[Local administration of tranexamic acid for prevention and treatment of bleeding].

Abstract

Tranexamic acid (TXA) is an antifibrinolytic drug found on WHO's list of "essential medicines". TXA is effective in reducing bleeding by 30-40% in a wide range of clinical scenarios and is most often administered systemically. Concerns regarding increased risk of thromboembolic events have prompted research into local administration of TXA. Local administration of TXA has therefore been investigated in a wide range of clinical scenarios with most studies showing an effect approximately equal to systemically administrated TXA and with minimal risk of systemic side effects, as argued in this review.