Charlotta Pisinger, Anders Løkke, Nina Skavlan Godfredsen
{"title":"[E-cigarettes cannot be recommended as a means of smoking cessation and long-term impacts are unresolved].","authors":"Charlotta Pisinger, Anders Løkke, Nina Skavlan Godfredsen","doi":"10.61409/V02240114","DOIUrl":"https://doi.org/10.61409/V02240114","url":null,"abstract":"<p><p>E-cigarettes are popular, especially among youth. However, controversies surround their harm-reduction potential vs risks, and this review explores the current knowledge. Reviews have compared e-cigarettes to established quit medication, and although some studies suggest efficacy, overall evidence quality is low. Thousands of studies have examined the health effects of e-cigarettes, revealing conclusive evidence of acute harm. Short-term studies highlight negative cardiovascular and pulmonary effects, while limited data on long-term impacts underscore the need for further research and continued caution.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lisa Neerup Jensen, Bodil Helenius Hvingel, Christina Hjørnet Kamper, Pernille Nørgaard, Pernille Christina Martens, Mette Bendixen Thorup, Annika Reynberg Langkilde, Vibeke Andrée Larsen, Puk Sandager
{"title":"[Prenatal diagnosis of anomalies in the central nervous system].","authors":"Lisa Neerup Jensen, Bodil Helenius Hvingel, Christina Hjørnet Kamper, Pernille Nørgaard, Pernille Christina Martens, Mette Bendixen Thorup, Annika Reynberg Langkilde, Vibeke Andrée Larsen, Puk Sandager","doi":"10.61409/V11240764","DOIUrl":"https://doi.org/10.61409/V11240764","url":null,"abstract":"<p><p>Anomalies of the central nervous system (CNS) are some of the most common anomalies in the fetus. Severe neural tube defects can be detected by ultrasound in the 1st trimester. An accurate diagnosis at the prenatal ultrasound is essential for parents' prenatal counseling. Since the CNS develops throughout pregnancy, it is important to know the normal anatomy at different gestational ages. Fetal MRI is an important supplement to ultrasound for diagnostic accuracy. Genetic testing with microarray and whole genome sequencing can provide important information on the prognosis as argued in this review.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dansk føtalmedicin i front – og ved en skillevej.","authors":"Olav Bjørn Petersen","doi":"10.61409/V04250264","DOIUrl":"https://doi.org/10.61409/V04250264","url":null,"abstract":"","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Steffen Ernesto Kristensen, Emilie Thorup Nielsen, Lotte Harmsen, Olav Bjørn Petersen, Lise Neerup Jensen, Lone Nikoline Nørgaard, Karin Sundberg
{"title":"[Invasive foetal treatment in Denmark].","authors":"Steffen Ernesto Kristensen, Emilie Thorup Nielsen, Lotte Harmsen, Olav Bjørn Petersen, Lise Neerup Jensen, Lone Nikoline Nørgaard, Karin Sundberg","doi":"10.61409/V10240751","DOIUrl":"https://doi.org/10.61409/V10240751","url":null,"abstract":"<p><p>Foetal medicine in Denmark has evolved over 40 years, driven by advancements in ultrasound imaging. Initially targeting lethal conditions, the focus has expanded to include procedures that prolong pregnancy and reduce prematurity risks. Centralized at Rigshospitalet, the field features notable Danish contributions, such as the world's first ultrasound-guided foetal blood transfusion and significant advancements in chorionic villus sampling. In this review, treatments encompass a range of foetal anaemias, twin complications, and organ-specific interventions.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iben Riishede, Martin Overgaard, Henriette Ladegård Skov, Puk Sandager, Ann Tabor, Line Rode, Charlotte Kvist Ekelund
{"title":"[First-trimester screening for pre-eclampsia].","authors":"Iben Riishede, Martin Overgaard, Henriette Ladegård Skov, Puk Sandager, Ann Tabor, Line Rode, Charlotte Kvist Ekelund","doi":"10.61409/V11240762","DOIUrl":"10.61409/V11240762","url":null,"abstract":"<p><p>Pre-eclampsia is a common and serious pregnancy complication. This review describes that low-dose acetylsalicylic acid can reduce the risk of preterm pre-eclampsia in high-risk pregnant women if treatment is started before the 16th week of pregnancy. A new screening algorithm can already, in the first trimester of pregnancy, predict an individual woman's risk of developing pre-eclampsia by combining a series of biophysical and biochemical markers with maternal risk factors. The screening has been validated internationally and in Denmark. In 2025, a national implementation project will be initiated to evaluate the effectiveness of a change in screening strategy in Denmark.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simon Horsholt Thomsen, Tina Duelund Hjortshøj, Malou Barbosa, Lone Laursen, Martin Larsen, Marie Skov Hvidbjerg, Pernille Tørring, Lene Sperling, Ida Charlotte Bay Lund, Lotte Andreasen, Anja Ernst, Lone Sunde, Marie Balslev-Harder, Olav Bjørn Petersen, Stina Lou, Naja Becher, Ida Vogel
