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Cardiac involvement in eosinophilic granulomatosis with polyangiitis. 嗜酸性粒细胞肉芽肿伴多血管炎的心脏受累。
Ugeskrift for laeger Pub Date : 2024-08-19 DOI: 10.61409/V02240141
Michella Dinithi Peiris, Lotte Saaby, Keld-Erik Byg
{"title":"Cardiac involvement in eosinophilic granulomatosis with polyangiitis.","authors":"Michella Dinithi Peiris, Lotte Saaby, Keld-Erik Byg","doi":"10.61409/V02240141","DOIUrl":"https://doi.org/10.61409/V02240141","url":null,"abstract":"<p><p>This case report describes a 40-year-old male patient with severe cardiac failure due to eosinophilic granulomatosis with polyangiitis (EGPA) and myocarditis. The fast diagnostic approach with cardiac MRI (CMR) and immunosuppressive treatment with glucocorticoid and cyclophosphamide near-normalized the patient's cardiac function. Myocarditis due to EGPA is rare, however life-threatening, so a systematic approach and early CMR should be considered in patients with known asthma presenting with eosinophilia and cardiac involvement.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placebo effect in clinical practice. 临床实践中的安慰剂效应
Ugeskrift for laeger Pub Date : 2024-08-19 DOI: 10.61409/V02240121
Jakob Mejdahl Bentin, Lars Arendt-Nielsen, Asger Reinstrup Bihlet
{"title":"Placebo effect in clinical practice.","authors":"Jakob Mejdahl Bentin, Lars Arendt-Nielsen, Asger Reinstrup Bihlet","doi":"10.61409/V02240121","DOIUrl":"10.61409/V02240121","url":null,"abstract":"<p><p>The term placebo poses challenges in definition, language and use in research and clinical settings. Placebo extends beyond inactive substances, and modern exploration has revealed complex neurobiological, psychological, and social factors influencing placebo mechanisms. With knowledge of the placebo effect, clinicians can assess and enhance the effectiveness of the most optimal treatments. Future research should explore ethical ways of promoting placebo effects, aligning with broader goals in medical practice, as argued in this review.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Her skal vi have en nulfejlskultur: kliniske og parakliniske kriterier for hjernedød i Danmark. 零缺陷文化：丹麦脑死亡的临床和准临床标准。
Ugeskrift for laeger Pub Date : 2024-08-19 DOI: 10.61409/V205184
Christian Bonde Pedersen
{"title":"Her skal vi have en nulfejlskultur: kliniske og parakliniske kriterier for hjernedød i Danmark.","authors":"Christian Bonde Pedersen","doi":"10.61409/V205184","DOIUrl":"10.61409/V205184","url":null,"abstract":"","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A simplified model to understand the targeted disease-modifying anti-inflammatory drugs. 了解靶向疾病调节抗炎药物的简化模型。
Ugeskrift for laeger Pub Date : 2024-08-12 DOI: 10.61409/V12230795
Tue Wenzel Kragstrup, Kristine Jagd Ottosen, Line Uhrenholt, Emil Barner Dalgaard
{"title":"A simplified model to understand the targeted disease-modifying anti-inflammatory drugs.","authors":"Tue Wenzel Kragstrup, Kristine Jagd Ottosen, Line Uhrenholt, Emil Barner Dalgaard","doi":"10.61409/V12230795","DOIUrl":"https://doi.org/10.61409/V12230795","url":null,"abstract":"<p><p>This review presents a simplified model to understand better how disease-modifying anti-inflammatory drugs (DMAIDs) work in immune-mediated inflammatory diseases (IMIDs) with a focus on rheumatology, dermatology, and gastroenterology. In this model, IMIDs are listed on a spectrum from autoinflammatory to autoimmune characterised by the involvement of either mostly the innate or the adaptive immune system. DMAIDs specifically target these immune components and have shown efficacy in distinct IMIDs. DMAID classes include TNF blockers, IL-1 blockers, IL-6 receptor blockers, IL-17 blockers, IL-23 blockers, and janus kinase inhibitors.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Akut luftvejsobstruktion og svær acidose efter indtagelse af hvalkød. 食用鲸鱼肉后出现急性气道阻塞和严重酸中毒。
Ugeskrift for laeger Pub Date : 2024-08-12 DOI: 10.61409/V72032
Michala Norsell, Carsten Sauer Mikkelsen, Luit Penninga
{"title":"Akut luftvejsobstruktion og svær acidose efter indtagelse af hvalkød.","authors":"Michala Norsell, Carsten Sauer Mikkelsen, Luit Penninga","doi":"10.61409/V72032","DOIUrl":"10.61409/V72032","url":null,"abstract":"","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Misdiagnosed case of acute angle closure caused severe visual field defects. 急性闭角误诊导致严重视野缺损。
Ugeskrift for laeger Pub Date : 2024-08-12 DOI: 10.61409/V04240244
Anna Elizabeth Mao, Daniella Bach-Holm
{"title":"Misdiagnosed case of acute angle closure caused severe visual field defects.","authors":"Anna Elizabeth Mao, Daniella Bach-Holm","doi":"10.61409/V04240244","DOIUrl":"10.61409/V04240244","url":null,"abstract":"<p><p>In this case report, a 33-year-old pregnant woman with migraine and visual aura complained of headache, nausea, and blurred vision. Clinically, she presented with bilateral dilated and fixed pupils, ptosis, and tearing. She was erroneously diagnosed as having a migraine attack, but after referral to an ophthalmological department she was diagnosed with bilateral acute angle closure. At one-year follow-up her visual acuity was normalized but the severe visual field defects affected her daily activities and prevented her from having a driving licence.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indications for nuclear medicine imaging in prostate cancer. 前列腺癌核医学成像的适应症。
