Travel Medicine and Infectious Disease最新文献

{"title":"Locally acquired cutaneous larva migrans in Ontario?","authors":"Manreet Dhaliwal, Isaac I. Bogoch","doi":"10.1016/j.tmaid.2024.102765","DOIUrl":"10.1016/j.tmaid.2024.102765","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"62 ","pages":"Article 102765"},"PeriodicalIF":6.3,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Malaria vaccine a boon to Endemic regions - Doubling efficacy rates, at lower cost","authors":"Amrit Kahlon, Steven Lippmann, Rachana Mehta, Vini Mehta, Jack Feehan, Vasso Apostolopoulos , Ranjit Sah","doi":"10.1016/j.tmaid.2024.102763","DOIUrl":"10.1016/j.tmaid.2024.102763","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"62 ","pages":"Article 102763"},"PeriodicalIF":6.3,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rabies post-exposure prophylaxis: A retrospective analysis of timing of initiation and antibody responses in a Belgian cohort","authors":"Matilde Hens ,&nbsp;Steven Declercq ,&nbsp;Nicole Berens-Riha ,&nbsp;Ula Maniewski ,&nbsp;Caroline Theunissen ,&nbsp;Steven Van Den Broucke ,&nbsp;Felix De Bièvre ,&nbsp;Isabel Brosius ,&nbsp;Laurens Liesenborghs ,&nbsp;Christophe Van Dijck ,&nbsp;Christophe Burm ,&nbsp;Inne Nauwelaers ,&nbsp;Katleen Balliauw ,&nbsp;Benjamin J. Visser ,&nbsp;Emmanuel Bottieau ,&nbsp;Patrick Soentjens","doi":"10.1016/j.tmaid.2024.102761","DOIUrl":"10.1016/j.tmaid.2024.102761","url":null,"abstract":"<div><h3>Background</h3><div>We aimed to determine the timeliness of rabies post-exposure prophylaxis (PEP) and the proportion of individuals with an adequate antibody response post-PEP among those attending the Belgian national reference center.</div></div><div><h3>Methods</h3><div>Retrospective analysis of patient records who attended our center from 2018 to 2023. Delay was defined as rabies immunoglobulin (RIG) and vaccine initiation beyond 2 calendar days after exposure. Antibodies were measured by rapid fluorescent focus inhibition test (RFFIT) after PEP in high-risk exposures. A titer ≥0.5 IU/ml was considered adequate.</div></div><div><h3>Results</h3><div>We reviewed 317 patient records. Among individuals with inland exposure (n = 103), 85 % timely received PEP. Among travelers exposed abroad (n = 214), administration of RIG and vaccine initiation were timely in 30 % and 50 % of cases, respectively. An adequate antibody response was detected in 99.5 % (195/196) individuals.</div></div><div><h3>Conclusion</h3><div>Substantial PEP delays among travelers were observed. The robust antibody responses suggest that routine serological follow-up is not necessary for all patients.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"62 ","pages":"Article 102761"},"PeriodicalIF":6.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000784/pdfft?md5=f19e91b9c75bfe6b45881439671e8a65&pid=1-s2.0-S1477893924000784-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dengue fever as autochthonous infectious disease in Italy: Epidemiological, clinical and virological characteristics","authors":"Serena Vita ,&nbsp;Eleonora Lalle ,&nbsp;Priscilla Caputi,&nbsp;Francesca Faraglia,&nbsp;Alessandra D'Abramo,&nbsp;Licia Bordi,&nbsp;Gabriella De Carli,&nbsp;Giuseppe Sberna,&nbsp;Maria Letizia Giancola,&nbsp;Gaetano Maffongelli,&nbsp;Cosmina Mija,&nbsp;Andrea Antinori,&nbsp;Stefania Cicalini,&nbsp;Fabrizio Maggi,&nbsp;Enrico Girardi,&nbsp;Francesco Vairo,&nbsp;Emanuele Nicastri","doi":"10.1016/j.tmaid.2024.102762","DOIUrl":"10.1016/j.tmaid.2024.102762","url":null,"abstract":"<div><h3>Background</h3><div>Since August to November 2023, 82 cases of autochthonous or non-travel related Dengue virus (DENV) infection have been reported in Italy, highlighting a concerning trend of local transmission. We describe the clinical and laboratory findings of 10 autochthonous DENV in the metropolitan area of Rome admitted to the Lazzaro Spallanzani National Institute for Infectious Diseases.