Urolithiasis最新文献

{"title":"Do urologists actually comply with the ALARA principle in pediatric urolithiasis management?","authors":"Mehmet Serkan Özkent, Muzaffer Tansel Kılınç, Yunus Emre Göger, Mehmet Mesut Pişkin","doi":"10.1007/s00240-025-01705-4","DOIUrl":"https://doi.org/10.1007/s00240-025-01705-4","url":null,"abstract":"<p><p>The purpose of the study was to determine the urologists' knowledge of ionizing radiation and the frequency of CT scan utilization for pediatric patients with urolithiasis. The second aim is to examine the factors that affect the choice of the CT imaging method in these patients. We sent a quantitative online questionnaire to urologists and pediatric urologists in various regions and practice settings of Turkey via a web survey database in June 2022. The survey consisted of 22 items in a multiple-choice or yes/no format and was divided into three sections: participant characteristics, knowledge, and current practice. One hundred and fifty-four participants fully completed this questionnaire. Forty-two participants (27.3%) correctly stated the radiation dose of an abdominal CT scan. Thirty of the participants (19.5%) thought that there was no relationship between exposure to radiation and cancer development. In addition, 76 participants (49.4%) were aware of any scientific literature about this relationship. Ninety-eight participants (63.6%) think that they did not receive adequate training on imaging methods for pediatric patients during their residency program. The choice of CT scans as the first imaging method was increased with age. Even if the choice of imaging method is mostly decided according to the guidelines, various factors such as medicolegal causes, long ultrasound appointment dates, poor quality of assessment, and clinical experiences are inevitable facts that guide the choice of computed tomography. Urologists are responsible for knowing the effects of ionizing radiation and the ALARA principle. Our findings emphasize the lack of knowledge about ionizing radiation. Encouragement of the literature, provision of the mandatory curriculum, and supervision of the use of ionizing radiation will contribute to the elimination of the deficiency in this area.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"36"},"PeriodicalIF":2.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of flexible vacuum-assisted ureteral access sheath versus conventional sheath combined with single-use flexible ureteroscope in the treatment of renal calculi.","authors":"Ming Xu, Lu Jin, Dongrong Yang, Boxin Xue, Chuanyang Sun, Wei Tao","doi":"10.1007/s00240-025-01699-z","DOIUrl":"10.1007/s00240-025-01699-z","url":null,"abstract":"<p><p>To evaluate the safety and efficacy of the flexible vacuum-assisted ureteral access sheath combined with the single-use flexible ureteroscopy in the treatment of renal calculi. We prospectively analyzed the patients treated with single-use flexible ureteroscopy from January 2023 to December 2023, among which 113 cases were treated with flexible vacuum-assisted ureteral access sheath (FV-UAS group) and 113 cases were treated with conventional sheath (conventional sheath group). Patient data ofthe two groups were collected and recorded before and after operation. No significant differences were observed between the two groups regarding demographics and pre-operative clinical characteristics. The duration of the operation was significantly longer in the FV-UAS group (79.5 ± 6.8 min) compared to the conventional UAS group (65.2 ± 7.3 min). However, the stone free rate (SFR) at one day and one month post-operation in the FV-UAS group was 85.6% and 98.2%, respectively, significantly higher than that in the conventional UAS group (72.6%, 90.3%). Complications such as infection and urosepsis were more common in conventional UAS group. Notably, hospitalization costs were lower in the FV-UAS group. Flexible vacuum-assisted ureteral access sheath combined with flexible single-use ureteroscope is a feasible and effective method for treating renal calculi. It offers higher SFR and lower rate of infectious complications.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"37"},"PeriodicalIF":2.