{"title":"前列腺活检慢性炎症与根治性前列腺切除术后ISUP评分升高的关系。","authors":"Hakan Polat, Ubeyd Sungur, Mithat Ekşi, Ekrem Güner, Serdar Altınay, Esra Karabulut, Taner Kargı, Alper Bitkin","doi":"10.1159/000546326","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the relationship between the International Society of Urological Pathology (ISUP) score upgrade and inflammation in transrectal ultrasound-guided prostate biopsy (TRUS-Bx) specimens.</p><p><strong>Methods: </strong>The data of 340 patients who underwent robot-assisted radical prostatectomy were retrospectively evaluated, and two groups were formed based on the presence (Group 1, n=168) or absence (Group 2, n=172) of an ISUP score upgrade. Prostate characteristics, imaging findings, and inflammation on TRUS-Bx were recorded in both groups for statistical analysis. Univariate and multivariate analyses were used to identify factors predicting the development of the upgrade.</p><p><strong>Results: </strong>Total inflammation was significantly greater in Group 1 compared to Group 2 (p=0.04). Glandular-located inflammation was significantly higher in Group 2 compared to Group 1 (p=0.001). When the factors predicting ISUP score upgrade were examined, glandular inflammation was found to be significant in univariate analysis (p=0.001), while seminal vesicle invasion in multiparametric magnetic resonance imaging and ISUP grade in TRUS-Bx were found to be significant predictors in multivariate analysis (p=0.022, p=0.009, respectively).</p><p><strong>Conclusion: </strong>Prostatitis accompanying prostate cancer is observed more frequently in patients with an ISUP score upgrade. The location of inflammation may offer insights into predicting an upgrade.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-11"},"PeriodicalIF":1.5000,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Relationship Of Chronic Inflammation In Prostate Biopsies With ISUP Score Upgrade After Radical Prostatectomy.\",\"authors\":\"Hakan Polat, Ubeyd Sungur, Mithat Ekşi, Ekrem Güner, Serdar Altınay, Esra Karabulut, Taner Kargı, Alper Bitkin\",\"doi\":\"10.1159/000546326\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>This study aimed to investigate the relationship between the International Society of Urological Pathology (ISUP) score upgrade and inflammation in transrectal ultrasound-guided prostate biopsy (TRUS-Bx) specimens.</p><p><strong>Methods: </strong>The data of 340 patients who underwent robot-assisted radical prostatectomy were retrospectively evaluated, and two groups were formed based on the presence (Group 1, n=168) or absence (Group 2, n=172) of an ISUP score upgrade. Prostate characteristics, imaging findings, and inflammation on TRUS-Bx were recorded in both groups for statistical analysis. Univariate and multivariate analyses were used to identify factors predicting the development of the upgrade.</p><p><strong>Results: </strong>Total inflammation was significantly greater in Group 1 compared to Group 2 (p=0.04). Glandular-located inflammation was significantly higher in Group 2 compared to Group 1 (p=0.001). When the factors predicting ISUP score upgrade were examined, glandular inflammation was found to be significant in univariate analysis (p=0.001), while seminal vesicle invasion in multiparametric magnetic resonance imaging and ISUP grade in TRUS-Bx were found to be significant predictors in multivariate analysis (p=0.022, p=0.009, respectively).</p><p><strong>Conclusion: </strong>Prostatitis accompanying prostate cancer is observed more frequently in patients with an ISUP score upgrade. The location of inflammation may offer insights into predicting an upgrade.</p>\",\"PeriodicalId\":23414,\"journal\":{\"name\":\"Urologia Internationalis\",\"volume\":\" \",\"pages\":\"1-11\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-05-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Urologia Internationalis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000546326\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Urologia Internationalis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000546326","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
The Relationship Of Chronic Inflammation In Prostate Biopsies With ISUP Score Upgrade After Radical Prostatectomy.
Introduction: This study aimed to investigate the relationship between the International Society of Urological Pathology (ISUP) score upgrade and inflammation in transrectal ultrasound-guided prostate biopsy (TRUS-Bx) specimens.
Methods: The data of 340 patients who underwent robot-assisted radical prostatectomy were retrospectively evaluated, and two groups were formed based on the presence (Group 1, n=168) or absence (Group 2, n=172) of an ISUP score upgrade. Prostate characteristics, imaging findings, and inflammation on TRUS-Bx were recorded in both groups for statistical analysis. Univariate and multivariate analyses were used to identify factors predicting the development of the upgrade.
Results: Total inflammation was significantly greater in Group 1 compared to Group 2 (p=0.04). Glandular-located inflammation was significantly higher in Group 2 compared to Group 1 (p=0.001). When the factors predicting ISUP score upgrade were examined, glandular inflammation was found to be significant in univariate analysis (p=0.001), while seminal vesicle invasion in multiparametric magnetic resonance imaging and ISUP grade in TRUS-Bx were found to be significant predictors in multivariate analysis (p=0.022, p=0.009, respectively).
Conclusion: Prostatitis accompanying prostate cancer is observed more frequently in patients with an ISUP score upgrade. The location of inflammation may offer insights into predicting an upgrade.
期刊介绍：
Concise but fully substantiated international reports of clinically oriented research into science and current management of urogenital disorders form the nucleus of original as well as basic research papers. These are supplemented by up-to-date reviews by international experts on the state-of-the-art of key topics of clinical urological practice. Essential topics receiving regular coverage include the introduction of new techniques and instrumentation as well as the evaluation of new functional tests and diagnostic methods. Special attention is given to advances in surgical techniques and clinical oncology. The regular publication of selected case reports represents the great variation in urological disease and illustrates treatment solutions in singular cases.
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