Urolithiasis最新文献

{"title":"Comment on\"CT-based radiomics of machine-learning to screen high-risk individuals with kidney stones\".","authors":"Shuangying Zhang, Hao Xu, Yuxuan Song","doi":"10.1007/s00240-025-01752-x","DOIUrl":"https://doi.org/10.1007/s00240-025-01752-x","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"80"},"PeriodicalIF":2.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Optimal parameter settings of thulium fiber laser for ureteral stone lithotripsy: a comparative study in two different testing environments.","authors":"Zhilong Li, Shaojie Wu, Tongzu Liu, Sheng Li, Xinghuan Wang","doi":"10.1007/s00240-025-01727-y","DOIUrl":"https://doi.org/10.1007/s00240-025-01727-y","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"76"},"PeriodicalIF":2.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of flexible ureteroscopic suction techniques: efficacy and safety of flexible and navigable access sheath (FANS) vs. direct in-scope suction (DISS) in the management of 2-3 cm lower pole renal stones.","authors":"Ümit Yildirim, Mehmet Uslu, Mehmet Ezer, Çağlayan Erdoğdu, Ramazan Kocaaslan, Kemal Sarica","doi":"10.1007/s00240-025-01748-7","DOIUrl":"https://doi.org/10.1007/s00240-025-01748-7","url":null,"abstract":"<p><p>This study compares the efficacy and safety of two techniques for flexible ureteroscopy (FURS) in managing 2-3 cm lower pole renal stones: the use of flexible and navigable access sheath (FANS) versus direct in-scope suction (DISS) without an access sheath. A retrospective analysis of 60 patients undergoing FURS for lower pole renal stones was conducted between March 2023 and January 2025. Group 1 (n = 32) underwent FANS-assisted procedures, while Group 2 (n = 28) underwent sheathless FURS with DISS. Stone-free rates (SFR) were assessed with non-contrast computed tomography (NCCT) after four weeks. Operative time, peri- and postoperative complications, and hospitalization duration were also compared. The mean operative time was significantly shorter in the FANS group (71.8 ± 11.5 min) compared to the DISS group (79.1 ± 11.7 min, p = 0.026). The difference between the SFRs obtained in the FANS group (62.5%) and the DISS group (46.4%) after the first session was not statistically significant (p = 0.162). After the second session, SFRs were also comparable (87.5% vs. 82.1%, p = 0.412) (Residual stones < 4 mm were considered stone-free). Completely stone-free rates (CSFR), defined as the absence of residual fragments after the first session were 43.7% in the FANS group and 32.1% in the DISS group (p = 0.256), while after the second session, these rates increased to 84.3% and 75%, respectively (p = 0.280). Postoperative fever rates (9.3% vs. 10.7%, p = 0.598) and hospitalization duration (2.5 ± 1.3 vs. 2.6 ± 1.4 days, p = 0.819) were similar. Both techniques achieved high overall SFRs for large lower pole stones in a staged manner. However, FANS was associated with a shorter operative time. While DISS eliminates the need for an access sheath, its longer operative time may be a limitation. Larger studies are needed to further evaluate these techniques.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"75"},"PeriodicalIF":2.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vitro and in-vivo evaluation for anti-urolithiasis potential of Ficus racemosa L. bark extract in ethylene glycol induced rat model.","authors":"Ankita Yelne, Vaibhav Shinde","doi":"10.1007/s00240-025-01745-w","DOIUrl":"https://doi.org/10.1007/s00240-025-01745-w","url":null,"abstract":"<p><p>Even after stone removal, urolithiasis might reoccur, affecting patients' quality of life. Our study tested Ficus racemosa L. bark hydroalcoholic extract (FRBHE) for anti-urolithiasis efficacy. First, the extract was tested for dissolution of calcium oxalate as well as calcium phosphate crystal in-vitro. Also in-vivo, 0.75% w/v of Ethylene glycol (EG) for 28 days with drinking water was used to induce urolithiasis. By day 14, EG consumption developed calcium oxalate crystals, altered urine pH, urine volume, levels of minerals, and nephrological indicators in urine and serum that indicates urolithiasis. From day 15 to day 28, while EG consumption continued, FRBHE (200 and 