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and nation burden of urolithiasis in young adults from 1990 to 2021: analysis of data from the global burden of disease study 2021.","authors":"Dingguo Zhang, Jinjun Tian, Guoliang Lu, Zijian Zhou, Dawei Wang","doi":"10.1007/s00240-025-01712-5","DOIUrl":"https://doi.org/10.1007/s00240-025-01712-5","url":null,"abstract":"<p><p>The global burden of urolithiasis has attracted increasing attention, but there is still a lack of data on the trends and regional disparities of urolithiasis among young adults. Utilizing data from the Global Burden of Disease (GBD) 2021 Results Tool, this study analyzed annual incidence and disability-adjusted life years (DALYs) rates across 204 countries and 21 regions among young adults aged 15-49 years. Age-standardized rates (ASRs) were calculated to facilitate direct comparisons, and temporal trends were assessed using the Joinpoint Regression Program to determine average annual percentage changes (AAPC). The relationship between urolithiasis burden and the sociodemographic index (SDI) was evaluated through Spearman and Pearson correlation analyses. Globally, the number of incident cases rose from 34.6 million in 1990 to 50.7 million in 2021, while the ASR of incidence declined (AAPC: - 0.35%, 95% confidence interval[CI]: - 0.38% to - 0.29%). Similarly, the ASR of DALYs decreased (AAPC: -0.71%, 95% CI: -0.80% to - 0.62%). Males consistently exhibited higher ASRs than females, though both sexes showed declining trends. Regions with higher SDI values experienced decreasing burdens, while some low- and low-middle SDI regions saw increasing ASRs. In 2021, Eastern Europe recorded the highest ASRs of incidence and DALYs, whereas South Asia reported the highest absolute number of cases. A significant positive correlation was observed between SDI and ASR of incidence. These findings underscore the shifting global burden of urolithiasis among young adults, with a general decline in incidence and DALYs over the past three decades. However, the increasing trends in certain low SDI regions highlight the need for targeted public health interventions to address regional disparities.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"38"},"PeriodicalIF":2.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What are the trends and key insights into the landscape of the gut microbiota and urolithiasis research from 2004 to 2023? A global bibliometric analysis.","authors":"Sa'ed H Zyoud, Faris Abushamma, Muna Shakhshir, Sari Taha, Samah W Al-Jabi","doi":"10.1007/s00240-024-01688-8","DOIUrl":"https://doi.org/10.1007/s00240-024-01688-8","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"35"},"PeriodicalIF":2.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent developments in the study of cellular inflammation in the papillae of stone formers.","authors":"James C Williams, Tarek M El-Achkar","doi":"10.1007/s00240-025-01707-2","DOIUrl":"https://doi.org/10.1007/s00240-025-01707-2","url":null,"abstract":"<p><p>Kidney stone disease has long been thought to involve tissue inflammation, but direct evidence linking inflammation as a causative factor in human stone formation remains limited. This review focuses on studies in human stone formers, highlighting variation in stone former phenotypes. Histological and molecular studies of kidney tissues reveal increased immune cell density and gene expression changes in stone formers, with notable differences between calcium oxalate and brushite stone pathologies. Phenotyping stone formers by tissue mineralization patterns-such as Randall's plaque or ductal plugging-shows significant heterogeneity in tissue damage, and thus presumably also inflammation. Systemic markers, such as elevated serum C-reactive protein, suggest a link between active stone disease and inflammation, although relationships vary with age, gender, and comorbidities. Such systemic markers have not been studied well in stone formers separated by phenotype. These insights underline the importance of stratifying patients by stone type and tissue pathology to identify inflammation pathways specific to each phenotype. Such an approach may pave the way for targeted anti-inflammatory therapies to reduce recurrence in this heterogeneous disease.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"34"},"PeriodicalIF":2.