Turkish journal of urology最新文献

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The Relationship Between Metabolic Syndrome and Benign Prostate Enlargement: A Case-Control Study in a Peruvian Military Hospital. 代谢综合征与良性前列腺增生的关系:秘鲁某军事医院的病例对照研究
IF 1.3
Turkish journal of urology Pub Date : 2023-01-01 DOI: 10.5152/tud.2023.22236
Valeria Ugarte-Carbajal, José M Vela-Ruiz, Vela-Rui Guillen-Ponce, Lucy E Correa-López, Verónica Rubin-de-Celis, Jhony A De La Cruz-Vargas
{"title":"The Relationship Between Metabolic Syndrome and Benign Prostate Enlargement: A Case-Control Study in a Peruvian Military Hospital.","authors":"Valeria Ugarte-Carbajal,&nbsp;José M Vela-Ruiz,&nbsp;Vela-Rui Guillen-Ponce,&nbsp;Lucy E Correa-López,&nbsp;Verónica Rubin-de-Celis,&nbsp;Jhony A De La Cruz-Vargas","doi":"10.5152/tud.2023.22236","DOIUrl":"10.5152/tud.2023.22236","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to determine how metabolic syndrome is related to benign prostatic enlargement in males under 60 years old in a national military hospital in Peru.</p><p><strong>Materials and methods: </strong>We conducted a retrospective, quantitative, case-control study. By simple random sampling, 87 cases with benign prostatic enlargement and 174 controls were included, with a statistical power of 80%. The benign prostatic enlargement was evaluated by clinical picture and ultrasound and the metabolic syndrome was evaluated according to the Adult Treatment Panel III criteria. The statistical analysis was performed using the STATAv14 program, the chi-square statistical test was used and odds ratio was obtained, at a significance level of 5%.</p><p><strong>Results: </strong>The mean age of the cases and controls was 55 (51-58) and 52 (46-57), respectively. By multivariate analysis, the factors related to benign prostatic enlargement were the presence of benign prostatic enlargement (adjusted odds ratio: 2.71, 95% CI: 1.27-5.80; P=.010), waist circumference ≥102 cm (adjusted odds ratio: 6.51, 95% CI: 3.09-13.71; P < .001), elevated fasting glucose (adjusted odds ratio: 1.38, 95% CI: 0.65-2.91; P=.399), high triglycerides (adjusted odds ratio: 5.29, 95%: CI 2.40-11.64; P < .001), and arterial hypertension (adjusted odds ratio: 4.67, 95% CI 2.19-9.95; P < .001). Elevated high-density lipoprotein cholesterol was a protective factor (adjusted odds ratio: 0.09, 95% CI: 0.04-0.20; P < .001).</p><p><strong>Conclusion: </strong>The present study showed that metabolic syndrome and its components (waist circumference, hypertension, triglycerides, and high-density lipoprotein cholesterol) are factors related to benign prostatic enlargement in patients under 60 years old in a military hospital in Peruvian population. Waist circumference as an indicator of overweight/obesity is a practical anthropometric marker of interest in public health.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/52/15/tju-49-1-19.PMC10081046.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47529592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies to Increase Testosterone in Men Seeking Fertility. 寻求生育能力的男性增加睾丸激素的策略。
IF 1.3
Turkish journal of urology Pub Date : 2023-01-01 DOI: 10.5152/tud.2020.20436
Kevin Y Chu, Justin K Achua, Ranjith Ramasamy
{"title":"Strategies to Increase Testosterone in Men Seeking Fertility.","authors":"Kevin Y Chu,&nbsp;Justin K Achua,&nbsp;Ranjith Ramasamy","doi":"10.5152/tud.2020.20436","DOIUrl":"10.5152/tud.2020.20436","url":null,"abstract":"<p><p>Prevalence of testosterone deficiency is increasing in the adolescent and young adult male population. As the average paternal age rises, there is a significant population of men with hypogonadism seeking testosterone therapy wishing to achieve or maintain fertility potential. Identification of potential lifestyle modifications that may improve the testosterone