Urolithiasis最新文献_第6页

Gut Microbiota-Derived butyric acid attenuates kidney stone formation in humans and mice. 肠道微生物来源的丁酸可减轻人和小鼠肾结石的形成。

IF 2.2 2区医学

Urolithiasis Pub Date : 2025-07-28 DOI: 10.1007/s00240-025-01812-2

Masahiko Isogai, Shuzo Hamamoto, Rei Unno, Kazumi Taguchi, Atsushi Okada, Takahiro Yasui

{"title":"Gut Microbiota-Derived butyric acid attenuates kidney stone formation in humans and mice.","authors":"Masahiko Isogai, Shuzo Hamamoto, Rei Unno, Kazumi Taguchi, Atsushi Okada, Takahiro Yasui","doi":"10.1007/s00240-025-01812-2","DOIUrl":"10.1007/s00240-025-01812-2","url":null,"abstract":"Metabolic syndromes, particularly obesity, are associated with kidney stone formation (KSF). The gut microbiota and its metabolites, including butyrate, play critical roles in regulating inflammation and obesity-related disorders. In this study, using human tissue samples and in vivo mice experiments, we examined the effects of butyrate on KSF. We compared the gut microbiota of healthy individuals and patients with kidney stones, using 16 S rRNA gene sequencing. For in vivo analysis, five-week-old male C57BL/6J mice were administered butyric acid-supplemented water for 12 weeks, followed by intraperitoneal injection of glyoxylate (80 mg/kg) for 6 days to induce renal crystal formation (RCF). Patients with kidney stones exhibited reduced gut microbiota diversity (P = 0.037) and a lower abundance of butyrate-producing bacteria (P = 0.023) compared to healthy controls, although no significant differences were observed in the proportions of individual bacterial species. In mice, butyric acid administration significantly reduced RCF (P < 0.001). Moreover, butyric acid treatment attenuated inflammation, as evidenced by decreased expression of interleukin (Il)6 and C-C motif ligand 2 (Ccl2). The liver X receptor/retinoid X receptor (LXR/RXR) pathway was activated, as revealed by quantitative real-time polymerase chain reaction and RNA sequencing. Additionally, western blotting and transmission electron microscopy showed that butyric acid mitigated early mitochondrial and microvillar damage. In conclusion butyric acid protects against RCF by reducing inflammation and oxidative stress. This is the first report to elucidate the potential therapeutic role of butyrate, a gut microbiota-derived metabolite, based on both human and in vivo evidence.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"146"},"PeriodicalIF":2.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methodological considerations and technical limitations in the evaluation of ESWL success using SWE. 使用SWE评估ESWL成功的方法考虑和技术限制。

IF 2.2 2区医学

Urolithiasis Pub Date : 2025-07-28 DOI: 10.1007/s00240-025-01813-1

Enes Gurun, Mesut Ozturk, Mustafa Basaran

引用次数: 0

Comparison of minimally invasive suction-evacuation versus standard nephrostomy sheaths for the treatment of partial staghorn stones. 微创吸排术与标准肾造口术治疗部分鹿角结石的比较。

IF 2 2区医学

Urolithiasis Pub Date : 2025-07-24 DOI: 10.1007/s00240-025-01807-z

Jian Liang, Jingwei He, Hansheng Lin, Nengzhuo Feng, Wenchao Qin, Yumin Zhuo

{"title":"Comparison of minimally invasive suction-evacuation versus standard nephrostomy sheaths for the treatment of partial staghorn stones.","authors":"Jian Liang, Jingwei He, Hansheng Lin, Nengzhuo Feng, Wenchao Qin, Yumin Zhuo","doi":"10.1007/s00240-025-01807-z","DOIUrl":"10.1007/s00240-025-01807-z","url":null,"abstract":"We conducted a prospective, randomized study to compare the safety and efficacy of using a conventional nephrostomy sheath (CNS) versus a minimally invasive suction-evacuation nephrostomy sheath (SENS) for treating partial staghorn stones. Eighty-six patients with partial staghorn stones were randomly assigned into two groups, with 43 patients in each group. One group underwent standard percutaneous nephrolithotomy (sPCNL) using CNS, whereas the other group underwent minimally invasive percutaneous nephrolithotomy (mPCNL) with SENS. Patient demographics, stone characteristics, intraoperative data, perioperative data, and surgical results were collected and analyzed.The patient demographics and stone characteristics were similar in both groups. The SENS group had significantly lower peak and mean intrarenal pressure (IRP) during the procedure. The stone-free rate (SFR) was comparable between groups. The SENS group removed stones more efficiently, with shorter treatment time and less frequent use of the stone extractor. Lower IRP and shorter treatment time led to fewer postoperative complications.mPCNL with SENS results in lower IRP, faster stone removal, and reduced use of stone forceps while preserving SFR and safety.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"143"},"PeriodicalIF":2.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tri-layer ureteral stents, with anti-encrustation surface, offer improved comfort: results from an international stent registry. 三层输尿管支架，具有抗结痂表面，提供更好的舒适性：来自国际支架注册的结果。

