Urolithiasis最新文献

{"title":"Brown adipose tissue detection using positron emission tomography could help reduce urolithiasis risk.","authors":"Teruaki Sugino, Kazumi Taguchi, Takahiro Yanase, Rei Unno, Ryosuke Ando, Takahiro Yasui","doi":"10.1007/s00240-025-01739-8","DOIUrl":"10.1007/s00240-025-01739-8","url":null,"abstract":"<p><p>Urolithiasis is associated with metabolic syndrome, and reactivation of brown adipose tissue (BAT) may improve metabolic syndrome. In this study, we aimed to evaluate the association of BAT, as detected using positron emission tomography-computed tomography (PET-CT), with urolithiasis in humans. This single center retrospective cohort study involved patients who underwent PET-CT for cancer screening as part of a medical checkup between January 2006 and December 2020. We obtained data on participant demographics, presence of urolithiasis, and metabolic factors (such as obesity, hypertension, diabetes, and hyperlipidemia) from 182 medical records. BAT data and calcification of the abdominal aorta (CAA) rate, determined using abdominal CT, were also recorded. Any association between urolithiasis and other factors was evaluated using logistic regression analysis. Body mass index was higher in participants with BAT than in those without BAT (26.92 vs. 22.86 kg/m², p = 0.001). Participants with BAT had less urolithiasis and a lower CAA rate than those without BAT (10% vs. 37%, p = 0.031 and 50% vs. 79.6%, p = 0.008, respectively). Metabolic factors between the groups were similar (45.0% vs. 48.8%, p = 0.936). Furthermore, BAT and age were associated with a decreased odds ratio (OR) for urolithiasis (OR = 0.186, p = 0.037 and OR = 0.959, p = 0.02, respectively). We demonstrated that high BAT content is associated with a low risk of urolithiasis and CAA. Our findings may contribute to the development of novel preventive methods for urolithiasis.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"64"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophils as mediators of the association between lipid accumulation product and kidney stones, but not for recurrent kidney stones in US adults.","authors":"Shang Gao, Jingteng He, Hongtao Liu, Lianhui Fan, Renli Tian","doi":"10.1007/s00240-025-01735-y","DOIUrl":"10.1007/s00240-025-01735-y","url":null,"abstract":"<p><p>Kidney stones (KS) are prevalent and often recur, with obesity, metabolic disorders, and inflammation significantly impacting their pathophysiology. The traditional body mass index (BMI) has limitations, as it cannot effectively differentiate between fat and lean body mass or provide information about fat distribution. In contrast, the lipid accumulation product (LAP), which combines waist circumference and triglyceride levels, serves as a crucial indicator of visceral fat. This study examines the relationship between LAP and KS, including recurrent kidney stones (RKS), using data from the National Health and Nutrition Examination Survey (NHANES). It also investigates whether neutrophils mediate the connection between LAP and KS/RKS, comparing the predictive accuracy of LAP and BMI. Data from 2007 to 2014 covered 9910 KS participants and 880 RKS participants. Weighted logistic regression assessed the LAP-KS/RKS relationship, while mediation analysis explored the role of neutrophils. Receiver Operating Characteristic (ROC) curves evaluated the predictive capabilities of LAP and BMI. Results showed LAP was significantly associated with KS (OR = 1.629; 95% CI 1.296-2.047) and RKS (OR = 1.561; 95% CI 1.145-2.128). Neutrophils partially mediated the LAP-KS relationship (7.6%, p = 0.018), with no effect found for RKS. Moreover, LAP outperformed BMI in diagnostic accuracy. These findings suggest that LAP is an effective marker for assessing KS and RKS, aiding in the early identification of potential patients to reduce the incidence and recurrence of kidney stones.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"62"},"PeriodicalIF":2.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.","authors":"Yuexian Xu, Jianmin You, Junfeng Yao, Bingbing Hou, Wei Wang, Zongyao Hao","doi":"10.1007/s00240-025-01734-z","DOIUrl":"10.1007/s00240-025-01734-z","url":null,"abstract":"<p><p>Klotho is an antiaging protein that is primarily secreted by the kidneys. This study aimed to explore the protective effects of Klotho against calcium oxalate (CaOx) crystal-induced renal aging and the underlying mechanisms involved. We established a mouse model of CaOx crystal deposition via the intraperitoneal injection of glyoxylate (Gly) and constructed an in vitro model by stimulating HK2 cells with calcium oxalate monohydrate (COM). Renal aging levels were assessed through β-galactosidase (SA-β-gal) staining and the detection of senescence-associated markers. By overexpressing Klotho both in vitro and in vivo, we examined oxidative stress, mitochondrial function, and renal aging levels. We then evaluated the role of Nrf2/HO-1 signalling pathway-mediated oxidative stress in CaOx crystal-induced