American Journal of Pharmacy And Health Research最新文献_第5页

Synthesis and Evaluation of 2-Chloro-3-[3-(6-Methyl-1H-Benzimidazol-2-Yl)-4, 5-Dihydro-1H-Pyrazol-5-Yl] Quinolines as Potent Antimicrobial Agents 2-氯-3-[3-(6-甲基- 1h -苯并咪唑-2-基)- 4,5 -二氢- 1h -吡唑-5-基]喹啉类强效抗菌药物的合成及评价

American Journal of Pharmacy And Health Research Pub Date : 2018-12-20 DOI: 10.46624/ajphr.2018.v6.i12.004

B. Shivakumar, Indira. M. Madawali, S. Hugar, N. Kalyane

引用次数: 0

Effect of Allium sativum on the Pharmacodynamics of Pioglitazone in Normal and Alloxan Induced Diabetic Rats 大蒜对正常及四氧嘧啶诱导的糖尿病大鼠吡格列酮药效学的影响

American Journal of Pharmacy And Health Research Pub Date : 2018-12-20 DOI: 10.46624/ajphr.2018.v6.i12.001

R. T., S. P, E. K.

引用次数: 0

Diarrheal Diseases and Awareness at Displaced People Camp 流离失所者营地的腹泻病和认识

American Journal of Pharmacy And Health Research Pub Date : 2018-12-20 DOI: 10.46624/ajphr.2018.v6.i12.005

Maria Mubarak., F. Ali, M. Elamin, Alfatih Aburass

{"title":"Diarrheal Diseases and Awareness at Displaced People Camp","authors":"Maria Mubarak., F. Ali, M. Elamin, Alfatih Aburass","doi":"10.46624/ajphr.2018.v6.i12.005","DOIUrl":"https://doi.org/10.46624/ajphr.2018.v6.i12.005","url":null,"abstract":"Comparing estimates of the current global burden of the diarrheal diseases with previously published estimates, highlights that the incidences of diarrhea have not changed much, although overall diarrhea mortality has declined. For children aged less than five years in developing countries, a median of 3.2 episodes of diarrhea occurred per child-year, which is similar to that reported previously. Estimates of mortality indicate that 4.9 children per 13.6 per 1000 per year died in the developing regions because of diarrhea illness in the first 5 years of life. A cross sectional institution based study was conducted in Alhajaj IDPs camp in Elgeneina locality, Sudan for the Assessment of knowledge, attitudes and practices of displaced people towards diarrheal diseases. Assessment of Knowledge, attitudes and practice leading diarrheal diseases at the Alhajaj internal displace people camp. The study found that, the knowledge of the community about the common methods of transmission of diarrhoea in the camp are contamination of food, flies, contamination of hands, and contamination of water, in addition 67% of people in camp use tanks as a source of water, 22% of the people use wells, 44% of people are practicing open defecation. The study recommended that activities for raising health awareness of the community and provision of safe water supply and sanitation in the camp are a major priorities.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124936489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Efficacy of K-Tape in Chronic Mechanical Low Back Pain k -胶带治疗慢性机械性腰痛的疗效观察

American Journal of Pharmacy And Health Research Pub Date : 2018-12-20 DOI: 10.46624/ajphr.2018.v6.i12.003

