Turkish Journal of Chemistry最新文献

{"title":"pH-responsive intermediary layer cross-linked micelles from zwitterionic triblock copolymers and investigation of their drug-release behaviors","authors":"Agung Ari Wibowo, VURAL BÜTÜN","doi":"10.55730/1300-0527.3597","DOIUrl":"https://doi.org/10.55730/1300-0527.3597","url":null,"abstract":"ABC-type triblock copolymers, namely poly[(ethylene glycol)methyl ether]-block-poly(tert-butyl methacrylate)-block-poly[2-N-(diisopropylamino)ethyl methacrylate] (MPEG-b-PBuMA-b-PDPA), were first synthesized and then the middle blocks were successfully converted into poly(methacrylic acid) to obtain MPEG-b-PMAA-b-PDPA zwitterionic triblock copolymers. These block copolymers were soluble in water and formed micellar aggregates with complex cores via hydrogen bonding interactions between MPEG and PMAA blocks below pH 4.0. When the pH was between 5.0 and 7.0, due to charge compensation between partially protonated PDPA and partially ionized PMAA blocks, micelles with polyion complex cores were observed. If the solution pH was above 8.0, deprotonation of tertiary amine groups provided a hydrophobic character to the PDPA block, which resulted in the formation of PDPAcore micelles while MPEG/anionic PMAA hybrid blocks formed hydrated coronas. Intermediary layer cross-linked (ILCL) micelles from PDPA-core micelles were also prepared by cross-linking the inner PMAA shell. The hydrophobic drug dipyridamole (DIP) was used to investigate the release profile of ILCL micelles. DIP can be loaded to the PDPA cores of the micelles in basic aqueous media. An increase in the degree of cross-linking causes slower release for the model drug. It was concluded that the more complex matrix formation in the intermediary layer of the micelles via cross-linking retards the drug release from the core.","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135930603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of ketamine using melamine-modified gold nanoparticles","authors":"GÜLER GÜNEŞ, ZİYA CAN, AYŞEM ARDA, MUSTAFA REŞAT APAK","doi":"10.55730/1300-0527.3593","DOIUrl":"https://doi.org/10.55730/1300-0527.3593","url":null,"abstract":"Ketamine is used in medicine because of its anaesthetic and antidepressant effects at low doses. Unfortunately, due to its narcotic effect when used at high doses, its abuse among young people is increasing. It is also one of the most common drugs used in rape. Therefore, there is a need for fast and inexpensive tests that can be performed on-site. With the advancement of nanotechnology, nanoparticle-based approaches have found their place in selective analyses as in many fields. In the developed method, firstly gold nanoparticles were modified with melamine (AuNPs@Mel). Under optimized conditions, hydrogen bonds formed between ketamine and AuNPs@Mel cause the red colour of AuNPs@Mel to shift to blue-purple (i.e. aggregation-induced surface plasmon absorption shift). The association between absorbance and concentration produced a calibration line (curve) having a linearity correlation coefficient of 0.9981 for ketamine concentrations ranging from 4.76 to 47.6 mg L-1. The detection limit of the proposed method was 1.5 mg L-1 and the RSD (relative standard deviation) values of concentrations were changed ranging from 5.2% to 8.2%. The intra-assay and inter-assay measurements using the suggested method resulted in coefficients of variation (CVs) of 5.7% and 8.5%, respectively. Scan transmission electron microscopy (STEM), UV-vis spectrophotometry and FTIR spectroscopy were used to characterize the synthesized and modified AuNPs. Additionally, the procedure was successfully carried out with some interference materials and a real sample of fetal bovine serum. Lastly, using the Student t-test and F tests, the suggested technique was compared to and confirmed against an LC-MS/ MS procedure previously published","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"72 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135930899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green catalyst for clean fuel production via hydrodeoxygenation","authors":"SELVA BİLGE YÜCEL, YUSUF OSMAN DONAR, SAMED ERGENEKON, BEYZA ÖZOYLUMLU, ALİ SINAĞ","doi":"10.55730/1300-0527.3589","DOIUrl":"https://doi.org/10.55730/1300-0527.3589","url":null,"abstract":"The development of new fuel sources to replace nonrenewable fossil fuels has received substantial attention due to the ongoing demand for fossil fuels. Biomass and raw waste materials are crucial sources to produce suitable alternative fuels instead of nonrenewable fuels and offer a greener approach. Therefore, improving the fuel properties of biooils produced