Urologia Internationalis最新文献

Acute kidney injury in a cancer patient exposed to relugolix and abiraterone. 暴露于雷鲁高利和阿比特龙的癌症患者的急性肾损伤。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2025-07-12 DOI: 10.1159/000547373

Moustafa Elleisy, Irene Resch, Ozan Yurdakul, Nicolai A Huebner, Shahrokh Shariat

{"title":"Acute kidney injury in a cancer patient exposed to relugolix and abiraterone.","authors":"Moustafa Elleisy, Irene Resch, Ozan Yurdakul, Nicolai A Huebner, Shahrokh Shariat","doi":"10.1159/000547373","DOIUrl":"https://doi.org/10.1159/000547373","url":null,"abstract":"Introduction: Abiraterone acetate is an inhibitor of androgen biosynthesis and is approved as a treatment for metastatic castration-resistant and metastatic castration-sensitive prostate cancer. Neither relugolix nor abiraterone is known to cause acute kidney injury.Case presentation: A 72-year-old Caucasian man with metastatic prostate cancer presented with non-oliguric severe acute kidney injury (AKI) one week after receiving simultaneous therapy with relugolix and abiraterone. The patient had been on abiraterone for three weeks. His physical examination was unremarkable. Blood work on admission revealed hypocalcemia, and elevated creatinine at 3.6 mg/dL. A kidney biopsy confirmed the diagnosis of a high-grade subacute tubular damage, most likely due to nephrotoxicity. The patient did not respond to intravenous isotonic fluids, the discontinuation of relugolix, abiraterone, and rosuvastatin, as well as to hemodialysis. He died 22 days after hospital admission.Conclusion: We report the first case of biopsy-proven drug-induced AKI in a cancer patient acutely exposed to relugolix and abiraterone. Whether one of these drugs individually, or their combination, was the cause of the AKI is unknown. Nonetheless, our report is hypothesis-generating for further investigations on the effect of these drugs.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-6"},"PeriodicalIF":1.5,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glanular ischemia following glans penis augmentation: A rare case report. 龟头阴茎增大后的腺体缺血：罕见病例报告。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2025-07-12 DOI: 10.1159/000547421

Kaan Karamık, Ali Yıldız, Ömer Koraş, Murat Arslan

{"title":"Glanular ischemia following glans penis augmentation: A rare case report.","authors":"Kaan Karamık, Ali Yıldız, Ömer Koraş, Murat Arslan","doi":"10.1159/000547421","DOIUrl":"https://doi.org/10.1159/000547421","url":null,"abstract":"Introduction: Premature ejaculation is a common problem in men and filler injection into the glans penis has become a prevalent practice in treatment. Since the glans penis augmentation is an invasive treatment method, it also carries the risk of complications. Herein, we aimed to present a case of glans penis ischemia due to hyaluronic acid filler injection.Case presentation: The patient was a 29-year-old male with premature ejaculation. The physical examination was normal, and sensory testing with a biothesiometer revealed vibration perception threshold values of 5.3V for the glans, 4.1V for the frenulum, and 3.9V for the penile shaft. Under local anesthesia, hyaluronic acid filler was applied with the multiple puncture technique, 2 ml in total, 0.2 ml per injection. One day after the procedure, the patient referred with complaints of discoloration of the glans penis. The physical examination revealed blackening at the distal tip of the glans with a visible demarcation line. Hyaluronidase was applied for the treatment of glanular glans penis ischemia secondary to hyaluronic acid filler injection. A significant improvement in the glans penis color was observed after hyaluronidase injection. The patient was prescribed 100 mg of aspirin, a warm saline dressing, and a nitroglycerin-containing cream and was discharged for daily follow-up.Conclusion: Although vascular complications are rare after hyaluronic acid filling into the glans penis, early diagnosis and treatment are crucial. Patients should be informed about possible adverse events. The main treatment method for vascular complications is urgent hyaluronidase injection. In addition, prevention of clot propagation with oral aspirin and vasodilatation treatments should be applied. In the glans penis ischemia after hyaluronic acid injection, early diagnosis and immediate hyaluronidase administration can reverse ischemia without necrosis or surgical intervention.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Course of Multimodal Therapy and Genetic Profile of HLRCC with Early Recurrence During Adjuvant Therapy After Radical Nephrectomy. 根治性肾切除术后辅助治疗中早期复发的HLRCC的多模式治疗过程和遗传谱。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2025-07-12 DOI: 10.1159/000547393