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the natural history of incidentally recognized clinically silent nephrolithiasis in healthy adults: an updated systematic review with meta-analysis.","authors":"Mohammadreza Padooiy Nooshabadi, Behnam Shakiba, Hamid Reza Baradaran, Seyyed Amir Yasin Ahmadi, Hosein Akbarnataj Bishe, Asaad Moradi","doi":"10.1007/s00240-025-01704-5","DOIUrl":"https://doi.org/10.1007/s00240-025-01704-5","url":null,"abstract":"<p><p>The incidental detection of asymptomatic renal stones has risen with increased use of imaging and screening programs. While guidelines exist for treating kidney stones, managing asymptomatic stones remains controversial due to limited understanding of their natural history. A systematic search of the PubMed, Web of Science, Embase, and Scopus databases was conducted on 3rd June 2024 with a distinct search strategy and citation tracking to identify English language publications evaluating the natural history of asymptomatic renal stones in healthy adults. systematic report of the included studies was provided; besides, meta-analysis of proportions and meta regression was conducted to find the pooled estimation of stone-related events and to evaluate factors affecting natural history of these stones. Quality assessment of the included articled was conducted by means of the Newcastle-Ottawa Scale. This study was registered on PROSPERO (CRD42023409454). Out of 4,574 identified publications, twelve studies met inclusion criteria. Reported outcome rates ranged from 28.12% to 32.27% for symptomatic events, 7.1% to 31.88% for requiring intervention, 7.5% to 32.08% for spontaneous passage, 11.11% to 45.9% for stone growth, 31.77% to 77% for stone-related events, and 23% to 68.22% for remaining asymptomatic. Meta-analysis identified the pooled proportion of 30% (95% CI 27% to 33%) for developing symptoms, 22% (95% CI 18% to 27%) for requiring intervention, 25% (95% CI 16% to 36%) for stone growth, 18% (95%CI 13% to 23%) for spontaneous stone passage, 49% (95% CI 39% to 59%) for all stone-related events, 50% (95% CI 48% to 52%) for remaining asymptomatic. Notably, our investigation done by meta-regression did not reveal any specific risk factor for developing symptoms and stone growth. However, multiple and bilateral stones were less likely to pass spontaneously. Moreover, the analyses indicated a positive correlation between multiple stones and requiring intervention and between male sex and all stone-related events, albeit it trended toward significance. The findings offer some guidance for managing asymptomatic renal stones, suggesting that active surveillance could be a potentially viable option. However, further meta-analysis incorporating additional studies with consistent criteria for patient inclusion, standardized stone size categorization, and uniform reporting of effect sizes is needed to validate our findings. Unfortunately, this is not currently feasible due to the limitations outlined above.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"31"},"PeriodicalIF":2.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of thulium fiber laser versus holmium: yttrium-aluminum-garnet laser in lithotripsy for urolithiasis: a systematic review and meta-analysis.","authors":"Rui Chen, Yuxuan Song, Yang Liu, Jincong Li, Caipeng Qin, Tao Xu","doi":"10.1007/s00240-025-01709-0","DOIUrl":"https://doi.org/10.1007/s00240-025-01709-0","url":null,"abstract":"<p><p>This meta-analysis compares the efficacy and safety of thulium fiber laser (TFL) with holmium: yttrium-aluminum-garnet (Ho: YAG) laser in lithotripsy for urolithiasis. A literature search was conducted across PubMed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov to identify studies published up to July 2024. Studies evaluating clinical outcomes for urolithiasis treated with either Ho: YAG laser or TFL were included. The meta-analysis, using RevMan 5.4 software, focused on comparing the stone-free rate (SFR) between the two lasers. A total of 21 studies were included. TFL was associated with a significantly higher SFR (RR 1.09, 95% CI: 1.02 to 1.16; P = 0.01), shorter operation time (SMD - 1.24, 95% CI: -1.82 to -0.66; P < 0.001), shorter lasing time (SMD - 1.26, 95% CI: -1.98 to -0.54; P < 0.001), shorter hospital stay (SMD - 2.08, 95% CI: -4.15 to -0.02; P = 0.05), reduced stone basket usage (SMD 0.50, 95% CI: 0.33 to 0.76; P = 0.001), and a lower total number of intraoperative complications (RR 0.67, 95% CI: 0.47 to 0.96; P = 0.03). However, TFL was also associated with a higher risk of postoperative sepsis (RR 5.32, 95% CI: 1.71 to 16.56; P = 0.004). Subgroup analyses revealed that TFL achieved a higher SFR in several subgroups, including ureteral stones, non-MOSES technology, and follow-up periods of ≥ 3 months, among others. In conclusion, TFL lithotripsy shows superior efficiency and safety compared to the Ho: YAG laser, though the increased risk of postoperative sepsis warrants further investigation.