Travel Medicine and Infectious Disease最新文献

{"title":"Assessing dengue seroprevalence among people living with HIV (PLWH) in rome, Italy: Insights from the 2023 Italian autochthonous outbreak","authors":"Pierluigi Francesco Salvo ,&nbsp;Francesca Lombardi ,&nbsp;Alessia Sanfilippo ,&nbsp;Valentina Iannone ,&nbsp;Gianmaria Baldin ,&nbsp;Alberto Borghetti ,&nbsp;Carlo Torti ,&nbsp;Simona Di Giambenedetto","doi":"10.1016/j.tmaid.2025.102832","DOIUrl":"10.1016/j.tmaid.2025.102832","url":null,"abstract":"<div><h3>Background</h3><div>Global warming has facilitated the spread of mosquito-borne diseases, including dengue, to non-endemic areas like Italy. People living with HIV (PLWH) are at increased risk of severe dengue, especially during secondary infections, but current vaccination options are constrained by safety considerations. This study assesses the seroprevalence of IgG anti-DENV among PLWH in Italy, after the 2023 Italian autochthonous outbreak.</div></div><div><h3>Methods</h3><div>This cross-sectional study enrolled PLWH from July to November 2023 in Rome during the abovementioned outbreak. Blood samples were collected and analyzed for IgG anti-DENV using ELISA. Participants were stratified by country of birth and those with immune profiles suitable for live attenuated virus vaccination were identified. Cryopreserved serum samples from 2021 to 2022 were tested to trace the timing of infections.</div></div><div><h3>Results</h3><div>We included 475 PLWH of whom 37 tested positive for IgG anti-DENV, resulting in an overall seroprevalence of 7.79 % (95 % CI 5.54–10.6). The seroprevalence was significantly higher among PLWH born in DENV-endemic countries (37.14 %) compared to Italian (2.86 %). Notably, among the Italian participants, three individuals who had not traveled outside Italy in the past 12 months showed seroconversion during the 2023 outbreak, providing further evidence of autochthonous dengue transmission in the country. This finding underscores the growing relevance of dengue as an emerging public health concern in Italy. Of the 37 seropositive individuals, 34 (91.9 %) had a CD4 count ≥200 cells/μl, indicating that a significant portion of the at-risk population could safely be vaccinated.</div></div><div><h3>Conclusions</h3><div>Many PLWH have been exposed to DENV, with some experiencing seroconversion during the 2023 outbreak. Most of these individuals could feasibly receive live attenuated virus vaccination without significant risks, but further studies are needed to confirm vaccine safety for PLWH.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102832"},"PeriodicalIF":6.3,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of scrub typhus encephalitis in a pediatric patient with different serotypes detected in blood and cerebrospinal fluid","authors":"Lijiao Yuan ,&nbsp;Wenrui Ding ,&nbsp;Hao Wu ,&nbsp;Xin Ma ,&nbsp;Mengyue Tong ,&nbsp;Xiaotao Yang ,&nbsp;Yanchun Wang ,&nbsp;Yonghan Luo","doi":"10.1016/j.tmaid.2025.102831","DOIUrl":"10.1016/j.tmaid.2025.102831","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102831"},"PeriodicalIF":6.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemorrhagic fevers caused by South American Mammarenaviruses: A comprehensive review of epidemiological and environmental factors related to potential emergence","authors":"Esteban Ortiz-Prado ,&nbsp;Jorge Vasconez-Gonzalez ,&nbsp;D.A. Becerra-Cardona ,&nbsp;María José Farfán-Bajaña ,&nbsp;Susana García-Cañarte ,&nbsp;Andrés López-Cortés ,&nbsp;Juan S. Izquierdo-Condoy","doi":"10.1016/j.tmaid.2025.102827","DOIUrl":"10.1016/j.tmaid.2025.102827","url":null,"abstract":"<div><div>South American hemorrhagic fevers (SHF), a group of zoonotic diseases caused by various virus families including Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae, are primarily confined to geographic areas where their host species reside. Transmission to humans occurs through direct contact with infected animals, especially rodents, and when infected, humans can transmit diseases to other humans through person-to-person interactions and other means, leading to illnesses that range from mild to life-threatening conditions. Diseases such as Argentine hemorrhagic fever, caused by the Junin virus, Brazilian hemorrhagic fever, caused by the Sabia virus, Venezuelan hemorrhagic fever, caused by the Guanarito virus, and Chapare hemorrhagic fever, are responsible for most hemorrhagic fevers excluding hemorrhagic consequences of diseases such as those caused by dengue. These diseases were first described in the late 1950s, coinciding with environmental and agricultural changes that led to