Hiroshi Masuda, Tomonori Sato, Satoko Sato, Takuro Goto, Hiromichi Katayama, Yohei Satake, Takuma Sato, Yoshihide Kawasaki, Naoki Kawamorita, Hidekazu Shirota, Akihiro Ito

{"title":"Course of Multimodal Therapy and Genetic Profile of HLRCC with Early Recurrence During Adjuvant Therapy After Radical Nephrectomy.","authors":"Hiroshi Masuda, Tomonori Sato, Satoko Sato, Takuro Goto, Hiromichi Katayama, Yohei Satake, Takuma Sato, Yoshihide Kawasaki, Naoki Kawamorita, Hidekazu Shirota, Akihiro Ito","doi":"10.1159/000547393","DOIUrl":"https://doi.org/10.1159/000547393","url":null,"abstract":"Introduction Fumarate hydratase-deficient renal cell carcinoma is a rare and aggressive subtype associated with hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome, characterized by germline mutations in the fumarate hydratase (FH) gene. Here, we report a case of HLRCC with early recurrence during adjuvant therapy following radical nephrectomy. Case presentation A 34-year-old woman with FH-deficient RCC presented with fever, right flank pain, and a large renal mass with a tumor thrombus. Open radical nephrectomy and IVC tumor thrombectomy were performed. Pathological findings and genetic analyses confirmed the diagnosis of HLRCC. Despite adjuvant pembrolizumab therapy after nephrectomy, bone metastases were detected within nine weeks. The patient was treated with stereotactic body radiotherapy (SBRT), followed by systemic therapy with nivolumab and cabozantinib. After 16 months since the recurrence, no further disease progression was observed. Genetic counseling revealed the same FH mutation in her daughter, prompting annual surveillance. Conclusion This case highlights the potential efficacy of combining tyrosine kinase inhibitor therapy with SBRT in managing aggressively progressive HLRCC.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Statement. 撤销声明。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2025-07-07 DOI: 10.1159/000547043

引用次数: 0

Predictors of Treatment Failure, Second-Line Therapy Outcomes, and Patient Satisfaction After Prostatic Artery Embolization: A Retrospective Study in Benign Prostatic Hyperplasia. 前列腺动脉栓塞后治疗失败、二线治疗结果和患者满意度的预测因素：一项良性前列腺增生的回顾性研究。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2025-07-01 DOI: 10.1159/000547152

Khaled Alghueiri, Philipp C Engert, Mohamed Alhabib, Peter Schott, Waseem Arafat, Armin Soave, Martin G Friedrich

{"title":"Predictors of Treatment Failure, Second-Line Therapy Outcomes, and Patient Satisfaction After Prostatic Artery Embolization: A Retrospective Study in Benign Prostatic Hyperplasia.","authors":"Khaled Alghueiri, Philipp C Engert, Mohamed Alhabib, Peter Schott, Waseem Arafat, Armin Soave, Martin G Friedrich","doi":"10.1159/000547152","DOIUrl":"https://doi.org/10.1159/000547152","url":null,"abstract":"Introduction: This study aims to evaluate the effectiveness of prostatic artery embolization (PAE) in treating benign prostatic hyperplasia (BPH), focusing on identifying the predictors of treatment failure and assessing patient satisfaction and second-line therapies for patients who undergo reoperation.Methods: We conducted a monocentric, retrospective study involving 344 patients who underwent PAE from 2017 to 2022. The minimum follow-up time was 12 months. Baseline data were retrospectively collected. A single follow-up questionnaire was Administered at the time of the study. Included were patients ≥50 years, with a prostate volume ≥40 mL, an International Prostate Symptom Score (IPSS) ≥8 and were unresponsive to medical therapy.Results: Among 156 participants, the reoperation rate at 5 years was 28.2%. Baseline IPSS and post-void residual volumes (PVR) were significant predictors of therapy failure. Higher satisfaction was associated with younger age (p = 0.01), larger prostate volume (p = 0.02), and lower PVR (p = 0.03). Patients with higher satisfaction had better reoperation-free rates at 60 months (p = 0.002).Conclusions: PAE is effective in reducing symptoms in patients with BPH; however, the reoperation rate emphasizes the importance of careful patient selection. Study limitations include potential selection bias, missing data, the single-center setting, and the use of a single follow-up questionnaire.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-23"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing urinary microbiota in chronic cystitis based on midstream urine sample. 基于中游尿样评估慢性膀胱炎患者尿微生物群。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2025-06-28 DOI: 10.1159/000547112

Margarita Boldyreva, Maria Petrunicheva, Anastasia Ivanova, Andrey Morozov, Svetlana Koroleva, Zoya Moskvina, Ksenia Rossolovskaya, Leonid Spivak

