Urologia Internationalis最新文献

{"title":"The Relationship of Chronic Inflammation in Prostate Biopsies with International Society of Urological Pathology Score Upgrade after Radical Prostatectomy.","authors":"Hakan Polat, Ubeyd Sungur, Mithat Ekşi, Ekrem Güner, Serdar Altınay, Esra Karabulut, Taner Kargı, Alper Bitkin","doi":"10.1159/000546326","DOIUrl":"10.1159/000546326","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the relationship between the International Society of Urological Pathology (ISUP) score upgrade and inflammation in transrectal ultrasound-guided prostate biopsy (TRUS-Bx) specimens.</p><p><strong>Methods: </strong>The data of 340 patients who underwent robot-assisted radical prostatectomy were retrospectively evaluated, and two groups were formed based on the presence (Group 1, n = 168) or absence (Group 2, n = 172) of an ISUP score upgrade. Prostate characteristics, imaging findings, and inflammation on TRUS-Bx were recorded in both groups for statistical analysis. Univariate and multivariate analyses were used to identify factors predicting the development of the upgrade.</p><p><strong>Results: </strong>Total inflammation was significantly greater in Group 1 compared to Group 2 (p = 0.04). Glandular-located inflammation was significantly higher in Group 2 compared to Group 1 (p = 0.001). When the factors predicting ISUP score upgrade were examined, glandular inflammation was found to be significant in univariate analysis (p = 0.001), while seminal vesicle invasion in multiparametric magnetic resonance imaging and ISUP grade in TRUS-Bx were found to be significant predictors in multivariate analysis (p = 0.022, p = 0.009, respectively).</p><p><strong>Conclusion: </strong>Prostatitis accompanying prostate cancer is observed more frequently in patients with an ISUP score upgrade. The location of inflammation may offer insights into predicting an upgrade.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-7"},"PeriodicalIF":1.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propensity-Score-Based Comparative Analysis of Transperitoneal and Retroperitoneal Approaches in Open and Minimally Invasive Renal Surgery: Impact on Operative Outcomes.","authors":"Marcel Schwinger, Lena Knaier, Charis Kalogirou, Robert Woidich, Oliver Hahn, Hubert Kübler, Vincent Scheper","doi":"10.1159/000546230","DOIUrl":"10.1159/000546230","url":null,"abstract":"<p><strong>Introduction: </strong>Renal cancer is among the ten most common cancers in western societies, with renal cell carcinoma (RCC) accounting for 95% of malignant renal neoplasms. Recent advances in surgical techniques and approaches have expanded treatment options, necessitating an evaluation of optimal approaches.</p><p><strong>Methods: </strong>A retrospective, propensity-matched cohort with 814 patients (1999-2021) was conducted comparing open and minimally invasive (laparoscopic and robotic-assisted) nephrectomy and partial nephrectomy techniques, focusing on operative time, blood loss, hospital stay, complications, and perioperative complications.</p><p><strong>Results: </strong>The retroperitoneal (RP) approach demonstrated shorter operation times, reduced blood loss, and quicker recovery compared to the transperitoneal (TP) approach. Minimal invasive techniques, whether laparoscopic or robotic, had shorter hospital stays, fewer complications, and better postoperative renal function. The RP approach showed advantages in operative efficiency and reduced postoperative morbidity.</p><p><strong>Conclusion: </strong>The findings support that the RP approach is at least as effective as, or superior to, the TP approach in terms of perioperative outcomes. Minimally invasive approaches, including robotic-assisted and laparoscopic techniques, are associated with improved recovery and fewer complications, highlighting their advantages in the surgical treatment of renal tumors. Further studies are needed to assess long-term oncologic and functional outcomes. These findings underline the importance of tailored surgical planning to optimize patient outcomes.