400 mg/kg) and marketed formulation Cystone tablet (150 mg/kg) were given to rats. FRBHE treatment lowered the calcium, uric acid and urea and increase the creatinine, magnesium in urine in contrast to disease control group (P < 0.001). In plasma of EG consuming rats, level of calcium, potassium, magnesium, creatinine, uric acid and urea were elevated compared to normal rats (P < 0.001). FRBHE, similar to Cystone, normalized plasma parameters. On days 14 and 28, glutathione (P < 0.001) and catalase (P < 0.05) decreased and malondialdehyde (P < 0.001) increased in the kidney as compared to normal control group, indicating oxidative stress in urolithiatic rats. Treatment groups showed increased levels of glutathione and decreased malondialdehyde indicating oxidative stress recovery as compared to disease control group ((P < 0.001). Histopathological study of the kidney reveals medication therapy can reduce EG and calcium oxalate stone-mediated cellular damage. Current study proves Ficus racemosa L. bark may inhibit urolithiasis in-vitro and in-vivo warranting further clinical trials to confirm therapeutic efficacy.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"74"},"PeriodicalIF":2.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: A double-blind, randomized, placebo-controlled study to evaluate the efficacy of Oxybutynin Chloride Extended-Release tablets on the double-J stent related symptoms following uncomplicated ureteroscopic lithotripsy.","authors":"Xi Meng, Ming Jin, Weizhong Zhang, Daibing Lv, Xiaoxing Liao, Jianghua Yang","doi":"10.1007/s00240-025-01747-8","DOIUrl":"https://doi.org/10.1007/s00240-025-01747-8","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"73"},"PeriodicalIF":2.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of antegrade guidewire positioning outside the external urethral meatus in supine PCNL: the through and through technique.","authors":"Federico Dotta, Manfredi Bruno Sequi, Damiano Graziani, Mattia Tosi, Andrea Benelli, Antonio Carbone, Carlo Introini","doi":"10.1007/s00240-025-01742-z","DOIUrl":"https://doi.org/10.1007/s00240-025-01742-z","url":null,"abstract":"<p><p>This study aims to evaluate the impact of through-and-through (T-T) guidewire positioning versus conventional guidewire positioning in percutaneous nephrolithotomy (PCNL) with endoscopic combined intrarenal surgery (ECIRS) on complication rates (CR), surgical outcomes, and predictors of post-operative complications. We analyzed data from patients who underwent PCNL in our institution. Patients were divided into the T-T group (guidewire positioned through the urethral meatus) and the No-T-T group (guidewire positioned within the renal pelvis or down the ureter). Pre-, peri-, and post-operative data were collected, including demographics, clinical characteristics, stone parameters, and surgical outcomes. Statistical analyses, including t-tests, chi-square tests, and logistic regression, were performed to compare outcomes and identify complication predictors. The T-T group exhibited a lower overall CR (28.57% vs. 53.68%, p < 0.05), a higher stone-free rate (SFR) (78.09% vs. 62.1%, p = 0.02), and resulted in reduced blood loss (∆Hb 1.30 g/dL vs. 1.73 g/dL, p < 0.05), radiation exposure time (RET) (383.1 vs. 469.1 s, p < 0.05), and hospital stay (HS) (3.97 vs. 4.8 days, p < 0.05). The T-T technique was a protective factor against complications (OR = 0.26, p < 0.05). In patients with high stone complexity, the T-T technique was associated with lower CR (34.78% vs. 61.5%, p = 0.03) and higher SFR (71.74% vs. 51.28%, p = 0.04). Higher BMI, positive urine culture, and hydronephrosis were predictors of increased complication risk. The T-T guidewire technique is associated with lower CR, higher SFR, reduced blood loss, and shorter HS. These findings suggest that the T-T technique may enhance surgical outcomes and should be considered a valuable approach in managing large renal calculi. Further studies are recommended to confirm these results.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"72"},"PeriodicalIF":2.