Urologia Internationalis最新文献

{"title":"Seminoma Caused by PDE11A Frameshift Variant with Multiple Abnormalities: A Case Report.","authors":"Weidong Xie, Qinquan Wang, Yunbei Xiao","doi":"10.1159/000546283","DOIUrl":"https://doi.org/10.1159/000546283","url":null,"abstract":"<p><p>Testicular germ cell tumor (TGCT) is a relatively rare malignant tumor. In addition to recognized risk factors such as cryptorchidism, the role of genetic factors has been increasingly acknowledged. We report a case of a seminoma patient presenting with multiple abnormalities, including brain dysplasia, social difficulties, and learning impairments. Subsequent exome sequencing did not detect other genetic abnormalities but identified a frameshift variant in the phosphodiesterase 11A (PDE11A) gene. Predictions from AlphaFold3 suggest that this variant may significantly affect protein function. This variant may provide a plausible explanation for the patient's multiple abnormalities as well as the development of seminoma.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of an Early Prostate-Specific Antigen Response on Biochemical Progression During Upfront Androgen Receptor Signal Inhibitor Therapy for Metastatic Hormone-Sensitive Prostate Cancer.","authors":"Asumi Nirazuka, Akinori Nakayama, Minoru Inoue, Hiroki Tsujioka, Keita Izumi, Kiyoshi Setoguchi, Gaku Arai, Kazutaka Saito","doi":"10.1159/000546327","DOIUrl":"https://doi.org/10.1159/000546327","url":null,"abstract":"<p><strong>Introduction: </strong>We examined the impact of prostate-specific antigen (PSA) response, which is associated with survival, on patients with metastatic hormone-sensitive prostate cancer (mHSPC) treated with androgen receptor signal inhibitors (ARSIs).</p><p><strong>Methods: </strong>We retrospectively reviewed 82 patients with mHSPC who received upfront ARSI treatment. The primary endpoint was PSA progression-free survival (PFS). Patients whose PSA levels decreased to ≤0.2 ng/mL at 3 months after ARSI initiation were classified as deep early, those with >0.2-≤1.0 ng/mL as early, and others as non- PSA responders.</p><p><strong>Results: </strong>The median age of patients was 73 years old, and the median baseline PSA value was 361 ng/ml. Among 82 patients, 32 (39%), 16 (20%) and 34 (41%) were categorized into deep early, early and non-early PSA responders, respectively. There was a significant association between PSA response status, hemoglobin and PSA value. During follow-up (median, 23.0 months), 31 (37.8%) patients experienced PSA progression. The PSA progression rates of the deep early, early, and non-early PSA responders were 15.6%, 31.2%, and 61.8% (p < 0.001), and their 2-year PSA PFS rates were 90.5%, 70.7%, and 38.9%, respectively.</p><p><strong>Conclusion: </strong>An early PSA response within 3 months after ARSI initiation was associated with PSA progression in patients with mHSPC.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-18"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of a Novel <5mm Ureteral Dilation Balloon Catheter in Holmium Laser Surgery for Ureteral Calculi with Physiological Narrowing: A Randomized Controlled Trial.","authors":"He Zhang, Lin Zhang, Yuhan Hou, Xiangmin Zhang, Yiyang Liu, Zhihui Dong, Jian Chu, Jianwei Cao","doi":"10.1159/000546458","DOIUrl":"https://doi.org/10.1159/000546458","url":null,"abstract":"<p><strong>Background: </strong>The \"difficult ureter\" specifically denotes narrow and tortuous ureters typically requiring two-stage surgery. We firstly proposed combining a visible ureteral dilation balloon catheter with holmium laser for treating ureteral calculi in patients with ureteral stenosis.</p><p><strong>Methods: </strong>A prospective, multicenter, randomized, open-label, and controlled study enrolled 60 ureteral calculi patients with ureteral stricture from July 2021 to July 2023. Patients were randomly assigned to either first-stage ureteroscopic lithotripsy with direct visualization balloon dilation (DVBD+FUS) or dilation using a scope and inner core (DUS+S). The primary outcome was the success of sheath placement at first-stage surgery, assessed by the secondary operation rate. Secondary outcomes included stone clearance rates, postoperative serum creatinine increase, decreased hemoglobin, total hospital stay, operation time, ureteral stent removal time, ureteral injury, and total surgery costs.