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Prospective Evaluation of Li-ESWT with or without PDE5 Inhibitors for Erectile Dysfunction following Nerve-Sparing Radical Prostatectomy.","authors":"Rashad Sholan, Rufat Aliyev, Seymur Karimov, Malahat Sultan, Anar Almazkhanli","doi":"10.1159/000546359","DOIUrl":"10.1159/000546359","url":null,"abstract":"<p><strong>Introduction: </strong>Erectile dysfunction (ED) is a common complication following radical prostatectomy (RP). Although phosphodiesterase type 5 inhibitors (PDE5is) are used for penile rehabilitation, their efficacy post-RP is limited. Low-intensity extracorporeal shockwave therapy (Li-ESWT) has emerged as a potential noninvasive treatment, promoting tissue regeneration. This study evaluates the effectiveness of Li-ESWT, with or without PDE5i, for post-RP ED.</p><p><strong>Methods: </strong>This prospective study included 104 patients who underwent nerve-sparing RP and received Li-ESWT. Patients were divided into two groups: group 1 received daily 5 mg tadalafil along with Li-ESWT, while group 2 received Li-ESWT alone. Erectile function was assessed using the International Index of Erectile Function (IIEF-5) at baseline, 6, 12, and 24 months postoperatively.</p><p><strong>Results: </strong>The preoperative mean IIEF-5 score was 15.7 ± 4.7, with 54.8% of patients scoring below 17. Postoperatively, significant improvements in IIEF-5 scores were observed at 12 and 24 months in both groups compared to the 6th month. In patients with preoperative IIEF-5 <17, group 1 showed significantly greater improvement in IIEF-5 scores compared to group 2 (p = 0.008). No significant difference was observed between the groups in patients with preoperative IIEF-5 ≥17 (p = 0.893).</p><p><strong>Conclusion: </strong>Li-ESWT is an effective treatment for ED following nerve-sparing RP, with or without PDE5i. In patients with mild-to-moderate or greater preoperative ED, the combination of PDE5i and Li-ESWT may provide additional benefits, whereas Li-ESWT alone appears sufficient for those with milder cases.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-7"},"PeriodicalIF":1.5,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Circulating Tumor DNA in the Prognostic Diagnosis of Bladder Cancer: A Systematic Review and Meta-Analysis.","authors":"Yu Lu, Huajun Wu, Jian Jiang, Siwen Bao, Chen Ling","doi":"10.1159/000546014","DOIUrl":"10.1159/000546014","url":null,"abstract":"<p><strong>Introduction: </strong>Circulating tumor DNA (ctDNA) is a noninvasive liquid biopsy technique that can reflect the dynamic changes of tumors in real time. This study aims to clarify the predictive value of ctDNA detection for disease progression and metastasis risk in bladder cancer patients through systematic review and meta-analysis, providing a scientific basis for clinicians' individualized treatment decisions and risk stratification management for patients.</p><p><strong>Methods: </strong>Studies related to ctDNA in prognostic assessment of bladder cancer were screened by systematically searching PubMed, Cochrane Library, Web of Science, Willey library, CNKI, and other databases, and the search was from inception to December 2024, and the data were extracted and analyzed by Meta-analysis.</p><p><strong>Results: </strong>A total of 9 papers were included, and the results showed that ctDNA testing had a sensitivity of 0.68 (95% CI: 0.54-0.78), specificity of 0.76 (95% CI: 0.51-0.90), and an area under the curve of 0.75 (95% CI: 0.71-0.79), suggesting that it has a moderate level of diagnostic efficacy in the assessment of prognosis in bladder cancer. Positive likelihood ratio and negative likelihood ratio were 2.8 (95% CI: 1.24-6.35) and 0.43 (95% CI: 0.28-0.65), respectively, with a diagnostic odds ratio of 6.56 (95% CI: 2.12-20.33). Fagan's nomogram analysis showed that when the prior probability was 50%, the posttest probability increased to 74% for positive results and decreased to 30% for negative results. Deeks' funnel plot analysis indicated no significant publication bias (p = 0.24). A high level of heterogeneity (I2 > 80%) was observed among the studies, which may stem from differences in detection techniques, disease stages of patients, and follow-up periods. Publication bias analysis revealed no significant bias (p = 0.24).