IF 2 2区医学

Urolithiasis Pub Date : 2025-07-23 DOI: 10.1007/s00240-025-01774-5

Runhan Ren, K F Victor Wong, Connor M Forbes, Yuanyuan Ji, Alexander P Glaser, Ryan F Paterson, Kazumi Taguchi, Ojas Shah, Edouard Tariel, Channa Amarasekera, Shuzo Hamamoto, Dirk Lange, Wilson R Molina, John J Knoedler, Amy E Krambeck, Marcelino E Rivera, Karen L Stern, Mitchell R Humphreys, Ben H Chew

{"title":"Tri-layer ureteral stents, with anti-encrustation surface, offer improved comfort: results from an international stent registry.","authors":"Runhan Ren, K F Victor Wong, Connor M Forbes, Yuanyuan Ji, Alexander P Glaser, Ryan F Paterson, Kazumi Taguchi, Ojas Shah, Edouard Tariel, Channa Amarasekera, Shuzo Hamamoto, Dirk Lange, Wilson R Molina, John J Knoedler, Amy E Krambeck, Marcelino E Rivera, Karen L Stern, Mitchell R Humphreys, Ben H Chew","doi":"10.1007/s00240-025-01774-5","DOIUrl":"https://doi.org/10.1007/s00240-025-01774-5","url":null,"abstract":"A tri-layer ureteral stent with novel coating lining the inner and outer surfaces (Tria™) was designed to reduce encrustation. We assessed technical success, complications, and patient symptoms in an international prospective stent registry conducted from 2020 to 2023. Outcomes included technical success, infections, and encrustation rates. Patient-reported PROMIS Pain Intensity (3a) and Pain Interference (6b) scores were obtained at time of index procedure, stent removal, and post-stent removal. Tria stents were compared to non-Tria stents grouped together. Of 359 total patients, 271 had a unilateral stent placed for stone management procedures. Tria vs. non-Tria groups were comparable in age (55.9y vs. 58.7y), gender (57.8% vs. 56.4% male), BMI (28.9 vs. 29.7 kg/m2), and stent indwell times (11.8 vs. 9.9 days). Pain interference scores (p = 0.025) were lower in patients with Tria stents, and pain intensity scores approached significance (p = 0.052). Non-Tria patients reported significantly larger decreases from the week prior to stent removal to post-stent removal in both domains (p = 0.0245, p = 0.0216). Infection (Tria 1.9% vs. non-Tria 3.4%, p = 0.45) and encrustation rates (Tria 1.3% vs. non-Tria 0%, p = 0.36) were both low and non-significantly different. Patients with Tria stents were more comfortable than non-Tria stents in the week prior to stent removal and post-stent removal visits.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"142"},"PeriodicalIF":2.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comments on the "Does suction in Mini PCNL mitigate rise in intrarenal pressure?" 关于“Mini PCNL抽吸是否能缓解肾内压升高？”的评论

IF 2 2区医学

Urolithiasis Pub Date : 2025-07-22 DOI: 10.1007/s00240-025-01814-0

Yinying Chai, Yibo He, Shengliang Qiu

引用次数: 0

The Gut-Kidney Axis in urolithiasis: extending Microbiome research beyond correlation to mechanism. 尿石症的肠肾轴：将微生物组研究扩展到机制之外。

IF 2 2区医学

Urolithiasis Pub Date : 2025-07-21 DOI: 10.1007/s00240-025-01811-3

Yuxuan Song, Jingyi Chen, Yun Peng, Ning Chen, Tao Xu

引用次数: 0

Advancing decision-making in shock wave lithotripsy for upper ureteral stones: the role of radiological stone impaction markers. 输尿管上段结石冲击波碎石的推进决策：放射性结石嵌塞标记物的作用。

IF 2 2区医学

Urolithiasis Pub Date : 2025-07-17 DOI: 10.1007/s00240-025-01797-y

Marcin Popiolek, Johan Jendeberg, Max Olin, Magnus Wagenius, Pernilla Sundqvist, Mats Lidén