</p><p><strong>Results: </strong>Sixty patients aged 24-68 were enrolled, with stone diameters ranging from 0.6 to 2 cm (average 1.4 cm). After first-stage surgeries, 17 (56.67%) in the DUS+S group and 4 (13.3%) in the DVBD+FUS group required secondary surgery (P < 0.001). The DVBD+FUS group had a significantly shorter hospital stay by 3.2 days (6.60 vs. 3.4 days, P < 0.001) and a shorter operation time by 11 minutes (P = 0.010). After 3 months, ureteral stent removal times were similar (28.1±8.5 vs. 26.1±6.3 days). Total costs were ￥7800yuan lower in the DVBD+FUS group (P < 0.001). Intraoperative and postoperative complications were comparable. Six-month follow-ups showed no hydronephrosis in either group.</p><p><strong>Conclusion: </strong>Our study firstly indicated that DVBD+FUS could be an efficacy and safe strategy for treatment of ureteral calculi in patients with ureteral stricture. Moreover, the total hospital stays, total operation time, and costs were largely decreased by DVBD+FUS treatment.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-14"},"PeriodicalIF":1.5,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Of Chronic Inflammation In Prostate Biopsies With ISUP Score Upgrade After Radical Prostatectomy.","authors":"Hakan Polat, Ubeyd Sungur, Mithat Ekşi, Ekrem Güner, Serdar Altınay, Esra Karabulut, Taner Kargı, Alper Bitkin","doi":"10.1159/000546326","DOIUrl":"https://doi.org/10.1159/000546326","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the relationship between the International Society of Urological Pathology (ISUP) score upgrade and inflammation in transrectal ultrasound-guided prostate biopsy (TRUS-Bx) specimens.</p><p><strong>Methods: </strong>The data of 340 patients who underwent robot-assisted radical prostatectomy were retrospectively evaluated, and two groups were formed based on the presence (Group 1, n=168) or absence (Group 2, n=172) of an ISUP score upgrade. Prostate characteristics, imaging findings, and inflammation on TRUS-Bx were recorded in both groups for statistical analysis. Univariate and multivariate analyses were used to identify factors predicting the development of the upgrade.</p><p><strong>Results: </strong>Total inflammation was significantly greater in Group 1 compared to Group 2 (p=0.04). Glandular-located inflammation was significantly higher in Group 2 compared to Group 1 (p=0.001). When the factors predicting ISUP score upgrade were examined, glandular inflammation was found to be significant in univariate analysis (p=0.001), while seminal vesicle invasion in multiparametric magnetic resonance imaging and ISUP grade in TRUS-Bx were found to be significant predictors in multivariate analysis (p=0.022, p=0.009, respectively).</p><p><strong>Conclusion: </strong>Prostatitis accompanying prostate cancer is observed more frequently in patients with an ISUP score upgrade. The location of inflammation may offer insights into predicting an upgrade.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propensity-Score-Based Comparative Analysis of Transperitoneal and Retroperitoneal Approaches in Open and Minimally Invasive Renal Surgery: Impact on Operative Outcomes.","authors":"Marcel Schwinger, Lena Knaier, Charis Kalogirou, Robert Woidich, Oliver Hahn, Hubert Kübler, Vincent Scheper","doi":"10.1159/000546230","DOIUrl":"https://doi.org/10.1159/000546230","url":null,"abstract":"<p><strong>Introduction: </strong>Renal cancer is among the ten most common cancers in western societies, with renal cell carcinoma (RCC) accounting for 95% of malignant renal neoplasms. Recent advances in surgical techniques and approaches have expanded treatment options, necessitating an evaluation of optimal approaches.