increased rodent populations and the expansion of urban areas into rural zones. Pathogenically, these viruses typically initiate infection in the lungs and subsequently disseminate to regional lymphatic vessels and other organs, resulting in severe vascular and coagulation dysfunction. Clinical manifestations start with a prodromal phase characterized by general malaise and fever, progressing to more severe neurological and hemorrhagic symptoms, and concluding with a convalescent phase that may result in long-term neurological conditions. We comprehensively reviewed the literature on these South American hemorrhagic fevers. The dynamics of these diseases highlight the complex interactions between environmental factors, human behavior, and viral pathogenicity that drive the epidemiology of hemorrhagic fevers in South America.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102827"},"PeriodicalIF":6.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical validation and evaluation of the EasyNAT Malaria assay and the Alethia Malaria assay in a non-endemic setting: rapid and sensitive assays for detecting Plasmodium spp. in returning travellers","authors":"Charlotte van der Veer ,&nbsp;Julian Apako ,&nbsp;Anja Sonneveld-Hendriks ,&nbsp;Annemarie Kaak ,&nbsp;Cindy Arias-Claro Handgraaf ,&nbsp;Erik Schaftenaar ,&nbsp;Guido J.H. Bastiaens ,&nbsp;Jacky Flipse","doi":"10.1016/j.tmaid.2025.102830","DOIUrl":"10.1016/j.tmaid.2025.102830","url":null,"abstract":"<div><div>This study assessed the analytical and clinical performance of the EasyNAT Malaria cross-priming amplification assay and the Alethia Malaria loop-mediated isothermal amplification assay in screening for <em>Plasmodium</em> spp. in febrile patients with recent travel history to malaria endemic regions.</div><div>Using the composite microbial reference, the overall sensitivity and specificity were: 100 % and 97.5 % for the EasyNAT Malaria assay and 97.8 % and 98.3 % for the Alethia Malaria assay, respectively. When comparing both molecular assays, high congruency was seen (96.3 %; 158/164). We observed a negative correlation between the EasyNAT reported time-to-positivity and parasitemia, where higher parasitemia resulted in shorter time-to-positivity.</div><div>The EasyNAT Malaria assay and Alethia Malaria assay show high sensitivity and specificity for malaria screening in the Dutch non-endemic setting. The EasyNAT Malaria assay has the added benefit that it is compatible with laboratory information systems and requires fewer sample handling steps compared with the Alethia Malaria assay. Moreover, time-to-positivity values indicative of low parasitemia may aid laboratories to potentially shorten the diagnostic process for patients with mild symptoms as these patients may be evaluated by the consultant clinical microbiologist without the need for urgent microscopy outside regular office hours.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102830"},"PeriodicalIF":6.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rabies exposure in international travellers: Experience from a single travel clinic in Paris, France, 2018–2022","authors":"Patrick Hochedez ,&nbsp;Kaoutar Jidar ,&nbsp;Fabien Taieb ,&nbsp;Oula Itani ,&nbsp;Ghania Benabdelmoumen ,&nbsp;Perrine Parize ,&nbsp;Hervé Bourhy ,&nbsp;Paul-Henri Consigny ,&nbsp;Philippe Poujol","doi":"10.1016/j.tmaid.2025.102821","DOIUrl":"10.1016/j.tmaid.2025.102821","url":null,"abstract":"<div><h3>Background</h3><div>Rabies is a vaccine-preventable zoonotic disease which causes thousands of deaths every year, mainly in Asia and Africa, and dogs are the main source of human cases. Although rabies is rare in international travellers, rabies exposure is relatively frequent and the number of travellers seeking post-exposure treatment may rise as international travel continues to increase. We aimed to better understand the characteristics of travellers exposed to rabies abroad, in order to deliver targeted advice and rabies vaccination during pre-travel clinics.</div></div><div><h3>Methods</h3><div>During 2018–2022, we studied all returning travellers who attended a single travel clinic in Paris, France, for animal exposures abroad and requiring rabies post-exposure prophylaxis (n = 2916).</div></div><div><h3>Results</h3><div>During the study period, 2916 returning travellers were included, and 59.7 % of exposures occurred in Southeast Asia (mainly Thailand and Indonesia) and North-Africa. Dogs were predominantly responsible for exposures, but the animals involved varied significantly according to the region visited and the age of the traveller. Monkey exposures were more frequently reported in Asia, and cat exposures in North Africa and among children. Exposures were reported as unprovoked in 22.9 % of cases, and 91 % of travellers had not received anti-rabies vaccines before travelling.