</p><p><strong>Conclusion: </strong>ctDNA demonstrates some clinical application value in the prognostic assessment of bladder cancer and can assist in predicting patient recurrence and survival. However, its independent predictive efficacy is not enough to replace traditional assessment methods. Future studies should aim to optimize the detection technology, unify the study design, expand the sample size, and combine multi-omics data for joint analysis, in order to further improve its potential application in the prognostic assessment of bladder cancer.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-13"},"PeriodicalIF":1.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of a Plasmacytoid and Sarcomatoid Differentiated Urothelial Bladder Carcinoma with a Single Metastasis to the Right Ventricle of the Heart and Rapid Review of Single Heart Metastasis in Bladder Cancer.","authors":"Kai Alexander Münker, David Reineke, Laila Schneidewind, Charlotte Müssgens","doi":"10.1159/000546149","DOIUrl":"10.1159/000546149","url":null,"abstract":"<p><strong>Introduction: </strong>Distant metastases and especially single side metastases of non-muscle invasive bladder cancer (NMIBC) without regional progression in lymph nodes are extremely uncommon and rare.</p><p><strong>Case presentation: </strong>We report a case of a plasmacytoid and sarcomatoid differentiated urothelial NMIIC with a single metastasis to the right ventricle of the heart, which was surgically resected, but the patient died shortly after the resection with progressive metastatic disease. To the best of our knowledge, this is the first case with two different variant histologies in NMIBC with a single heart metastasis. Furthermore, we conducted a rapid review using MEDLINE regarding single heart metastasis of bladder cancer. Four cases have been identified. Interestingly, with 2 cases of variant histology and one with single plasmacytoid differentiation, also being NMIBC.</p><p><strong>Conclusion: </strong>These findings underline the aggressiveness of the variant histologies in NMIBC, especially plasmacytoid differentiation, and may favor an early and aggressive treatment regimen. Further scientific research concerning the optimal treatment of histologically variant bladder cancer is absolutely needed.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Positive Rate of Antisperm Antibody and Its Impact on in vitro Fertilization/Intracytoplasmic Sperm Injection Embryo Culture.","authors":"Han Zhang, Dong-Qing Mi, Yan Jiang, Cai-Hong Zhang, Li-Sen Wu, Fei Lin, Xiao-Pu Zhou, Ge Song","doi":"10.1159/000545912","DOIUrl":"10.1159/000545912","url":null,"abstract":"<p><strong>Introduction: </strong>To explore the prevalence of antisperm antibodies (ASA) and its impact on the embryo culture outcomes of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), a retrospective analysis of the Center for Reproductive Medicine's data was conducted.</p><p><strong>Methods: </strong>8,265 semen samples were detected for ASA using mixed antiglobulin reaction. In addition, 934 IVF/ICSI cycles were included to compare the effects of ASA on embryo culture outcomes during IVF/ICSI, including normal fertilization rate, D3 good-quality embryo rate, available blastocyst formation rate, and available embryo rate.</p><p><strong>Results: </strong>The positive rate of ASA in semen was relatively low, about 1.03%. We found ASA may weaken the normal fertilization rate of IVF cycles. In addition, there was no statistical difference in outcomes between the positive groups and negative groups of ICSI cycles with a threshold 10% in ASA, but ASA significantly reduced the normal fertilization rate and D3 good-quality embryo rate of ICSI cycles with a threshold 50% in ASA. It was speculated that the high ratio of rescue ICSI cycles resulted in the poor embryo culture outcomes. We supposed that the higher of the ASA-positive rate, the higher of the likelihood of fertilization failure of IVF. Comparing with IVF, ICSI is more recommended as a fertilization method for ASA-positive patients who need assisted reproductive technology.</p><p><strong>Conclusions: </strong>ASA may have a negative impact on the embryo culture outcomes of IVF. Therefore, for ASA-positive patients who require IVF/ICSI treatment, it is suggested embryologists wash the sperm thoroughly and use short-term fertilization of IVF or conventional ICSI to assist with pregnancy.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-7"},"PeriodicalIF":1.