Urolithiasis最新文献_第4页

Commentary on "Machine learning constructs a diagnostic prediction model for Calculous Pyophrosis". 关于 "机器学习构建结石性脓病诊断预测模型 "的评论。

IF 2 2区医学

Urolithiasis Pub Date : 2024-10-07 DOI: 10.1007/s00240-024-01646-4

Xin Chang Zou, Rong Man Yuan, Tao Zeng

引用次数: 0

Heatwave and upper urinary tract stones morbidity: effect modification by heatwave definitions, disease subtypes, and vulnerable populations. 热浪与上尿路结石发病率：热浪定义、疾病亚型和易感人群的效应修正。

IF 2 2区医学

Urolithiasis Pub Date : 2024-10-03 DOI: 10.1007/s00240-024-01619-7

Chenlu Yang, Shi Li, Yunmeng Yang, Cunrui Huang, Yike Li, Chaoming Tan, Junzhe Bao

{"title":"Heatwave and upper urinary tract stones morbidity: effect modification by heatwave definitions, disease subtypes, and vulnerable populations.","authors":"Chenlu Yang, Shi Li, Yunmeng Yang, Cunrui Huang, Yike Li, Chaoming Tan, Junzhe Bao","doi":"10.1007/s00240-024-01619-7","DOIUrl":"10.1007/s00240-024-01619-7","url":null,"abstract":"As heatwave occurs with increased frequency and intensity, the disease burden for urolithiasis, a heat-specific disease, will increase. However, heatwave effect on urolithiasis subtypes morbidity and optimal heatwave definition for urolithiasis remain unclear. Distributed lagged linear models were used to assess the associations between 32 defined heatwave and upper urinary tract stones morbidity. Relative risk (RR) and attributable fraction (AF) of upper urinary tract stone morbidity associated with heatwave of different intensities (low, middle, and high) were pooled by meta-analysis. Optimal heatwave definition was selected based on the combined score of AF, RR, and quasi-Akaike Information Criterion (QAIC) value. Stratified analyses were conducted to investigate the modification effects of gender, age, and disease subtypes. Association between heatwave and upper urinary tract stones morbidity was mainly for ureteral calculus, and AF was highest for low-intensity heatwave. This study's optimal heatwave was defined as average temperature > 93rd percentile for ≥ 2 consecutive days, with AF of 7.40% (95% CI: 2.02%, 11.27%). Heatwave was associated with ureteral calculus morbidity in males and middle-aged adults. While heatwave effect was statistically insignificant in females and other age groups. Managers should develop appropriate definitions to address heatwave based on regional characteristics and focus on heatwave effects on urolithiasis.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"52 1","pages":"134"},"PeriodicalIF":2.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two distinct phenotypes of calcium oxalate stone formers could imply different long-term risks for renal function. 草酸钙结石形成者的两种不同表型可能意味着对肾功能的长期风险不同。

IF 2 2区医学

Urolithiasis Pub Date : 2024-09-28 DOI: 10.1007/s00240-024-01631-x

James C Williams, William S Bowen, James E Lingeman, Marcelino Rivera, Elaine M Worcester, Tarek M El-Achkar

{"title":"Two distinct phenotypes of calcium oxalate stone formers could imply different long-term risks for renal function.","authors":"James C Williams, William S Bowen, James E Lingeman, Marcelino Rivera, Elaine M Worcester, Tarek M El-Achkar","doi":"10.1007/s00240-024-01631-x","DOIUrl":"10.1007/s00240-024-01631-x","url":null,"abstract":"Endoscopic and biopsy findings have identified two distinct phenotypes among individuals with calcium oxalate (CaOx) kidney stones. The first type has normal renal papillae but shows interstitial mineral deposition, known as Randall's plaque. The other phenotype presents with collecting duct plugging and a higher incidence of loss of papilla tissue mass. With Randall's plaque, renal papilla injury involves the loss of small patches of calcified tissue (Randall's plaque detaching with the stone), which likely results in damage to only a few nephrons. In contrast, collecting duct mineral plugs are very large, causing obstruction to tubular flow. Since each terminal collecting duct drains thousands of nephrons, ductal plugs could lead to the degeneration of many nephrons and a significant loss of renal glomeruli. New visualization techniques for immune cells in papillary biopsies have revealed that the Randall's plaque phenotype is marked by the accumulation of macrophages around the plaque regions. In contrast, preliminary data on the plugging phenotype shows collecting duct damage with mineral plugs and increased T-lymphocytes throughout the papilla. These regions also show tubulitis, i.e., T-cell infiltration into nearby collecting duct epithelium. This suggests that while some CaOx stone formers may have some papillary inflammation but with minimal damage to nephrons, others suffer from obstruction to flow for many nephrons that may also include destructive inflammation in the renal tissue. We propose that CaOx stone formers with the plugging phenotype will have a higher long-term risk for loss of renal function.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"52 1","pages":"133"},"PeriodicalIF":2.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-invasive approaches to hydration assessment: a literature review. 无创水合评估方法：文献综述。