</div></div><div><h3>Method and results</h3><div>Ten patients (3 males, 7 females; median age: 51) with classic dengue fever symptoms were admitted between August and November 2023. Laboratory tests confirmed dengue infection through DENV non-structural protein 1 and/or immunoglobulins (IgM/IgG) positive tests, moreover leukopenia, thrombocytopenia, elevated transaminases were detected. A subset of patients underwent extensive biological sampling, including real-time RT-PCR and immunofluorescence, to monitor DENV-RNA and antibody levels over 30 days. DENV-1 was detected in 8 patients and DENV-3 in 2. Upon admission specific IgM antibodies were found in 7 patients while IgG antibodies in 4 patients. DENV RNA was consistently detected in blood within the first 8 days but was less common in saliva and urine. No DENV RNA was detected after day 24.</div></div><div><h3>Conclusion</h3><div>These findings contribute to the understanding of the clinical course of DENV infection in a non-endemic setting as integrated epidemiological and clinical model to increase syndromic surveillance and timely diagnosis of DENV infections.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"62 ","pages":"Article 102762"},"PeriodicalIF":6.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000796/pdfft?md5=406a09249a1a59ee06646985a531d633&pid=1-s2.0-S1477893924000796-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of omicron infection on maternal and neonatal delivery outcomes: A retrospective cohort study","authors":"Jing Wang ,&nbsp;Lingfei Ge ,&nbsp;Kai Zhou ,&nbsp;Yi Jiang ,&nbsp;Mengqi Pang ,&nbsp;Jiaqi Wang ,&nbsp;Yuxian Zhu ,&nbsp;Lingli Zhu ,&nbsp;Xiaoxiao Jin ,&nbsp;Zeying Chai ,&nbsp;Tao Hsin Tung ,&nbsp;Hongping Lu ,&nbsp;Bo Shen ,&nbsp;Lingzhi Zheng","doi":"10.1016/j.tmaid.2024.102759","DOIUrl":"10.1016/j.tmaid.2024.102759","url":null,"abstract":"<div><h3>Background</h3><div>People are very concerned about the adverse effects of Omicron infection on delivery modes, duration of labor, and the postpartum status of pregnant women and neonates.</div></div><div><h3>Methods</h3><div>382 pregnant women (Omicron group: 136 cases; non-Omicron group: 246 cases) giving birth in our hospital were collected, demographic characteristics, vaccination, clinical manifestation and medication, delivery outcomes of pregnant women and neonates were recorded. Delivery outcomes were compared between the Omicron and non-Omicron groups, acute infection and non-acute infection groups to explore the relationship between adverse delivery outcomes and Omicron infection.</div></div><div><h3>Results</h3><div>Pregnant women in the Omicron group had a longer hospitalization time (6.3 ± 3.6 days vs.5.5 ± 2.3 days), more 2-hour postpartum hemorrhage (291.7 ± 104.9 mL vs.262.7 ± 91.2 mL) and higher neonatal-pediatric transfer rate (20.6 % vs. 2.8 %), which might be associated with fetal distress, prenatal fever and pneumonia/respiratory distress. Neonates transferred to pediatrics due to jaundice were unique in the Omicron group. Fever-pregnant women have a more prolonged second stage of labor and hospital stay while coughing or expectoration ones have a shorter third stage of labor. Delivery outcomes did not differ whether the infected pregnant women were in the acute phase and whether to use antipyretics.</div></div><div><h3>Conclusion</h3><div>Omicron infection can increase the 2-hour postpartum hemorrhage volume and the neonatal-pediatric transfer rate. The symptoms can affect the duration of labor and hospital stay. However, whether the infected pregnant women are in the acute phase or use antipyretics do not affect the delivery outcome.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"62 ","pages":"Article 102759"},"PeriodicalIF":6.