Ugeskrift for laeger Pub Date : 2024-08-12 DOI: 10.61409/V01240036
Andreas Underbjerg Raade, Karen Middelbo Buch-Olsen, Lars Lund, Helle D Zacho, Michael Borre, Jorun Holm, Kasper Tholstrup Pedersen, Malene Brubbe Hildebrandt
{"title":"Indications for nuclear medicine imaging in prostate cancer.","authors":"Andreas Underbjerg Raade, Karen Middelbo Buch-Olsen, Lars Lund, Helle D Zacho, Michael Borre, Jorun Holm, Kasper Tholstrup Pedersen, Malene Brubbe Hildebrandt","doi":"10.61409/V01240036","DOIUrl":"https://doi.org/10.61409/V01240036","url":null,"abstract":"<p><p>Nuclear medicine imaging for prostate cancer has advanced significantly over the past decade. A survey is presented in this review. PSMA-PET/CT is a new highly accurate method that has been introduced, but bone scans and bone-PET continue to be widely applied. PSMA-PET/CT still lacks sufficient patient outcome data to be recommended for treatment allocation when used for primary staging. However, the literature and clinical guidelines support its use at the stage of biochemical recurrence. In Denmark, the use of nuclear medicine examinations for prostate cancer aligns with clinical guideline recommendations.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The indication for total hip arthroplasty and its durability. 全髋关节置换术的适应症及其耐用性。
Ugeskrift for laeger Pub Date : 2024-08-12 DOI: 10.61409/V03240219
Jonathan Bjerre-Bastos, Claus Varnum, Søren Overgaard
{"title":"The indication for total hip arthroplasty and its durability.","authors":"Jonathan Bjerre-Bastos, Claus Varnum, Søren Overgaard","doi":"10.61409/V03240219","DOIUrl":"https://doi.org/10.61409/V03240219","url":null,"abstract":"<p><p>The most frequent indication for total hip arthroplasty (THA) is hip osteoarthritis. THA is inserted to improve function, reduce pain, and improve quality of life. Results are generally good, and 90-95% of the patients are satisfied. However, there are risks associated with THA, and patients must be well informed. Before THA is considered, non-surgical treatment must be completed, as the need for surgery often is postponed. Patients can expect rapid mobilisation and a return to a near-habitual level of physical activity within a year. In Denmark, 95% have their THA after five years and 76% after 25 years.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital malformations of the hand and fingers. 手部和手指的先天性畸形。
Ugeskrift for laeger Pub Date : 2024-08-05 DOI: 10.61409/V04230238
Casper Smedegaard Ottesen, Hanne Hove, Tine Weis
{"title":"Congenital malformations of the hand and fingers.","authors":"Casper Smedegaard Ottesen, Hanne Hove, Tine Weis","doi":"10.61409/V04230238","DOIUrl":"https://doi.org/10.61409/V04230238","url":null,"abstract":"<p><p>Congenital anomalies of the upper limb are in Denmark estimated to have an incidence of around 20 in 10,000 live births. This covers a wide array of conditions summarised in this review. At the time of referral, the patient is thoroughly examined, and a treatment plan is discussed with the family. In some cases, no treatment is needed, in others there might be a need for surgery, night splinting, or an upper limb prosthesis. In case an underlying syndromatic cause is suspected, the patient is referred for paediatric evaluation at specialized centre.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy and infection. 怀孕和感染。
Ugeskrift for laeger Pub Date : 2024-08-05 DOI: 10.61409/V03240175
Ellen Moseholm, Lene Ryom, Nina Riise, Majbritt Jeppesen, Lene S Knudsen, Isik S Johansen, Terese L Katzenstein, Gitte Pedersen, Nina Weis
{"title":"Pregnancy and infection.","authors":"Ellen Moseholm, Lene Ryom, Nina Riise, Majbritt Jeppesen, Lene S Knudsen, Isik S Johansen, Terese L Katzenstein, Gitte Pedersen, Nina Weis","doi":"10.61409/V03240175","DOIUrl":"https://doi.org/10.61409/V03240175","url":null,"abstract":"<p><p>Infections in pregnancy are common, and although often not harmful to the woman or her unborn child, some infections may be associated with severe adverse outcomes. Pregnancy causes physiological and immunological adaptations which may make pregnant women more susceptible to infections and at increased risk of more severe illness. Infections in pregnancy represent a challenging area of concern for many specialists and general practitioners. Center for Pregnancy and Infection was developed to enhance knowledge, diagnosis, treatment, and care for pregnant women with infection in Denmark, as pointed out in this review.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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