deficiency is one of the initial interventions of the holistic strategy in treatment. This is followed by drug therapy; however, traditional testosterone therapy acts as a contraceptive by suppressing the hypothalamus-pituitary-gonadal (HPG) axis and therefore cannot be used as a treatment strategy. A solution has been the off-label use of selective estrogen receptor modulators, human chorionic gonadotropin (hCG), and anastrozole inhibitors to treat hypogonadal symptoms while increasing intratesticular testosterone, a necessity for spermatogenesis. Recently, a novel therapy, Natesto intranasal testosterone gel, has been shown to increase serum testosterone levels while maintaining semen parameters. This is hypothesized to be because of its short-acting properties having lesser effect on the HPG axis, in contrast to the long-acting properties of traditional testosterone therapy. It is important to differentiate hypogonadal men between those seeking to achieve or maintain fertility status because the drug therapy of choice differs. This can be accomplished by determining the levels of 17-hydroxyprogesterone (17-OHP), because it is a biomarker for intratesticular testosterone. Those with low 17-OHP may wish to initiate treatment with alternative therapies, whereas those with high 17-OHP may trial short-acting testosterone therapies. As the urologist's armamentarium continues to increase, better strategies to increase testosterone levels in men seeking fertility can be achieved.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38513662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Artificial Urinary Sphincter in a High-Risk Urethra: Transcorporal Gullwing Modification Description of the Technique. 人工尿道括约肌在高危尿道:经下体鸥翼修饰技术描述。
IF 1.3
Turkish journal of urology Pub Date : 2022-11-01 DOI: 10.5152/tud.2022.22134
David Hernández-Hernández, María Yanira Ortega-González, Bárbara Padilla-Fernández, David Manuel Castro-Díaz
{"title":"Artificial Urinary Sphincter in a High-Risk Urethra: Transcorporal Gullwing Modification Description of the Technique.","authors":"David Hernández-Hernández,&nbsp;María Yanira Ortega-González,&nbsp;Bárbara Padilla-Fernández,&nbsp;David Manuel Castro-Díaz","doi":"10.5152/tud.2022.22134","DOIUrl":"https://doi.org/10.5152/tud.2022.22134","url":null,"abstract":"<p><strong>Background: </strong>In this report, we describe a modification of transcorporal artificial urinary sphincter place ment known as Gullwing modification.</p><p><strong>Description of technique: </strong>Using a penoscrotal approach, bilateral corpora cavernosa flaps are harvested and sutured in the midline covering the lateral and ventral surfaces of the urethra. Transcorporal cuff placement provides dorsal reinforcement, thus having extra tissue buttressing all the circumference in cases of a fragile urethra due to previous urethral cuff erosion, urethroplasty, or pelvic radiotherapy.</p><p><strong>Patient and methods: </strong>After previous urethral cuff erosion, radiotherapy, and urethral reconstruction, our patient complained of severe stress urinary incontinence. Due to the high risk of urethral complications, we proceed to a transcorporal artificial sphincter placement with urethral reinforcement through a bilateral cavernosal flap.</p><p><strong>Results: </strong>The surgery was successfully completed, and after 6 weeks, sphincter was activated with satisfac tory results. Two years after surgery, his continence status is stable without complications.</p><p><strong>Conclusion: </strong>Urethral complications associated with artificial urinary sphincter surgery remain a challenge for the reconstructive surgeon. Reinforcement of the ventral aspect of the urethra through corpora cavernosal flaps may reduce the likelihood of urethral erosion in high-risk cases.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10818557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AHNAK2 Urinary Protein Expression as Potential Biomarker for Bladder Cancer Detection: A Pilot Study. AHNAK2尿蛋白表达作为膀胱癌检测的潜在生物标志物:一项初步研究