</p><p><strong>Methods: </strong>A retrospective, propensity-matched cohort with 814 patients (1999-2021) was conducted comparing open and minimally invasive (laparoscopic and robotic-assisted) nephrectomy and partial nephrectomy techniques, focusing on operative time, blood loss, hospital stay, complications, and perioperative complications.</p><p><strong>Results: </strong>The retroperitoneal (RP) approach demonstrated shorter operation times, reduced blood loss, and quicker recovery compared to the transperitoneal (TP) approach. Minimal invasive techniques, whether laparoscopic or robotic, had shorter hospital stays, fewer complications and better postoperative renal function. The RP approach showed advantages in operative efficiency and reduced postoperative morbidity.</p><p><strong>Conclusion: </strong>The findings support that the RP approach is at least as effective as, or superior to, the TP approach in terms of perioperative outcomes. Minimally invasive approaches, including robotic-assisted and laparoscopic techniques, are associated with improved recovery and fewer complications, highlighting their advantages in the surgical treatment of renal tumors. Further studies are needed to assess long-term oncologic and functional outcomes. These findings underline the importance of tailored surgical planning to optimize patient outcomes.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-17"},"PeriodicalIF":1.5,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Prospective Evaluation of Li-ESWT with or without PDE5 Inhibitors for Erectile Dysfunction Following Nerve-Sparing Radical Prostatectomy.","authors":"Rashad Sholan, Rufat Aliyev, Seymur Karimov, Malahat Sultan, Anar Almazkhanli","doi":"10.1159/000546359","DOIUrl":"https://doi.org/10.1159/000546359","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) is a common complication following radical prostatectomy (RP). Although phosphodiesterase type 5 inhibitors (PDE5i) are used for penile rehabilitation, their efficacy post-RP is limited. Low-intensity extracorporeal shockwave therapy (Li-ESWT) has emerged as a potential non-invasive treatment, promoting tissue regeneration. This study evaluates the effectiveness of Li-ESWT, with or without PDE5i, for post-RP ED.</p><p><strong>Methods: </strong>This prospective study included 104 patients who underwent nerve-sparing RP and received Li-ESWT. Patients were divided into two groups: Group 1 received daily 5 mg tadalafil along with Li-ESWT, while Group 2 received Li-ESWT alone. Erectile function was assessed using the International Index of Erectile Function (IIEF-5) at baseline, 6, 12, and 24 months postoperatively.</p><p><strong>Results: </strong>The preoperative mean IIEF-5 score was 15.7±4.7, with 54.8% of patients scoring below 17. Postoperatively, significant improvements in IIEF-5 scores were observed at 12 and 24 months in both groups compared to the 6th month. In patients with preoperative IIEF-5 <17, Group 1 showed significantly greater improvement in IIEF-5 scores compared to Group 2 (p=0.008). No significant difference was observed between the groups in patients with preoperative IIEF-5 ≥17 (p=0.893).</p><p><strong>Conclusion: </strong>Li-ESWT is an effective treatment for ED following nerve-sparing RP, with or without PDE5i. In patients with mild-to-moderate or greater preoperative ED, the combination of PDE5i and Li-ESWT may provide additional benefits, whereas Li-ESWT alone appears sufficient for those with milder cases.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of circulating tumor DNA in the prognostic diagnosis of bladder cancer: a systematic review and meta-analysis.","authors":"Yu Lu, Huajun Wu, Jian Jiang, Siwen Bao, Chen Ling","doi":"10.1159/000546014","DOIUrl":"https://doi.org/10.1159/000546014","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to systematically evaluate the clinical efficacy of ctDNA in the prognostic assessment of bladder cancer, and to provide a basis for its application in individualized treatment and risk stratification management.