{"title":"作为泌尿系统癌症预后预测指标的老年营养风险指数：系统回顾和荟萃分析。","authors":"Yuefen Chen, Mei Wen, Zhe Yu, Fengjiao Xu","doi":"10.1159/000544793","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The geriatric nutritional risk index (GNRI) is being used to predict outcomes of several malignancies. However, its utility for urinary tract cancer has not been systematically analyzed. We present the first meta-analysis examining the association between GNRI and the prognosis of urological cancers.</p><p><strong>Methods: </strong>This PROSPERO registered review searched Embase, PubMed, Web of Science, and Scopus up to 25th November 2024 for studies examining the relationship between GNRI and overall survival (OS), cancer-specific survival (CSS), and progression-free survival (PFS) after urological cancers.</p><p><strong>Results: </strong>A total of 20 studies were eligible. Three studies on bladder cancer, four on prostate cancer, seven on renal cell carcinoma (RCC), and six on urothelial cancers. Meta-analysis showed that low GNRI was a statistically significant predictor of poor OS in prostate cancer (OR: 3.02 95% CI: 1.61, 5.67). Pooled analysis showed that low GNRI was associated with poor OS (OR: 2.17 95% CI: 1.46, 3.22) and CSS (OR: 2.60 95% CI: 1.57, 4.30) in RCC but not PFS (OR: 1.50 95% CI: 1.00, 2.24). Pooled analysis also found that low GNRI was a predictor of worse OS (OR: 2.24 95% CI: 1.52, 3.29) and CSS (OR: 3.07 95% CI: 1.38, 6.86) in urothelial carcinoma. A narrative review on bladder cancer and GNRI showed mixed results.</p><p><strong>Conclusion: </strong>GNRI may have a role in predicting outcomes of urological malignancies. Low GNRI was independently associated with worse OS after prostate, renal cell, and urothelial carcinoma. Further, it also predicted CSS after RCC and urothelial carcinoma.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-19"},"PeriodicalIF":1.5000,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The geriatric nutritional risk index as a predictor of outcomes in urological cancers: A systematic review and meta-analysis.\",\"authors\":\"Yuefen Chen, Mei Wen, Zhe Yu, Fengjiao Xu\",\"doi\":\"10.1159/000544793\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The geriatric nutritional risk index (GNRI) is being used to predict outcomes of several malignancies. However, its utility for urinary tract cancer has not been systematically analyzed. We present the first meta-analysis examining the association between GNRI and the prognosis of urological cancers.</p><p><strong>Methods: </strong>This PROSPERO registered review searched Embase, PubMed, Web of Science, and Scopus up to 25th November 2024 for studies examining the relationship between GNRI and overall survival (OS), cancer-specific survival (CSS), and progression-free survival (PFS) after urological cancers.</p><p><strong>Results: </strong>A total of 20 studies were eligible. Three studies on bladder cancer, four on prostate cancer, seven on renal cell carcinoma (RCC), and six on urothelial cancers. Meta-analysis showed that low GNRI was a statistically significant predictor of poor OS in prostate cancer (OR: 3.02 95% CI: 1.61, 5.67). Pooled analysis showed that low GNRI was associated with poor OS (OR: 2.17 95% CI: 1.46, 3.22) and CSS (OR: 2.60 95% CI: 1.57, 4.30) in RCC but not PFS (OR: 1.50 95% CI: 1.00, 2.24). Pooled analysis also found that low GNRI was a predictor of worse OS (OR: 2.24 95% CI: 1.52, 3.29) and CSS (OR: 3.07 95% CI: 1.38, 6.86) in urothelial carcinoma. A narrative review on bladder cancer and GNRI showed mixed results.</p><p><strong>Conclusion: </strong>GNRI may have a role in predicting outcomes of urological malignancies. Low GNRI was independently associated with worse OS after prostate, renal cell, and urothelial carcinoma. Further, it also predicted CSS after RCC and urothelial carcinoma.</p>\",\"PeriodicalId\":23414,\"journal\":{\"name\":\"Urologia Internationalis\",\"volume\":\" \",\"pages\":\"1-19\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-04-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Urologia Internationalis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000544793\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Urologia Internationalis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000544793","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
The geriatric nutritional risk index as a predictor of outcomes in urological cancers: A systematic review and meta-analysis.
Objective: The geriatric nutritional risk index (GNRI) is being used to predict outcomes of several malignancies. However, its utility for urinary tract cancer has not been systematically analyzed. We present the first meta-analysis examining the association between GNRI and the prognosis of urological cancers.
Methods: This PROSPERO registered review searched Embase, PubMed, Web of Science, and Scopus up to 25th November 2024 for studies examining the relationship between GNRI and overall survival (OS), cancer-specific survival (CSS), and progression-free survival (PFS) after urological cancers.
Results: A total of 20 studies were eligible. Three studies on bladder cancer, four on prostate cancer, seven on renal cell carcinoma (RCC), and six on urothelial cancers. Meta-analysis showed that low GNRI was a statistically significant predictor of poor OS in prostate cancer (OR: 3.02 95% CI: 1.61, 5.67). Pooled analysis showed that low GNRI was associated with poor OS (OR: 2.17 95% CI: 1.46, 3.22) and CSS (OR: 2.60 95% CI: 1.57, 4.30) in RCC but not PFS (OR: 1.50 95% CI: 1.00, 2.24). Pooled analysis also found that low GNRI was a predictor of worse OS (OR: 2.24 95% CI: 1.52, 3.29) and CSS (OR: 3.07 95% CI: 1.38, 6.86) in urothelial carcinoma. A narrative review on bladder cancer and GNRI showed mixed results.
Conclusion: GNRI may have a role in predicting outcomes of urological malignancies. Low GNRI was independently associated with worse OS after prostate, renal cell, and urothelial carcinoma. Further, it also predicted CSS after RCC and urothelial carcinoma.
期刊介绍：
Concise but fully substantiated international reports of clinically oriented research into science and current management of urogenital disorders form the nucleus of original as well as basic research papers. These are supplemented by up-to-date reviews by international experts on the state-of-the-art of key topics of clinical urological practice. Essential topics receiving regular coverage include the introduction of new techniques and instrumentation as well as the evaluation of new functional tests and diagnostic methods. Special attention is given to advances in surgical techniques and clinical oncology. The regular publication of selected case reports represents the great variation in urological disease and illustrates treatment solutions in singular cases.
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