Trends in Medicine最新文献

{"title":"Dyslipoproteinemia therapy with lipoprotein-apheresis and/or human monoclonal antibodies","authors":"R. Bambauer, R. Schiel","doi":"10.15761/TIM.1000182","DOIUrl":"https://doi.org/10.15761/TIM.1000182","url":null,"abstract":"The prognosis of patients suffering from severe dyslipoproteinemia, sometimes combined with elevated lipoprotein (a) (Lp(a)), and coronary artery disease (CAD) refractory to diet and lipid-lowering drugs has been improved by the introduction of the lipoprotein-apheresis, and the human monoclonal antibodies (HMA) in different studies. All severe forms of dyslipoproteinemia can be treated successfully with these methods alone or in combination. Different lipoprotein-apheresis systems are available which reduce LDL cholesterol, Lp(a), triglycerides and others: cascade filtration or lipoproteinfiltration, immunoadsorption, heparin-induced LDL precipitation, dextran sulfate LDL adsorption, LDL hemoperfusion, and/or different HMA. There is a strong correlation between dyslipoproteinemia and atherosclerosis. Besides the elimination of other risk factors in severe dyslipoproteinemia therapeutic strategies focus on a drastic reduction of serum lipoproteins. In such patients in whom the maximum drug therapy failed, lipoprotein-apheresis (LA) is indicated. Technical and clinical aspects of these different lipoproteinapheresis methods and results of the application of HMA are shown here. The published data clearly demonstrate that treatment with lipoprotein-apheresis in patients suffering from severe dyslipoproteinemia refractory to conservative therapy are effective and safe in long application. A disadvantage is the high costs and the expensive technologies of the different lipoprotein-apheresis methods. The costs of the therapy with HMA are lower than the costs of the lipoprotein-apheresis but larger studies are necessary to show what method could be preferred. *Correspondence to: Rolf Bambauer, MD, PhD, Frankenstrasse 4, 66424 Homburg, Germany, Tel: 0049/(0)6841/68500; Fax: 0049/(0)6841/68561; E-mail: rolf.bambauer@t-online.de","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88546820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community-acquired pneumonia as a cause of sepsis","authors":"G. Bozóky, É. Ruby","doi":"10.15761/tim.1000185","DOIUrl":"https://doi.org/10.15761/tim.1000185","url":null,"abstract":"Sepsis is an infectious agent attacking (invading) the organism, the immune response of the organism, the consequence of the cumulation of complex interaction developing between the inflammatory and coagulation systems [1-6]. The fundamental cornerstone of the determination of sepsis is the assumed or proved infection and the systemic inflammatory response reaction of the organism, (SIRS=systemic inflammatory response syndrome) accompanied with symptoms and clinical signs of fever, tachycardia, tachypnoea, hypotension and leucocytosis [1,7,8].","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88861609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental approach to the recognition of truthful and false mental responses based on the wavelet transform of the electroencephalogram","authors":"Yumatov Ea, Potapov Vyu, Karatygin Na, Dudnik En, Pertsov Ss","doi":"10.15761/tim.1000199","DOIUrl":"https://doi.org/10.15761/tim.1000199","url":null,"abstract":"An existing polygraph technique to evaluate the faithfulness of the verbal response is based on recoding of psychophysiological and somatic-and-autonomic indices, which do not reflect the actual deceitful or truthful state of the subject's brain. The advanced method of electroencephalogram wavelet transform was developed in recent years. This approach allowed us to determine a principle possibility for the direct, objective recording of mental activity in the human brain. The overall goal of the research is to develop a fundamentally new information technology to identify a truthful and deceitful state in the brain mental activity, which suggests the wavelet transform of the electroencephalogram and machine learning. For this purpose, an experimental model and software have been created and described in the article for recognizing the truthful and false mental responses of a person based on the electroencephalogram analysis. The software was developed with Microsoft Visual Studio 2017 and Net