renal aging by applying the oxidative stress scavenger N-acetylcysteine (NAC) and overexpressing or inhibiting Nrf2 in HK2 cells. We subsequently overexpressed Klotho while inhibiting Nrf2 to confirm that Klotho exerts its protective effects through the Nrf2/HO-1 pathway. Finally, we measured the methylation levels of the Klotho promoter and assessed the degree of renal aging induced by CaOx crystals after the inhibition of Klotho DNA methylation. We found that the overexpression of Klotho alleviated CaOx crystal-induced oxidative stress and mitochondrial dysfunction, thereby reducing renal aging. NAC mitigated CaOx crystal-induced renal aging. The overexpression of Nrf2 alleviated CaOx crystal-induced oxidative stress and mitochondrial dysfunction, thus reducing renal aging, whereas the knockdown of Nrf2 exacerbated CaOx crystal-induced oxidative stress and mitochondrial dysfunction, leading to more severe renal aging. The combination of Klotho overexpression and Nrf2 knockdown reversed the protective effects of Klotho. CaOx crystals induced an increase in the DNA methylation levels of Klotho in the kidneys, and the inhibition of DNA methylation alleviated CaOx-induced renal aging. This study revealed that Klotho plays a crucial role in calcium oxalate crystal-induced kidney senescence by influencing kidney oxidative stress and mitochondrial function through the Nrf2/HO-1 pathway.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"61"},"PeriodicalIF":2.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Access to the upper calyx in supine position: breaking a myth.","authors":"Jolien Van der Jeugt, Coral Manso Aparicio, Sebastián Valverde Martínez, Amal Aderghal Chikhaoui, Enrique González Martín, Marcos Cepeda","doi":"10.1007/s00240-025-01700-9","DOIUrl":"10.1007/s00240-025-01700-9","url":null,"abstract":"<p><p>The feasibility and safety of upper calyx access in supine percutaneous nephrolithotomy (PCNL) remains controversial. We aimed to detail our technique and describe the outcomes in effectivity as well as safety in a large cohort. The authors analyzed patients with renal and proximal ureteral stones who underwent supine PCNL using upper calyx access at Rio Hortega University Hospital Valladolid (Spain) between 2013 and 2023. Patients were placed in the Galdakao-modified supine Valdivia position. Transpapillary percutaneous access to the upper calyx was guided by a combination of ultrasound (US) and fluoroscopy. Stone-free rate (SFR) was assessed by residual fragments < 4 mm assessed by non-contrast CT scan (NCCT) two months postoperatively. The 30-days complications were classified using the PCNL-specific Clavien-Dindo score. One hundred patients were included in the study. Thirty-three (33.3%) were diagnosed with staghorn stones, and 44 (44.4%) with multiple calculi. Upper calyx access was achieved supra-11th rib in 31 (31.9%), supra-12th rib in 64 (66%) and subcostal in 2 (2.1%) cases. Miniaturized PCNL was performed in 64 (64.6%) patients. Median surgical time was 117.5 (100; 150) minutes. There were no intraoperative complications and in 62.1% of the cases, a nephrostomy tube was not necessary. The median hospital stay was 3 (1; 5) days. Twenty-seven postoperative complications occurred, including 8% grade I complications. Grade II complications including the need for blood transfusion and antibiotics occurred in 5% and 9%. Grade III complications were noted in 5%, and no grade IV or V were observed. There were no significant thoracic, liver or spleen complications. The single-procedure SFR was 85%, with only 3 patients requiring a second intervention. US and fluoroscopy guided percutaneous access to the upper calyx in the supine position is feasible and demonstrates a low complication rate alongside a high SFR.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"60"},"PeriodicalIF":2.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of osteopontin in modulating macrophage phagocytosis of calcium oxalate crystals.","authors":"Tatsuya Hattori, Kazumi Taguchi, Ryosuke Chaya, Shuzo Hamamoto, Atsushi Okada, Takahiro Yasui","doi":"10.1007/s00240-025-01732-1","DOIUrl":"10.1007/s00240-025-01732-1","url":null,"abstract":"<p><p>In inflammation, osteopontin (OPN) acts as both a stone matrix component for calcium oxalate (CaOx) crystal formation and an inflammatory mediator. While previous studies have demonstrated the individual roles of OPN and macrophages (Mφ) in renal CaOx stone formation during inflammation, their interaction remains poorly understood. This study aimed to elucidate the role of OPN in modulating Mφ function during crystal formation, using an ex vivo model. Bone marrow-derived macrophages (BMDM) were isolated from eight-week-old male C57BL/6J wild-type and OPN knockout mice. BMDMs from OPN-positive (BMDM^OPN+) and OPN-negative (BMDM^OPN-) mice were co-cultured with fluorescently labeled CaOx monohydrate (COM) crystals for phagocytosis assays and analyzed using the IN Cell Analyzer 6000. We further performed real-time quantitative