A Rare Case of a Plasmacytoid and Sarcomatoid Differentiated Urothelial Bladder Carcinoma with a Single Metastasis to the Right Ventricle of the Heart and Rapid Review of Single Heart Metastasis in Bladder Cancer.

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY

Urologia Internationalis Pub Date : 2025-04-26 DOI:10.1159/000546149

Kai Alexander Münker, David Reineke, Laila Schneidewind, Charlotte Müssgens

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引用次数: 0

Abstract

Introduction: Distant metastases and especially single side metastases of non-muscle invasive bladder cancer (NMIBC) without regional progression in lymph nodes are extremely uncommon and rare.

Case presentation: We report a case of a plasmacytoid and sarcomatoid differentiated urothelial NMIIC with a single metastasis to the right ventricle of the heart, which was surgically resected, but the patient died shortly after the resection with progressive metastatic disease. To the best of our knowledge, this is the first case with two different variant histologies in NMIBC with a single heart metastasis. Furthermore, we conducted a rapid review using MEDLINE regarding single heart metastasis of bladder cancer. Four cases have been identified. Interestingly, with 2 cases of variant histology and one with single plasmacytoid differentiation, also being NMIBC.

Conclusion: These findings underline the aggressiveness of the variant histologies in NMIBC, especially plasmacytoid differentiation, and may favor an early and aggressive treatment regimen. Further scientific research concerning the optimal treatment of histologically variant bladder cancer is absolutely needed.

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浆细胞样和肉瘤样分化的尿路上皮性膀胱癌伴右心室单一转移的罕见病例及膀胱癌单一心脏转移的快速回顾。

背景：无淋巴结局部进展的非肌肉浸润性膀胱癌（NMIBC）的远处转移，特别是单侧转移是非常罕见的。摘要：我们报告一例浆细胞样和肉瘤样分化的尿路上皮NMIIC，并伴有单一转移到右心室，手术切除，但患者在切除后不久死亡，并伴有进展性转移疾病。据我们所知，这是第一例NMIBC中有两种不同的组织学变异并伴有单一心脏转移的病例。此外，我们使用MEDLINE对膀胱癌的单心转移进行了快速回顾。已发现4例。有趣的是，有2例组织学变异，1例单核细胞质分化，也属于NMIBC。关键信息：这些发现强调了NMIBC变异组织学的侵袭性，特别是浆细胞分化，可能有利于早期和积极的治疗方案。组织学变异膀胱癌的最佳治疗方法有待进一步的科学研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urologia Internationalis 医学-泌尿学与肾脏学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

3-8 weeks

期刊介绍： Concise but fully substantiated international reports of clinically oriented research into science and current management of urogenital disorders form the nucleus of original as well as basic research papers. These are supplemented by up-to-date reviews by international experts on the state-of-the-art of key topics of clinical urological practice. Essential topics receiving regular coverage include the introduction of new techniques and instrumentation as well as the evaluation of new functional tests and diagnostic methods. Special attention is given to advances in surgical techniques and clinical oncology. The regular publication of selected case reports represents the great variation in urological disease and illustrates treatment solutions in singular cases.