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of actual and automated CT measurements of urinary stone size: a phantom study.","authors":"Myeong Seong Yoon, Dong-Hyun Jang, Juncheol Lee, Jaehoon Jeong, Do Gwon Kim, Hyojin Lim, Dong Keon Lee, Jaehoon Oh","doi":"10.1007/s00240-025-01708-1","DOIUrl":"https://doi.org/10.1007/s00240-025-01708-1","url":null,"abstract":"<p><p>Urinary stone size is key in determining treatment. Although computed tomography (CT) scans are widely used for diagnosing urinary stones, measurements of stone size obtained from CT images may be inaccurate compared to actual size. Twenty-four urinary stone phantoms were 3D printed at three densities (100, 1000, and 3000 Hounsfield units [HU]) and eight sizes. CT images of the phantoms were taken. Nineteen radiologists and 33 emergency physicians from two institutions measured stone sizes on CT images using mediastinum and bone settings. An automated algorithm segmented regions of interest and estimated stone size using pixel HUs. Mean absolute error (MAE) was assessed for the accuracy of each measurement method against known phantom sizes. For the mediastinum setting, MAEs for 100, 1000, and 3000 HU stone phantoms were 1.05 mm ± 0.06, 1.01 mm ± 0.06, and 2.38 mm ± 0.17, respectively. For the bone setting, MAEs were 0.98 mm ± 0.07, 0.55 mm ± 0.10, and 1.91 mm ± 0.06, respectively. For automated measurements, MAEs were 1.16 mm, 0.21 mm, and 2.10 mm, respectively. Participant-to-participant variability was observed across all measurement settings, regardless of the stone density or window used. For stone size measurements on CT images, the bone setting provided more accurate results than the mediastinum setting. Automated measurement methods, which estimate stone size by outlining its edges, were more accurate than manual measurements for 1000 HU stones, the most common stone density. However, for stones with densities above or below 1000 HU, the accuracy of the automated method may decrease.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"71"},"PeriodicalIF":2.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insight into obesity associated hyperoxaluria: identifying the shared biomarkers and pathways in kidney stones and obesity by integrative bioinformatic and in vivo studies.","authors":"Shridhar Hiremath, Rajesh N Ganesh, Pragasam Viswanathan","doi":"10.1007/s00240-025-01744-x","DOIUrl":"https://doi.org/10.1007/s00240-025-01744-x","url":null,"abstract":"<p><p>Obesity is a primary risk factor associated with kidney stones (KS), with evidence suggesting that increasing BMI, obesity, and metabolic syndrome over the past three decades correlate with an elevated risk of hyperoxaluria. However, the pathogenic mechanisms associated between obesity and kidney stones at the transcriptional level remain poorly understood. Thus, we aim to explore the hub genes related to obesity-associated hyperoxaluria (OAH) to improve the understanding of its underlying pathophysiology. To understand the gap in the underlying mechanism, we performed a comprehensive weighted gene co-expression network analysis (WGCNA) on two microarray datasets. Further, differently expressed genes (DEGs) of the kidney tissue dataset and significant key modules identified through WGCNA were analyzed to pinpoint shared biomarkers and biological pathways implicated in OAH. Subsequently, hub genes were identified by constructing Protein-protein interaction (PPI) networks. Furthermore, an in vivo animal model mimicking OAH was employed to validate the hub genes through quantitative PCR (qPCR) and histopathological evaluations. Four key modules associated with KS and obesity were identified using WGCNA. The DEGs analysis revealed 346 upregulated and 19 downregulated genes. Functional enrichment via Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses, combined with PPI network insights, highlighted seven potential genes shared between KS and obesity. Further, in vivo studies demonstrated gut inflammation and kidney stone formation, as confirmed by histopathological evidence. The validation through qPCR has identified five hub genes-IL-6, TLR-4, CD44, SPP-1, and CCL-2-as key contributors to OAH pathophysiology. These findings, which provide new insights into the molecular mechanisms driving OAH, underscore the need for further studies with larger sample sizes to corroborate these findings and expand on their implications.