IF 2 2区医学

Urolithiasis Pub Date : 2024-09-26 DOI: 10.1007/s00240-024-01630-y

Achraf Tahar, Hadil Zrour, Stéphane Dupont, Agnieszka Pozdzik

{"title":"Non-invasive approaches to hydration assessment: a literature review.","authors":"Achraf Tahar, Hadil Zrour, Stéphane Dupont, Agnieszka Pozdzik","doi":"10.1007/s00240-024-01630-y","DOIUrl":"https://doi.org/10.1007/s00240-024-01630-y","url":null,"abstract":"Traditional hydration assessment methods, while accurate, are often invasive and impractical for routine monitoring. In response, innovative non-invasive techniques such as bioelectrical impedance analysis (BIA), electrodermal activity (EDA), electrocardiogram (ECG) monitoring, and urine color charts have emerged, offering greater comfort and accessibility for patients. These methods use various types of sensors to capture a range of bio-signals, followed by machine learning-based classification or regression methods, providing real-time feedback on hydration status, which is crucial for effective management and prevention of urinary stones. This review explores the principles, applications, and efficacy of these non-invasive techniques, highlighting their potential to transform hydration monitoring in clinical and everyday settings. By facilitating improved patient compliance and enabling proactive hydration management, these approaches align with contemporary trends in personalized healthcare. This article presents a literature review on non-invasive approaches to hydration assessment, focusing on their significance in preventing kidney stone disease and enhancing kidney health.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"52 1","pages":"132"},"PeriodicalIF":2.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrathin semirigid retrograde ureteroscopy versus antegrade flexible ureteroscopy in treating proximal ureteric stones 1–2 cm, a prospective randomized multicenter study 超薄半刚性逆行输尿管镜与前向柔性输尿管镜在治疗 1-2 厘米输尿管近端结石中的对比，一项前瞻性随机多中心研究

IF 3.1 2区医学

Urolithiasis Pub Date : 2024-09-19 DOI: 10.1007/s00240-024-01626-8

Tarek Mohamed Gharib, Ibrahim Abdel-Al, Basheer N. Elmohamady, Hazem Deif, Ahmed Abdelazim Haty, Salah E. Shebl, Omar Safar, Gamal M. Hassan, Yasser M. Haggag, Adel Elatreisy

