Urolithiasis最新文献

{"title":"Increased risk of upper tract urothelial carcinoma in patients with kidney stones: a large-scale analysis of the UK biobank.","authors":"Hachem Ziadeh, Adam Calaway, Sanjay Gupta, Donald Bodner, Jason R Brown, Fredrick R Schumacher, Chen-Han Wilfred Wu","doi":"10.1007/s00240-025-01758-5","DOIUrl":"https://doi.org/10.1007/s00240-025-01758-5","url":null,"abstract":"<p><p>Kidney stone disease is a common and increasingly prevalent condition, with its incidence rising by 70% over the past two decades in the U.S. Lodgment of stones within the ureteral wall can cause urothelial injury, triggering inflammation, edema, and obstruction. Chronic inflammation has been linked to cancer development, contributing to tumorigenesis through cellular transformation, proliferation, invasion, angiogenesis, and metastasis. Studies suggest that recurrent nephrolithiasis can lead to a range of complications, including an increased risk of urinary tract cancer. This study investigates the association between kidney and ureteral stones and upper tract urothelial carcinoma (UTUC) risk using data from 502,144 individuals in the UK Biobank. We bidirectionally examined the presence of kidney stones and UTUC, applying a chi-square test to compute the odds ratio and assess statistical significance. A history of kidney stones was noted in 13,016 individuals, while 489,128 were stone-free. Among 511 UTUC cases, 50 had a history of kidney stones, whereas 461 were isolated UTUC. In contrast, 12,966 individuals had kidney stones without UTUC, and 488,667 were free of both conditions. Statistical analysis revealed an increased risk of UTUC in individuals with kidney stones [OR = 4.09 (95% CI 3.05-5.48), p < 0.001], indicating strong statistical significance. Our study demonstrates a fourfold increased risk of UTUC in individuals with a history of kidney stones. These findings highlight a significant association between kidney stones and UTUC, underscoring the need for further research on clinical management and cancer surveillance.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"87"},"PeriodicalIF":2.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on\"Evaluating the natural history of incidentally recognized clinically silent nephrolithiasis in healthy adults: an updated systematic review with meta-analysis\".","authors":"Zheng Wang, Jinxing Huang, Xierzhati Aizezi","doi":"10.1007/s00240-025-01759-4","DOIUrl":"https://doi.org/10.1007/s00240-025-01759-4","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"86"},"PeriodicalIF":2.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of a novel bendable-tip ureteral access sheath with integrated suction: an in vitro study.","authors":"Mario Basulto-Martínez, John Denstedt","doi":"10.1007/s00240-025-01753-w","DOIUrl":"https://doi.org/10.1007/s00240-025-01753-w","url":null,"abstract":"<p><p>Surgical management of urinary stones has significantly evolved with the advent of extracorporeal shockwave lithotripsy, flexible ureterorenoscopy (fURS), and percutaneous nephrolithotomy. For lower pole stones larger than 1 cm, the choice between fURS and miniaturized percutaneous nephrolithotomy remains debated. fURS with ureteric access sheaths (UAS) is a widely utilized technique, but fragment clearance is challenging in unfavorable anatomical conditions and/or lower pole stones. This study compares a novel flexible suction UAS (FANS) with a standard UAS in an in vitro model of lower pole stones. An in vitro experiment was conducted using an anatomical model of the urinary tract with artificial stones simulating complex 1-cm lower pole stones. Fourteen procedures were performed using either a 12/14 Fr diameter standard UAS or FANS. Every experiment was performed by a single surgeon using a 8.4 Fr single-use digital flexible ureteroscope and holmium:YAG laser set at 0.5 J, 25 Hz, and short pulse with a 272 μm fiber. Operative times, stone clearance rates, lasering times, were recorded and the residual stone masses (> 2 mm) was quantified. Complete stone clearance was achieved in 5 out of 7 procedures using FANS while no complete stone clearance was achieved using the standard UAS. The median laser time [27:33 (26:06-28:24) vs 24:02 (21:25-25:04) mm:ss, p = 0.017] and total energy output energy [20663 (19,575-21,325) vs 18,270 (16,069-18,931) J, p = 0.017] were significantly lower in the FANS group (p = 0.017), and the operative time was comparable. This in vitro experiment suggests that fURS with novel FANS may improve stone clearance and improve laser efficiency when compared to the standard UAS, without increasing operative times. Further clinical trials are warranted to confirm these findings.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"85"},"PeriodicalIF":2.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Advances in the mechanism of urinary proteins in calcium oxalate kidney stone formation.","authors":"Mingcheng Shi, Xiaozhe Su, Heng Xiang, Qianlin Song, Sixing Yang","doi":"10.1007/s00240-025-01729-w","DOIUrl":"https://doi.org/10.1007/s00240-025-01729-w","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"84"},"PeriodicalIF":2.