Tuberculosis and Respiratory Diseases最新文献

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Lack of Association between Inhaled Corticosteroid Use Based on the Exhaled Nitric Oxide and Acute Exacerbation of Chronic Obstructive Pulmonary Disease. 基于呼出一氧化氮的吸入皮质类固醇与慢性阻塞性肺病急性加重之间缺乏关联。
IF 2.5
Tuberculosis and Respiratory Diseases Pub Date : 2024-07-01 Epub Date: 2024-03-05 DOI: 10.4046/trd.2023.0175
Bo-Guen Kim, Sun Hye Shin, Jung-Wan Yoo, Yong Suk Jo, Hye Yun Park
{"title":"Lack of Association between Inhaled Corticosteroid Use Based on the Exhaled Nitric Oxide and Acute Exacerbation of Chronic Obstructive Pulmonary Disease.","authors":"Bo-Guen Kim, Sun Hye Shin, Jung-Wan Yoo, Yong Suk Jo, Hye Yun Park","doi":"10.4046/trd.2023.0175","DOIUrl":"10.4046/trd.2023.0175","url":null,"abstract":"<p><strong>Background: </strong>Fractional exhaled nitric oxide (FeNO) is known to useful biomarker for detecting eosinophilic airway inflammation. However, there is a lack of evidence regarding the role of FeNO in chronic obstructive pulmonary disease (COPD). We aimed to assess whether elevated FeNO and its impact on treatment change into an inhaled corticosteroid (ICS)-containing regimen and association with acute exacerbation (AE) in patients with COPD.</p><p><strong>Methods: </strong>We retrospectively analyzed 107 COPD patients without a history of asthma from March 2016 to December 2019. The patients whose FeNO value was more than 50 parts per billion (ppb) were defined into the high FeNO group. Multivariable analysis with logistic regression was used to identify factors associated with AE in COPD.</p><p><strong>Results: </strong>The median FeNO value was 32 ppb (interquartile range, 19 to 45) and 34 (20.0%) patients were classified as high FeNO group (median 74 ppb). In the high FeNO group, changes in inhaler treatment into an ICS-containing regimen occurred in 23 of 34 patients after the measurement of FeNO. In multivariate analysis, high FeNO was not a contributing factor for AE, but only the high blood eosinophil count (≥300 cells/μL) was associated with AE (adjusted odds ratio, 2.63; 95% confidence interval, 1.01 to 6.91; p=0.049).</p><p><strong>Conclusion: </strong>High FeNO value had a significant impact on the prescription of ICSs in COPD patients, but it did not show a significant association with AE either on its own or with changes in treatment.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"329-337"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Characteristics, Risk Factors, and Outcomes of Acute Pulmonary Embolism in Thailand: 6-Year Retrospective Study. 泰国急性肺栓塞的临床特征、风险因素和预后:6 年回顾性研究。
IF 2.5
Tuberculosis and Respiratory Diseases Pub Date : 2024-07-01 Epub Date: 2024-02-29 DOI: 10.4046/trd.2023.0108
Pattarin Pirompanich, Ornnicha Sathitakorn, Teeraphan Suppakomonnun, Tunlanut Sapankaew
{"title":"Clinical Characteristics, Risk Factors, and Outcomes of Acute Pulmonary Embolism in Thailand: 6-Year Retrospective Study.","authors":"Pattarin Pirompanich, Ornnicha Sathitakorn, Teeraphan Suppakomonnun, Tunlanut Sapankaew","doi":"10.4046/trd.2023.0108","DOIUrl":"10.4046/trd.2023.0108","url":null,"abstract":"<p><strong>Background: </strong>Acute pulmonary embolism (APE) is a fatal disease with varying clinical characteristics and imaging. The aim of this study was to define the clinical characteristics, risk factors, and outcomes in patients with APE at a university hospital in Thailand.</p><p><strong>Methods: </strong>Patients diagnosed with APE and admitted to our institute between January 1, 2017 and December 31, 2022 were retrospectively enrolled. The clinical characteristics, investigations, and outcomes were recorded.</p><p><strong>Results: </strong>Over the 6-year study period, 369 patients were diagnosed with APE. The mean age was 65 years; 64.2% were female. The most common risk factor for APE was malignancy (46.1%). In-hospital mortality rate was 23.6%. The computed tomography pulmonary artery revealed the most proximal clots largely in segmental pulmonary artery (39.0%), followed by main pulmonary artery (36.3%). This distribution was consistent between survivors and non-survivors. Multivariate logistic regression analysis revealed that APE mortality was associated with active malignancy, higher serum creatinine, lower body mass index (BMI), and tachycardia with adjusted odds ratio (95% confidence interval [CI]) of 3.70 (1.59 to 8.58), 3.54 (1.35 to 9.25), 2.91 (1.26 to 6.75), and 2.54 (1.14 to 5.64), respectively. The prediction model was constructed with area under the curve of 0.77 (95% CI, 0.70 to 0.84).