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integral Theory Paradigm: Common Pelvic Ligament Pathogenesis Guides Management for Urology, Gynecology, Coloproctology.","authors":"Peter Petros, Bernhard Liedl, Ahmet Akin Sivaslioglu, Klaus Goeschen, Hiromi Inoue, Yuki Sekiguchi, Burghard Abendstein, Dmitry Shkarupa, Nikita Kubin","doi":"10.1159/000545665","DOIUrl":"10.1159/000545665","url":null,"abstract":"<p><strong>Background: </strong>This work had its origins in the 1990s, when women having collagen-creating midurethral slings for stress urinary incontinence (SUI) and uterosacral slings for uterine prolapse began reporting cure or improvement in co-occurring fecal incontinence, obstructive defecation, and chronic pelvic pain.</p><p><strong>Summary: </strong>We briefly describe anatomical etiopathogenesis to explain how the same collagen-creating ligament repair system using a common ligament-based diagnostic system, can treat pelvic symptoms from 3 disciplines: Urology, Gynecology, Coloproctology. Collagen-induced laxity in ligaments and vagina diminishes contractile forces required by pelvic muscles to close urethra and anus for continence, open them for evacuation, and stretch the bladder base and rectum like a trampoline to prevent stretch receptors prematurely activating micturition and defecation reflexes. These are perceived cortically as bladder or fecal \"urge to go.\" The pictorial algorithm summarizes common ligament pathogeneses for prolapse/bladder/bowel/pain dysfunctions which can be confirmed by mechanical support of PUL for relief of urine loss on coughing, and uterosacral ligaments (USL) for relief of urge and chronic pelvic pain. The same minimally invasive ligament repairs used for SUI, prolapse, pain/bladder dysfunctions were demonstrated by X-ray defecography controlled studies to cure fecal incontinence, obstructive defecation, anterior rectal wall intussusception and descending perineal syndrome (as shown in 16 case managements in 3 disciplines; video: <ext-link ext-link-type=\"uri\" xlink:href=\"https://youtu.be/a6jJQXDx71U?si=MLdo3Yq9kAZ82RVb\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">https://youtu.be/a6jJQXDx71U?si=MLdo3Yq9kAZ82RVb</ext-link>).</p><p><strong>Key messages: </strong>Symptom relief can be achieved using standard operations which repair PUL or USL even with minimal prolapse. Whether the surgery is done laparoscopically or vaginally is of little consequence, as the same structure is repaired.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-13"},"PeriodicalIF":1.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Strategies in Oligo-Metastatic Prostate Cancer: A Nationwide Survey.","authors":"Angelika Borkowetz, Bernd Wullich, Matthias Saar, Nina Schmidt-Hegemann, Johannes Linxweiler","doi":"10.1159/000545630","DOIUrl":"10.1159/000545630","url":null,"abstract":"<p><strong>Introduction: </strong>Metastasis-directed therapy (MDT) is a promising approach for recurrent or de novo oligo-metastatic castration-sensitive prostate cancer (omCSPC). The aim of this study was to evaluate the treatment approaches in omCSPC among German physicians.</p><p><strong>Methods: </strong>An anonymous online questionnaire was sent via <ext-link ext-link-type=\"uri\" xlink:href=\"http://survio.com\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">survio.com</ext-link> to the members of the German Societies of Urology and Radiooncology.</p><p><strong>Results: </strong>Participants (n = 166; 33% urologists, 66% radiooncologists) define omCSPC as ≤3 (31%) or ≤4 (58%) metastases. Multimodal therapy consisting of local therapy of the primary tumor, MDT, and androgen deprivation therapy (ADT) was favored. For local therapy, radiotherapy was the preferred approach (radiotherapy: 84%, prostatectomy: 16%). Overall, 77% and 76% considered MDT as (very) highly important in synchronous and metachronous omCSPC, respectively. In total, 80% would complement MDT with time-limited ADT. Compared to urologists, radiooncologists more often include cases with ≥3 metastases (p = 0.006) and see a higher importance of radiotherapy (p = 0.023), a lower importance of prostatectomy (p < 0.001) as well as a higher importance of MDT (in de novo p = 0.038, in metachronous p = 0.010).