealed a pathogenic variation in the KCNQ2-gene, known to predict epilepsy with treatment difficulties. Targeted treatment with oxcarbazepine was started, resulting in seizure control and normal development. The case underscores the potentially positive outcome with early genetic testing and targeted treatment.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andreas Falkenberg Nielsen, Ali Al-Hamdani, Jeppe Vejlgaard Rasmussen, Bo Sanderhoff Olsen
{"title":"[Elbow arthroplasty].","authors":"Andreas Falkenberg Nielsen, Ali Al-Hamdani, Jeppe Vejlgaard Rasmussen, Bo Sanderhoff Olsen","doi":"10.61409/V04250287","DOIUrl":"https://doi.org/10.61409/V04250287","url":null,"abstract":"<p><p>Elbow arthroplasty is a rare treatment option and is primarily used to treat distal humeral fractures that are not amenable to open reduction and internal fixation, as well as degenerative and inflammatory arthritis. In Denmark, treatment has been centralised since 2008 to three specialised university hospitals to ensure a high quality of treatment. Elbow arthroplasty generally yields good functional and patient-reported outcomes, but with high rates of revision and complications. The current literature remains limited, particularly in terms of long-term outcomes.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Perforation af øsofagus efter gastroskopi.","authors":"Emma Lundby Kragh, Erik Gadsbøll","doi":"10.61409/V73039","DOIUrl":"https://doi.org/10.61409/V73039","url":null,"abstract":"","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Claus Kjærgaard, Annett Dalbøge, Pascal Madeleine, Tommy Kjærgaard Nielsen
{"title":"[Musculoskeletal pain among surgeons].","authors":"Claus Kjærgaard, Annett Dalbøge, Pascal Madeleine, Tommy Kjærgaard Nielsen","doi":"10.61409/V04250290","DOIUrl":"https://doi.org/10.61409/V04250290","url":null,"abstract":"<p><p>Work-related musculoskeletal pain is common among surgeons, with up to 68% experiencing pain, mainly in the lower back, neck, and shoulders. Minimally invasive procedures increase the risk compared with open surgery, while robot-assisted techniques appear less harmful. Key physical risk factors include static postures, awkward positions, and long-lasting surgeries. Productivity, career longevity, and healthcare efficiency may be impacted. Preventive strategies lack strong evidence, highlighting the need for further research to develop effective and cost-efficient solutions as argued in this review.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anne Stockmann, Anne Lindegaard Christiansen, Henrik Frank Lorentzen
{"title":"[Porphyria cutanea tarda and hepatitis C infection].","authors":"Anne Stockmann, Anne Lindegaard Christiansen, Henrik Frank Lorentzen","doi":"10.61409/V01250056","DOIUrl":"https://doi.org/10.61409/V01250056","url":null,"abstract":"<p><p>We present two case reports with resolution of PCT following treatment with direct-acting anti-virals for hepatitis C infection (HCV): An 82-year-old woman and a 60-year-old woman with PCT caused by HCV. Both patients were treated with venesection and hydroxychloroquine for their PCT. The patients received treatment with glecaprevir/pibrentasvir, resulting in the eradication of HCV and long-term remission of PCT. The cases illustrate the importance of screening patients with PCT for underlying HCV, and initiating relevant treatment for HCV, as this may lead to remission in PCT.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Astrid Johannesson Hjelholt, Thomas Johannesson Hjelholt, Samuel Azuz
{"title":"[Pharmacological prevention of recurrent urinary tract infections].","authors":"Astrid Johannesson Hjelholt, Thomas Johannesson Hjelholt, Samuel Azuz","doi":"10.61409/V01250039","DOIUrl":"https://doi.org/10.61409/V01250039","url":null,"abstract":"<p><p>For severe recurrent urinary tract infections (rUTIs), pharmacological prevention may be necessary. This review finds that existing data indicate that non-antibiotic treatments, such as cranberry products, methenamine hippurate, and vaginal estrogen for postmenopausal women, demonstrate efficacy comparable to low-dose antibiotics. These alternatives should be prioritised to reduce antibiotic use, development of resistance, and side effects. High-quality studies are needed to validate current evidence.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Josephine Mistegård, Anne Lindegaard Christiansen, Christian Vestergaard, Hans Christian Wulf, Henrik F Lorentzen
{"title":"[Porphyria cutanea tarda].","authors":"Josephine Mistegård, Anne Lindegaard Christiansen, Christian Vestergaard, Hans Christian Wulf, Henrik F Lorentzen","doi":"10.61409/V11240832","DOIUrl":"https://doi.org/10.61409/V11240832","url":null,"abstract":"<p><p>Porphyria cutanea tarda (PCT) is caused by decreased activity of uroporphyrinogen decarboxylase (UROD) due to various susceptibility factors, here among pathogenic variants in UROD and the presence of iron overload. Porphyrins are sensitive to light and cause cutaneous symptoms in the form of blisters and ulcers on sun-exposed skin. This review gives an update on diagnosing, monitoring and the treatment of PCT. PCT is often effectively treated with venesection or/and low-dose hydroxychloroquine. Additionally, patients must be informed about sufficient sun protection and reduction of susceptibility factors.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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