{"title":"Assessing urinary microbiota in chronic cystitis based on midstream urine sample.","authors":"Margarita Boldyreva, Maria Petrunicheva, Anastasia Ivanova, Andrey Morozov, Svetlana Koroleva, Zoya Moskvina, Ksenia Rossolovskaya, Leonid Spivak","doi":"10.1159/000547112","DOIUrl":"https://doi.org/10.1159/000547112","url":null,"abstract":"Objectives: This study aims to compare the urinary microbiota of healthy women, women with a predisposition to UTIs and patients with chronic recurrent cystitis using real-time PCR as well as identify diagnostic markers for urinary diseases.Patients and methods: The study enrolled three groups of patients: healthy control group, patients with chronic recurrent cystitis and patients with a risk of developing UTIs. Urine samples were analyzed by multiplex real-time PCR reagent kits Femoflor®16 and BacScreen OM.Results: Chronic recurrent cystitis is associated with an increase in total bacterial mass (TBM), genomic DNA and relative predominance of facultative anaerobic microorganisms. The most prevalent bacterial species found in chronic cystitis was E. coli in conjunction with other Enterobacteriaceae, most commonly, Serratia marcescens. An increased amount of genomic DNA and both facultative and obligate anaerobic microorganisms was observed in patients with a risk of developing UTIs. A relative decrease in Lactobacillus spp. was noted in both groups, with the chronic cystitis group showing a more pronounced reduction.Conclusion: In summary, the levels of genomic DNA, TBM and relative values of Lactobacillus spp. can be used as molecular diagnostics markers for chronic cystitis and a variety of other conditions, including micronephrolithiasis and bacterial vaginosis.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Etiopathogenesis of "bladder outlet obstruction" in the female- inability of pelvic muscles to sufficiently open urethra. 女性“膀胱出口梗阻”的病因——盆腔肌肉不能充分打开尿道。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2025-06-28 DOI: 10.1159/000547145

Peter Emanuel Petros, Bernhard Liedl, Maren Juliane Wenk, Paolo Palma

{"title":"Etiopathogenesis of \"bladder outlet obstruction\" in the female- inability of pelvic muscles to sufficiently open urethra.","authors":"Peter Emanuel Petros, Bernhard Liedl, Maren Juliane Wenk, Paolo Palma","doi":"10.1159/000547145","DOIUrl":"https://doi.org/10.1159/000547145","url":null,"abstract":"Etiopathogenesis of abnormal female voiding- posterior pelvic muscles cannot adequately open urethra ABSTRACT No of words 200. Background Historically, opening the bladder neck and urethra for evacuation has been solely by detrusor contraction with \"urethral relaxation.\" Summary We present a change in thinking based on clinical and experimental research, human and animal: the urethra is opened externally immediately prior to detrusor contraction by posterior pelvic floor muscles contracting against competent USLs (uterosacral ligaments). A binary feedback control system (EITHER open OR closed) with neurological and peripheral musculo-ligamentous components is presented. Three oppositely-acting muscle vectors contract against suspensory ligaments to close urethra distally and at bladder neck; relaxation of the forward closure vector allows the two posterior muscles to contract against USLs to open the posterior urethral wall prior to voiding. In this context, bladder emptying difficulties, whether neurological, musculoligamentous damage, or obstructive, means that the detrusor must contract against an unopened urethra which presents a high resistance to flow, clincally perceived as \"emptying difficulties\". Key message A change in thinking: posterior pelvic muscles contract against a firm USL to open posterior urethral wall prior to voiding: VIDEO https://www.youtube.com/watch?v=nK0CQmaS-5E&t=7s Weak USLs from birthing or age weaken the opening muscles. Strengthening the USLs, surgically, or by pelvic exercises, or mechanical support by pessaries can be effective in selected patients.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-19"},"PeriodicalIF":1.5,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the patient and stone related parameters on the likelihood of spontaneous ureteral stone passage: A critical evaluation focusing on the urinary tract infection without pyuria due to luminal obstruction. 评估患者和结石相关参数对输尿管结石自发通过可能性的影响：一项关键评估，重点关注因管腔梗阻而无脓尿的尿路感染。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2025-06-25 DOI: 10.1159/000547064