{"title":"Advancing decision-making in shock wave lithotripsy for upper ureteral stones: the role of radiological stone impaction markers.","authors":"Marcin Popiolek, Johan Jendeberg, Max Olin, Magnus Wagenius, Pernilla Sundqvist, Mats Lidén","doi":"10.1007/s00240-025-01797-y","DOIUrl":"10.1007/s00240-025-01797-y","url":null,"abstract":"This work aims to evaluate whether radiological signs of stone impaction (RSSI) measured on non-contrast computed tomography (CT) can predict shock wave lithotripsy (SWL) outcomes for upper ureteral stones and to assess whether integrating these markers into an existing prediction model (the Niwa nomogram) improves predictive performance. We retrospectively analysed 256 patients treated with SWL for upper ureteral stones between 2012 and 2019. Standard stone parameters and RSSI, including ureteral wall thickness (UWT), ureteral diameters and CT attenuations above and below the stone, were assessed. Multivariable logistic regression, receiver operating characteristic (ROC) analysis, net reclassification improvement (NRI) and decision curve analysis (DCA) were used to evaluate predictive performance. The Niwa nomogram was enhanced by incorporating significant RSSI parameters and was internally validated using k-fold cross-validation. Maximum ureteral attenuation below the stone (UABSmax), ureter diameter above the stone (UDAS) and renal pelvis diameter (RPD) were found to be associated with SWL outcome. UABSmax had the highest individual predictive value (area under the curve (AUC) 0.66), while UWT showed no significant association or predictive value. Incorporating UABSmax and RPD into the Niwa nomogram (Niwa+) marginally increased AUC (0.72 vs. 0.71) but did not lead to significant improvements in NRI or DCA. In conclusion, certain RSSI- particularly UABSmax and RPD- were associated with SWL outcome but provided limited value when added to an already validated nomogram.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"139"},"PeriodicalIF":2.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the role of gut microbiota on the formation of nephrolithiasis: insights from integrated analysis of GWAS, single-cell transcriptomics, bulk RNA sequencing and network Pharmacology. 揭示肠道微生物群在肾结石形成中的作用：来自GWAS、单细胞转录组学、大量RNA测序和网络药理学综合分析的见解。

IF 2 2区医学

Urolithiasis Pub Date : 2025-07-15 DOI: 10.1007/s00240-025-01809-x

Xuhui Zhang, Qiang Jing, Weitao Yao, Bin Zhang, Xiaobin Yuan

{"title":"Unraveling the role of gut microbiota on the formation of nephrolithiasis: insights from integrated analysis of GWAS, single-cell transcriptomics, bulk RNA sequencing and network Pharmacology.","authors":"Xuhui Zhang, Qiang Jing, Weitao Yao, Bin Zhang, Xiaobin Yuan","doi":"10.1007/s00240-025-01809-x","DOIUrl":"10.1007/s00240-025-01809-x","url":null,"abstract":"The gut microbiota (GM) are intimately correlated with the formation and progression of nephrolithiasis. However, the specific causal relationships and mechanisms between the GM and nephrolithiasis remain unclear. This study aims to explore the molecular mechanisms of key genes related to the GM in nephrolithiasis. The nephrolithiasis genome-wide association studies (GWAS) data (ukb-b-18372), GM data, GSE73680, GSE117518 and GSE231569 were all derived from public databases. Firstly, the GMs causally related to nephrolithiasis were identified through Mendelian randomization (MR), sensitivity analysis and Steiger test. Subsequently, key genes were determined through differential expression analysis and expression analysis. In addition, functional enrichment, construction of molecular regulatory networks, drug prediction and molecular docking were carried out, and key cells were identified through single-cell analysis. It was confirmed by the MR analysis that 35 GMs had a causal relationship with nephrolithiasis, and PALLD and R3HDM1 were identified as key genes. Enrichment analysis indicated that PALLD and R3HDM1 were co-enriched in multiple pathways, such as oxidative phosphorylation. The miRNA-mRNA network revealed that 9 miRNAs could act on both PALLD and R3HDM1 simultaneously, such as hsa-miR-1256. Drug prediction analysis found that drugs like benzo(a)pyrene could co-target PALLD and R3HDM1, and PALLD had the strongest binding ability with ICG-001, with a binding energy of -9.5 kcal/mol. Finally, fibroblasts (FIBs) and vascular smooth muscle cells/pericytes (VSM/Ps) were determined as key cells, and the expression of PALLD exhibited nonlinear change characteristics during the differentiation process of FIBs and VSM/Ps. PALLD and R3HDM1 were identified as GM-related key genes in nephrolithiasis, providing a reference for exploring the pathogenesis of nephrolithiasis.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"138"},"PeriodicalIF":2.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative stress, inflammation and kidney stones. 氧化应激，炎症和肾结石。

IF 2 2区医学

Urolithiasis Pub Date : 2025-07-09 DOI: 10.1007/s00240-025-01808-y

Saeed R Khan

引用次数: 0

Letter to the Editor: "Access to the upper calyx in supine position: breaking a myth". 给编辑的信：“在仰卧位接近上花萼：打破一个神话”。

IF 2 2区医学

Urolithiasis Pub Date : 2025-07-08 DOI: 10.1007/s00240-025-01810-4

Ahmet Burak Yilmaz

引用次数: 0