Trends in Medicine最新文献_第10页

Anticancer potential of Siddha formulations against oral cancer cell line in vitro 悉达制剂对口腔癌细胞系的体外抗癌潜力

Trends in Medicine Pub Date : 2019-01-01 DOI: 10.15761/tim.1000192

P. Ganapathy, K. Elumalai, M. Arumugam, Chinmayi Sri Amulya, R. Manivel

{"title":"Anticancer potential of Siddha formulations against oral cancer cell line in vitro","authors":"P. Ganapathy, K. Elumalai, M. Arumugam, Chinmayi Sri Amulya, R. Manivel","doi":"10.15761/tim.1000192","DOIUrl":"https://doi.org/10.15761/tim.1000192","url":null,"abstract":"Treatment of cancer without any side-effects is still a challenge in the medical system. This leads to an increasing search for improved anticancer drugs. Plant products have been used as a traditional medicine for thousands of years as it has been drawing a great deal of attention to overcome cancer. The main objective of this study is to evaluate and compare the anticancer effect of MahaVallathy Leghiyam (MVL) and Neeradi Muthu Vallathy Leghiyam (NMVL) against human oral cancer (KB) cells. Different concentrations of aqueous extracts of MVL and NMVL were subjected to cytotoxic study. The antiproliferative effects were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and IC50 concentration was found at 3.25 mg/mL for MVL and 1.25 mg/mL for NMVL, also apoptotic activities were studied by PI and AO/EB dual staining. The results acquired from the comparative in-vitro studies on KB cell lines revealed that the unique Siddha medicine NMVL has more potent anticancer activity compared to MVL. There was an increase in the cell growth inhibition when treated with NMVL at lower concentration compared to MVL. The current investigation suggested that the phyto constituents of NMVL are responsible for anticancer activity. Thus, the long-term consumption of NMVL could be considered and promoted as an adjuvant therapy for treating various malignancies. *Correspondence to: Kayalvizhi Elumalai, Associate Professor, Department of Physiology, Meenakshi Medical College Hospital and Research Institute, Kanchipuram, Chennai–600 119, Tamil Nadu, India, Tel: 8870365116; E-mail: kayalgkbs@gmail.com Madan Kumar Arumugam, Scientist ‘C’, Cancer Biology Lab, Molecular and Nanomedicine Research Unit, Sathyabama Institute of Science and Technology, Tamil Nadu, India, Tel: 91 9942110146; E-mail: madankumarbio@gmail.com","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89524440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Predictors of nausea and vomiting risk factors and its relation to anesthesia in a teaching hospital 某教学医院恶心呕吐危险因素预测及其与麻醉的关系

Trends in Medicine Pub Date : 2019-01-01 DOI: 10.15761/tim.1000171

Subhi M. Alghanem, Muayyad M. Ahmad, I. Qudaisat, Walid Samarah, Khaled R. Al‐zaben, Sami A. Abu Halaweh, O. Ababneh, Fathi Abu Masaid, Fadi Qutishat, Zaineh Altabari, A. Obeidat, Qusai Alamoudi, M. Zoubi

{"title":"Predictors of nausea and vomiting risk factors and its relation to anesthesia in a teaching hospital","authors":"Subhi M. Alghanem, Muayyad M. Ahmad, I. Qudaisat, Walid Samarah, Khaled R. Al‐zaben, Sami A. Abu Halaweh, O. Ababneh, Fathi Abu Masaid, Fadi Qutishat, Zaineh Altabari, A. Obeidat, Qusai Alamoudi, M. Zoubi","doi":"10.15761/tim.1000171","DOIUrl":"https://doi.org/10.15761/tim.1000171","url":null,"abstract":"Purpose: This study was conducted to estimate the incidence of postoperative nausea and vomiting (PONV) and to explore the risk factors that increase the development of PONV. Methods: A prospective study design was used to observe nausea and vomiting 24 hours postoperatively, over a 6-month period. The study sample was composed of 2,398 patients aged between 1 and 87 years. Chi-square and logistic regression were used to identify the risk factors for predicting PONV. Results: A total of 747 patients (31.2%) suffered from nausea, and 268 patients (11.2%), suffered from vomiting. Female patients and who received anesthesia more than 60 minutes, nauseated more in the recovery room and 24 hours after surgery. Female patients vomited more in the recovery and later during 24 hours; and those who received anesthesia more than 60 minutes, and who received postoperative opioids have vomited more during 24 hours after surgery. Female gender, postoperative opioids and anesthesia duration more than 60 minutes are predictive risk factors for nausea; while female gender and duration of anesthesia more than 60 minutes are predictive risk factors for vomiting. Conclusions: Female gender, use of postoperative opioids and duration of anesthesia are the most important predictive risk factors for PONV. Nonsmoking status, previous history of PONV and type of anesthesia were not found as risk factors for PONV. *Correspondence to: Muayyad Ahmad, Department of Clinical Nursing, School of Nursing, University of Jordan, 11942, Jordan, Tel: 962799313745; Fax: 96265300244; E-mail: mma4@ju.edu.jo/mma4jo@yahoo.com","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85646484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Non-necrotizing abdominal dermo-hypodermatitis with an unusual entry site 非坏死性腹部皮下皮炎，有不寻常的侵入部位

Trends in Medicine Pub Date : 1900-01-01 DOI: 10.15761/tim.1000221

A. Rasso, J. Ziani, S. Oukarfi, S. Elloudi, H. Baybay, Mernissi Fz

引用次数: 0

Epidemiology of Raoultella species in the context of human infections: a 10-year retrospective study in a tertiary-care hospital in Hungary 人类感染背景下Raoultella物种的流行病学:匈牙利一家三级保健医院的10年回顾性研究

Trends in Medicine Pub Date : 1900-01-01 DOI: 10.15761/tim.1000217

M. Gajdács

{"title":"Epidemiology of Raoultella species in the context of human infections: a 10-year retrospective study in a tertiary-care hospital in Hungary","authors":"M. Gajdács","doi":"10.15761/tim.1000217","DOIUrl":"https://doi.org/10.15761/tim.1000217","url":null,"abstract":"Introduction: Raoultella species are Gram-negative non-motile, aerobic, oxidase-negative and catalase-positive rods that are members of the Enterobacterales order that are infrequently described as significant pathogens in human disease. Objectives of the study: To report the incidence and the susceptibility levels of Raoultella species from clinical samples at a tertiary-care center in Hungary, during a 10-year study period (2008–2017). Method: Data collection was performed electronically by searching the records of the laboratory information system (LIS), regarding the samples with significant colony counts for Raoultella spp. Results: N=40 individual Raoultella isolates were identified (4.0±2.8/year, range: 0–9 isolates; highest in 2015, lowest in 2010 and 2011). Raoultella species were isolated from the following sample types: urine (catheterized and midstream): n=18, blood cultures: n=12, stool: n=6 and abscesses: n=4. 36 out of 40 isolates were R. ornithinolytica , while the remaining n=4 were R. planticola . All of the tested strains were susceptible to the group of β -lactam antibiotics. Conclusion: Raoultella species should be considered as emerging pathogens in the context of human infections, especially in older individuals in people with severe immunosuppression. The results suggest that in our local settings, there was-on average-one isolation of Raoultella every three months from various clinical samples and β -lactams may be considered safe choices for empiric therapy.","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86272847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4