Emre Bulbul, Fahri Yavuz Ilki, Ali Sezer, Oguz Evlice, Kemal Sarica

{"title":"Evaluation of the patient and stone related parameters on the likelihood of spontaneous ureteral stone passage: A critical evaluation focusing on the urinary tract infection without pyuria due to luminal obstruction.","authors":"Emre Bulbul, Fahri Yavuz Ilki, Ali Sezer, Oguz Evlice, Kemal Sarica","doi":"10.1159/000547064","DOIUrl":"https://doi.org/10.1159/000547064","url":null,"abstract":"Introduction: This study aimed to investigate the patient-, stone-, and laboratory-related parameters to predict the likelihood of spontaneous stone passage (SSP) in uncomplicated 5-10 mm ureteral stones.Methods: Between August 2020 and April 2024, 421 patients presenting with 5-10 mm ureteral stones were included in the study program. Patients were divided into two groups based on the spontaneous passage status of the stones during the 4-week close follow-up period. Group 1 [n: 252 (%59.8)] patients passing the stones during this period, Group 2 [n: 169 (%40.2)] patients who could not pass the stones. In addition to the stone (size and location), patient (associated co-morbidities, presence of UTI) and degree of hydronephrosis were assessed in all patients. Urinary tract infection (UTI) without pyuria was defined as the absence of pyuria in urinalysis due to ureteral obstruction despite the presence of an elevated blood level of white blood cells or C-reactive protein. UTI without pyuria patients were tested by a mid-stream urine sample for culture and were defined as no bacterial growth (<105 cfu/mL) in the urine culture.Results: The presence of comorbidities (p=0.006), degree of hydronephrosis (grade 3 vs. grade 2, p=0.011 and grade 3 vs. grade 1, p=0.008), transverse stone size (p=0.004), ureteral stone location (proximal vs. distal, p=0.010), and UTI without pyuria (p<0.001) were found to be independent predictors for SSP. Spontaneous passage of ureteral stones could be predicted with the help of some patient and stone related parameters.Conclusions: Associated co-morbidities and, most importantly, the presence of UTI without pyuria (due to luminal obstruction) were the most important independent predictors that decreased SSP in ureteral stones.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Mullerianosis in the Bladder: A Rare Case Report that may Mimic an Adenocarcinoma. 膀胱复发性穆勒氏菌病：一例罕见的可能与腺癌相似的病例报告。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2025-06-22 DOI: 10.1159/000547086

Ozge Aydin, Ilkay Cinar, Burhan Ozdemir

引用次数: 0

Sexually Transmitted Infections in Prostate Cancer: A Prospective Multicenter Analysis. 前列腺癌性传播感染：一项前瞻性多中心分析。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2025-06-21 DOI: 10.1159/000545208

Teresa Pina-Vaz, Alberto Costa Silva, Gabriel Costa, Micael Gonçalves, Angela Fernandes, Frederico Carmo Reis, Pedro Nobre, Carmen Lisboa, Acacio Rodrigues, João Alturas-Silva, Carlos Martins-Silva

{"title":"Sexually Transmitted Infections in Prostate Cancer: A Prospective Multicenter Analysis.","authors":"Teresa Pina-Vaz, Alberto Costa Silva, Gabriel Costa, Micael Gonçalves, Angela Fernandes, Frederico Carmo Reis, Pedro Nobre, Carmen Lisboa, Acacio Rodrigues, João Alturas-Silva, Carlos Martins-Silva","doi":"10.1159/000545208","DOIUrl":"10.1159/000545208","url":null,"abstract":"Introduction: Chronic inflammation and infections have been implicated in prostate cancer (PCa) pathogenesis. The association between sexually transmitted infections (STIs) and PCa remains inconclusive. The objective was to evaluate the presence of STI-related pathogens in patients with PCa compared to a control group.Methods: A prospective multicenter study involving 239 male patients with a clinical suspicion of PCa was conducted. Among the participants, 176 had histologically confirmed PCa, while 63 served as controls with benign histology. Urine, glans swabs, and prostate biopsy specimens were collected from each participant and analyzed using polymerase chain reaction (PCR) to detect a broad panel of STI-causing pathogens, including Candida spp., Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, Trichomonas vaginalis, herpes simplex virus types 1 and 2, and human papillomavirus.Results: A total of 717 samples were processed. The detection frequency of STI-related pathogens was relatively low across all sample types. M. genitalium was the most frequently detected pathogen, particularly in prostate biopsy samples. No statistically significant association was found between the presence of these pathogens and the incidence of PCa. N. gonorrhoeae and C. spp. were not detected in any of the samples.Conclusion: This study did not find a statistically significant association between the presence of STIs and PCa. The low prevalence of STI pathogens despite the use of highly sensitive PCR methods suggests that these infections may play a limited role in prostate carcinogenesis. Future research should consider focusing on the role of the urinary and prostatic microbiome in chronic prostatic inflammation.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0