{"title":"[Genetics in fetal medicine].","authors":"Simon Horsholt Thomsen, Tina Duelund Hjortshøj, Malou Barbosa, Lone Laursen, Martin Larsen, Marie Skov Hvidbjerg, Pernille Tørring, Lene Sperling, Ida Charlotte Bay Lund, Lotte Andreasen, Anja Ernst, Lone Sunde, Marie Balslev-Harder, Olav Bjørn Petersen, Stina Lou, Naja Becher, Ida Vogel","doi":"10.61409/V12240853","DOIUrl":"https://doi.org/10.61409/V12240853","url":null,"abstract":"<p><p>The Danish prenatal program and genetic testing provide pregnant couples with the opportunity to learn about serious and potentially life-threatening fetal conditions. While invasive diagnostic methods remain the gold standard, advances in non-invasive technologies are emerging as valuable alternatives but they still have reduced resolution. Whole genome sequencing offers much increased resolution but raises challenges related to costs, uncertain findings, and secondary results. Counselling and multidisciplinary collaboration are critical to supporting couples navigating these complex decisions.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caroline Taksøe-Vester, Zahra Bashir, Emilie Pi Fogtmann Sejer, Mary Le Ngo, Lars Henning Pedersen, Mikkel Friis, Olav Bjørn Petersen, Aasa Feragen, Mads Nielsen, Anders Nymark Christensen, Martin G Tolsgaard
{"title":"[Artificial intelligence and ultrasound in fetal medicine].","authors":"Caroline Taksøe-Vester, Zahra Bashir, Emilie Pi Fogtmann Sejer, Mary Le Ngo, Lars Henning Pedersen, Mikkel Friis, Olav Bjørn Petersen, Aasa Feragen, Mads Nielsen, Anders Nymark Christensen, Martin G Tolsgaard","doi":"10.61409/V10240748","DOIUrl":"https://doi.org/10.61409/V10240748","url":null,"abstract":"<p><p>Ultrasound is essential in fetal medicine for diagnosing and monitoring, but it requires extensive training. Artificial intelligence (AI) shows a great promise in enhancing the clinical training and practice, by improving workflow and standardising diagnostics. Despite its potential, AI's limitations and regulatory challenges must be addressed before full integration. Research should focus on implementation to achieve successful use in clinical practice. Ultimately, AI is expected to support clinicians rather than replace them, improving diagnostic accuracy and efficiency in fetal medicine.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Malou Barbosa, Finn Stener Jørgensen, Marianne Christiansen, Jesper Normann Steensberg, Charlotte Kvist Ekelund, Cathrine Vedel
{"title":"[Prenatal screening for severe congenital heart defects in Denmark].","authors":"Malou Barbosa, Finn Stener Jørgensen, Marianne Christiansen, Jesper Normann Steensberg, Charlotte Kvist Ekelund, Cathrine Vedel","doi":"10.61409/V11240763","DOIUrl":"10.61409/V11240763","url":null,"abstract":"<p><p>In Denmark, screening for congenital heart defects is a key component of the second-trimester ultrasound with > 95% of pregnant women participating. The screening boasts high detection rates, identifying > 80% of severe congenital heart defects before birth. Early detection enables accurate diagnosis and genetic testing, as well as timely planning and intervention. A national virtual conference platform connecting paediatric cardiologists and foetal medicine specialists enhances the detection and coordination of treatment, improving outcomes for children with congenital heart defects.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kasper Gadsbøll, Karin Sundberg, Ida Kirkegaard, Richard Farlie, Lene Sperling, Lars Henning Pedersen, Olav Bjørn Petersen, Finn Stener Jørgensen
{"title":"[Combined first trimester screening in Denmark and the Danish Fetal Medicine Database].","authors":"Kasper Gadsbøll, Karin Sundberg, Ida Kirkegaard, Richard Farlie, Lene Sperling, Lars Henning Pedersen, Olav Bjørn Petersen, Finn Stener Jørgensen","doi":"10.61409/V12240874","DOIUrl":"10.61409/V12240874","url":null,"abstract":"<p><p>All pregnant women in Denmark are offered a first-trimester ultrasound screening examination between 11 and 14 weeks of gestation. Additionally, women are offered a risk assessment for foetal chromosomal abnormalities. The main results in this review are that more than 90% of pregnant women attend the first-trimester screening, and of those, 5% receive a high-risk screening result for trisomy 21. The first-trimester screening detects more than 90% of trisomy 21 cases and a large proportion of severe structural malformations. The Danish Fetal Medicine Database (DFMD) was established in 2008-2010. DFMD is a national clinical research and quality database.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"187 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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