Urolithiasis最新文献

{"title":"Letter to the Editor: \"Renal pelvis density on preoperative CT: a novel predictor of infectious complications after percutaneous nephrolithotomy\".","authors":"Ahmet Burak Yilmaz","doi":"10.1007/s00240-025-01841-x","DOIUrl":"https://doi.org/10.1007/s00240-025-01841-x","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"164"},"PeriodicalIF":2.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of nephrostomy tube removal and its association with stone-related morbidity following endoscopic management of obstructive urolithiasis: a retrospective cohort study.","authors":"Kemal Kayar, Ridvan Kayar, Recep Cikrikci, Bugrahan Buhur Ozdemir, Cagatay Tosun, Metin Ishak Ozturk, Omer Ergin Yucebas","doi":"10.1007/s00240-025-01840-y","DOIUrl":"https://doi.org/10.1007/s00240-025-01840-y","url":null,"abstract":"<p><p>This study aimed to evaluate the impact of nephrostomy tube removal timing on postoperative outcomes in patients undergoing definitive stone surgery after percutaneous nephrostomy (PCN) placement for obstructive urolithiasis. We retrospectively analyzed 159 patients who underwent PCN followed by endoscopic stone surgery between January 2021 and June 2025. Patients were categorized into two groups based on nephrostomy tube removal timing: intraoperative removal (Group 1) and postoperative day 1 removal (Group 2). Demographic data, perioperative outcomes, Clavien-Dindo grade ≥ 3 complications, postoperative fever, and length of hospital stay were compared. Univariable logistic regression analysis was performed to identify predictors of major complications and fever; however, a multivariable analysis to control for potential confounders was precluded by the low event rate. Group 1 (n = 95) and Group 2 (n = 64) were similar in baseline characteristics. Postoperative fever (1.1% vs. 7.8%, p = 0.028) and Clavien-Dindo grade ≥ 3 complications (1.1% vs. 15.6%, p < 0.001) were significantly lower in Group 1. Median hospital stay was also shorter (12 [9-15] vs. 15 [11-19] days, p = 0.008). Intraoperative tube removal was associated with significantly lower odds of major complications (OR: 17.41, 95% CI: 2.17-139.71, p = 0.007) and fever (OR: 7.97, 95% CI: 0.91-69.88, p = 0.061). In patients undergoing definitive stone surgery after PCN placement, intraoperative nephrostomy tube removal is associated with lower complication and fever rates and a shorter hospital stay. This approach may be a safe and preferable option in selected patients.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"165"},"PeriodicalIF":2.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel ionic liquids with antibacterial and low cytotoxic properties for double-J stents.","authors":"Omar Alhomsi, Leman Yalçıntepe, Vildan Enisoğlu Atalay, Tarek Swellam, Başak Günçer","doi":"10.1007/s00240-025-01831-z","DOIUrl":"https://doi.org/10.1007/s00240-025-01831-z","url":null,"abstract":"<p><p>Infections are common postoperative complications associated with the use of medical implants such as ureteric double-J stents. However, bacterial resistance to antibiotics poses serious risks to human health. These complications highlight the need for novel antibacterial agents. This study aimed to synthesize ionic liquids (ILs) with antibacterial potential, namely, 1-benzyl-3-(2-nitrobenzoyl)-1 H-imidazol-3-ium chloride (OM-1) and 4-(dimethyl amino)-1-(4-nitrobenzoyl) pyridin-1-ium chloride (OM-2), for use as biocompatible coating materials on double-J stents. The chemical structures of the synthesized ILs were confirmed by Nuclear Magnetic Resonance (NMR) and Fourier Transform Infrared (FTIR) spectroscopy. The antibacterial properties were evaluated using the Kirby-Bauer Disk Diffusion method on Klebsiella pneumoniae and Escherichia coli. Cytotoxicity was evaluated in a human skin fibroblast cell line (HFF-1) using a 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2 H tetrazolium (MTS) assay. Molecular docking and ADMETox analyses were also performed to calculate binding affinities and pharmacokinetic properties. At 50 µg/mL, OM-1 and OM-2 exhibited significant activity against Klebsiella pneumoniae (p = 0.04), with OM-1 differing significantly from Gentamicin (p = 0.017). In Escherichia coli, both ILs exhibited significant differences compared to piperacillin/tazobactam (p < 0.001 and p = 0.002, respectively). At 100 µg/mL, both ILs demonstrated statistically significant differences compared to Ceftazidime and Piperacillin/Tazobactam. The IC₅₀ values for OM-1 and OM-2 in HFF-1 cells were calculated as 260.90 µg/mL and 216.35 µg/mL, respectively. Docking studies performed on OM-1 revealed stronger binding affinity as antifungal and antioxidant, while OM-2 was a stronger candidate for antibacterial applications due to its ADMETox profile. These findings, supported by both experimental and computational studies, confirm the biocoating potential of OM-1 and OM-2 for double-J stents.