IF 1.3
Turkish journal of urology Pub Date : 2022-11-01 DOI: 10.5152/tud.2022.22132
Selim Komina, Gordana Petrusevska, Rubens Jovanovic, Slavica Kostadinova Kunovska, Sotir Stavridis, Saso Dohcev, Skender Saidi, Sonja Topuzovska
{"title":"AHNAK2 Urinary Protein Expression as Potential Biomarker for Bladder Cancer Detection: A Pilot Study.","authors":"Selim Komina,&nbsp;Gordana Petrusevska,&nbsp;Rubens Jovanovic,&nbsp;Slavica Kostadinova Kunovska,&nbsp;Sotir Stavridis,&nbsp;Saso Dohcev,&nbsp;Skender Saidi,&nbsp;Sonja Topuzovska","doi":"10.5152/tud.2022.22132","DOIUrl":"https://doi.org/10.5152/tud.2022.22132","url":null,"abstract":"Objective: This study aimed to measure the AHNAK2 urinary levels in bladder cancer patients. Material and methods: This prospective case–control study enrolled 67 participants between January and March 2019 and were categorized into bladder cancer group (n = 37), with histologically proven bladder cancer, and control group (n = 30), with histologically verified benign lesions or with no bladder cancer indication during follow-up. Urine samples of 15 mL were collected in the mid-morning before cystoscopy/surgery and an enzyme-linked immunosorbent assay was performed as per the manufacturer’s protocol. Bladder malignancies were classified according to the World Health Organization Tumor Classification. Group’s associations were evaluated with the Student t-test, Spearman’s rank correlation, and Mann–Whitney U test, while receiver operating curve was plotted for assessing the test’s performance. Results: Mean age of the bladder cancer group was 66.41 years (standard deviation = 10.04, range = 43-82 years) and the control group was 59.67 years (standard deviation = 10.44, range = 38-77 years). All bladder cancers were of the urothelial histotype, with the following pT distribution: pTa/papillary urothelial neoplasm of low malignant potential (n = 19; 28.4%), Primary tumor (pT) in situ (n = 4; 6%), pT1 (n = 7; 10.4%), and pT≥2 (n = 7; 10.48%). Mean AHNAK2 levels were higher in bladder cancer patients 49.08 pg/mL (standard deviation = 114.91) compared to controls 5.28 pg/mL (standard deviation = 6.65), P < .05). Significant differences were noted between non-invasive bladder cancer (n = 23; mean = 7.14 pg/mL; standard deviation = 7.26) and invasive bladder cancer (n = 14; mean = 117.99 pg/mL; standard deviation = 168.08) and between non-muscle invasive bladder cancer (mean = 23.19 pg/mL; standard deviation = 66.93) and muscle-invasive bladder cancer (mean = 160.05 pg/mL; standard deviation = 199.65) (P < .001). The result of the assays was given as follows: sensitivity: 64.19%, specificity: 66.67%, positive predictive value: 22.07%, negative predictive value: 92.37%, area under curve: 0.695, and 95% CI: 0.57-0.82. Conclusion: AHNAK2 protein could be used as bladder cancer surveillance biomarker. The inclusion of AHNAK2 levels in stratification nomograms might reduce the number of unnecessary cystoscopies.","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10452061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Revision Labiaplasty After Penile Inversion Vaginoplasty Using Costal Cartilage Allograft. 异体肋软骨移植阴茎内翻阴道成形术后阴唇矫正成形术。
IF 1.3
Turkish journal of urology Pub Date : 2022-11-01 DOI: 10.5152/tud.2022.22079
Nicholas Sellke, Michael Callegari, Kirtishri Mishra, Tobias Long, Shubham Gupta
