Turkish Journal of Ophthalmology最新文献

{"title":"Glaucoma Management in High Myopia: A Case of Hypotony-Related Serous Retinal Detachment Following Trabeculectomy and Successful Treatment with Intravitreal SF6 Gas.","authors":"Ahmet Kaderli, Ozan Tekin, Cansu Kaya Bal, Sema Tamer Kaderli, Sabahattin Sül","doi":"10.4274/tjo.galenos.2026.05950","DOIUrl":"10.4274/tjo.galenos.2026.05950","url":null,"abstract":"","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 4","pages":"290-293"},"PeriodicalIF":0.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13514476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The First Case Series of Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy in Türkiye Identified with <i>EFEMP1</i> Gene Mutation.","authors":"Atakan İşbilir, Ahmet Güzel, Mehmet Kocabey, Ahmet Okay Çağlayan, Ömer Kartı, Ziya Ayhan, Ali Osman Saatci","doi":"10.4274/tjo.galenos.2026.22892","DOIUrl":"10.4274/tjo.galenos.2026.22892","url":null,"abstract":"<p><p>This report aims to describe the clinical characteristics of the first Turkish family diagnosed with Malattia Leventinese/Doyne honeycomb retinal dystrophy (ML/DHRD) associated with an <i>EFEMP1</i> mutation. Four affected individuals from the same family (one male and three females; aged 25, 51, 53, and 73 years) underwent comprehensive ophthalmological evaluation. The assessment included best-corrected visual acuity, spectral-domain optical coherence tomography (OCT), color fundus photography, and OCT angiography. In addition, genetic analysis for <i>EFEMP1</i> mutations was performed. The <i>EFEMP1</i> variant was identified in all four patients. Clinical examination revealed numerous drusen-like deposits with a radial distribution in the posterior pole, consistent with the ML/DHRD phenotype. OCT imaging demonstrated subretinal and retinal pigment epithelium alterations, which were more advanced in the 73-year-old female patient. Visual acuity was largely preserved in the youngest patient but markedly reduced in older individuals. This case series describes the first Turkish family with genetically confirmed ML/DHRD. Structural imaging demonstrated progressive macular changes associated with aging, highlighting the value of multimodal imaging in assessing disease course.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 4","pages":"269-278"},"PeriodicalIF":0.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13514489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Approaches in the Management of Complicated Macular Holes.","authors":"Remzi Avcı, Ayşegül Mavi Yıldız, Zofia Anna Nawrocka, Stanislao Rizzo, Sami Yılmaz, Emre Avcı, Federico Giannuzzi, Asad Loya, Tamer H Mahmoud","doi":"10.4274/tjo.galenos.2026.21604","DOIUrl":"10.4274/tjo.galenos.2026.21604","url":null,"abstract":"<p><p>Kelly and Wendel reported the first successful intervention for idiopathic full-thickness macular holes in 1991. Since then, pars plana vitrectomy and internal limiting membrane peeling have become the standard treatment approach, with >90% hole closure rates. However, the results were not satisfactory in cases of complicated macular holes, including large, recurrent, refractory, and myopic macular holes. To date, several surgical approaches, including the inverted internal limiting membrane flap technique, autologous retinal transplantation, the human amniotic membrane plug, and the autologous Tenon's capsule plug, have been described by various authors to improve the anatomical and functional outcomes of challenging cases. Although these techniques have significantly increased hole closure rates, each technique has its own strengths and weaknesses. Currently, there is no consensus among vitreoretinal surgeons on a single ideal technique for treating challenging macular holes. In this review, the inventors of each innovative surgical technique will discuss the indications, pros and cons, complications, and anticipated future applications.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 4","pages":"256-268"},"PeriodicalIF":0.