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"163"},"PeriodicalIF":2.2,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"improved control of renal pelvis pressure using a prototype fluid management system incorporating ureteroscope pressure feedback\".","authors":"Huizhe Ding, Yinying Chai, Yibo He","doi":"10.1007/s00240-025-01838-6","DOIUrl":"https://doi.org/10.1007/s00240-025-01838-6","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"162"},"PeriodicalIF":2.2,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the gut-immune-kidney axis in kidney stone disease: a two-step Mendelian randomization investigation.","authors":"Jian Hou, Junxiong Li, Yupeng Wu, Yumin Wang, Guoqiang Liao, Runan Dong","doi":"10.1007/s00240-025-01830-0","DOIUrl":"https://doi.org/10.1007/s00240-025-01830-0","url":null,"abstract":"<p><p>The gut microbiota (GM) is increasingly acknowledged for its regulatory role in host immune responses and its influence on various systemic diseases. Nevertheless, whether GM modulates kidney stone disease (KSD) through immune-related mechanisms remains uncertain. To investigate these associations, we conducted Mendelian randomization (MR) analyses in two sequential steps, employing summary-level data sourced from comprehensive genome-wide association studies (GWAS). Specifically, the potential causal influence of 430 GM features on 731 immune-cell-related traits, and subsequently their effects on KSD susceptibility, was assessed. The primary analysis utilized the inverse variance weighted (IVW) method, alongside complementary approaches including MR-Egger regression, weighted median analysis, and various sensitivity evaluations. Moreover, a mediation MR analysis was conducted to determine if specific immune cell subsets mediated relationships between GM and KSD. Our analysis revealed significant causal associations between 15 GM taxa and KSD. Protective effects were observed for genera such as Prevotella, Phascolarctobacterium, and Ruminococcaceae, whereas elevated risks of KSD were associated with Bacteroides, Clostridiales, and Subdoligranulum. Furthermore, 35 immune-cell-related phenotypes displayed causal links to KSD risk. Importantly, CD28 expression on CD39 + CD4 + T cells was identified as a mediator in the protective pathway from Prevotella to KSD, with a mediation effect estimated at -9.019% (P = 0.044). No significant directional pleiotropy or heterogeneity was observed. These findings provide novel causal evidence supporting the existence of a gut-immune-kidney axis, where certain gut microbes influence KSD susceptibility via immune mechanisms. This may guide the development of microbiota- or immune-targeted strategies for the prevention of KSD.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"160"},"PeriodicalIF":2.2,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing causal associations of FGF23 and α-Klotho with urolithiasis using Mendelian randomization analysis.","authors":"Liang Chen, Li Xie, Bo Wu, Wentao Zhao","doi":"10.1007/s00240-025-01836-8","DOIUrl":"https://doi.org/10.1007/s00240-025-01836-8","url":null,"abstract":"<p><p>Fibroblast growth factor 23 (FGF23) and α-Klotho may involve in the occurrence and development of urolithiasis. However, the underlying relationship is still unclear. Mendelian randomization (MR) analysis was performed on datasets from genome-wide association studies (GWASs) to investigate the causal relationship between FGF23, α-Klotho, and urolithiasis. The main focus was on determining the odds ratio (OR) using the inverse-variance weighted (IVW) approach. Reverse causal associations were also examined. IVW estimates suggested that a correlation between a heightened α-Klotho level and a reduced likelihood of kidney and ureter calculi (OR = 0.86, 95%CI: 0.81-0.92, P = 8.90e - 06), And reverse MR analysis revealed a unidirectional correlation (p > 0.05). However, no