{"title":"Revision Labiaplasty After Penile Inversion Vaginoplasty Using Costal Cartilage Allograft.","authors":"Nicholas Sellke,&nbsp;Michael Callegari,&nbsp;Kirtishri Mishra,&nbsp;Tobias Long,&nbsp;Shubham Gupta","doi":"10.5152/tud.2022.22079","DOIUrl":"https://doi.org/10.5152/tud.2022.22079","url":null,"abstract":"<p><strong>Background: </strong>Gender-affirming surgery leads to high satisfaction for patients; however, patients often require revision surgery. Revision labiaplasty is one of the most common surgeries following vaginoplasty. The labia minora commonly become incorporated into the labia majora and lose definition even after revision leading to patient dissatisfaction.</p><p><strong>Description of technique: </strong>We propose a technique of incorporating cadaveric costal cartilage allograft into the revised labia minora to increase the definition.</p><p><strong>Patient and methods: </strong>The procedure was demonstrated in a 38-year-old MTF patient who had previously undergone inversion vaginoplasty. The cartilage allograft was incorporated within the labia minora flaps dur ing labiaplasty.</p><p><strong>Results: </strong>The patient had lasting definition of her labia minora post-operatively at 6 weeks without adverse effects.</p><p><strong>Conclusion: </strong>We believe that this technique may be effective and safe in patients requesting more defined labia minora after vaginoplasty.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10818560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Evaluation of the First Bahname Written in Turkish in the Ottoman Era Concerning Current Urology. 对奥斯曼帝国时期第一本用土耳其语撰写的有关当前泌尿外科的书名的评价。
IF 1
Turkish journal of urology Pub Date : 2022-11-01 DOI: 10.5152/tud.2022.22104
Muhammet Ihsan Karaman, Adem Az
{"title":"The Evaluation of the First Bahname Written in Turkish in the Ottoman Era Concerning Current Urology.","authors":"Muhammet Ihsan Karaman, Adem Az","doi":"10.5152/tud.2022.22104","DOIUrl":"10.5152/tud.2022.22104","url":null,"abstract":"<p><strong>Objective: </strong>Our study investigated the oldest known Turkish bahname, translated by Musa b. Mes'ud, in comparison with the current literature.</p><p><strong>Material and methods: </strong>First, the original manuscript of the translation was transcribed in Latin. The final version of the text was analyzed in the results. In discussion, findings were examined and interpreted within the framework of current knowledge of sexology, urology, and andrology.</p><p><strong>Results: </strong>Although the work mostly mentions supportive and therapeutic practices in sexual health, it also provides advice on sexuality and sexual life, discussing several topics regarding sexual intercourse types, explaining which ones are good or harmful, and their timing or frequency. The author recommends many foods and compounds or specific drugs and ointments to enhance sexual stamina and avoid erectile dysfunc tion. In addition, he also tries to find solutions to some other sexual health problems related to men and women. These issues are generally evaluated in the context of health; a religious perspective is also provided when needed.</p><p><strong>Conclusion: </strong>Interestingly, the author's recommendations on sexual health and herbal or animal drugs are consistent with the current literature. Nevertheless, some information and suggestions in works are entirely irrational and unscientific. Consequently, this study is an original investigation of the first translated bahname into Turkish. There is no other study examining the bahnames with this method. Thus, we believe that our work will be a significant contribution to the research literature.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10452060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intestinal Microbiota Correction in the Treatment and Prevention of Urinary Tract Infection. 纠正肠道菌群在治疗和预防尿路感染中的作用。
IF 1.3
Turkish journal of urology Pub Date : 2022-11-01 DOI: 10.5152/tud.2022.22119
Nikolay V Sturov, Sergey V Popov, Vladimir A Zhukov, Tatiana V Lyapunova, Ekaterina I Rusanova, Georgy N Kobylyanu