from the thermochemical conversion of biomass and raw waste materials is critical as it is used as an alternative to nonrenewable fuel. Developing an economical and eco-friendly method to produce sustainable and renewable oil by improving biooil containing large amounts of phenolic compounds has become imperative. One of the most intriguing and promising technologies for refining biooil to produce renewable fuels of comparable quality to conventional fossil fuels is the hydrodeoxygenation (HDO)-based process for converting biooil to renewable fuels. This method is almost one of the best improving methods described in the literature. At this point, it is of great importance that the HDO process is carried out catalytically. Carbon materials are preferred for both designing catalysts for HDO and supporting metal nanoparticles by providing chemically inert surfaces and tunable functional groups, high surface area and active sites. The HDO of biomass and raw waste materials has significantly advanced thanks to carbon-based catalysts. In this review, the effect of the surface character and catalytic ability of the carbon support, especially prepared by the green synthesis technique, on the HDO reaction during biooil improvement is discussed. Moreover, HDO reaction parameters and recent studies have been investigated in depth. Thus, green carbon catalysts? role in clean fuel production via the HDO process has been clarified.","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135930902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical DNA biosensors developed for the monitoring of biointeractions with drugs: a review","authors":"KADRİYE ARZUM ERDEM GÜRSAN, MUHAMMED HÜSEYİN ŞENTÜRK, ESMA YILDIZ GÖZ, MELTEM MARAL, AYLA YILDIRIM, AYŞEN BOZOĞLU, BURAK KIVRAK, NESLİHAN CEREN AY","doi":"10.55730/1300-0527.3584","DOIUrl":"https://doi.org/10.55730/1300-0527.3584","url":null,"abstract":"The interaction of drugs with DNA is important for the discovery of novel drug molecules and for understanding the therapeutic effects of drugs as well as the monitoring of side effects. For this reason, many studies have been carried out to investigate the interactions of drugs with nucleic acids. In recent years, a large number of studies have been performed to electrochemically detect drug-DNA interactions. The fast, sensitive, and accurate results of electrochemical techniques have resulted in a leading role for their implementation in this field. By means of electrochemical techniques, it is possible not only to demonstrate drug-DNA interactions but also to quantitatively analyze drugs. In this context, electrochemical biosensors for drug-DNA interactions have been examined under different headings including anticancer, antiviral, antibiotic, and central nervous system drugs as well as DNA-targeted drugs. An overview of the studies related to electrochemical DNA biosensors developed for the detection of drug-DNA interactions that were reported in the last two decades in the literature is presented herein along with their applications and they are discussed together with their future perspectives.","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"49 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135930903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amplifying the dielectric constant of shellac by incorporating natural clays for organic field effect transistors (OFETs)","authors":"SUNWOO KIM, CIGDEM YUMUSAK, CRISTIAN-VLAD IRIMIA, MATEUSZ BEDNORZ, ESMA YENEL, MAHMUT KUŞ, NİYAZİ SERDAR SARIÇİFTÇİ, BONG SUP SHIM, MIHAI IRIMIA","doi":"10.55730/1300-0527.3603","DOIUrl":"https://doi.org/10.55730/1300-0527.3603","url":null,"abstract":"We demonstrate in this work the practical use of uniform mixtures of a bioresin shellac and four natural clays, i.e. montmorillonite, sepiolite, halloysite and vermiculate as dielectrics in organic field effect transistors (OFETs). We present a thorough characterization of their processability and film forming characteristic, surface characterization, elaborate dielectric investigation and the fabrication of field effect transistors with two classic organic semiconductors, i.e. pentacene and fullerene C60. We show that low operating voltage of approximately 4 V is possible for all the OFETs using several combinations of clays and shellac. The capacitance measurements show an improvement of the dielectric constant of shellac by a factor of 2, to values in excess of 7 in the uniform mixtures of sepiolite and montmorillonite with this bioresin.","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"25 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135930910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterocyclic molecules with ESIPT emission: synthetic approaches, molecular diversities, and application strategies","authors":"NURETTİN MENGEŞ","doi":"10.55730/1300-0527.3585","DOIUrl":"https://doi.org/10.55730/1300-0527.3585","url":null,"abstract":"Excited-state intramolecular proton transfer (ESIPT) is one of the most essential emission processes in most circumstances because of its dual emission band in most cases and its high Stokes shifts. These distinguishing properties make ESIPT-based probes more suitable for a variety of applications, including analyte sensors, solid-state sensing mechanisms, optical technologies, and biomarkers for endogenous or exogenous compounds in various settings. As a result, researchers around the world are working on ESIPT emissions and developing different scaffolds for various applications or industry demands. This field of study is rapidly expanding and there is a need for an up-to-date review of synthesis methodologies and applications. This paper provides the highlights of ESIPT-based heterocyclic scaffolds, synthesis strategies, and application scenarios in the literature from 2017 to 2023","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135930606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of electrochemical-based sensors and immunosensors in terms of advantageous features for detection of cancer biomarkers","authors":"GÖKSU ÖZÇELİKAY, AHMET ÇETİNKAYA, SARİYE İREM KAYA, SİBEL AYŞIL ÖZKAN","doi":"10.55730/1300-0527.3587","DOIUrl":"https://doi.org/10.55730/1300-0527.3587","url":null,"abstract":"Cancer, becoming increasingly common globally, has a high mortality rate. Despite the much research on diagnosis and treatment methods, the benefits of technological developments, and newly developed sensor devices, cancer is still one of the leading causes of death worldwide. Early detection using powerful and noninvasive tools could be a future focus for prognosis and treatment follow-up. Therefore, electrochemical biosensors can be a strong choice for the detection of cancer biomarkers (such as alpha-fetoprotein, cytochrome c, prostate-specific antigen, myoglobin, carcinoembryonic antigen, alpha-fetoprotein, a cancer antigen, epidermal growth factor receptor, vascular endothelial growth factor, circulating tumor cell, and breast cancer antigen 1/2) due to their advantages such as high sensitivity, excellent selectivity, low cost, short analysis time, and simplicity. Furthermore, electrochemical biosensors are better suited for point-of-care applications due to their mass production and miniaturization ease. This review provides an overview of different electrochemical measurement techniques, bioreceptor surfaces, signal production and amplification, and the integration of electrochemical-modified sensors. Cancer biomarkers based on electrochemical biosensors were given in detail. In addition, studies with MIP-based sensors and immunosensors have been extensively discussed. Integrating electrochemical biosensors with cancer biomarkers was also emphasized as a new research trend. Finally, we provide an overview of current advances in measuring and analyzing cancer biomarkers using electrochemical biosensors and detail current challenges and future perspectives","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"72 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135930908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chromium speciation in water using magnetic polyaniline nanoparticles coupled with microsampling injection-flame atomic absorption spectroscopy.","authors":"Osman Çaylak","doi":"10.55730/1300-0527.3636","DOIUrl":"10.55730/1300-0527.3636","url":null,"abstract":"<p><p>The chromium speciation procedure was optimized using magnetic polyaniline nanoparticles (Fe₃O₄@PANI NPs) solid-phase extraction coupled with microsampling injection-flame atomic absorption spectrometry (MIS-FAAS). Chromium speciation was successfully achieved by Fe₃O₄@PANI NPs at pH 8.0. The recoveries obtained for Cr(III) and Cr(VI) were above 95% and under 5%, respectively. Recoveries of over 95% for Cr(III) from 40.0 mL of the sample were obtained using 25 mg Fe₃O₄@PANI NPs and 500 μL of 0.2% (w/v) thiourea (TU) solution prepared in 2 mol L^-1 HCl as eluent. Total chromium as Cr(III) was extracted quantitatively after reducing the Cr(VI) to Cr(III). The linear range, detection limit, preconcentration factor, and precision of the optimized method for Cr(III) in aqueous solution were 2.5-94.0 μg L^-1, 0.335 μg L^-1, 80, and 3.07%, respectively. The validation of the method was controlled using SPS-WW2 Batch 114 wastewater and BCR-715 industrial wastewater as standard reference materials (SRMs) for environmental water, and the obtained results were in close agreement with the certified values.