{"title":"Ultrathin semirigid retrograde ureteroscopy versus antegrade flexible ureteroscopy in treating proximal ureteric stones 1–2 cm, a prospective randomized multicenter study","authors":"Tarek Mohamed Gharib, Ibrahim Abdel-Al, Basheer N. Elmohamady, Hazem Deif, Ahmed Abdelazim Haty, Salah E. Shebl, Omar Safar, Gamal M. Hassan, Yasser M. Haggag, Adel Elatreisy","doi":"10.1007/s00240-024-01626-8","DOIUrl":"https://doi.org/10.1007/s00240-024-01626-8","url":null,"abstract":"To compare the outcomes of using Ultrathin semirigid retrograde ureteroscopy and antegrade flexible ureteroscopy to treat proximal ureteric stones of sizes 1–2 cm. A prospective randomized multicenter study included patients who had proximal ureteric stones 1–2 cm, amenable for ureteroscopy and laser lithotripsy between August 2023 and February 2024. Two hundred thirty patients were divided evenly into two treatment groups. Group I included patients treated with antegrade flexible ureteroscopy and holmium laser stone fragmentation, and Group II included patients treated with retrograde ultrathin semirigid ureteroscopy. The study groups were compared in terms of patient demographics, stone access success, operation time, reoperation rates, peri-operative complications, and stone-free status. Group I included 114 patients, while Group II included 111. The mean age of the patients was 33.92 ± 10.37 years, and the size of the stones was 15.88 ± 3 mm. The study groups had comparable demographics and stone characteristics. The mean operative time was significantly longer in group I than in group II (102.55 ± 72.46 min vs. 60.98 ± 14.84 min, respectively, P < 0.001). Most reported complications were MCCS grades I and II, with no significant difference between the study groups. The stone-free rate after four weeks was 92.1% and 81.1% for groups I and II, respectively, which increased to 94.7% and 85.6% after eight weeks (P > 0.05). Antegrade flexible ureteroscopy is equivalent to retrograde ultrathin semirigid ureteroscopy in treating proximal ureteric stones regarding stone-free status and procedure-related morbidity. However, the antegrade approach has a longer operative time, greater fluoroscopy exposure, and longer hospital stays.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"8 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142261092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of cat stone matrix and cat urine proteomes to human calcium oxalate stone matrix and urine proteomes 猫结石基质和猫尿蛋白质组与人类草酸钙结石基质和尿蛋白质组的比较

IF 3.1 2区医学

Urolithiasis Pub Date : 2024-09-13 DOI: 10.1007/s00240-024-01629-5

Jeffrey A. Wesson, Roman Zenka, Katherine Sherman, Jessica Eisenhauer, Jody Lulich, Carley Davis

{"title":"Comparison of cat stone matrix and cat urine proteomes to human calcium oxalate stone matrix and urine proteomes","authors":"Jeffrey A. Wesson, Roman Zenka, Katherine Sherman, Jessica Eisenhauer, Jody Lulich, Carley Davis","doi":"10.1007/s00240-024-01629-5","DOIUrl":"https://doi.org/10.1007/s00240-024-01629-5","url":null,"abstract":"Cat calcium oxalate monohydrate kidney stone matrix proteome showed great similarity to human calcium oxalate monohydrate stone matrix proteome, but inference of mechanistic similarity was limited by the absence of cat urine proteomic data. In this study, urine proteome distributions were measured by the same methods in 7 healthy cats for comparison to both the published human urine and cat calcium oxalate stone matrix proteomes to assess for similar enrichment patterns in both species. Furthermore, proteomic distributions were determined in cat struvite stone matrix to test for similarity to calcium oxalate monohydrate stone matrix and urine proteomes. Cat urine proteins demonstrated a similar distribution of abundance as a function of isoelectric points or net charge to human urine samples, and consequently the similarly altered patterns of protein distributions seen in calcium oxalate monohydrate stone matrix seen from both cat and human stones likely derives from the same preferential adsorption mechanism. Furthermore, the fact that protein abundance patterns seen in cat struvite stone matrix samples differ from both urine and calcium oxalate monohydrate stone matrix proteomes in systematic ways suggests that a combination of protein–protein and protein crystal interactions underly the formation of the crystal aggregates that comprise stones.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"31 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142261093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analyzing learning curve for supine percutaneous nephrolithotomy in urology resident training programme: comparative analysis. 分析泌尿科住院医师培训课程中仰卧位经皮肾镜取石术的学习曲线：对比分析。

IF 2 2区医学

Urolithiasis Pub Date : 2024-09-09 DOI: 10.1007/s00240-024-01624-w

Yusuf Arıkan, Yavuz Onur Danacioğlu, Deniz Noyan Özlü, Ömer Koraş, Büşra Emir, Mehmet Zeynel Keskin