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory pathways of Toxoplasma gondii infection in pregnancy","authors":"Reyhaneh Moghaddami ,&nbsp;Mahdi Mahdipour ,&nbsp;Ehsan Ahmadpour","doi":"10.1016/j.tmaid.2024.102760","DOIUrl":"10.1016/j.tmaid.2024.102760","url":null,"abstract":"<div><div><em>Toxoplasma gondii</em> (<em>T. gondii</em>), an obligate intracellular parasite, is considered as an opportunistic infection and causes toxoplasmosis in humans and animals. Congenital toxoplasmosis can influence pregnancy and cause mild to severe consequences for the fetal and neonatal. During early <em>T. gondii</em> infection, neutrophils as the most abundant white blood cells provide a front line of defense mechanism against infection. The activated dendritic cells are then responsible for initiating an inflammatory response via T-helper 1 (Th1) cells. As part of its robust immune response, the infected host cells produce interferon (IFN<strong>-γ</strong>). IFN<strong>-γ</strong> inhibits <em>T. gondii</em> replication and promotes its transformation from an active form to tissue cysts. Although anti- <em>T. gondii</em> antibodies play an important role in infection control, T-helper 2 (Th2) immune response, can facilitate the growth and proliferation of <em>T. gondii</em> in the host cell. In pregnant women infected with <em>T. gondii</em>, the expression of cytokines may vary and in response diverse outcomes are expected. Cytokine profiles serve as valuable indicators for estimating the patho-immunological effects of <em>T. gondii</em> infection. This demonstrates the intricate relationship between pro-inflammatory and anti-inflammatory cytokines, as well as their influence on the various pregnancy outcomes in <em>T. gondii</em> infection.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"62 ","pages":"Article 102760"},"PeriodicalIF":6.3,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000772/pdfft?md5=03656e32206536a764d002b86c73f16c&pid=1-s2.0-S1477893924000772-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fever in a traveler returning from Kenya","authors":"Christoffer Ellegård Christensen,&nbsp;Terese L. Katzenstein,&nbsp;Marie Helleberg","doi":"10.1016/j.tmaid.2024.102755","DOIUrl":"10.1016/j.tmaid.2024.102755","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"62 ","pages":"Article 102755"},"PeriodicalIF":6.3,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000723/pdfft?md5=92226e525183dbac25557d393bee9d9f&pid=1-s2.0-S1477893924000723-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating seroprevalence of IgG antibodies against Monkeypox Virus (MPXV) in a cohort of people living with HIV (PLWH) in Rome, during the 2022 outbreak: Moving beyond traditional at-risk populations","authors":"Pierluigi Francesco Salvo ,&nbsp;Alessia Sanfilippo ,&nbsp;Gianmaria Baldin ,&nbsp;Valentina Iannone ,&nbsp;Arturo Ciccullo ,&nbsp;Damiano Farinacci ,&nbsp;Domenico Benvenuto ,&nbsp;Alberto Borghetti ,&nbsp;Simona Di Giambenedetto ,&nbsp;Francesca Lombardi","doi":"10.1016/j.tmaid.2024.102757","DOIUrl":"10.1016/j.tmaid.2024.102757","url":null,"abstract":"<div><h3>Background</h3><p>High incidence mpox rates suggest asymptomatic individuals may contribute to virus transmission. We undertook this study to assess the seroprevalence of IgG <em>anti</em>-MPXV in a cohort of asymptomatic PLWH, to analyze the size of the phenomenon of asymptomatic infections.</p></div><div><h3>Materials and methods</h3><p>From October 2022 to March 2023 we serially collected serum samples from PLWH attending our Clinic. IgG against MPXV have been assessed on stored cryopreserved samples with an ELISA. Only people with no previous reported vaccine against smallpox or mpox nor previous clinical manifestations consistent with a mpox diagnosis were included.