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Virgin ureter\" vs. \"non-virgin ureter\"? A comparative analysis on complications and failure of retrograde intrarenal surgery: a multicentre case-control study from RIRSearch Group.","authors":"Kerem Teke, Naci Burak Çınar, Önder Çınar, Murat Akgül, Cem Başataç, Muhammet Fatih Şimşekoğlu, Hakan Çakır, Oktay Özman, Mustafa Bilal Tuna, Duygu Sıddıkoğlu, Eyüp Burak Sancak, Cenk Murat Yazıcı, Barbaros Başeskioğlu, Haluk Akpınar, Bülent Önal","doi":"10.1007/s00240-025-01750-z","DOIUrl":"https://doi.org/10.1007/s00240-025-01750-z","url":null,"abstract":"<p><p>It is unclear whether ureteral virginity has an effect on retrograde intrarenal surgery (RIRS). We aimed to evaluate the impact of ureteral virginity on RIRS outcomes in a multicenter study. Data from the RIRSearch study group database were retrospectively reviewed. Patients with a history of endoluminal interventions or extrinsic ureteral surgery were categorized as having a \"non-virgin ureter,\" while those without such histories were classified as \"virgin ureters.\" Case-control matching was performed based on age, gender, uretral access sheath size, and stone characteristics. Demographic, clinical, surgical and complication data were compared after-matching. A total of 894 procedures were included, with 119 (13.3%) involving non-virgin ureters. Pre-matching, the non-virgin ureter group had higher mean age (50.6 ± 13.2 vs. 46.6 ± 13.6 years) and Charlson comorbidity index ≥ 2 (51.3% vs. 40.4%). In addition, number of stones, total-stone volume and rate of multiple stone localization were significantly higher in non-virgin ureter group. Operation time, hospital stay, surgical failure, need for auxiliary treatment, and perioperative complications were significantly higher in non-virgin ureter group (p < 0.05). After case-matching, perioperative complications (18.7% vs. 5.3%), hospital stay (1.54 ± 1.30 vs. 1.18 ± 0.98 days), and auxiliary treatment requirements (20% vs. 8.4%) remained significantly higher in non-virgin ureter group (p < 0.05). There was no significant difference in postoperative complication rates (17.3% vs. 19.8%) or surgical failure rates (36% vs. 26%). Non-virgin ureters were associated with higher perioperative complication rate, longer hospital stays and increased need for auxiliary treatments during RIRS. Patients with non-virgin ureters may be informed about these potential risks before surgery.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"83"},"PeriodicalIF":2.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of video-animated information on anxiety, satisfaction, and pain perception in patients undergoing ESWL: a randomized controlled study.","authors":"Recep Burak Degirmentepe, Yasir Muhammed Akca, Osman Sami Akman, Haci Ibrahim Cimen, Deniz Gul, Muammer Bozkurt, Tuncay Toprak, Osman Kose","doi":"10.1007/s00240-025-01757-6","DOIUrl":"https://doi.org/10.1007/s00240-025-01757-6","url":null,"abstract":"<p><p>Extracorporeal Shock Wave Lithotripsy (ESWL) is a widely used non-invasive treatment for kidney stones, but it can cause significant patient anxiety due to procedural unfamiliarity and discomfort. This study aimed to evaluate the effects of video-animated information on anxiety levels, procedural satisfaction, willingness to undergo ESWL again, and perceived pain during the procedure. A prospective randomized controlled trial was conducted with 80 patients scheduled for ESWL. Patients were randomized into two groups: the video group (n = 40) received video-animated information in addition to standard verbal and written information, while the non-video group (n = 40) received only standard information. Anxiety levels were assessed using the State-Trait Anxiety Inventory (STAI), and pain perception, satisfaction, and willingness to repeat the procedure were evaluated using the Visual Analog Scale (VAS). The video group showed a significant reduction in situational anxiety (STAI-S scores: 40.1 ± 3.7 to 35.3 ± 2.7, p < 0.001) compared to the non-video group (39.7 ± 4.2 to 38.5 ± 4.5, p = 0.106). The video group also reported higher satisfaction scores (8.8 ± 1.3 vs. 7.2 ± 2.0, p < 0.01) and greater willingness to repeat the procedure (5.6 ± 2.0 vs. 3.6 ± 1.9, p < 0.01). No significant difference was observed in VAS pain scores between the groups (4.9 ± 1.3 vs. 5.4 ± 1.6, p = 0.298). Video-animated information significantly reduces situational anxiety and improves patient satisfaction and willingness to undergo ESWL again, without significantly affecting perceived pain levels. These findings support the use of multimedia tools in patient education to enhance the ESWL experience.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"81"},"PeriodicalIF":2.