{"title":"Analyzing learning curve for supine percutaneous nephrolithotomy in urology resident training programme: comparative analysis.","authors":"Yusuf Arıkan, Yavuz Onur Danacioğlu, Deniz Noyan Özlü, Ömer Koraş, Büşra Emir, Mehmet Zeynel Keskin","doi":"10.1007/s00240-024-01624-w","DOIUrl":"https://doi.org/10.1007/s00240-024-01624-w","url":null,"abstract":"Introduction: This article attempts to provide a comprehensive review of the learning objectives and importance of the supine percutaneous nephrolithotomy (PCNL) technique.Material method: We retrospectively reviewed the cases of Supine PCNL between January 2018 and January 2024. We divided the groups into 3: residents between 2 and 3 years (Group 1), residents between 4 and 5 years (Group 2), and endourologist (Group 3). The 2-3-year resident started to perform PCNL for the first time, while the 4-5-year resident started to perform Supine PCNL for the first time while previously performing prone PCNL.Results: Access, fluoroscopy, and operation time were higher in Group 1, shorter in Group 2, and shortest in Group 3 (p < 0.001). Postoperative length of stay and the need for additional treatment were found to be shorter (p < 0.001), and the stone-free rate (SFR) increased (p < 0.001) from Group 1 to Group 3. The highest complication rates were observed in Group 1 (p = 0.002). SFR rate increased as the number of cases increased in Group 1 patients. Success was stable after 46-60 cases in terms of SFR. In Group 2, the SFR rate was stable after 31-45.Cases: The most complications were observed in Group 1 and the least in Group 3.Conclusion: In 2-3-year residents, access time and fluoroscopy time decrease with experience. In 4-5-year residents, due to their expertise in prone PCNL, the operation time and fluoroscopy time decrease with the number of cases performed. SFR is higher after 46-60 cases for 2-3-year residents and 31-45 cases for 4-5-year residents.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"52 1","pages":"129"},"PeriodicalIF":2.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of gaseous end products produced by thulium fiber laser lithotripsy of cystine, uric acid, and calcium oxalate monohydrate stones: A gas chromatographic and electron microscopic analysis. 铥纤维激光碎石术治疗胱氨酸、尿酸和一水草酸钙结石产生的气体终产物研究：气相色谱和电子显微镜分析。

IF 2 2区医学

Urolithiasis Pub Date : 2024-09-06 DOI: 10.1007/s00240-024-01625-9

Muzaffer Tansel Kılınç, Mehmet Serkan Özkent, Mehmet Mesut Pişkin, Yunus Emre Göger

{"title":"Investigation of gaseous end products produced by thulium fiber laser lithotripsy of cystine, uric acid, and calcium oxalate monohydrate stones: A gas chromatographic and electron microscopic analysis.","authors":"Muzaffer Tansel Kılınç, Mehmet Serkan Özkent, Mehmet Mesut Pişkin, Yunus Emre Göger","doi":"10.1007/s00240-024-01625-9","DOIUrl":"https://doi.org/10.1007/s00240-024-01625-9","url":null,"abstract":"Laser lithotripsy mechanisms can cause the chemical decomposition of stone components and the emergence of different end products. However, the potentially toxic end products formed during thulium fiber laser (TFL) lithotripsy of cystine stones have not been sufficiently investigated. The aim of our in vitro study is to analyze the chemical content of the gas products formed during the fragmentation of cystine stone with TFL. Human renal calculi consisting of 100% pure cystine, calcium oxalate monohydrate, or uric acid were fragmented separately with TFL in experimental setups and observed for gas release. After the lithotripsy, only the cystine stones showed gas formation. Gas chromatography-mass spectrometry was used to analyze the gas qualitatively, and scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDX) and X-ray diffraction was used to examine the dried cystine stone fragments. Fragmentation of the cystine stones released free cystine, sulfur, hydrogen sulfide, and carbon disulfide gas. The SEM-EDX and X-ray diffraction analyses revealed that the free cystine in the dried fragments contained 43.1% oxygen, 28.7% sulfur, 16.1% nitrogen, and 12.1% carbon atoms according to atomic weight. The detection of potentially toxic gases after lithotripsy of cystine stones with TFL indicates a risk of in vivo production. Awareness needs to be increased among healthcare professionals to prevent potential inhalation and systemic toxicity for patients and operating room personnel during TFL lithotripsy of cystine stones.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"52 1","pages":"125"},"PeriodicalIF":2.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morin hydrate mitigates calcium oxalate urolithiasis by inhibiting oxalate synthesis and modulating crystal formation. 水合吗啉通过抑制草酸盐合成和调节晶体形成，缓解草酸钙性尿路结石。