reverse transcription PCR and RNA sequencing to identify gene expression profiles and clarify the role of OPN in Mφ function. The assay analysis demonstrated that phagocytosis rates were significantly higher in BMDM^OPN- than in BMDM^OPN+. Inflammatory markers, such as IL-6, TNF, CD44, were upregulated following COM exposure, and IL-6 expression was significantly lower in BMDM^OPN- than in BMDM^OPN+. RNA sequencing revealed that BMDM^OPN- exhibited a less pro-inflammatory and more anti-inflammatory phenotype (Csf2^low, Irf5^low, Itgax^low, Csf1^high, Cd163^high), resembling M2-like Mφs. Further functional analysis indicated that OPN knockdown in Mφs increased the S100 family and CREB signaling, which enhanced the M2-like phenotype shift and phagosome formation. In conclusion, OPN plays a critical role in enhancing pro-inflammatory Mφ function, potentially limiting COM phagocytosis. Modulating OPN expression in circulating Mφs may represent a therapeutic approach for kidney stone disease.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"58"},"PeriodicalIF":2.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on:'' ultrasound versus fluoroscopy-guided extracorporeal shockwave lithotripsy in renal calculi: a systematic review and meta-analysis''.","authors":"Yalong Zhang, Kangyu Wang, Li Yang","doi":"10.1007/s00240-025-01731-2","DOIUrl":"https://doi.org/10.1007/s00240-025-01731-2","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"59"},"PeriodicalIF":2.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the clinical genetics of kidney stone disease using the Natera Renasight panel.","authors":"Andrewe L Baca, Rutul D Patel, Kevin Labagnara, Benjamin Green, Michael Zhu, Kavita Gupta, Beth Edelblute, Andrea A Asencio, Deep Sharma, Wei Chen, Dima Raskolnikov, Jillian Donnelly, Kara L Watts, Alexander C Small","doi":"10.1007/s00240-025-01723-2","DOIUrl":"10.1007/s00240-025-01723-2","url":null,"abstract":"<p><p>We aimed to characterize the underlying genetics of kidney stone disease (KSD) in an urban and diverse population using the Natera Renasight genetic panel. This was a single-center prospective study of high-risk KSD patients, defined as recurrent stone formers or those with a family history with KSD. Buccal saliva DNA samples were collected with the commercially available Natera Renasight genetic panel and were analyzed using next-generation sequencing. The panel assesses 385 kidney disease related genes, including 45 linked to KSD. One hundred eleven high-risk KSD patients were enrolled. The majority were female (56%) with a median age of 50 (IQR 39.5-59.5), compromising a diverse ethnic background with 62% Hispanic, 23% White and 11% Black. Patients had median 3 (IQR 2-5) lifetime stone episodes, and 41% had family history of KSD. Genetic analysis was possible for 105 patients (95%). Eight (8%) had positive tests with only one patient found to have a pathogenic mutation associated with KSD (SLC7A9, cystinuria). The other 7 positive tests included amyloidosis (TTR, N = 3), Alport syndrome (COL4A3, N = 2), polycystic kidney disease (PKD1, N = 1), and susceptibility to ESRD (APOL1, N = 1). Patients with positive tests were more likely to have chronic kidney disease (38% vs 5%, p < 0.01), gout (13% vs 1%, p = 0.02) and carbonate apatite stones (38% vs 7%, p < 0.01). Our study sheds light on genetic factors of KSD in a diverse patient population. The results suggest that KSD is unlikely monogenetic in nature, but is more likely due to a complex interplay of polygenetic and environmental influences. Genetic testing may be most useful in KSD patients with chronic kidney disease.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"57"},"PeriodicalIF":2.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective evaluation of efficacy, safety, cumulative laser energy, and stone-free rates in the post-market SOLTIVE^™ SuperPulsed laser system registry: insights from team of worldwide endourological researchers' (T.O.W.E.R.) research consortium.","authors":"Ben H Chew, Victor K F Wong, Mitchell R Humphreys, Wilson Molina, Bodo Knudsen, Mantu Gupta, Duane D Baldwin, Peter Kronenberg, Palle Osther, Olivier Traxer","doi":"10.1007/s00240-025-01720-5","DOIUrl":"10.1007/s00240-025-01720-5","url":null,"abstract":"<p><p>The Thulium fiber laser (TFL) is a relatively new tool for endoscopic laser lithotripsy. The Endourological Society's T.O.W.E.R. registry sought to evaluate the stone-free rate (SFR) at 3 months following URS. A subset of the study sought to determine the association between cumulative TFL energy and SFRs. 423 patients with planned ureteroscopic lithotripsy using TFL (SOLTIVE^™, Gyrus ACMI, Inc. d/b/a Olympus Surgical Technologies America) were prospectively enrolled between December 2020 and May 2023 at nine international sites. Baseline clinical characteristics and SFR data for kidney and ureteral stones were separately analyzed according to quartile cumulative TFL energy ranges. Median patient age was 58.0 (IQR: 44-67) years and