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing infusion-suction diameter ratio (ISDR) in ureteroscopy: in vitro pressure and flow prediction and management.","authors":"Fengqi Wang, Yanqi Xie, Baiyang Song, Wanzhang Liu, Ting Huang, Zhengyi Wang, Pengfei Qin, Dan Jin, Yingzhi Chen, Li Fang, Yue Cheng","doi":"10.1007/s00240-025-01756-7","DOIUrl":"https://doi.org/10.1007/s00240-025-01756-7","url":null,"abstract":"<p><p>To optimize channel configurations for a flexible ureteroscope incorporating both irrigation and suction channels, in vitro experiments were conducted with the aim of achieving safer and more efficient surgical procedures. Upper urinary tract models with integrated pressure-sensing ports were constructed based on CT urography reconstructions. Functional ureteroscope prototypes with various combinations of infusion and suction channel diameters were developed. Using a controlled constant-pressure irrigation system, intrarenal pressure measurements were obtained from the upper, middle, and lower calyces, as well as the renal pelvis. The effects of varying infusion pressures on irrigation flow rates and intrarenal pressure distribution were assessed. Regression models were subsequently established for renal pelvic pressure (RPP) and irrigation flow rate, allowing for the determination of the optimal channel diameter configuration by integrating model predictions with clinical requirements. At an infusion pressure of 500 cmH₂O without active suction, the maximum Infusion-to-Suction Diameter Ratio (ISDR) that maintained RPP below the safety threshold was approximately 0.525, corresponding to an Infusion-to-Suction cross-sectional Area Ratio (ISAR) of about 0.276. Theoretically, the optimal combination of infusion and suction channel diameters that satisfies both pressure and flow criteria is 1.03 mm and 1.93 mm, respectively. These findings demonstrate that the ISDR, infusion channel caliber, and irrigation pressure are critical determinants of RPP and flow rate during ureteroscopic procedures. For ureteroscopes with integrated infusion and suction channels, maintaining an ISDR below 0.525-or an ISAR below 0.276-provides favorable balance between procedural safety and irrigation efficiency.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"82"},"PeriodicalIF":2.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: \"The Impact of Antegrade Guidewire Positioning Outside the External Urethral Meatus in PCNL: The Through-and-Through Technique\".","authors":"Mucahit Gelmis","doi":"10.1007/s00240-025-01755-8","DOIUrl":"https://doi.org/10.1007/s00240-025-01755-8","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"79"},"PeriodicalIF":2.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonsteroidal anti-inflammatory drugs, blood metabolites, and kidney stones: a comprehensive Mendelian randomization study.","authors":"Hao Yu, Feng Zeng, Jian Wu, Hequn Chen, Fang Huang, Zewu Zhu","doi":"10.1007/s00240-025-01749-6","DOIUrl":"https://doi.org/10.1007/s00240-025-01749-6","url":null,"abstract":"<p><p>It remains unclear for the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on kidney stones. This study aimed to investigate the causal relationship between NSAIDs medication usage and the risk of kidney stones, and further determine whether blood metabolites mediate this association. We conducted a two-sample Mendelian randomization (MR) analysis using genetic data from the FinnGen consortium to explore the causal impact of NSAIDs medication usage on kidney stone formation. Furthermore, a two-step MR analysis was performed to assess whether blood metabolites significantly mediate the effects of NSAIDs on kidney stone risk. Genetic variants associated with NSAIDs medication usage or blood metabolites were employed as instrumental variables. The inverse variance weighted (IVW) method serves as the primary analytical approach to assess the causal relationship. We found that NSAIDs usage was causally associated with an increased risk of kidney stones (OR: 1.70, 95% CI: 1.33-2.16, P < 0.001). Additionally, we revealed that the risk of kidney stones was causally affected by 67 blood metabolites, among which NSAIDs usage was causally associated with three metabolites, including β-hydroxyisovaleroylcarnitine level, Mannose level, and Deoxycholic acid 12-sulfate. Furthermore, mediation analysis revealed that β-hydroxyisovaleroylcarnitine partially mediated the effect of NSAIDs usage on kidney stones, accounting for approximately 5.6%. Our study suggests a potentially causal association between NSAIDs medication usage and an increased risk of kidney stones, with blood metabolites possibly mediating this effect. These insights underline the necessity of monitoring blood metabolite levels during NSAIDs therapy, especially in patients at risk for kidney stones. However, further studies are required to validate these findings.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"77"},"PeriodicalIF":2.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"Ureteral access sheath or percutaneous nephrostomy during flexible ureteroscopy: which is better\".","authors":"Ruohui Huang, Wei Xia","doi":"10.1007/s00240-025-01751-y","DOIUrl":"https://doi.org/10.1007/s00240-025-01751-y","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"78"},"PeriodicalIF":2.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}