</p>","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"48 1","pages":"21-35"},"PeriodicalIF":1.4,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10965163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of convective heat transfer coefficients on thermal behaviour of a lithium-ion cell: a numerical study.","authors":"Uğur Morali","doi":"10.55730/1300-0527.3645","DOIUrl":"https://doi.org/10.55730/1300-0527.3645","url":null,"abstract":"<p><p>In the current study, the impact of C-ratio, convective heat transfer coefficient, and free stream temperature on the maximal cell temperature and temperature uniformity was computationally and statistically examined. Results revealed that the free stream temperature was the main influential factor for the maximal cell temperature for both natural and forced convection conditions while the C-ratio was the most effective parameter for the temperature uniformity for both natural and forced convections. On the other hand, the contribution of the free stream temperature to the maximum battery temperature increased from 63% to 94% when the conditions were changed from natural convection to forced convection. Moreover, the contribution of the C-rate to the temperature uniformity decreased from 89% to 79% when the conditions were changed from natural convection to forced convection. The results obtained from this study are significant in terms of determining which factor should be given more importance under natural and forced convection conditions.</p>","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"48 1","pages":"128-136"},"PeriodicalIF":1.4,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10965165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection and characterization of the <i>Pichia manshurica</i> biofilm on the traditionally produced homemade apple vinegar.","authors":"Zeynep Işlek Köklü, Pınar Akkuş Süt, Esra Eskihoran Üçüncüoğlu, Sadık Kalayci, Fikrettin Şahin","doi":"10.55730/1300-0527.3640","DOIUrl":"10.55730/1300-0527.3640","url":null,"abstract":"<p><p><i>Pichia</i> yeasts are capable of forming biofilms during vinegar production and causing spoilage in various beverages. In addition, there exists a significant likelihood of encountering yeast contamination which can prevent vinegar production. The present study investigates the detection and characterization of the <i>Pichia manshurica</i> (<i>P. manshurica</i>) biofilm on traditionally produced homemade apple vinegar. The unique characteristics of vinegar were analyzed with a focus on the constituent, known as the \"mother of vinegar\", whose composition is comprised of cellulosic biofilm and acetic acid bacteria, including <i>Gluconobacter oxydans</i> (<i>G. oxydans</i>) Briefly, <i>P. manshurica</i> was isolated from apple vinegar and characterized in terms of the effect of biofilm formation on the surface of the cellulosic film on vinegar production. Microbial identification of vinegar with/without contamination by <i>P. manshurica</i> was analyzed through MALDI-TOF mass spectrometry (MS), and biofilm was characterized by Fourier transform infrared spectroscopy (FT-IR), Scanning electron microscopy (SEM), and crystal violet staining. Accordingly, MS spectrum of isolates was identified as <i>G. oxydans</i> and <i>P. manshurica</i> with a ratio of 2.01 and 1.94, respectively. The FTIR analysis indicated that the peaks within the range of 1150-900 cm^-1 revealed a high content of polysaccharide in <i>P. manchuria-</i>contaminated biofilm, which is attributed to the stretching vibration of C-C and C-O bonds. The spectral region from 2921.51 to 2853.71 cm^-1 exhibited the characteristic of lipids in bacterial cell walls and membranes. SEM images of bacterial biofilms revealed a three-dimensional network composed of ultrafine fibers with a ribbon-like shape; however, the condensed reticulated structure was observed in contaminated biofilms. The presence of two microbial populations was detected regarding the morphological analysis. Crystal violet staining of contaminated-cellulosic biofilms visualized bacterial and yeast colonization. Concisely, this study emphasizes that the proliferation of <i>Pichia</i> during apple fermentation has the potential to adversely affect the quality of the homemade vinegar, due to its distinct biofilm characteristics.</p>","PeriodicalId":23367,"journal":{"name":"Turkish Journal of Chemistry","volume":"48 1","pages":"76-84"},"PeriodicalIF":1.4,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10965164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}