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"33"},"PeriodicalIF":2.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An analysis of the burden of urolithiasis: differences between the global, China, India and the United States, with projections through 2050.","authors":"Siyu Han, Shiyu Zhao, Ran Zhong, Heyang Liu, Li Liu, Yongji Yan","doi":"10.1007/s00240-025-01695-3","DOIUrl":"https://doi.org/10.1007/s00240-025-01695-3","url":null,"abstract":"<p><p>This report analyzes the patterns of urolithiasis in China, India, the United States, and globally from 1990 to 2021 using data from the Global Burden of Disease Study (GBD) 2021. Various techniques such as the Joinpoint model, age-period-cohort analysis, decomposition analysis, health inequities analysis, and the Bayesian age-period-cohort model were applied. According to the Joinpoint model, the average annual percent change (AAPC) for incidence, disability-adjusted life years, and mortality related to urolithiasis globally was negative. However, Indian women showed a positive AAPC of 0.20 in age-standardized incidence rate (ASIR). Both sexes in the United States showed positive AAPCs for age-standardized mortality rate (ASMR). The age-period-cohort analysis indicates that the peak ASIR occurs around ages 50-60. According to decomposition analysis, the main factors contributing to the rising burden of urolithiasis are population aging and growth, whereas changes in the disease's epidemiology slow its growth. Health inequities analysis shows increasing disparities between regions with high and low socio-demographic index (SDI). Forecasting models predict continued rise in prevalence without intervention. Overall, among the three countries, India faces the highest health burden, particularly among younger populations and women, whereas the United States experiences higher mortality rates among the elderly. Despite significant progress made by China in controlling urinary health burdens over the past three decades, the high incidence of urolithiasis and its subsequent impacts remain a concern, particularly in light of the country's demographic structure.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"32"},"PeriodicalIF":2.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular insights into cell signaling pathways in kidney stone formation.","authors":"Manpreet Kaur, Roja Varanasi, Debadatta Nayak, Simran Tandon, Vishal Agrawal, Chanderdeep Tandon","doi":"10.1007/s00240-025-01702-7","DOIUrl":"https://doi.org/10.1007/s00240-025-01702-7","url":null,"abstract":"<p><p>Urolithiasis, or kidney stones, has emerged as a significant public health concern. Despite this, effective treatments targeting stone formation and recurrence are limited. This review delves into the molecular mechanisms underlying the condition. Investigating these molecular aspects can address existing gaps in treatment options. Future research can uncover new therapeutic strategies by targeting downstream pathways, and effector molecules. Cell signaling pathways offer potential targets, as they involve complex interactions that can be modulated to address multiple clinical symptoms. An imbalance in calcium and oxalate levels can lead to kidney stone formation which is characterized by oxidative stress, inflammation, and cell death. The interplay between key organelles like the endoplasmic reticulum and mitochondria triggers stress pathways, including oxidative stress and apoptosis. This review consolidates recent advances in understanding the pathophysiology and signaling events associated with kidney stones.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"30"},"PeriodicalIF":2.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent predictive factors for febrile urinary tract infection after retrograde intrarenal surgery.","authors":"Akif Erbin, Sami Sekkeli, Caglar Dizdaroglu, Feyzi Sinan Erdal","doi":"10.1007/s00240-025-01706-3","DOIUrl":"https://doi.org/10.1007/s00240-025-01706-3","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"28"},"PeriodicalIF":2.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}