</p><p><strong>Conclusion: </strong>MDT with time-limited ADT is a common treatment strategy in omCSPC. Especially in synchronous omCSPC, radiotherapy as local treatment for the primary is the preferred option rather than radical prostatectomy.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usage of the Internet and Digital Health among Urological Patients: Findings from a Cross-Sectional Study.","authors":"Rashid Al Sliman, Timur H Kuru, Julian P Struck, Anna L Heinrichs, Katharina Arndt, Johannes Salem, Hendrik Borgmann","doi":"10.1159/000544873","DOIUrl":"10.1159/000544873","url":null,"abstract":"<p><strong>Introduction: </strong>The rising prevalence of Internet usage and smartphone applications among urology patients underscores the critical role of digital health literacy. This study investigates the acceptability of digital health technologies among urology patients and identifies factors influencing their acceptance.</p><p><strong>Materials and methods: </strong>A cross-sectional, anonymous survey consisting of 12 questions was developed based on literature research. It was conducted online using SurveyMonkey and targeted patients in the CUROS network in Germany. The data were analyzed descriptively using SPSS.</p><p><strong>Results: </strong>Of 1,039 participants, 99.1% reported using the Internet, with 84.4% using it several times daily. YouTube emerged as the most popular social media platform. While 90.2% searched for health information online, trust in online resources was low (mean score 4.63). Only 35.2% used medical apps, but 62.8% expressed willingness to use them if prescribed. Furthermore, 74.2% supported the use of electronic patient records, although concerns regarding privacy were noted.</p><p><strong>Conclusions: </strong>Urology patients demonstrate a high engagement with digital resources but express concerns about the reliability of online health information. Enhancing education on digital health tools and fostering trust in these resources is essential for improving patient outcomes and encouraging the integration of digital health in urological care.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-7"},"PeriodicalIF":1.5,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Geriatric Nutritional Risk Index as a Predictor of Outcomes in Urological Cancers: A Systematic Review and Meta-Analysis.","authors":"Yuefen Chen, Mei Wen, Zhe Yu, Fengjiao Xu","doi":"10.1159/000544793","DOIUrl":"10.1159/000544793","url":null,"abstract":"<p><strong>Introduction: </strong>The geriatric nutritional risk index (GNRI) is being used to predict outcomes of several malignancies. However, its utility for urinary tract cancer has not been systematically analyzed. We present the first meta-analysis examining the association between GNRI and the prognosis of urological cancers.</p><p><strong>Methods: </strong>This PROSPERO registered review searched Embase, PubMed, Web of Science, and Scopus up to 25 November 2024 for studies examining the relationship between GNRI and overall survival (OS), cancer-specific survival (CSS), and progression-free survival (PFS) after urological cancers.</p><p><strong>Results: </strong>A total of 20 studies were eligible. Three studies were on bladder cancer, four on prostate cancer, seven on renal cell carcinoma (RCC), and six on urothelial cancers. Meta-analysis showed that low GNRI was a statistically significant predictor of poor OS in prostate cancer (OR: 3.02; 95% CI: 1.61, 5.67). Pooled analysis showed that low GNRI was associated with poor OS (OR: 2.17; 95% CI: 1.46, 3.22) and CSS (OR: 2.60; 95% CI: 1.57, 4.30) in RCC but not PFS (OR: 1.50; 95% CI: 1.00, 2.24). Pooled analysis also found that low GNRI was a predictor of worse OS (OR: 2.24; 95% CI: 1.52, 3.29) and CSS (OR: 3.07; 95% CI: 1.38, 6.86) in urothelial carcinoma. A narrative review on bladder cancer and GNRI showed mixed results.</p><p><strong>Conclusion: </strong>GNRI may have a role in predicting outcomes of urological malignancies. Low GNRI was independently associated with worse OS after prostate, renal cell, and urothelial carcinoma. Further, it also predicted CSS after RCC and urothelial carcinoma.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-14"},"PeriodicalIF":1.5,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}