Trends in Medicine最新文献_第9页

Effects of herbal medicine on acute cough and quality of life in children and their parents - A prospective real life study 草药对儿童及其父母急性咳嗽和生活质量的影响-一项前瞻性现实生活研究

Trends in Medicine Pub Date : 2019-01-01 DOI: 10.15761/TIM.1000173

I. Baljošević, A Bajec-Opancina, Subarevic, K. Stankovic, M. Novković, A. Agic, I. Filipovic

{"title":"Effects of herbal medicine on acute cough and quality of life in children and their parents - A prospective real life study","authors":"I. Baljošević, A Bajec-Opancina, Subarevic, K. Stankovic, M. Novković, A. Agic, I. Filipovic","doi":"10.15761/TIM.1000173","DOIUrl":"https://doi.org/10.15761/TIM.1000173","url":null,"abstract":"Introduction: Most children have about 4–6 respiratory infections each year. The term “herbal medicine” is used to identify medicinal herbs or some substances obtained from such herbs that help the body to fight different diseases, including infections, and for improving overall health. This research was aimed at assessing the quality of life of children in the acute phase of the respiratory infection, who got natural syrup for the control of cough. Patients and method: The prospective study was conducted at the institute for children. The study included 99 respondents who were given the unique natural syrup for children twice a day for 10 days. The research was done using a questionnaire filled by the parents of children with cough. Results: After the supplementation it is evident decrease in number of subjects with above various disturbances (cough disturbs night sleep and regular daily activities) and thus quality of life improvement. There is significant improvement of their respiratory secretion characteristics. 70% of subjects reported improvement of cough symptoms, 27% no change. Syrup taste children considered as tasty (63%). It was determined significant positive correlation between children’s and parents’/ family life quality during visit. Conclusion: It can be concluded that after the application of the syrup in conjunction with a therapeutic therapy, the overall quality of life is improved. *Correspondence to: Ivana Filipovic, University Children Hospital, Serbia, Tel: 38163512678, E-mail: drivanica@yahoo.com","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81595371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geriatric neurosurgery: Analysis of a single tertiary centre in Hong Kong 老年神经外科:香港单一三级医疗中心的分析

Trends in Medicine Pub Date : 2019-01-01 DOI: 10.15761/TIM.1000195

R. Chan, C. H. Mak, T. Tse, F. Cheung, Hm Chiu

{"title":"Geriatric neurosurgery: Analysis of a single tertiary centre in Hong Kong","authors":"R. Chan, C. H. Mak, T. Tse, F. Cheung, Hm Chiu","doi":"10.15761/TIM.1000195","DOIUrl":"https://doi.org/10.15761/TIM.1000195","url":null,"abstract":"The elderly aged 80 years and older represent a rapidly growing proportion of Hong Kong’s population. It was 3.1% in 2007 and has increased to 4.9% in 2017. It is expected to further raise to 10% in 2037. A retrospective cross-sectional study was conducted for all neurosurgery admission of aged 80 years and above in Queen Elizabeth Hospital from 1st January 2007 to 31st December 2016. Data was retrieved from Clinical Management System from Hospital Authority. Patient demographics, principal diagnosis, operation performed, perioperative complications, length of stay and mortality were collected and analyzed. A total of 2611 geriatric admissions were included, which accounted for 11.9% of all neurosurgery admission in that period. The majority (51%) of the elderly were admitted for head trauma. There were 397 elderly patients (15.2%) underwent neurosurgical operations. About 1/8 of elderly patients succumbed during the index hospital stay. When we dichotomized this 10-year period, our elderly population increased from 3.5% to 4.5%, however our geriatric admission percentage doubled from 7.8% to 15%. There was increased rate of performing neurosurgical operations on the elderly, from 9.3% rose up to 17.5% (p=0.129). The operation mortality rate dropped from 11.8% to 10.3% (p=0.157) and their average length of stay reduced from 38.9 days to 25 days (p=0.368). There was increasing demand for elderly neurosurgical care in the setting of growing geriatric population in Hong Kong. They were mostly trauma related. Nearly one-fifth of them required neurosurgical interventions. In recent years, we could achieve lower operation mortality rate and shorter length of stay. *Correspondence to: Robert SK Chan, Department of Neurosurgery, Queen Elizabeth Hospital, Hong Kong, E-mail: lwrobert@hotmail.com","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75687493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Hyperhemolysis syndrome by Bystander mechanism in siblings with sickle cell disease 镰状细胞病兄弟姐妹中旁观者机制引起的高溶血综合征