</p><p><strong>Conclusion: </strong>The overall mortality rate among APE patients was 23.6%, with APE-related death accounting for 5.1%. APE mortality was associated with active malignancy, higher serum creatinine, lower BMI, and tachycardia.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"349-356"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonal Hematopoiesis of Indeterminate Potential Is Associated with Current Smoking Status and History of Exacerbation in Patients with Chronic Obstructive Pulmonary Disease. 具有不确定潜能的克隆性造血与慢性阻塞性肺病患者目前的吸烟状况和病情加重史有关。
IF 2.5
Tuberculosis and Respiratory Diseases Pub Date : 2024-07-01 Epub Date: 2024-02-06 DOI: 10.4046/trd.2023.0165
Jung-Kyu Lee, Hongyul An, Youngil Koh, Chang-Hoon Lee
{"title":"Clonal Hematopoiesis of Indeterminate Potential Is Associated with Current Smoking Status and History of Exacerbation in Patients with Chronic Obstructive Pulmonary Disease.","authors":"Jung-Kyu Lee, Hongyul An, Youngil Koh, Chang-Hoon Lee","doi":"10.4046/trd.2023.0165","DOIUrl":"10.4046/trd.2023.0165","url":null,"abstract":"<p><strong>Background: </strong>There is limited data regarding the clinical outcomes of clonal hematopoiesis of indeterminate potential (CHIP) in patients with chronic obstructive pulmonary disease (COPD). This study aimed to evaluate the clinical significance of CHIP as a COPD biomarker.</p><p><strong>Methods: </strong>This retrospective study was conducted on patients with COPD who were enrolled prospectively in the Seoul National University Hospital Airway Registry from January 2013 to December 2019 and underwent pulmonary function and blood tests. We evaluated the CHIP score according to smoking status and severity of airflow obstruction.</p><p><strong>Results: </strong>We analyzed next-generation sequencing data to detect CHIP in 125 patients with COPD. Current smokers had a higher prevalence of CHIP in combination of DNMT3A, TET2, and PPM1D (DTP), DNA methyltransferase 3 alpha (DNMT3A), and protein phosphatase, Mg2+/Mn2+ dependent 1D (PPM1D) genes than in never- or ex-smokers. CHIP of DTP and DNMT3A genes was significantly associated with current smokers (adjusted odds ratio [aOR], 2.80; 95% confidence interval [CI], 1.01 to 7.79) (aOR, 4.03; 95% CI, 1.09 to 14.0). Patients with moderate-to-severe airflow obstruction had a higher prevalence of CHIP in most of the explored genes than those with mild obstruction, although the difference was not statistically significant. CHIP in ASXL transcriptional regulator 1 (ASXL1) genes was significantly associated with history of mild, severe, and total acute exacerbation.</p><p><strong>Conclusion: </strong>Given that CHIP in specific genes was significantly associated with current smoking status and acute exacerbation, CHIP can be considered as a candidate biomarker for COPD patients.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"309-318"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age Distribution and Clinical Results of Critically Ill Patients above 65-Year-Old in an Aging Society: A Retrospective Cohort Study. 老龄化社会中 65 岁以上重症患者的年龄分布和临床结果:回顾性队列研究
IF 2.5
Tuberculosis and Respiratory Diseases Pub Date : 2024-07-01 Epub Date: 2024-02-29 DOI: 10.4046/trd.2023.0155
Song I Lee, Jin Won Huh, Sang-Bum Hong, Younsuck Koh, Chae-Man Lim
{"title":"Age Distribution and Clinical Results of Critically Ill Patients above 65-Year-Old in an Aging Society: A Retrospective Cohort Study.","authors":"Song I Lee, Jin Won Huh, Sang-Bum Hong, Younsuck Koh, Chae-Man Lim","doi":"10.4046/trd.2023.0155","DOIUrl":"10.4046/trd.2023.0155","url":null,"abstract":"<p><strong>Background: </strong>Increasing age has been observed among patients admitted to the intensive care unit (ICU). Age traditionally considered a risk factor for ICU mortality. We investigated how the epidemiology and clinical outcomes of older ICU patients have changed over a decade.</p><p><strong>Methods: </strong>We analyzed patients admitted to the ICU at a university hospital in Seoul, South Korea. We defined patients aged 65 and older as older patients. Changes in age groups and mortality risk factors over the study period were analyzed.