{"title":"[局部应用氨甲环酸预防和治疗出血]。","authors":"Jeppe Hjembæk-Brandt, Mathias Maagaard, Christine Nygaard Svendsen, Preben Homø, Jakob Felbo Paulsen","doi":"10.61409/V11240825","DOIUrl":null,"url":null,"abstract":"<p><p>Tranexamic acid (TXA) is an antifibrinolytic drug found on WHO's list of \"essential medicines\". TXA is effective in reducing bleeding by 30-40% in a wide range of clinical scenarios and is most often administered systemically. Concerns regarding increased risk of thromboembolic events have prompted research into local administration of TXA. Local administration of TXA has therefore been investigated in a wide range of clinical scenarios with most studies showing an effect approximately equal to systemically administrated TXA and with minimal risk of systemic side effects, as argued in this review.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 26","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Local administration of tranexamic acid for prevention and treatment of bleeding].\",\"authors\":\"Jeppe Hjembæk-Brandt, Mathias Maagaard, Christine Nygaard Svendsen, Preben Homø, Jakob Felbo Paulsen\",\"doi\":\"10.61409/V11240825\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Tranexamic acid (TXA) is an antifibrinolytic drug found on WHO's list of \\\"essential medicines\\\". TXA is effective in reducing bleeding by 30-40% in a wide range of clinical scenarios and is most often administered systemically. Concerns regarding increased risk of thromboembolic events have prompted research into local administration of TXA. Local administration of TXA has therefore been investigated in a wide range of clinical scenarios with most studies showing an effect approximately equal to systemically administrated TXA and with minimal risk of systemic side effects, as argued in this review.</p>\",\"PeriodicalId\":23428,\"journal\":{\"name\":\"Ugeskrift for laeger\",\"volume\":\"187 26\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ugeskrift for laeger\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.61409/V11240825\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ugeskrift for laeger","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.61409/V11240825","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
[Local administration of tranexamic acid for prevention and treatment of bleeding].
Tranexamic acid (TXA) is an antifibrinolytic drug found on WHO's list of "essential medicines". TXA is effective in reducing bleeding by 30-40% in a wide range of clinical scenarios and is most often administered systemically. Concerns regarding increased risk of thromboembolic events have prompted research into local administration of TXA. Local administration of TXA has therefore been investigated in a wide range of clinical scenarios with most studies showing an effect approximately equal to systemically administrated TXA and with minimal risk of systemic side effects, as argued in this review.
期刊介绍:
The Ulster Medical Journal is an international general medical journal with contributions on all areas of medical and surgical specialties relevant to a general medical readership. It retains a focus on material relevant to the health of the Northern Ireland population. The Honorary Editor would welcome offers of papers for publication. Prospective authors are invited to read the notice to contributors.