Trends in Medicine Pub Date : 2019-01-01 DOI: 10.15761/tim.1000205

Smita Mahapatra, Barsha Baisakhi Panda, Sabita Palai, Binay Bhusan Sahoo, Pankaj Parida

引用次数: 1

TRPM8 ion channel in neuro-immune regulation of antigen binding function of spleen cells TRPM8离子通道在脾细胞抗原结合功能的神经免疫调节中的作用

Trends in Medicine Pub Date : 2019-01-01 DOI: 10.15761/TIM.1000191

T. Kozyreva, L. Eliseeva, G. Khramova, Voronova Ip, A. Evtushenko

{"title":"TRPM8 ion channel in neuro-immune regulation of antigen binding function of spleen cells","authors":"T. Kozyreva, L. Eliseeva, G. Khramova, Voronova Ip, A. Evtushenko","doi":"10.15761/TIM.1000191","DOIUrl":"https://doi.org/10.15761/TIM.1000191","url":null,"abstract":"Ion channels, localized in cells with different specialization, may participate in the performance of various functions. In the experiments on rats, quantitative PCR has shown that spleen cells express the genes of thermosensitive TRP ion channels (TRPV1, TRPV2, TRPV3, TRPV4, TRPM8, and TRPA1). Experiments in vitro with the addition of an agonist of the TRPM8 ion channel menthol (10-5 M and 10-8 M) to the incubation medium indicate the presence of the TRPM8 on immune cells, and its stimulatory effect on the antigen binding, the number of rosette-forming cells doubles under the influence of menthol at concentration of 10-8 M. Stimulation of the TRPM8 ion channel localized in the skin nerve afferents by menthol (1% L-menthol) also has a stimulating effect on the antigen-binding function of spleen cells without interfering with the additional stimulation of this function when exposed to the TRPM8 agonist directly on spleen cells. The obtained results testify to the important role of the TRPM8 ion channel of different localization (in spleen cells and in the peripheral sensory neurons) in the regulation of the antigen binding function in the spleen. This indicates new moments of the neuro-immune interaction. *Correspondence to: Kozyreva TV, Institute of Physiology and Basic Medicine, Timakov str. 4, Novosibirsk, 630117, Russia, Novosibirsk State University, Novosibirsk, Pirogov str. 2, Novosibirsk, 630090, Russia, E-mail: Kozyreva@physiol.ru","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84498664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Inhibition of cell proliferation by wortmannin in T98G cells involved induced inhibition of NF-kB transcriptional activity wortmannin对T98G细胞增殖的抑制涉及诱导NF-kB转录活性的抑制

Trends in Medicine Pub Date : 2019-01-01 DOI: 10.15761/tim.1000208

E. Parra, Luís Gutierréz, P. Hecht

{"title":"Inhibition of cell proliferation by wortmannin in T98G cells involved induced inhibition of NF-kB transcriptional activity","authors":"E. Parra, Luís Gutierréz, P. Hecht","doi":"10.15761/tim.1000208","DOIUrl":"https://doi.org/10.15761/tim.1000208","url":null,"abstract":"Wortmannin is an important regulator of Phosphoinositide 3-kinase (PI(3)K) signaling pathway. Changes in expression and activity of PI3-kinase and PDGF are major positive and negative regulators, respectively, of the PI3-kinase pathway, which regulates growth, survival, and proliferation. Here we have shown that cells dosed with platelet-derived-growth-factor (PDGF) and /or wortmannin, an inhibitor of PI3 kinase, proliferated at expected rates with respect to cells deprived of any additions. Cells with added platelet-derived-growth-factor (PDGF) multiplied substantially faster than naturally growing cells-some thirty percent. As anticipated, cells given only wortmannin divided over forty percent slower than cells without any dosage. Additionally, cells transfected with a luciferase reporter carrying a consensus sequences of the nuclear factor NF-κB binding site and treated with wortmannin inhibited the activation of luciferase in T98G cells. However, this inhibition was not affected by the treatment of PDFG. Our data indicate that Wortmannin and PDGF play different role in the control of expression of Phosphoinositide 3-kinase in glioma T98G cell line. *Correspondence to: Eduardo Parra, Laboratorio de Biomedicina Experimental, Escuela de Medicina, Universidad de Tarapacá. Campus Saucache, Edificio de la Escuela de Medicina, Avenida Senador Luis Alberto Rossi, Arica, Chile, E-mail: eparraarica@gmail.com","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81860705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding the journey of saving lives 扩大拯救生命的旅程

Trends in Medicine Pub Date : 2019-01-01 DOI: 10.15761/tim.1000181

C. Callender, P. Miles

引用次数: 0

Monoclonal antibodies in non-small-cell lung cancer: Light at the end of the tunnel 非小细胞肺癌的单克隆抗体:隧道尽头的光