</p><p><strong>Results: </strong>A total of 32,322 patients were enrolled who aged ≥65 years admitted to the ICUs between January 1, 2007, and December 31, 2017. Patients aged ≥65 years accounted for 35% and of these, the older (O, 65 to 74 years) comprised 19,630 (66.5%), very older (VO, 75 to 84 years) group 8,573 (29.1%), and very very older (VVO, ≥85 years) group 1,300 (4.4%). The mean age of ICU patients over the study period increased (71.9±5.6 years in 2007 vs. 73.2±6.1 years in 2017) and the proportions of the VO and VVO group both increased. Over the period, the proportion of female increased (37.9% in 2007 vs. 43.3% in 2017), and increased ICU admissions for medical reasons (39.7% in 2007 vs. 40.2% in 2017). In-hospital mortality declined across all older age groups, from 10.3% in 2007 to 7.6% in 2017. Hospital length of stay (LOS) decreased in all groups, but ICU LOS decreased only in the O and VO groups.</p><p><strong>Conclusion: </strong>The study indicates a changing demographic in ICUs with an increase in older patients, and suggests a need for customized ICU treatment strategies and resources.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"338-348"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhaled Corticosteroids May Not Affect the Clinical Outcomes of Pneumonia in Patients with Chronic Obstructive Pulmonary Disease. 吸入皮质类固醇可能不会影响慢性阻塞性肺病患者肺炎的临床疗效。
IF 2.5
Tuberculosis and Respiratory Diseases Pub Date : 2024-07-01 Epub Date: 2024-02-19 DOI: 10.4046/trd.2023.0176
Min-Seok Chang, In-So Cho, Iseul Yu, Sunmin Park, Seok Jeong Lee, Suk Joong Yong, Won-Yeon Lee, Sang-Ha Kim, Ji-Ho Lee
{"title":"Inhaled Corticosteroids May Not Affect the Clinical Outcomes of Pneumonia in Patients with Chronic Obstructive Pulmonary Disease.","authors":"Min-Seok Chang, In-So Cho, Iseul Yu, Sunmin Park, Seok Jeong Lee, Suk Joong Yong, Won-Yeon Lee, Sang-Ha Kim, Ji-Ho Lee","doi":"10.4046/trd.2023.0176","DOIUrl":"10.4046/trd.2023.0176","url":null,"abstract":"<p><strong>Background: </strong>Although inhaled corticosteroids (ICS) is reportedly associated with a higher risk of pneumonia in chronic obstructive pulmonary disease (COPD), the clinical implications of ICS have not been sufficiently verified to determine their effect on the prognosis of pneumonia.</p><p><strong>Methods: </strong>The electronic health records of patients hospitalized for pneumonia with underlying COPD were retrospectively reviewed. Pneumonia was confirmed using chest radiography or computed tomography. The clinical outcomes of pneumonia in patients with COPD who received ICS and those who received long-acting bronchodilators other than ICS were compared.</p><p><strong>Results: </strong>Among the 255 hospitalized patients, 89 met the inclusion criteria. The numbers of ICS and non-ICS users were 46 and 43, respectively. The CURB-65 (confusion, uremia, respiratory rate, blood pressure, age ≥65 years) scores at the initial presentation of pneumonia were comparable between the two groups. The proportions of patients with multilobar infiltration, pleural effusion, and complicated pneumonia in the radiological studies did not vary between the two groups. Additionally, the defervescence time, proportion of mechanical ventilation, intensive care unit admission, length of hospital stays, and mortality rate at 30 and 90 days were not significantly different between the two groups. ICS use and blood eosinophils count were not associated with all pneumonia outcomes and mortality in multivariate analyses.</p><p><strong>Conclusion: </strong>The clinical outcomes of pneumonia following ICS use in patients with COPD did not differ from those in patients treated without ICS. Thus, ICS may not contribute to the severity and outcomes of pneumonia in patients with COPD.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"319-328"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proposed Etiotypes for Chronic Obstructive Pulmonary Disease: Controversial Issues. 慢性阻塞性肺病的拟议病因:有争议的问题。
IF 2.5
Tuberculosis and Respiratory Diseases Pub Date : 2024-07-01 Epub Date: 2024-02-06 DOI: 10.4046/trd.2023.0194
Sang Hyuk Kim, Ji-Yong Moon, Kyung Hoon Min, Hyun Lee