Muteb Al Sulaimy, Nezar S. Al Torairi, Sharick Shamsi, S. Khan

{"title":"Efficacy of K-Tape in Chronic Mechanical Low Back Pain","authors":"Muteb Al Sulaimy, Nezar S. Al Torairi, Sharick Shamsi, S. Khan","doi":"10.46624/ajphr.2018.v6.i12.003","DOIUrl":"https://doi.org/10.46624/ajphr.2018.v6.i12.003","url":null,"abstract":"Efficacy of K-Tape in Chronic Mechanical Low Back Pain. Randomized Control Trial. A total of 30 patients were included as per pre define inclusion and exclusion criteria and randomly assigned into two groups, consisting of 15 patients in each group. Group A was given K-Tape along with standardized exercise program. Group B was given standardized exercise program along with moist hot pack for 4 weeks, 3 sessions per week one session per day. The patient’s outcome measures were assessed by visual analog scale, ODI and Goniometry for Lumbar Range of Motion. Measurements were recorded before and after the end of the treatment period. Results revealed that means and S.D of both group were significant (p=0.000 ) statically but clinically the Group of patients treated with K-Tape along with standardized exercise program managed pain (pre=7.50±1.21,post=0.71±0.37),ODI(pre=41±18.16,post= 8±4.49) and range of motion (flexion pre=31±5.04,post=50±10.12,extension pre=17±2.13,post=29±4.20 Rt side flexion pre=10±2.55,post=22±4.75 and Lt. side flexion pre=10±2.35, post=22±4.63, Rt side rotation pre= 8±1.27,post=19±2.65) Lt. side rotation pre=8±2.15, post=18±2.46 better than group of patients treated with standardized exercise program along with Moist hot pack in terms of pain (pre=7.81±1.16,post=2.35±1.27), ODI (pre=44±21.32,post=22±10.6) and range of motion (flexion pre=25±5.65,post=37±10.16, extension pre=15±2.55,post=21±5.32, Rt side flexion pre=10±2.35 post=15±2.28, Lt Side flexion pre=11±2.35, post=19±2.36, Rt side rotation pre=9±1.90 post=16.±2.71, Lt Side rotation pre=8±1.63, post=15±3.15. The result of study suggests that both K-Tape and exercises improves the symptoms of chronic low back pain. Better improvement was shown by K-Tape group when compared with exercise group. Based on these results K-Tape and Exercise should be the treatment of choice for chronic mechanical low back pain rather than Exercise with HP.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125604209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Cytotoxic Effect and Antiproliferative Activity of 3-Carboxylated Coumarins Derivatives in an In Vitro Model 体外模型评价3-羧基香豆素衍生物的细胞毒作用和抗增殖活性

American Journal of Pharmacy And Health Research Pub Date : 2018-11-20 DOI: 10.46624/ajphr.2018.v6.i11.002

Cuauhtémoc Alvarado-Sánchez, A. González-González, Nancy Romero-Ceronio, E. Cruz-Hernández

{"title":"Evaluation of the Cytotoxic Effect and Antiproliferative Activity of 3-Carboxylated Coumarins Derivatives in an In Vitro Model","authors":"Cuauhtémoc Alvarado-Sánchez, A. González-González, Nancy Romero-Ceronio, E. Cruz-Hernández","doi":"10.46624/ajphr.2018.v6.i11.002","DOIUrl":"https://doi.org/10.46624/ajphr.2018.v6.i11.002","url":null,"abstract":"Herein we report an exploratory study based on the cytotoxicity and antiproliferative activity of four previously synthesized coumarins derivatives (compounds 1a-d). The cytotoxic effect of the compounds was assessed on mononuclear cells, which were obtained from blood samples of healthy donors and measured by XTT method. The antiproliferative activity experiments were developed using HeLa, CaSKi and SiHa cervical cancer cell lines, and was evaluated by the MTT assay. In every single experiment, Cisplatin as internal control was employed. The cytotoxic assessment revealed that the four compounds did not significantly affect the viability on normal cells, whereas the antiproliferative activity on cancer cells was variable, according to the substituent located at position 3 of the coumarin core. It is worth mentioning that compound 1c, compared with the other products, presented a remarkable effect against CaSKi cell line, likewise 1d but in HeLa cells. These findings suggest that there is a relationship between biological activity and the alkoxycarbonyl chain since this is the only structural difference among the four tested compounds. The results lead to conclude that butyl group which is the substituent in compound 1d, was the key element in the antiproliferative effect presented by the molecule against SiHa, CaSKi and HeLa cell lines.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"182 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134123548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Evaluation of Aloe Vera Gel and Film From Fresh Pulp of the Leaves of Aloe Barbadensis 巴巴多斯芦荟叶鲜浆芦荟凝胶膜的制备及评价

American Journal of Pharmacy And Health Research Pub Date : 2018-11-20 DOI: 10.46624/ajphr.2018.v6.i11.001

T. Rasala, Shivani Dani, S. Waikar, A. Ittadwar

引用次数: 1

Case Study on Management of T.B Meningitis 结核性脑膜炎管理个案研究

American Journal of Pharmacy And Health Research Pub Date : 2018-11-20 DOI: 10.46624/ajphr.2018.v6.i11.003

Brahma Reddy D.R, S. V, Bhavani M, S. M., T. R., Sharon S

引用次数: 0

Preformulation Study of Dolasetron: An Insight for Formulation and Development of Nasal Formulation 多拉司琼的预处方研究:对鼻腔制剂的配方和发展的见解

American Journal of Pharmacy And Health Research Pub Date : 2018-10-20 DOI: 10.46624/ajphr.2018.v6.i10.001