{"title":"Intestinal Microbiota Correction in the Treatment and Prevention of Urinary Tract Infection.","authors":"Nikolay V Sturov,&nbsp;Sergey V Popov,&nbsp;Vladimir A Zhukov,&nbsp;Tatiana V Lyapunova,&nbsp;Ekaterina I Rusanova,&nbsp;Georgy N Kobylyanu","doi":"10.5152/tud.2022.22119","DOIUrl":"https://doi.org/10.5152/tud.2022.22119","url":null,"abstract":"<p><p>Intestinal microbiota is a topical subject of modern research. The maintenance of a healthy intestinal micro biota is an important component of homeostasis, and violations of its composition and functions, called dysbiosis, are associated with a number of diseases, including urinary tract infections. Antimicrobial therapy leads to significant changes in the intestinal microbiota and causes the possibility of urinary tract infection recurrence. In this regard, it is important to study methods of microbiota correction in order to restore its structural and functional integrity.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10818554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Initial Experience of Hybrid Technique in Robot-Assisted Intracorporeal Ileal Conduit. 混合技术在机器人辅助体内回肠导管中的初步应用。
IF 1.3
Turkish journal of urology Pub Date : 2022-11-01 DOI: 10.5152/tud.2022.22125
Shugo Yajima, Yasukazu Nakanishi, Yousuke Umino, Naoya Ookubo, Kenji Tanabe, Madoka Kataoka, Hitoshi Masuda
{"title":"Initial Experience of Hybrid Technique in Robot-Assisted Intracorporeal Ileal Conduit.","authors":"Shugo Yajima,&nbsp;Yasukazu Nakanishi,&nbsp;Yousuke Umino,&nbsp;Naoya Ookubo,&nbsp;Kenji Tanabe,&nbsp;Madoka Kataoka,&nbsp;Hitoshi Masuda","doi":"10.5152/tud.2022.22125","DOIUrl":"https://doi.org/10.5152/tud.2022.22125","url":null,"abstract":"<p><strong>Objective: </strong>This study was designed to describe our hybrid approach to intracorporeal urinary diversion and evaluate surgical experience during initial induction.</p><p><strong>Material and methods: </strong>Clinical data from 38 patients with bladder cancer undergoing robot-assisted radical cystectomy with ileal conduit hybrid approach to intracorporeal urinary diversion at our institution between May 2020 and January 2022 were reviewed. The hybrid approach to intracorporeal urinary diversion pro cedure involved the following: radical cystectomy, removing a specimen through a 4- to 6-cm skin incision, harvesting an ileal conduit, redocking the robot, and uretero-uretero anastomosis. The relationship between surgical experience and operative time and a Clavien-Dindo classification of grade >3 was evaluated.</p><p><strong>Results: </strong>Of the 38 patients, 30 (79%) were male, and the median age was 75 years (interquartile range, 71-80 years). The total operative time was 384 minutes (interquartile range, 348-409 minutes). The estimated blood loss was 244 mL (interquartile range, 124-445 mL). No bowel injuries or conversions to laparoscopy or laparotomy were encountered. High-grade postoperative complications (Clavien-Dindo classification grade > 3) occurred in 7 cases (19%). The overall 90-day readmission rate following discharge after surgery was 5%. The relationship between surgical experience and operative time was nonlinear. A plateau was not reached in all 38 patients.</p><p><strong>Conclusion: </strong>Our hybrid approach to intracorporeal urinary diversion technique can be accomplished safely with acceptable operative times, even with little surgical experience. This procedure might be a safe treat ment option that is relatively easy to perform, particularly in an institution that has not yet introduced intra corporeal urinary diversion. Future randomized trials with larger samples and longer follow-up periods are required to confirm our findings.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10452057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biopsy with Ureterorenoscopy Before Radical Nephroureterectomy is Associated with Increased Intravesical Recurrence in Urothelial Cancer Located in the Kidney. 根治性肾输尿管切除术前输尿管镜活检与位于肾脏的尿路上皮癌膀胱内复发增加相关。