Framework 4.5. This software is simple in use and works with the Russian language interface. The developed experimental model and information-software allow us to compare electroencephalographic indicators of two mental states of brain activity, one of which is deceitful, and the other is truthful. *Correspondence to: Yumatov EA, PK Anokhin Research Institute of Normal Physiology, Moscow, Russia, E-mail: eayumatov@mail.ru","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73947609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclavian aneurysm-tracheal fistula presenting with massive hemoptysis, a diagnostic dilemma to the emergency room personnel - A case report","authors":"Logn Falsk","doi":"10.15761/TIM.1000169","DOIUrl":"https://doi.org/10.15761/TIM.1000169","url":null,"abstract":"Introduction: Subclavian aneurysm presenting as a massive hemoptysis has never been reported in the literature, the aim of the current study is to report for the first time, subclavian aneurysm-tracheal fistula presenting with massive hemoptysis. Case report: A 56-year-old female presented with massive hemoptysis which was aggravated in the last two days. The patient was known case of TB received antituberculosis and cured. General examination showed pallor. Chest X-ray, CT scan and bronchoscopy was normal. Subclavian conventional angiography showed a fistula between left proximanl subclavian artery aneurysm and upper part of the trachea. After stabilization, the patient underwent operation, ligation of the right proximal subclavian artery, division, and transposition of the subclavian artery to the left bracheocephalic trunk. Conclusion: Subclavian aneurysm-tracheal fistula presenting with massive hemoptysis has been reported for the first time in the literature. It presented as a diagnostic dilemma to the emergency room personnel. *Correspondence to: Logn Falsk, MD, Blekinge Hospital, Department of Vascular Surgery, Karlskrona, Sweden, Tel: 00467234652; Fax: 105157247950; E-mail: lognfalsk1@gmail.com","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91421305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and reliability of the finkelstein test","authors":"Areti-zoi Cheimonidou, D. Lamnisos, A. Lisacek-Kiosoglous, C. Chimonas, D. Stasinopoulos","doi":"10.15761/tim.1000183","DOIUrl":"https://doi.org/10.15761/tim.1000183","url":null,"abstract":"1Physiotherapy Program, Department of Health Sciences, School of Sciences, European University Cyprus, Diogenes 6 Street. Engomi, P.O.Box 22006, 1516, Nicosia, Cyprus 2Department of Health Sciences, School of Sciences, European University Cyprus, Diogenes 6 Street. Engomi, P.O. Box 22006, 1516, Nicosia, Cyprus 3School of Medicine, European University Cyprus, Diogenes 6 Street. Engomi, P.O. Box 22006, 1516, Nicosia, Cyprus 4Director of Cyprus Musculoskeletal and Sports Trauma Research Centre (CYMUSTREC), Diogenes 6 Street. Engomi, P.O. Box 22006, 1516, Nicosia, Cyprus","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91514143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypotensive effect of resistance exercises performed with different intensities in hypertensive elderly women","authors":"Nívea Maria de Oliveira Jacques, Felipe J Aidar, L. Leitão, M. Espada, Aldo M. Costa, Ana Pereira","doi":"10.15761/tim.1000211","DOIUrl":"https://doi.org/10.15761/tim.1000211","url":null,"abstract":"Systemic arterial hypertension represents one of the principal risk factors for the increase of cardiovascular diseases, especially in the elderly people. On post-exercise, blood pressure responses (BP) may decrease and this effect have a relevant clinical importance. However, further studies are needed to better understand the effects of different intensities and exercise modes. The aim of this study was to analyse the hypotensive effect of resistance exercises on BP of controlled hypertensive women performed at different intensities. The study sample was composed by 13 hypertensive elderly women (65.5±4.2 years), submitted to two different training intensities: 50% and 70% of 10 RM. After the resistant exercise systolic and diastolic blood pressure were measured during 1 hour and every 10 minutes. Significant differences were found only in diastolic blood pressure (DBP) measured at 10 (p=0.034), 20 (p=0.042), 30 (p=0.031), 45 (p=0.035) and 60 minutes (p=0.017) after the