M. Rathod, Dharmik Mehta, P. Shelat, P. Parejiya

{"title":"Preformulation Study of Dolasetron: An Insight for Formulation and Development of Nasal Formulation","authors":"M. Rathod, Dharmik Mehta, P. Shelat, P. Parejiya","doi":"10.46624/ajphr.2018.v6.i10.001","DOIUrl":"https://doi.org/10.46624/ajphr.2018.v6.i10.001","url":null,"abstract":"The objective of preformulation study is to develop the elegant, stable, effective and safe dosage form by establishing kinetic profile, compatibility with other formulation excipients and to establish physico-chemical parameter of new drug substance. This could provide important information for formulation design or support the need for molecular modification. So, in the present study preformulation studies were performed on Dolasetron (DS) to assess its suitability for nasal formulation. DS is a specific and selective serotonin subtypes 3 (5-HT) receptor antagonists, used to treat chemotherapy induced nausea and vomiting. The authenticity of DS was established by DSC and FITR spectra. An UV spectrophotometric method and HPLC method were employed for determination of DS in bulk and blood plasma respectively. Saturation solubility, micromeritical properties, melting point, pH, hygroscopicity and stability profile were studied. The UV method was linear in the range of 5-50 μg/ml. The low % CV values of intra-day and inter-day variations revealed that the proposed method is robust. The retention time of DS in HPLC method was found to be 2.8 min. The method was proven robust by obtaining very high regression coefficient value (0.999). The results of the physicochemical study of drug revealed suitability of DS for nasal route. Moreover, the drug was found stable in both solid as well as liquid state at different conditions.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122677058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Formulation and Comparative Standardization of Polyherbal Swadisht Virechan Churna 翠绿草复方配方及比较标准研究

American Journal of Pharmacy And Health Research Pub Date : 2018-10-20 DOI: 10.46624/ajphr.2018.v6.i10.003

H. A. Navthale, M. B. Bhaltadak, R. Thenge, S. Shinde, V. Adhao

引用次数: 0

Chemical Screening, Antioxidant Potential and Antiangiogenic Effect of Microporus Xanthopus (fr.) Kuntze, Ganoderma Orbiforme (fr.) Ryvarden and Polyporus Fasciculatus (pat) lloyd, Medicinal Mushrooms from Gabon 加蓬药用蘑菇黄小孢子、圆形灵芝和束状波孢子的化学筛选、抗氧化活性和抗血管生成作用

American Journal of Pharmacy And Health Research Pub Date : 2018-10-20 DOI: 10.46624/ajphr.2018.v6.i10.002

Orango-Bourdette Juliette-Ornely, Eyi-Ndong Hugues Calixte, N. Roger, N. Rick-Léonid, S. Cédric, Ondo Joseph-Privat, Obame-Engonga Louis-Clément

{"title":"Chemical Screening, Antioxidant Potential and Antiangiogenic Effect of Microporus Xanthopus (fr.) Kuntze, Ganoderma Orbiforme (fr.) Ryvarden and Polyporus Fasciculatus (pat) lloyd, Medicinal Mushrooms from Gabon","authors":"Orango-Bourdette Juliette-Ornely, Eyi-Ndong Hugues Calixte, N. Roger, N. Rick-Léonid, S. Cédric, Ondo Joseph-Privat, Obame-Engonga Louis-Clément","doi":"10.46624/ajphr.2018.v6.i10.002","DOIUrl":"https://doi.org/10.46624/ajphr.2018.v6.i10.002","url":null,"abstract":"The objective of the present study was investigation of the chemical screening, antioxidant potential and antiangiogenic effect of Microporus xanthopus, Ganoderma orbiforme and Polyporus fasciculatus, medicinal mushrooms from Gabon. Theantioxidant activities of water, water-ethanol and ethanol extracts of three fungi were tested by measuring the trapping power of DPPH radical. The anti-angiogenic activity was evaluated for some water extracts by chicken chorioallantoic membrane method (CAM). The results obtained for DPPH trapping test showed that the various extracts tested had antioxidant activities going from low to very high. The greatest activities were found in Microporus xanthopus with IAAs of 3.88 and 4.13, respectively, for water and water-ethanol extracts. Polyporus fasciculatus fungi exhibited strong antioxidant activities. The moderate activity was found in the extract of Ganoderma orbiforme. The water extracts tested for their anti-angiogenic activity acted by decreasing the density and/or number of blood vessels of the CAM with inhibition percentages of 66.67%, 55.45% and 37%, for Ganoderma orbiforme, Microporus xanthopus and Polyporus fasciculatus, respectively. Thus, angiogenesis can be neutralized by the antioxidant molecules contained in the fungi, but these molecules are not the only ones to possess these potentialities. Harvested mushrooms could be potential agents for the fight against cancer.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127389074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4