{"title":"Proposed Etiotypes for Chronic Obstructive Pulmonary Disease: Controversial Issues.","authors":"Sang Hyuk Kim, Ji-Yong Moon, Kyung Hoon Min, Hyun Lee","doi":"10.4046/trd.2023.0194","DOIUrl":"10.4046/trd.2023.0194","url":null,"abstract":"<p><p>The 2023 Global Initiative for Chronic Obstructive Lung Disease (GOLD) revised the definition of chronic obstructive pulmonary disease (COPD) to broadly include a variety of etiologies. A new taxonomy, composed of etiotypes, aims to highlight the heterogeneity in causes and pathogenesis of COPD, allowing more personalized management strategies and emphasizing the need for targeted research to understand and manage COPD better. However, controversy arises with including some diseases under the umbrella term of COPD, as their clinical presentations and treatments differ from classical COPD, which is smoking-related. COPD due to infection (COPD-I) and COPD due to environmental exposure (COPD-P) are classifications within the new taxonomy. Some disease entities in these categories show distinct clinical features and may not benefit from conventional COPD treatments, raising questions about their classification as COPD subtypes. There is also controversy regarding whether bronchiectasis with airflow limitations should be classified as an etiotype of COPD. This article discusses controversial issues associated with the proposed etiotypes for COPD in terms of COPD-I, COPD-P, and bronchiectasis. While the updated COPD definition by GOLD 2023 is a major step towards recognizing the disease's complexity, it also raises questions about the classification of related respiratory conditions. This highlights the need for further research to improve our understanding and approach to COPD management.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"221-233"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Economic Burden of Chronic Obstructive Pulmonary Disease: A Systematic Review. 慢性阻塞性肺病的经济负担:系统回顾。
IF 2.5
Tuberculosis and Respiratory Diseases Pub Date : 2024-07-01 Epub Date: 2024-02-16 DOI: 10.4046/trd.2023.0100
Hai Quang Pham, Kiet Huy Tuan Pham, Giang Hai Ha, Tin Trung Pham, Hien Thi Nguyen, Trang Huyen Thi Nguyen, Jin-Kyoung Oh
{"title":"Economic Burden of Chronic Obstructive Pulmonary Disease: A Systematic Review.","authors":"Hai Quang Pham, Kiet Huy Tuan Pham, Giang Hai Ha, Tin Trung Pham, Hien Thi Nguyen, Trang Huyen Thi Nguyen, Jin-Kyoung Oh","doi":"10.4046/trd.2023.0100","DOIUrl":"10.4046/trd.2023.0100","url":null,"abstract":"<p><p>Globally, providing evidence on the economic burden of chronic obstructive pulmonary disease (COPD) is becoming essential as it assists the health authorities to efficiently allocate resources. This study aimed to summarize the literature on economic burden evidence for COPD from 1990 to 2019. This study examined the economic burden of COPD through a systematic review of studies from 1990 to 2019. A search was done in online databases, including Web of Science, PubMed/Medline, Scopus, and the Cochrane Library. After screening 12,734 studies, 43 articles that met the inclusion criteria were identified. General study information and data on direct, indirect, and intangible costs were extracted and converted to 2018 international dollars (Int$). Findings revealed that the total direct costs ranged from Int$ 52.08 (India) to Int$ 13,776.33 (Canada) across 16 studies, with drug costs rannging from Int$ 70.07 (Vietnam) to Int$ 8,706.9 (China) in 11 studies. Eight studies explored indirect costs, while one highlighted caregivers' direct costs at approximately Int$ 1,207.8 (Greece). This study underscores the limited research on COPD caregivers' economic burdens, particularly in developing countries, emphasizing the importance of increased research support, particularly in high-resource settings. This study provides information about the demographics and economic burden of COPD from 1990 to 2019. More strategies to reduce the frequency of hospital admissions and acute care services should be implemented to improve the quality of COPD patients' lives and reduce the disease's rising economic burden.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"234-251"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sarcopenia in Outcome in Chronic Obstructive Pulmonary Disease: Is the Tip of the Iceberg? 慢性阻塞性肺病患者的Sarcopenia结局:这只是冰山一角吗?