</p><p><strong>Methods: </strong>Studies related to ctDNA in prognostic assessment of bladder cancer were screened by systematically searching PubMed, Cochrane Library, Web of Science, Willey library, CNKI and other databases, and the search was from inception to December 2024, and the data were extracted and analyzed by Meta-analysis. A random-effects model was used to calculate SEN, SPE, PLR, NLR, DOR, and AUC, and the heterogeneity among studies and publication bias were also assessed.</p><p><strong>Results: </strong>A total of 9 papers were included, and the results showed that ctDNA testing had a SEN of 0.68 (95% CI: 0.54-0.78), SPE of 0.76 (95% CI: 0.51-0.90), and an AUC of 0.75 (95% CI: 0.71-0.79), suggesting that it has a moderate level of diagnostic efficacy in the assessment of prognosis in bladder cancer. PLR and NLR were 2.8 (95% CI: 1.24-6.35) and 0.43 (95% CI: 0.28-0.65), respectively, with a DOR of 6.56 (95% CI: 2.12-20.33).Fagan plot analysis showed that the posterior probability of a positive result rose to 74% and the posterior probability of a negative result decreased to 30% when the prior probability was 50%. Deeks funnel plot analysis showed no significant publication bias (P=0.24). However, inter-study heterogeneity was high (all I² values >80%), which may have been influenced by factors such as assay technique, patient characteristics, and follow-up time.</p><p><strong>Conclusion: </strong>ctDNA demonstrates some clinical application value in the prognostic assessment of bladder cancer, and can assist in predicting patient recurrence and survival. However, its independent predictive efficacy is not enough to replace traditional assessment methods. Future studies should aim to optimize the detection technology, unify the study design, expand the sample size, and combine multi-omics data for joint analysis, in order to further improve its potential application in the prognostic assessment of bladder cancer.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-17"},"PeriodicalIF":1.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of a plasmacytoid and sarcomatoid differentiated urothelial bladder carcinoma with a single metastasis to the right ventricle of the heart and rapid review of single heart metastasis in bladder cancer.","authors":"Kai Alexander Münker, David Reineke, Laila Schneidewind, Charlotte Müssgens","doi":"10.1159/000546149","DOIUrl":"https://doi.org/10.1159/000546149","url":null,"abstract":"<p><strong>Background: </strong>Distant metastases and especially single side metastases of non-muscle invasive bladder cancer (NMIBC) without regional progression in lymph nodes are extremely uncommon and rare.</p><p><strong>Summary: </strong>We report a case of a plasmacytoid and sarcomatoid differentiated urothelial NMIIC with a single metastasis to the right ventricle of the heart, which was surgically resected, but the patient died shortly after the resection with progressive metastatic disease. To the best of our knowledge, this is the first case with two different variant histologies in NMIBC with a single heart metastasis. Furthermore, we conducted a rapid review using MEDLINE regarding single heart metastasis of bladder cancer. Four cases have been identified. Interestingly, with two cases of variant histology and one with single plasmocytoid differentiation, also being NMIBC.</p><p><strong>Key messages: </strong>These findings underline the aggressiveness of the variant histologies in NMIBC, especially plasmocytoid differentiation, and may favor an early and aggressive treatment regimen. Further scientific research concerning the optimal treatment of histologically variant bladder cancer is absolutely needed.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-15"},"PeriodicalIF":1.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The positive rate of antisperm antibody and its impact on IVF/ICSI embryo culture.","authors":"Han Zhang, Dong-Qing Mi, Yan Jiang, Cai-Hong Zhang, Li-Sen Wu, Fei Lin, Xiao-Pu Zhou, Ge Song","doi":"10.1159/000545912","DOIUrl":"https://doi.org/10.1159/000545912","url":null,"abstract":"<p><strong>Objective: </strong>To explore the prevalence of antisperm antibodies(ASA) and its impact on the embryo culture outcomes of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), a retrospective analysis of the Center for Reproductive Medicine's data was conducted.