effort. Our data suggest that resistance exercise does not result in PEH in hypertensive elderly women without significant effects on diastolic blood pressure at different intensities. *Correspondence to: Aldo M. Costa, Department of Sports Sciences, University of Beira Interior, Covilhã, Portugal, Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, Vila Real, Portugal, Health Sciences Research Center, CICS-UBI, Covilhã, Portugal, E-mail: anapereiraphd@gmail.com","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86497339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of frequency of Rhopalurus junceus scorpion venom collection on protein content and biological activity","authors":"A. Díaz-García, Arianna Yglesias-Rivera, Jenny L. Ruiz-Fuentes, Rayner Ochoa-Cardentey, Jose Raúl Torres Viltres, Hermis Rodríguez-Sánchez, Tania Gómez Peña","doi":"10.15761/tim.1000216","DOIUrl":"https://doi.org/10.15761/tim.1000216","url":null,"abstract":"Frequency of scorpion venom extraction could influence the quality of venom and as a result may vary their biological activity, whether pharmacological or toxicological behavior, due to venom regeneration is an asynchronous process. In the present study we evaluate the protein content, concentration and biological activity of Rhopalurus junceus scorpion varying the extended periods of venom collection. Three scorpion groups were re-milked at 7, 15 and 21 days after first extraction. Differences in protein content were analyzed by SDSPAGE and HPLC techniques. The biological effect against A549, C6/36HT and Vero cells was assayed by MTT using different venom concentration (0.062; 0.125; 0.25; 0.5; 1 mg/mL). Venom from day 7 and 15 showed significant differences in protein concentration (p<0.05) respect to first extraction. SDS-PAGE and HPLC showed the highest and lowest variation in venom content, at day 7 and 21 respectively. Vero normal cells viability was not affected at all extraction periods. Meanwhile, insect cells, C6/36HT was sensitive at all extraction periods. Extended periods of venom collection was positively correlated with the regeneration of venom composition and the increase of cytotoxic effect against A549 cancer cells. R. junceus venom regeneration showed to be asynchronous depending of the target cell. Besides, venom seems to be completely renewal after 21 days showing high protein content and reproducible results against cancer cells respect to former extraction. *Correspondence to: Alexis Díaz-García, Millennium Nucleus of Ion ChannelsAssociated Diseases (MiNICAD), University of Chile, Faculty of Medicine, North Campus, Ave. Independencia 1027 Hall B, First Floor, Chile, E-mail: alexisdg76@gmail.com","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82199034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does COPD severity stage change comorbidities pattern?","authors":"S. Popović-Grle, Višnja Dukić, Josipa Škugor, D. Oroz, D. Ogresta","doi":"10.15761/tim.1000209","DOIUrl":"https://doi.org/10.15761/tim.1000209","url":null,"abstract":"Aim: Estimation of the difference in frequency and type of comorbidities in patients with chronic obstructive pulmonary disease (COPD), grouped by COPD severity stages according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD), from 1 to 4. The data subjects and methods: This study included 168 COPD patients with an equal share of patients in each GOLD stage (GOLD I 47 subjects, GOLD II 43, GOLD III 41 and GOLD IV 37 subjects). All data subjects, 106 men and 62 women (median age 66), were processed according to the successive arrival at the Clinical Center for Pulmonary Diseases Jordanovac, University Hospital Center Zagreb, for their medical examination. Results: The most common comorbidities were cardiovascular diseases with 60.1%, regardless of the GOLD stage. These are followed by pneumonia in 25.6% of COPD patients, anxiety and depression in 16.1%, diabetes in 12.5% and osteoporosis in 11.9% of the COPD patients. The most frequent malignant disease was the urinary bladder cancer. The share of the patients who suffered from pneumonia is consistently increasing with the severity of GOLD stages. Conclusion: The average number of comorbidities in GOLD I stage was 1.5, in GOLD II stage 1.8, GOLD III stage 2.1 and in GOLD IV stage 1.7. This suggests that the difference in the number of comorbidities according