causal relationship was observed between FGF23 and urolithiasis. It was found that genetically predicted elevations in FGF23 (IVW OR = 0.98, 95%CI = 0.83-1.16) did not show any correlation with the likelihood of developing kidney and ureter calculi. We did not find any causal relationship between FGF23 and lower urinary tract stones (IVW OR = 0.91, 95%CI = 0.69-1.21, p = 0.529). There was no heterogeneity or pleiotropy evident in any of the results. Elevated levels of circulating α-Klotho may have a protective effect against kidney and ureter calculi. These findings could offer valuable insights into the underlying mechanisms involved in this pathway and help identify potential targets for preventing kidney and ureter calculi.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"161"},"PeriodicalIF":2.2,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota: a novel target and new perspective for the prevention and treatment of kidney stones.","authors":"Songhe Chen, Ying Zhang","doi":"10.1007/s00240-025-01835-9","DOIUrl":"10.1007/s00240-025-01835-9","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"159"},"PeriodicalIF":2.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing the evidence base in extracorporeal shock wave lithotripsy: the need for consensus outcomes and standardized reporting.","authors":"Mohammed Ramadhan, Mohammed Alzaid, Tarek Benzouak, Arthur Braga, Fadl Hamouche, Ahmad Almarzouq","doi":"10.1007/s00240-025-01827-9","DOIUrl":"10.1007/s00240-025-01827-9","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"156"},"PeriodicalIF":2.2,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From body mass index to waist circumference: a paradigm shift in assessing access complexity in percutaneous nephrolithotomy- comparative study.","authors":"Timucin Sipal, Erdal Yilmaz, Ferhat Yakup Suceken, Abdullah Yilmaz, Kemal Sarica","doi":"10.1007/s00240-025-01834-w","DOIUrl":"10.1007/s00240-025-01834-w","url":null,"abstract":"<p><p>To compare waist circumference (WC) and body mass index (BMI) on renal access difficulty during percutaneous nephrolithotomy surgery (PCNL) with fluoroscopic guided PCNL (FPCNL) and ultrasonographic guided PCNL (UPCNL) access techniques. 109 patients underwent PCNL, with 63 FGPNL and 46 UPCNL techniques. Patients were categorized as WC ≥ 90 or less cm and BMI ≥ 30 or less. Stone-free rate (SFR) was presented as Grade A (no stone), Grade B (≤ 2 mm), Grade C (A + B + 2.1-4 mm), and > 4 mm, based on a non-contrast computed tomography scan. The difficulty level of access was evaluated by number of accesses attempted (NAA) and access time (AT). SFR was similar between patients with low and high WC and BMI (40% for BMI < 30 vs. 42% for BMI > 30, p = 0.389 and 43.7% for WC < 90 vs. 30.7% for WC > 90, p = 0.779). SFR is also similar between UPCNL (41.3%) and FPCNL (44.4%) techniques, p = 0.733. In the UPCNL technique, increased WC, not BMI, is associated with increased NAA and AT. In the FPCNL technique, however, BMI and WC did not affect access parameters. A linear regression analysis indicated that only WC and hydronephroses levels had reached a prediction power for an AT and NAA (p < 0.05). In patients with central obesity, WC may be a more reliable predictor than BMI for estimating access difficulty in the UPCNL technique. While UPCNL appears to have a safety advantage over FPCNL regarding radiation exposure, FPCNL may be a more suitable option for obese patients.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"157"},"PeriodicalIF":2.2,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary metabolic evaluation, medical and minimally invasive management of stones in children.","authors":"Francesco Ripa, Shiv Sarna, Simon K S Choong, Giorgio Mazzon","doi":"10.1007/s00240-025-01824-y","DOIUrl":"10.1007/s00240-025-01824-y","url":null,"abstract":"<p><p>The last 3 years have seen tremendous advances in the management of urinary tract stones in children. Technological advances and miniaturisation of equipment and instruments have made it possible to treat larger stones in younger children. Focus is now being made in controlling intrarenal pressures and temperatures to minimise sepsis and complications. The future of paediatric stone management is looking increasingly promising.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"158"},"PeriodicalIF":2.2,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}