maximal stone diameters were 9.9 (IQR: 7-12.9) mm and 7.4 (IQR 6.1-9.4) mm for kidney and ureteral stones, respectively. Overall SFR (no fragments) for renal and ureteral stones were 73.0% and 85.7% at 3-months. Cumulative energy levels were divided into quartiles and lower SFRs were observed with the highest quartile for kidney stones (p = 0.001), but not in ureteral stones. This correlated with kidney stone size as larger stones required more energy. The rate of adverse events related to the procedure was 1.9% (8/423). Higher stone burdens had lower stone free rates and required more cumulative laser energy. The TFL is effective in endoscopic lithotripsy. This post-marketing survey demonstrates that TFL is a safe and effective tool for endoscopic laser lithotripsy.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"56"},"PeriodicalIF":2.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of methylene blue-assisted tract visualization in ultrasound-guided percutaneous nephrolithotomy: a salvage technique for failed renal access.","authors":"Amir Hossein Hassani, Hooman Kamran, Abdolreza Haghpanah","doi":"10.1007/s00240-025-01728-x","DOIUrl":"10.1007/s00240-025-01728-x","url":null,"abstract":"<p><p>We propose using methylene blue with ultrasound-guided percutaneous nephrolithotomy (US-PCNL) as a salvage method when ultrasonography access is challenging, to prevent the necessity of creating a new tract or access failure. We retrospectively evaluated adult patients who underwent US-PCNL over two years by a single surgeon. Patients were divided into two groups based on methylene blue usage. In cases with challenging renal access, diluted methylene blue was injected via the ureteral catheter, and the nephroscope was used to locate the parenchymal defect by visualizing the blue area. Among 120 patients, 34 (28.3%) required methylene blue for renal access. Recurrent stones (70.6% vs. 47.7%; p-value: 0.023) and previous PCNL (41.2% vs. 18.6%; p-value: 0.010) were more common in these patients. All achieved successful access with a single tract. Although access time (median: 235 vs. 160 s; p-value: < 0.001) and operative duration (median: 90 vs. 85 min; p-value: 0.023) were statistically longer when methylene blue was used, the differences were not clinically significant. Analgesic use, hospital stay, hemoglobin drop, and creatinine rise were similar between groups. Stone-free rates after the first session were 50.0% with methylene blue and 57.0% without it (p-value: 0.489). Residual stone rates requiring ancillary procedures were higher when methylene blue was needed (20.6% vs. 9.4%), but the difference was not statistically significant (p-value: 0.126). Complication rates were similar between the groups. Methylene blue injection into the ureteral catheter is a safe and effective procedure for US-PCNL, reducing access failure and the need for new tracts.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"55"},"PeriodicalIF":2.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiurolithic activity of vanillin in ethylene glycol-induced hyperoxaluric rat model.","authors":"Aslam Khan, Sara Salim, Syed Muzzammil Masaud, Ashfaq Ahmad, Muhammad Furqan Akhtar, Safur Rehman Mandukhail","doi":"10.1007/s00240-025-01733-0","DOIUrl":"10.1007/s00240-025-01733-0","url":null,"abstract":"<p><p>Vanillin, a natural compound derived from vanilla beans, exhibits antioxidant and anti-inflammatory properties, which may contribute to the prevention and treatment of renal stones. Therefore, this study is aimed to investigate the potential antiurolithic effect of vanillin in male hyperoxaluric Wistar rats. Computational molecular docking studies were used to investigate the interaction process and verify vanillin's role in the prevention of kidney stones containing calcium oxalate. Software tools were utilized to analyze the drug ligands' additional molecular characteristics, absorption, distribution, metabolism, and excretion (ADME), and toxicity. Urinary crystals were induced in rats by adding 0.75% ethylene glycol (EG) in drinking water for 3 weeks, along with 1% ammonium chloride (AC) during the initial three days. Molecular docking analysis revealed strong binding interactions of vanillin with Human CTP: Phosphoethanolamine Cytidylyltransferase (PDB ID: 3ELB) at the C5P binding site, with a binding affinity of -7.6 kcal/mol, suggesting a potential molecular basis for its antiurolithic activity. In vivo study showed that vanillin treatment dose dependently (30, 100 and 300 mg/kg body weight) reduced hyperoxaluria, hypercalciuria and crystal counts in kidneys of hyperoxaluric rats. The current results of our study suggest that vanillin possesses potential antiurolithic activity, showing enhanced therapeutic effects in urolithiasis, which could be a safe, effective and non-invasive option in modern medicine for the management of urinary stones.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"54"},"PeriodicalIF":2.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}