</div></div><div><h3>Conclusions</h3><div>Travellers to rabies endemic countries should benefit from more targeted information based on the region visited, the animals they are likely to encounter, and the age of the travellers. Critically, they should be counselled on the importance of avoiding contact with animals, the long-lasting benefit of pre-travel rabies vaccination, and the need for adequate post-exposure prophylaxis.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102821"},"PeriodicalIF":6.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collapse on a flight to Paris returning from Bangalore: A sentinel cholera case in a man visiting friends and relatives in India","authors":"Marin Caumartin ,&nbsp;Sophie Nagle ,&nbsp;Racha Eid ,&nbsp;Caroline Rouard ,&nbsp;Jean Baptiste Destival ,&nbsp;Marie Christine Bouton ,&nbsp;Lou Macaux ,&nbsp;Vladimir Adrien ,&nbsp;Olivier Bouchaud ,&nbsp;Fatma el Alaoui ,&nbsp;Nicolas Vignier","doi":"10.1016/j.tmaid.2025.102824","DOIUrl":"10.1016/j.tmaid.2025.102824","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102824"},"PeriodicalIF":6.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Travel patterns, pretravel preparation, and travel-associated morbidity in travelers with diabetes in Taiwan","authors":"Yi-Chen Lee ,&nbsp;Yi-Hsuan Lee ,&nbsp;Chia-Wen Lu ,&nbsp;Kuo-Chin Huang","doi":"10.1016/j.tmaid.2025.102828","DOIUrl":"10.1016/j.tmaid.2025.102828","url":null,"abstract":"<div><h3>Background</h3><div>International travel poses unique health risks for individuals with diabetes. This study explored their travel patterns, preparations, and morbidity, as well as identify factors influencing pre-travel health-seeking behavior from primary healthcare providers.</div></div><div><h3>Methods</h3><div>This cross-sectional, questionnaire-based study recruited adults with diabetes who had traveled internationally within the past 12 months. Data on sociodemographic and clinical characteristics, travel patterns, preparations, and travel-associated morbidity were collected via questionnaires and electronic medical records. Multivariate logistic regression analyses were conducted to identify predictors of patients informing physicians about travel plans.</div></div><div><h3>Results</h3><div>Among 250 participants (median age: 65 years [57–69]; median HbA1c: 7.1 % [6.6–7.9]), 16.4 % were on insulin therapy. The median travel duration was 6 days (5–10), with a median of one time zone crossed. Insulin-treated individuals tended to plan shorter trips to closer destinations than their non-insulin-treated counterparts. While 70.8 % of participants carried medicines for acute illness, only 10.8 % informed their primary care physicians about travel plans, and 11.2 % experienced travel-associated morbidity, including acute illness, falls, and hypoglycemia. Predictors of informing physicians about travel plans included travel duration exceeding ten days (OR: 4.87, 95 % CI: 1.34–17.63), insulin therapy (OR: 4.37, 95 % CI: 1.21–15.80), taking preventive measures against hypoglycemia during travel (OR: 3.40, 95 % CI: 1.26–9.14), and good antidiabetic medication adherence (OR: 2.96, 95 % CI: 1.10–7.96).</div></div><div><h3>Conclusions</h3><div>This study underscored the impact of diabetes self-care practices on pre-travel health-seeking behavior and demonstrated how insulin therapy shapes travel patterns, highlighting the need for reinforced self-management skills and targeted pre-travel guidance, especially for insulin-treated patients.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102828"},"PeriodicalIF":6.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in body composition during acute exposure to high altitude is related to acute mountain sickness","authors":"Simin Zhou ,&nbsp;Huaping Dong ,&nbsp;Pei Huang ,&nbsp;Yaling Li ,&nbsp;Zhifeng Zhong ,&nbsp;Heng Xiao ,&nbsp;Jiaxin Xie ,&nbsp;Yu Wu ,&nbsp;Peng Li","doi":"10.1016/j.tmaid.2025.102815","DOIUrl":"10.1016/j.tmaid.2025.102815","url":null,"abstract":"<div><h3>Background</h3><div>Acute hypoxia exposure leads to a high incidence of acute mountain sickness (AMS) and changes in body composition, while the relationship between body composition and AMS remains unclear. We designed this study to detect the body composition and discern its relationship with AMS.