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13514483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Contemporary Intraocular Lens Calculation Formulas Based on Swept-Source OCT Biometry in Eyes with Capsular Tension Ring.","authors":"Ali Devebacak, Müge Yılmaz, Gül Arıkan","doi":"10.4274/tjo.galenos.2026.33338","DOIUrl":"10.4274/tjo.galenos.2026.33338","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the refractive prediction accuracy of contemporary intraocular lens (IOL) calculation formulas based on swept-source optical coherence tomography (OCT) biometry in cataract surgery with capsular tension ring (CTR) implantation, and to assess for systematic postoperative refractive tendencies.</p><p><strong>Materials and methods: </strong>This retrospective study included 98 eyes of 92 patients who underwent phacoemulsification with in-the-bag IOL and CTR implantation. Preoperative biometry utilized swept-source OCT (ARGOS, Alcon). Refractive prediction accuracy was evaluated for the Barrett Universal II, Haigis, SRK/T, and Holladay II formulas. Main outcomes included mean prediction error, mean absolute error (MAE), median absolute error (MedAE), and percentages of eyes within ±0.25, ±0.50, and ±1.00 diopter (D).</p><p><strong>Results: </strong>The mean age was 73.0±8.1 years, and the mean axial length was 23.03±1.04 mm. Barrett Universal II yielded the lowest MAE and MedAE (0.36±0.34 D and 0.24 D, respectively), followed by Holladay II (0.40±0.32 D and 0.30 D). Higher MAE was observed with SRK/T (0.45±0.37 D) and Haigis (0.54±0.45 D). MAE differed significantly among the formulas (p<0.001), with pairwise comparisons showing that Barrett Universal II and Holladay II performed similarly (p>0.05) and better than both Haigis and SRK/T (all p≤0.003). The highest percentage of eyes within ±0.25 D was observed with Barrett Universal II (52.04%), whereas Holladay II showed the highest percentage within ±0.50 D (69.39%), and the two formulas tied within the ±1.00 D range (both 92.86%). Prediction errors were positive for all formulas, indicating a mild hyperopic shift.</p><p><strong>Conclusion: </strong>In eyes undergoing cataract surgery with CTR implantation, Barrett Universal II and Holladay II showed more favorable refractive prediction accuracy than Haigis and SRK/T. A mild hyperopic shift was observed across all formulas. This finding may be clinically relevant when selecting the target refraction or IOL power in these eyes.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 3","pages":"166-171"},"PeriodicalIF":0.0,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148309633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Idiopathic Retinal Venous Beading.","authors":"Ege Karslıoğlu, Almila Sarıgül Sezenöz, Gürsel Yılmaz","doi":"10.4274/tjo.galenos.2026.38927","DOIUrl":"10.4274/tjo.galenos.2026.38927","url":null,"abstract":"","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 3","pages":"208-210"},"PeriodicalIF":0.0,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Re: Long-Term Intravitreal Dexamethasone Implant Monotherapy in Naïve Patients with Diabetic Macular Edema.","authors":"Çağatay Çağlar","doi":"10.4274/tjo.galenos.2026.63598","DOIUrl":"10.4274/tjo.galenos.2026.63598","url":null,"abstract":"","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 3","pages":"216-217"},"PeriodicalIF":0.0,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presentation of Bilateral Optic Disc Coloboma-Morning Glory Syndrome in Mother and Son, with Retinitis Pigmentosa in the Father.","authors":"Yersultan İslambekov, Burçin Çakır, Kübra Ateş","doi":"10.4274/tjo.galenos.2026.16050","DOIUrl":"10.4274/tjo.galenos.2026.16050","url":null,"abstract":"","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 3","pages":"211-215"},"PeriodicalIF":0.0,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unseen Consequences: The Expanding Burden of Iatrogenic Dry Eye Disease in Surgical and Cosmetic Practice.","authors":"Arzu Taşkıran Çömez","doi":"10.4274/tjo.galenos.2025.69812","DOIUrl":"10.4274/tjo.galenos.2025.69812","url":null,"abstract":"<p><p>Iatrogenic dry eye disease (DED) has emerged as a significant but overlooked complication in both ophthalmic surgery and aesthetic medicine. Characterized by disruption of tear film homeostasis, ocular surface inflammation, and neurosensory dysfunction, this condition may arise acutely or chronically following medical interventions. The Tear Film and Ocular Surface Society Dry Eye Workshop II and III