</p><p><strong>Methods: </strong>8265 semen samples were detected for ASA using mixed antiglobulin reaction (MAR). In addition, 934 IVF/ICSI cycles were included to compare the effects of ASA on embryo culture outcomes during IVF/ICSI, including normal fertilization rate, D3 good-quality embryo rate, available blastocyst formation rate, and available embryo rate.</p><p><strong>Results: </strong>The positive rate of ASA in semen was relatively low, about 1.03%. We found ASA may weaken the normal fertilization rate of IVF cycles. In addition, there was no statistical difference in outcomes between the positive groups and negative groups of ICSI cycles with a threshold 10% in ASA, but ASA significantly reduced the normal fertilization rate and D3 good-quality embryo rate of ICSI cycles with a threshold 50% in ASA. It was speculated that the high ratio of rescue ICSI cycles resulted in the poor embryo culture outcomes. We supposed that the higher of the ASA positive rate, the higher of the likelihood of fertilization failure of IVF. Comparing with IVF, ICSI is more recommended as a fertilization method for ASA positive patients who need assisted reproductive technology.</p><p><strong>Conclusions: </strong>ASA may have a negative impact on the embryo culture outcomes of IVF. Therefore, for ASA positive patients who require IVF/ICSI treatment, it is suggested embryologists wash the sperm thoroughly and use short-term fertilization of IVF or conventional ICSI to assist with pregnancy.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integral Theory Paradigm: Common Pelvic Ligament Pathogenesis Guides Management for Urology, Gynecology, Coloproctology.","authors":"Peter Petros, Bernhard Liedl, Ahmet Akin Sivaslioglu, Klaus Goeschen, Hiromi Inoue, Yuki Sekiguchi, Burghard Abendstein, Dmitry Shkarupa, Nikita Kubin","doi":"10.1159/000545665","DOIUrl":"10.1159/000545665","url":null,"abstract":"<p><strong>Background: </strong>This work had its origins in the 1990s, when women having collagen-creating midurethral slings for stress urinary incontinence (SUI) and uterosacral slings for uterine prolapse began reporting cure or improvement in co-occurring fecal incontinence, obstructive defecation, and chronic pelvic pain.</p><p><strong>Summary: </strong>We briefly describe anatomical etiopathogenesis to explain how the same collagen-creating ligament repair system using a common ligament-based diagnostic system, can treat pelvic symptoms from 3 disciplines: Urology, Gynecology, Coloproctology. Collagen-induced laxity in ligaments and vagina diminishes contractile forces required by pelvic muscles to close urethra and anus for continence, open them for evacuation, and stretch the bladder base and rectum like a trampoline to prevent stretch receptors prematurely activating micturition and defecation reflexes. These are perceived cortically as bladder or fecal \"urge to go.\" The pictorial algorithm summarizes common ligament pathogeneses for prolapse/bladder/bowel/pain dysfunctions which can be confirmed by mechanical support of PUL for relief of urine loss on coughing, and uterosacral ligaments (USL) for relief of urge and chronic pelvic pain. The same minimally invasive ligament repairs used for SUI, prolapse, pain/bladder dysfunctions were demonstrated by X-ray defecography controlled studies to cure fecal incontinence, obstructive defecation, anterior rectal wall intussusception and descending perineal syndrome (as shown in 16 case managements in 3 disciplines; video: <ext-link ext-link-type=\"uri\" xlink:href=\"https://youtu.be/a6jJQXDx71U?si=MLdo3Yq9kAZ82RVb\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">https://youtu.be/a6jJQXDx71U?si=MLdo3Yq9kAZ82RVb</ext-link>).</p><p><strong>Key messages: </strong>Symptom relief can be achieved using standard operations which repair PUL or USL even with minimal prolapse. Whether the surgery is done laparoscopically or vaginally is of little consequence, as the same structure is repaired.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-13"},"PeriodicalIF":1.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}