IF 2 2区医学

Urolithiasis Pub Date : 2024-09-06 DOI: 10.1007/s00240-024-01628-6

Mounica Ponugoti, Chakravarthi Guntupalli, Narender Malothu

{"title":"Morin hydrate mitigates calcium oxalate urolithiasis by inhibiting oxalate synthesis and modulating crystal formation.","authors":"Mounica Ponugoti, Chakravarthi Guntupalli, Narender Malothu","doi":"10.1007/s00240-024-01628-6","DOIUrl":"https://doi.org/10.1007/s00240-024-01628-6","url":null,"abstract":"Calcium oxalate (CaOx) urolithiasis is a prevalent urinary disorder with significant clinical impact. This study investigates the therapeutic potential of Morin Hydrate (MH), a natural bioflavonoid, in preventing CaOx stone formation. Molecular docking studies revealed that MH binds strongly to glycolate oxidase (GO), suggesting its inhibitory effect on oxalate synthesis. In vitro assays demonstrated that MH effectively inhibits CaOx crystal nucleation, aggregation, and growth, altering crystal morphology to less stable forms. Diuretic activity studies in Wistar rats showed that MH substantially increased urine volume and ion excretion, indicating its moderate diuretic effect. In vivo experiments further supported these findings, with MH treatment improving urinary and serum markers, reducing oxidative stress, and protecting renal tissue, as evidenced by histopathological analysis. Notably, MH administration significantly decreased GO and lactate dehydrogenase activities in urolithiatic rats, indicating a reduction in oxalate production. These results suggest that MH is a promising candidate for the prevention and treatment of CaOx urolithiasis, with the potential for clinical application in reducing the risk and recurrence of kidney stones.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"52 1","pages":"127"},"PeriodicalIF":2.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteome-wide mendelian randomization identifies therapeutic targets for nephrolithiasis. 全蛋白质组孟德尔随机化确定了肾炎的治疗靶点。

IF 2 2区医学

Urolithiasis Pub Date : 2024-09-06 DOI: 10.1007/s00240-024-01627-7

Li Wang, Kun-Peng Li, Si-Yu Chen, Shun Wan, Xiao-Ran Li, Li Yang

{"title":"Proteome-wide mendelian randomization identifies therapeutic targets for nephrolithiasis.","authors":"Li Wang, Kun-Peng Li, Si-Yu Chen, Shun Wan, Xiao-Ran Li, Li Yang","doi":"10.1007/s00240-024-01627-7","DOIUrl":"https://doi.org/10.1007/s00240-024-01627-7","url":null,"abstract":"Kidney Stone Disease (KSD) constitutes a multifaceted disorder, emerging from a confluence of environmental and genetic determinants, and is characterized by a high frequency of occurrence and recurrence. Our objective is to elucidate potential causative proteins and identify prospective pharmacological targets within the context of KSD. This investigation harnessed the unparalleled breadth of plasma protein and KSD pooled genome-wide association study (GWAS) data, sourced from the United Kingdom Biobank Pharma Proteomics Project (UKBPPP) and the FinnGen database version R10. Through Mendelian randomization analysis, proteins exhibiting a causal influence on KSD were pinpointed. Subsequent co-localization analyses affirmed the stability of these findings, while enrichment analyses evaluated their potential for pharmacological intervention. Culminating the study, a phenome-wide association study (PheWAS) was executed, encompassing all phenotypes (2408 phenotypes) catalogued in the FinnGen database version R10. Our MR analysis identified a significant association between elevated plasma levels of proteins FKBPL, ITIH3, and SERPINC1 and increased risk of KSD based on genetic predictors. Conversely, proteins CACYBP, DAG1, ITIH1, and SEMA6C showed a protective effect against KSD, documented with statistical significance (PFDR<0.05). Co-localization analysis confirmed these seven proteins share genetic variants with KSD, signaling a shared genetic basis (PPH3 + PPH4 > 0.8). Enrichment analysis revealed key pathways including hyaluronan metabolism, collagen-rich extracellular matrix, and serine-type endopeptidase inhibition. Additionally, our PheWAS connected the associated proteins with 356 distinct diseases (PFDR<0.05), highlighting intricate disease interrelations. In conclusion, our research elucidated a causal nexus between seven plasma proteins and KSD, enriching our grasp of prospective therapeutic targets.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"52 1","pages":"126"},"PeriodicalIF":2.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0