Trends in Medicine Pub Date : 2019-01-01 DOI: 10.15761/TIM.1000190

F. Naddafi

引用次数: 1

Medicinal effects of Propolis diet on biochemicals and histological factors in rats 蜂胶日粮对大鼠生化及组织学因子的影响

Trends in Medicine Pub Date : 2019-01-01 DOI: 10.15761/tim.1000213

Mahdi Bayrami, M. Khakpoor, E. Safavi, A. Bayrami

{"title":"Medicinal effects of Propolis diet on biochemicals and histological factors in rats","authors":"Mahdi Bayrami, M. Khakpoor, E. Safavi, A. Bayrami","doi":"10.15761/tim.1000213","DOIUrl":"https://doi.org/10.15761/tim.1000213","url":null,"abstract":"Background/aim: There is increasing interest in the healing potential of natural products, such as Propolis, considering the availability and low cost of these products. The present study was conducted to evaluate biochemical and histological effects of ethanol extract of Propolis (EEP) on intestinal tissue in rats. Materials and methods: Healthy Wistar rats were indiscriminately assigned into three groups (A-C) and five rats in each. The group A were orally given 0.2 mL of dimethyl sulfoxide daily as a control, while rats in Groups B and C were administered the same 0.2 mL dimethyl sulfoxide containing 300 and 600 mg/kg body weight ethanol extract of bee Propolis for 21 days respectively. Results: It has been concluded that ethanol extract of Propolis significantly increases globulin levels in group 300 mg/kg ( p <0.05). It also, significantly increases the height of the villi, the of the mucous membrane and muscles in the group 600 mg/kg ( p <0.05). Conclusion: It could be concluded from the present investigation that the Propolis has positive effect on animal hygiene by increasing the immunity and decreasing the stress via increase the globulin level in the blood, but the beneficial effect of Propolis seems to be dose dependent.","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73457747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Gastrointestinal parasitic infections in children aged less than 5 years in Ouagadougou, Burkina Faso 布基纳法索瓦加杜古5岁以下儿童胃肠道寄生虫感染

Trends in Medicine Pub Date : 2019-01-01 DOI: 10.15761/TIM.1000172

A. Zongo, A. Ouattara, A. Yonli, P. A. Sorgho, S. Soubeiga, F. Djigma, Hassanata Millogo, J. Simporé

{"title":"Gastrointestinal parasitic infections in children aged less than 5 years in Ouagadougou, Burkina Faso","authors":"A. Zongo, A. Ouattara, A. Yonli, P. A. Sorgho, S. Soubeiga, F. Djigma, Hassanata Millogo, J. Simporé","doi":"10.15761/TIM.1000172","DOIUrl":"https://doi.org/10.15761/TIM.1000172","url":null,"abstract":"Background : Parasitic gastroenteritis is a public health problem in Burkina Faso. However, there is lack of epidemiological data for better management of the disease. This study aimed at identifying the intestinal parasites responsible for diarrhoea and assessing their prevalence among children aged 0 - 5 years in Ouagadougou, Burkina Faso. Methods : This hospital-based cross-sectional study consisted of 317 children aged from 0 - 5 years, with gastrointestinal disorders, were recruited at Saint Camille Hospital of Ouagadougou (HOSCO) and Notre Dame de Fatima Reception Centre (CANDAF). Stool samples were collected and processed by direct microscopic examination for the presence of intestinal parasites. Results : An overall prevalence of 20.8% (66/317) of parasitosis was observed. Giardia intestinalis , Entamoeba histolytica/dispar , Entamoeba coli , Trichomonas intestinalis and Hymenolopis nana species were found with respective frequencies of 12.0% (38/317), 4.4% (14/317), 4.4% (14/317) and 3.5% (11/317). Children aged 25 to 60 months were the most affected by parasitosis with 57.6% (38/66) of cases. Approximately 19.0% (60/317) of the patients presented with diarrhoea. Children aged 12 to 24 months were the most affected and represented 65% (39/60) of diarrheal cases. The most etiologic agents of diarrhoea were Giardia intestinalis and Entamoeba histolytica/dispar found in 15% of cases. Conclusions : Parasites were weakly associated with childhood gastroenteritis which mainly affects children under 2 years.","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84939870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human telomerase reverse transcriptase as a major therapeutic target in different cancer types 人类端粒酶逆转录酶作为不同癌症类型的主要治疗靶点

Trends in Medicine Pub Date : 2019-01-01 DOI: 10.15761/TIM.1000177

Z. Singh, Priya Khangotra

引用次数: 1