Synthesis and Evaluation of 2-Chloro-3-[3-(6-Methyl-1H-Benzimidazol-2-Yl)-4, 5-Dihydro-1H-Pyrazol-5-Yl] Quinolines as Potent Antimicrobial Agents

Abstract

A new series of 2-chloro-3-[3-(6-methyl-1H-benzimidazol-2-yl)-4,5-dihydro-1H-pyrazol-5yl]quinoline (Va-k) have been synthesized by the reaction of 3-(2-chloroquinolin-3-yl)-1-(6methyl-1H-benzimidazol-2-yl)prop-2-en-1-one (IVa-k) with hydrazine hydrate in ethanol and glacial acetic acid. The synthesized compounds were characterized by their IR, H NMR and Mass spectral studies. Further, compounds were screened for their antimicrobial activity by cup plate method, using Ciprofloxacin and Fluconazole as a standard drugs. Results of the activities reveal that, compounds exhibited moderate to good antibacterial and antifungal activities.