IF 1.3
Turkish journal of urology Pub Date : 2022-11-01 DOI: 10.5152/tud.2022.22143
Meftun Culpan, Mehmet Caglar Cakici, Ferhat Keser, Mehmet Yigit Yalcin, Taner Kargi, Rıdvan Kayar, Erdal Abay, Gorkem Ozenc, Ali Kumcu, Mehmet Pehlivanoglu, Semih Turk, Erdem Kisa, Selcuk Sahin, Metin Ishak Ozturk, Alper Otunctemur, Resul Sobay, Huseyin Cihan Demirel, Omer Yilmaz, Gokhan Atis, Muhammet Abdurrahim Imamoglu, Asif Yildirim
{"title":"Biopsy with Ureterorenoscopy Before Radical Nephroureterectomy is Associated with Increased Intravesical Recurrence in Urothelial Cancer Located in the Kidney.","authors":"Meftun Culpan,&nbsp;Mehmet Caglar Cakici,&nbsp;Ferhat Keser,&nbsp;Mehmet Yigit Yalcin,&nbsp;Taner Kargi,&nbsp;Rıdvan Kayar,&nbsp;Erdal Abay,&nbsp;Gorkem Ozenc,&nbsp;Ali Kumcu,&nbsp;Mehmet Pehlivanoglu,&nbsp;Semih Turk,&nbsp;Erdem Kisa,&nbsp;Selcuk Sahin,&nbsp;Metin Ishak Ozturk,&nbsp;Alper Otunctemur,&nbsp;Resul Sobay,&nbsp;Huseyin Cihan Demirel,&nbsp;Omer Yilmaz,&nbsp;Gokhan Atis,&nbsp;Muhammet Abdurrahim Imamoglu,&nbsp;Asif Yildirim","doi":"10.5152/tud.2022.22143","DOIUrl":"https://doi.org/10.5152/tud.2022.22143","url":null,"abstract":"<p><strong>Objective: </strong>Diagnostic ureterorenoscopy is used to identify upper tract urothelial cancer before radical nephro ureterectomy, especially for uncertain lesions in imaging modalities or urine cytology. However, diagnostic ureterorenoscopy can potentially cause intravesical tumor spillage and can increase intravesical recurrence rates. We aimed to investigate the impact of diagnostic ureterorenoscopy before radical nephroureterectomy, with and without biopsy, on intravesical recurrence rates of patients with upper tract urothelial cancer.</p><p><strong>Material and methods: </strong>Patients with localized upper tract urothelial cancer from 8 different tertiary referral centers, who underwent radical nephroureterectomy between 2001 and 2020, were included. Three groups were made: no URS (group 1); diagnostic ureterorenoscopy without biopsy (group 2); and diagnostic ure terorenoscopy with biopsy (group 3). Intravesical recurrence rates and survival outcomes were compared. Univariate and multivariate Cox regression analyses were performed to determine the factors that were asso ciated with intravesical recurrence-free survival.</p><p><strong>Results: </strong>Twenty-two (20.8%), 10 (24.4%), and 23 (39%) patients experienced intravesical recurrence in groups 1, 2, and 3, respectively (P=.037) among 206 patients. The 2-year intravesical recurrence-free sur vival rate was 83.1%, 82.4%, and 69.2%, for groups 1, 2, and 3, respectively (P=.004). Cancer-specific survival and overall survival were comparable (P=.560 and P=.803, respectively). Diagnostic ureterore noscopy+biopsy (hazard ratio: 6.88, 95% CI: 2.41-19.65, P < .001) was the only independent predictor of intravesical recurrence in patients with upper tract urothelial cancer located in the kidney, according to tumor location.</p><p><strong>Conclusion: </strong>Diagnostic ureterorenoscopy+biopsy before radical nephroureterectomy significantly increased the rates of intravesical recurrence in tumors located in kidney. This result suggests tumor spillage with this type of biopsy, so further studies with different biopsy options or without biopsy can be designed.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10818556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Algorithm for the Management of Hematospermia. 血精症治疗的新算法。
IF 1.3
Turkish journal of urology Pub Date : 2022-11-01 DOI: 10.5152/tud.2020.20428
Ozan Efesoy, Selahittin Çayan, Erdem Akbay
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