to the GOLD stages could be significant. This preliminary result was confirmed by a statistical chi-squared test with a significance level of 5% ( α = 0.05), whereas the difference in the types of comorbidities according to the GOLD stages was not statistically significant.","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79698531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the adherence to subcutaneous immunotherapy in patients with pollen allergy in usual clinical practice: The CITY study","authors":"Francisco Javier Solá Martínez, M. L. G. Gutiérrez, Maria Rodriguez, E. Vera, Ana Montoro De Francisco, Elena Laffond Yges, D. H. Rojas, M. R. Mosquera, Lourdes Pérez González, S. Cimbollek, A. M. Pulido, N. Cancelliere, B. López, Javier Herranz","doi":"10.15761/TIM.1000196","DOIUrl":"https://doi.org/10.15761/TIM.1000196","url":null,"abstract":"","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82779988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of elastic band assisted gait training to improve the gait kinematics in stroke survivors - a randomized control trial","authors":"Priya Sudarshan Visoi, P. Mohanty, M. Pattnaik","doi":"10.15761/TIM.1000197","DOIUrl":"https://doi.org/10.15761/TIM.1000197","url":null,"abstract":"Introduction: Stroke is the leading cause of serious long-term disabilities, the restoration of walking plays a prime role in his rehabilitation. The reduction in gait performance may prevent the resumption of activities of daily living. Aim of the study: To compare the effectiveness of elastic band assisted gait training over the task-oriented circuit interval gait training in stroke survivors. Methodology: A total of 50 male stroke survivors with functional ambulatory category score ≥4, mini mental state 24-30, normal cardio-pulmonary status and age between 30-60 years were recruited and randomly distributed in two groups. Group 1 received conventional exercises (task-oriented approach in the form of circuit interval gait training) and Group 2 received elastic band assisted gait training with task-oriented approach in the form of circuit interval gait training. Outcome measures: Stride length (both side), cadence, walking speed and gait profile score (both side). Measurements were taken with gait laboratory before and at the end of 6 weeks of treatment, for 45 minutes divided into nine 5-minute blocks separated by 5-minute rest periods 5 days/week. Results: Overall result of this study showed that experiment group had significantly improved in terms of speed, cadence, stride length of paretic limb, gait profile score of non paretic limb from pre to post test measurements, but no significant improvement in conventional group. Gait profile score of paretic limbs had significantly improved. Both the groups had significantly improved in terms of stride length of non paretic limb from pre to post-test measurements; however, the experiment group showed more improvement than the conventional group. Conclusion: Elastic band assisted gait training over the task-oriented circuit interval gait training is found to be effective for the hemiplegic gait. *Correspondence to: Patitapaban Mohanty, PhD, Assoc. Prof. (PT), Swami Vivekanand National Institute of Rehabilitation Training and Research, Olatpur, Bairoi, Cuttack, India, E-mail: ppmphysio@rediffmail.com Received: May 13, 2019; Accepted: June 18, 2019; Published: June 21, 2019 Introduction Stroke is the leading cause of serious long-term disabilities, including loss of motor, sensory or cognitive function [1]. The restoration of walking plays a prime role in rehabilitation [2]. The reduction in gait performance may prevent the resumption of activities of daily living, which can have an adverse effect on perceived participation [3]. Hemiparetic gait pattern is characterized by being stereotyped with reduced weight bearing on the paretic lower limb. Over activity or shortening of plantar flexor muscles at swing phase giving the equinovarus foot placement [4]. Reduced knee flexion, exaggerated hip circumduction and hip hiking during the swing phase are a common disability in people with stroke [5]. Which movements are energetically demanding and may lead to chronic joint pain [6,7]. Manual assistance during","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82364323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}