reports have highlighted iatrogenic DED as a distinct clinical entity, underscoring its multifactorial etiology and the need for tailored risk mitigation strategies. Refractive procedures such as laser in situ keratomileusis and photorefractive keratectomy are frequently implicated due to corneal nerve transection and subsequent hypoesthesia, which impair blink dynamics and lacrimal gland feedback. Cataract surgery, though largely safe, contributes via surface desiccation, intraoperative light exposure, and topical medication toxicity. Oculoplastic interventions, including blepharoplasty, introduce mechanical alterations that disrupt eyelid function and tear film distribution. Moreover, the growing demand for periocular cosmetic procedures such as botulinum toxin injections and permanent eyeliner tattooing has introduced additional risks, particularly in individuals with preexisting meibomian gland dysfunction or marginal tear function. Emerging evidence suggests that the cumulative effect of repeated exposures and inadequate preoperative screening has led to a rise in persistent ocular surface morbidity. Prevention therefore necessitates a multidisciplinary approach encompassing ophthalmologists, dermatologists, plastic surgeons, and primary care providers. Systematic pretreatment ocular surface assessment, patient counseling, and adoption of minimally disruptive techniques are essential. By integrating evidence-based risk stratification into routine care, clinicians can significantly reduce the burden of iatrogenic DED and preserve long-term visual quality and patient satisfaction in the face of expanding therapeutic and cosmetic practices.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 3","pages":"187-197"},"PeriodicalIF":0.0,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA Profiles Targeting Angiopoietin-1, Angiopoietin-2, and TEK Receptor Tyrosine Kinase-2 Genes Associated with Angiogenesis in Proliferative Diabetic Retinopathy.","authors":"Hilal Sancar, İrfan Akaray, Sadık Altan Özal, Lokman Ayaz","doi":"10.4274/tjo.galenos.2026.72361","DOIUrl":"10.4274/tjo.galenos.2026.72361","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to assess the concentrations of angiopoietin-1, angiopoietin-2, and Tie-2, which are implicated in the pathophysiology of proliferative diabetic retinopathy (PDR), in the vitreous fluid and to evaluate the expression profiles of microRNA (miR)-145-5p, miR-542-3p, miR-5195-3p, miR-126-3p, miR-211-3p, and miR-204-5p.</p><p><strong>Materials and methods: </strong>The study included 25 patients with PDR and 25 non-diabetic individuals as controls. Vitreous angiopoietin-1, angiopoietin-2, and Tie-2 levels were measured using enzyme-linked immunosorbent assay (ELISA). miRNA expression levels were evaluated using real-time polymerase chain reaction.</p><p><strong>Results: </strong>Vitreous angiopoietin-1 and 2 levels were significantly lower in the PDR group when compared to controls (p<0.05). The PDR group also had a lower angiopoietin-1/angiopoietin-2 ratio and higher Tie-2 levels, but these differences did not reach statistical significance (p>0.05). Significantly higher levels of miR-126-3p and miR-204-5p were detected in the PDR group (p<0.05), whereas miR-211-3p, miR-5195-3p, miR-542-3p, and miR-145-5p did not show statistically significant differences (p>0.05).</p><p><strong>Conclusion: </strong>Our data demonstrate that increased miR-204-5p and miR-126-3p expression may be associated with angiogenesis-related alterations in PDR. These findings provide insight into PDR-related angiogenesis and suggest that these microRNAs may represent potential biomarkers of disease-related vascular alterations.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 3","pages":"172-179"},"PeriodicalIF":0.0,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148309674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Gamze Karataş, Akın Çakır, Öznur Aday, Tahsin Uzundede, Furkan Kırık, Ahmet Melih Özoğuz, Hakan Özdemir, Mustafa Nuri Elçioğlu","doi":"10.4274/tjo.galenos.2026.83993","DOIUrl":"10.4274/tjo.galenos.2026.83993","url":null,"abstract":"","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 3","pages":"217-219"},"PeriodicalIF":0.0,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}