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"70"},"PeriodicalIF":2.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial experience with augmented reality in planning renal access for PCNL.","authors":"Rinat Lasmanovich, Maayan Dagan, Orel Hemo, Shai Tejman-Yarden, Dorit E Zilberman, Oliana Vazhgovsky, Zohar A Dotan, Nir Kleinmann, Asaf Shvero","doi":"10.1007/s00240-025-01730-3","DOIUrl":"https://doi.org/10.1007/s00240-025-01730-3","url":null,"abstract":"<p><p>Achieving renal access during percutaneous nephrolithotomy is challenging, with a complication rate of 10-20%. This study aims to assess a novel technique for planning access to the renal collecting system using augmented reality (AR). Using Digital Imaging and Communications in Medicine software (DICOM 2-print), we generated 3-dimensional (3D) models of patients with different types of kidney stones (staghorn, lower pole, and pelvic stones) who underwent PCNL between 2018 and 2022. After viewing the patient's CT scans, surgeons explored the anatomical models using an AR system with a stereoscopic 3D lens array display. Using questionnaires, we quantitatively estimated the model's contribution on a scale of \"1\" (\"poor\") to \"5\" (\"excellent\") to the surgeon's understanding of stone location, patient anatomy, and ease of access compared to 2D CT imaging. A total of 38 questionnaires were completed by 13 urologists. Estimating renal location, renal pelvis, and stone mass were better demonstrated by AR (5 vs. 4, p < 0.001). The orientation of adjacent organs was better understood using AR (5 vs. 4, p = 0.004). In 86.8% of cases, surgeons preferred using AR models both before and during surgery, with 69.2% suggesting that AR could enhance procedural safety. The time frames for testing the models differed between senior and junior practitioners (p = 0.016) and were significantly reduced with model experience (p < 0.001). When comparing CT to 3D imaging, AR models provide a better understating of stone location, patient anatomy, and route of access to the collecting system. Further research is required to implement this innovative technique preoperatively and intra-operatively.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"69"},"PeriodicalIF":2.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ZJU index and kidney stone prevalence in the Chinese adult population: a retrospective propensity score-matched analysis.","authors":"Man Cao, Yan Chen, Xudong Shen","doi":"10.1007/s00240-025-01741-0","DOIUrl":"10.1007/s00240-025-01741-0","url":null,"abstract":"<p><p>The study aimed to explore the association between the ZJU (Zhejiang University) index and the prevalence of kidney stones in Chinese adults. Electronic health records of individuals undergoing routine physical examinations at Wuhu Second People's Hospital between January 2021 and June 2024 were retrospectively analyzed. Participants were divided into kidney stone recurrence and non-recurrence groups. Data on biochemical parameters, hypertension, and diabetes history were collected, and group differences were assessed using the chi-square test or Kruskal-Wallis rank-sum test. Logistic regression, propensity score matching, and dose-response curve modeling were used to evaluate the relationship between the ZJU index and kidney stone prevalence. Among 5,104 participants aged over 18 years, 462 were diagnosed with kidney stones. After adjusting for confounders, a higher ZJU index was identified as an independent risk factor for kidney stone prevalence (odds ratio [OR] = 1.05, 95% confidence interval [CI]: 1.02-1.08). Propensity score-matched analysis further confirmed this association (OR = 1.09, 95% CI: 1.04-1.13). Dose-response analysis revealed a positive linear relationship between the ZJU index and kidney stone recurrence. These findings suggest that elevated ZJU index levels are associated with a higher prevalence and recurrence of kidney stones, highlighting its potential as a clinical tool for identifying and managing at-risk patients.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"67"},"PeriodicalIF":2.0,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}