IF 2.9
Tuberculosis and Respiratory Diseases Pub Date : 2024-04-01 Epub Date: 2023-11-01 DOI: 10.4046/trd.2023.0146
Hulya Sungurtekin, Ugur Sungurtekin, Antonio M Esquinas
{"title":"Sarcopenia in Outcome in Chronic Obstructive Pulmonary Disease: Is the Tip of the Iceberg?","authors":"Hulya Sungurtekin, Ugur Sungurtekin, Antonio M Esquinas","doi":"10.4046/trd.2023.0146","DOIUrl":"10.4046/trd.2023.0146","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"200-201"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10990612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progressive Pulmonary Fibrosis: Where Are We Now? 进行性肺纤维化:我们现在在哪里?
IF 2.9
Tuberculosis and Respiratory Diseases Pub Date : 2024-04-01 Epub Date: 2023-12-18 DOI: 10.4046/trd.2023.0119
Hyung Koo Kang, Jin Woo Song
{"title":"Progressive Pulmonary Fibrosis: Where Are We Now?","authors":"Hyung Koo Kang, Jin Woo Song","doi":"10.4046/trd.2023.0119","DOIUrl":"10.4046/trd.2023.0119","url":null,"abstract":"<p><p>Interstitial lung diseases (ILDs) are a diverse collection of lung disorders sharing similar features, such as inflammation and fibrosis. The diagnosis and management of ILD require a multidisciplinary approach using clinical, radiological, and pathological evaluation. Progressive pulmonary fibrosis (PPF) is a distinct form of progressive and fibrotic disease, occurring in ILD cases other than in idiopathic pulmonary fibrosis (IPF). It is defined based on clinical symptoms, lung function, and chest imaging, regardless of the underlying condition. The progression to PPF must be monitored through a combination of pulmonary function tests (forced vital capacity [FVC] and diffusing capacity of the lung for carbon monoxide), an assessment of symptoms, and computed tomography scans, with regular follow-up. Although the precise mechanisms of PPF remain unclear, there is evidence of shared pathogenetic mechanisms with IPF, contributing to similar disease behavior and worse prognosis compared to non-PPF ILD. Pharmacological treatment of PPF includes immunomodulatory agents to reduce inflammation and the use of antifibrotics to target progressive fibrosis. Nintedanib, a known antifibrotic agent, was found to be effective in slowing IPF progression and reducing the annual rate of decline in FVC among patients with PPF compared to placebos. Nonpharmacological treatment, including pulmonary rehabilitation, supplemental oxygen therapy, and vaccination, also play important roles in the management of PPF, leading to comprehensive care for patients with ILD. Although there is currently no cure for PPF, there are treatments that can help slow the progression of the disease and improve quality of life.</p>","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"123-133"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10990610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138809314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment Outcomes of Fluoroquinolone-Resistant Multidrug-Resistant Tuberculosis: An Implication for Delamanid. 对氟喹诺酮类药物耐药的 XDR 前期肺结核患者的治疗结果:对德拉马尼的影响
IF 2.9
Tuberculosis and Respiratory Diseases Pub Date : 2024-04-01 Epub Date: 2023-12-18 DOI: 10.4046/trd.2023.0188
Oki Nugraha Putra, Telly Purnamasari
{"title":"Treatment Outcomes of Fluoroquinolone-Resistant Multidrug-Resistant Tuberculosis: An Implication for Delamanid.","authors":"Oki Nugraha Putra, Telly Purnamasari","doi":"10.4046/trd.2023.0188","DOIUrl":"10.4046/trd.2023.0188","url":null,"abstract":"","PeriodicalId":23368,"journal":{"name":"Tuberculosis and Respiratory Diseases","volume":" ","pages":"206-208"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10990615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138809392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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