</div></div><div><h3>Methods</h3><div>Eighty-one subjects were transported from the plain (300 m) to the plateau (3680 m). The body weight and body composition were measured in the plain and at the plateau. The occurrence of AMS was investigated by using the Lake Louise Scoring (LLS) system for six consecutive days. Then, the relationship between body composition and AMS was further analyzed.</div></div><div><h3>Results</h3><div>The body weight, fat-free mass (FFM), total body water (TBW), intracellular water (ICW), extracellular water (ECW) and segmental lean mass decreased significantly with the prolonged stay at the plateau. Compared with those in the plain, FM increased significantly at the plateau, and the mineral increased significantly on the third day while decreasing significantly on the sixth day. The daily incidence of AMS during the first 6 days at the plateau was 23.46 %, 7.41 %, 2.47 %, 2.47 %, 1.23 %, and 2.47 %, respectively. Correlation analysis showed that the decline of FFM, TBW, and ECW was positively correlated with the LLS score. Among the AMS relevant symptoms, only fatigue was positively correlated with the decline of FFM, TBW, ICW, and ECW.</div></div><div><h3>Conclusions</h3><div>Significant changes of body composition were observed in the early stage after ascent to plateau. The decline of FFM, TBW, and ECW might be related to the severity of AMS, and fatigue was positively correlated with the decline of FFM, TBW, ICW and ECW.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102815"},"PeriodicalIF":6.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of neglected tropical diseases among migrants living in Europe: A systematic review and meta-analysis","authors":"Giacomo Guido ,&nbsp;Luisa Frallonardo ,&nbsp;Sergio Cotugno ,&nbsp;Elda De Vita ,&nbsp;Giulia Patti ,&nbsp;Laura De Santis ,&nbsp;Francesco Vladimiro Segala ,&nbsp;Emanuele Nicastri ,&nbsp;Federico Gobbi ,&nbsp;Anna Morea ,&nbsp;Francesca Indraccolo ,&nbsp;Domenico Otranto ,&nbsp;Ana Requena-Mendez ,&nbsp;Nicola Veronese ,&nbsp;Annalisa Saracino ,&nbsp;Francesco Di Gennaro ,&nbsp;Roberta Iatta","doi":"10.1016/j.tmaid.2025.102823","DOIUrl":"10.1016/j.tmaid.2025.102823","url":null,"abstract":"<div><h3>Background</h3><div>Migration to Europe has intensified due to recent political conflicts, economic crises, and climate change, introducing an increased risk of neglected tropical diseases (NTDs) within this population. While NTDs typically impact tropical regions, their presence among migrants in Europe presents a growing challenge, compounded by limited research in this area. This study provides the first meta-analysis on the prevalence of NTDs in migrants across European nations.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis was conducted focusing on studies that included NTD prevalence among migrant populations in Europe, with data sourced until July 2024. Cross-sectional and longitudinal studies were eligible, with bias assessed using the Newcastle-Ottawa Scale. Prevalence rates for various NTDs were calculated using a random-effects model, and meta-regressions were performed to assess potential moderators like sample size, age, and gender.</div></div><div><h3>Results</h3><div>A total of 148 studies comprising 228,798 migrants were analyzed. The most prevalent NTDs were strongyloidiasis (11.53 %) and schistosomiasis (10.8 %), with American trypanosomiasis also present. Dengue and lymphatic filariasis showed significant rates, though high heterogeneity was noted. Data quality was frequently low, with most studies at a high risk of bias.</div></div><div><h3>Conclusions</h3><div>This study underscores the need for robust screening and diagnostic protocols in Europe for NTDs, particularly as clinician familiarity with these diseases is limited. Test-and-treat strategies appear promising, yet more comprehensive efforts are necessary. Establishing a European NTD registry could improve monitoring and management. Future studies should prioritize higher-quality data and address the barriers migrants face in accessing health services.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102823"},"PeriodicalIF":6.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avian Influenza – The next travel-associated pandemic? Proactive One Health surveillance is required to reduce the risk of the spread","authors":"Alfonso J. Rodriguez-Morales ,&nbsp;David S. Hui ,&nbsp;Giuseppe Ippolito ,&nbsp;Tieble Traore ,&nbsp;Giovanni Satta ,&nbsp;Dean B. Everett ,&nbsp;Alimuddin Zumla","doi":"10.1016/j.tmaid.2025.102829","DOIUrl":"10.1016/j.tmaid.2025.102829","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102829"},"PeriodicalIF":6.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}