</p></div><div><h3>Results</h3><p>285 PLWH were included. Twenty-one participants tested positive for IgG anti MPXV (7.37 %, 95 % CI 4.62–11.0). Seropositivity was predominant in male (15/285, 71.4) with a small fraction of female (6/285,28.6 %) and PWID (1/285,4.8 %).</p></div><div><h3>Conclusions</h3><p>Our findings suggest the possibility of an asymptomatic course of the mpox infection even in populations beyond traditional high-risk groups.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"62 ","pages":"Article 102757"},"PeriodicalIF":6.3,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000747/pdfft?md5=da722812945ac10b84a9a2a376d715d9&pid=1-s2.0-S1477893924000747-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global perspective of the risks of falsified and counterfeit medicines: A critical review of the literature","authors":"Aonghus J. Feeney ,&nbsp;Jeffery A. Goad ,&nbsp;Gerard T. Flaherty","doi":"10.1016/j.tmaid.2024.102758","DOIUrl":"10.1016/j.tmaid.2024.102758","url":null,"abstract":"<div><h3>Background</h3><p>The increasing prevalence of falsified and counterfeit medicines globally poses risks to international travellers. This narrative literature review examines the global challenge of falsified and counterfeit medicines, with a specific focus on risks for travellers. The aim is to provide a comprehensive understanding of this multidimensional issue, exploring potential solutions for effective intervention.</p></div><div><h3>Methods</h3><p>A comprehensive search of databases, including PubMed, MEDLINE, and Scopus, as well as relevant reports from international organisations, was undertaken. There was a focus on extracting information pertaining to the prevalence, types, and geographical patterns of falsified and counterfeit medicines encountered by international travellers. Synthesising this information helped to identify overarching trends and patterns. This narrative review utilised a thematic analysis approach to synthesise the findings.</p></div><div><h3>Results</h3><p>The findings revealed a diverse range of counterfeit drug categories, spanning from antibiotics to lifestyle medications, posing unique risks to travellers navigating the global pharmaceutical landscape. The review emphasises the geographical distribution of these drugs, with varying consequences for both high- and low-income nations. The inadequate formulations and inconsistent drug release arising from these practices pose severe threats to public health, especially for individuals travelling abroad. The review also highlights the significance of international collaboration in addressing this global challenge, as pharmaceutical supply chains seamlessly cross borders, necessitating a collaborative approach for effective regulation and enforcement.</p></div><div><h3>Conclusions</h3><p>This review underscores the need for targeted research, collaborative interventions, and technological innovations to address the complexities associated with falsified and counterfeit medicines, ensuring the safety and well-being of international travellers.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102758"},"PeriodicalIF":6.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000759/pdfft?md5=6ed47db6cd04cb45777d847f01cef5e0&pid=1-s2.0-S1477893924000759-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rickettsia sibirica caused infection in international traveler from Cambodia","authors":"Junrong Liang ,&nbsp;Biying Zhang ,&nbsp;Zhongqiu Teng ,&nbsp;Yuqing Cheng,&nbsp;Miao Lu,&nbsp;Qingzhu Huang,&nbsp;Xincheng Qin,&nbsp;JianGuo Xu,&nbsp;Tian Qin","doi":"10.1016/j.tmaid.2024.102754","DOIUrl":"10.1016/j.tmaid.2024.102754","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102754"},"PeriodicalIF":6.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000711/pdfft?md5=03a44c2e5b973edb623e68086e68c652&pid=1-s2.0-S1477893924000711-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}