Travel Medicine and Infectious Disease最新文献

{"title":"Imported Strongyloides stercoralis infections in Germany: descriptive study of cases over 5 years in a referral center in Berlin","authors":"Antonio Seigerschmidt ,&nbsp;Maria Cristina Moreno-del Castillo ,&nbsp;Gabriela Equihua Martinez ,&nbsp;Paul Pitzinger ,&nbsp;Janina Hammer ,&nbsp;Susanne Georgi ,&nbsp;Michael Nürnberg ,&nbsp;Julian Bernhard ,&nbsp;Franziska Olgemöller ,&nbsp;Beate Kampmann ,&nbsp;Frank P. Mockenhaupt ,&nbsp;Thomas Weitzel ,&nbsp;Andreas K. Lindner","doi":"10.1016/j.tmaid.2026.102952","DOIUrl":"10.1016/j.tmaid.2026.102952","url":null,"abstract":"<div><h3>Background</h3><div><em>Strongyloides stercoralis</em> is a widespread helminth in tropical and subtropical regions, which can persist in humans for life through autoinfection. The clinical picture varies from asymptomatic to life-threatening hyperinfection syndrome. There is concern about increasing prevalence in Europe due to the number of cases imported by migrants and travelers.</div></div><div><h3>Methods</h3><div>This is a retrospective chart review of patients evaluated at the Charité Tropical Medicine outpatient clinic in Berlin, Germany. Cases were identified based on either a positive serologic test for <em>Strongyloides</em> (i.e., probable cases) or the detection of <em>Strongyloides</em> larvae in stool samples (i.e., confirmed cases).</div></div><div><h3>Results</h3><div>From April 2018 to November 2023, 162 patients with <em>Strongyloides</em> infection were identified. Diagnosis was confirmed in 49 patients (30.2 %) and probable in 113 patients (69.8 %). About half of the patients (48.8 %) were classified as migrants, who were diagnosed through screening in 48.1 %. Eosinophilia was present in 27.6 % of all patients, with no significant differences between migrants and non-migrants, or between probable or confirmed infections. In patients with a positive stool microscopy, only 8/37 (21.6 %) had a positive serology.</div></div><div><h3>Conclusion</h3><div>Nearly half of the migrant cases were detected through serology as part of screening. Most patients had no eosinophilia, and the positivity of serological tests was very low in patients with positive stool microscopy. These findings highlight the usefulness of targeted screening strategies in risk populations and suggest implementing sensitive stool tests detecting larvae combined with serology, to improve case detection.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"70 ","pages":"Article 102952"},"PeriodicalIF":4.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Converging influenza threats: Seasonal A(H3N2) (including subclade K) dynamics and the persistent pandemic risk of A(H5N1)","authors":"Jaime David Acosta-España ,&nbsp;Jenny Belén Altamirano-Jara ,&nbsp;D. Katterine Bonilla-Aldana ,&nbsp;Erika Tatiana Chica-Granados ,&nbsp;Alfonso J. Rodriguez-Morales","doi":"10.1016/j.tmaid.2025.102949","DOIUrl":"10.1016/j.tmaid.2025.102949","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"69 ","pages":"Article 102949"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic biomarkers for cross-altitude prediction of acute mountain sickness: A prospective cohort study in young males","authors":"Xinjie Zhang ,&nbsp;Rui Wang ,&nbsp;Wenling Zhu ,&nbsp;Jie Tao ,&nbsp;Fen He ,&nbsp;Bao Liu ,&nbsp;Zhong Chen","doi":"10.1016/j.tmaid.2025.102947","DOIUrl":"10.1016/j.tmaid.2025.102947","url":null,"abstract":"<div><h3>Background</h3><div>Current prediction tools for acute mountain sickness (AMS) are mainly limited by single-altitude designs. This study aimed to evaluate the cross-altitude predictive value of pre-ascent echocardiography and investigate altitude-specific cardiac mechanisms.</div></div><div><h3>Methods</h3><div>This prospective study assigned 238 healthy young males to 3800 m (n = 106), 4300 m (n = 60), or 4500 m (n = 72) groups. Baseline echocardiography was performed at 200 m before ascent. AMS was assessed (days 1–7) using the Lake Louise Questionnaire. Candidate predictors were selected via a multi-stage process (univariate screening followed by LASSO regression) for subsequent multivariate logistic regression.</div></div><div><h3>Results</h3><div>AMS incidence was altitude-dependent (11.3 % at 3800 m, 16.7 % at 4300 m, 55.6 % at 4500 m; P &lt; 0.001). Pulmonary artery diameter (PAD) was a robust, consistent predictor across all altitudes (aOR = 1.53, 95 % CI 1.21–1.93, P &lt; 0.001). Altitude-stratified analysis identified distinct predictors: right ventricular pressure load (RVOT-PGmax, aOR = 0.21, 95 % CI 0.07–0.62, P = 0.004) and structural remodeling (RV ESAi, aOR = 1.52, 95 % CI 1.13–2.05, P = 0.006) were dominant at 3800 m, whereas right ventricular systolic function (TAPSE, aOR = 2.55, 95 % CI 1.76–3.69, P &lt; 0.001) was the primary predictor at 4500 m. The altitude-interaction model (AUC = 0.85) outperformed the global model (AUC = 0.80; P = 0.020).</div></div><div><h3>Conclusions</h3><div>Pre-ascent echocardiography predicts AMS risk across altitudes, with PAD emerging as a robust, cross-altitude predictor.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"69 ","pages":"Article 102947"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Child health in international travel: A German airport survey","authors":"Jonathan Remppis ,&nbsp;Rebekka Weitz ,&nbsp;Mohamed Aasi ,&nbsp;Elsa Taut ,&nbsp;Michael Sroka ,&nbsp;Holger Czerwonka ,&nbsp;Stefan Berberich-Kappe ,&nbsp;Carsten Köhler ,&nbsp;Sarah Kotsias-Konopelska ,&nbsp;Sabine Bélard","doi":"10.1016/j.tmaid.2025.102946","DOIUrl":"10.1016/j.tmaid.2025.102946","url":null,"abstract":"<div><h3>Background</h3><div>Despite rising global mobility, pediatric travel medicine remains underrepresented. Children are particularly vulnerable to travel-related health risks, yet evidence suggests that preventive measures are inconsistently applied. This study aimed to obtain unfiltered data on pediatric travel medicine outside a medical setting in Germany, and identify existing gaps and resources.</div></div><div><h3>Methods</h3><div>Between July 2024 and January 2025, face-to-face interviews with families returning from tropical or subtropical destinations were conducted in the baggage claim area at Frankfurt Airport. The survey collected data on travel profiles, medical preparation, behaviors and travel-related illnesses. In total, 200 families were included in the analysis, comprising 702 individuals, of whom 318 were children under 18 years.</div></div><div><h3>Results</h3><div>While 109 (55 %) families had received pre-travel advice by a pediatrician or general practitioner (GP), only 29 (15 %) had been consulted by travel medicine specialists. The children of 138 (69 %) families had not received any vaccinations in preparation for their trip. Among 31 families at high risk of malaria, only 19 (61 %) administered chemoprophylaxis to their children. Seventeen families carried standby emergency treatment, some in addition to chemoprophylaxis. Children of 51 (26 %) families had medical problems during travel, mostly respiratory symptoms, fever, and diarrhea; only one child required hospitalization.</div></div><div><h3>Conclusions</h3><div>Pediatricians and GPs play a key role in travel consultation. The study reveals substantial shortcomings in pediatric travel preparation, particularly regarding vaccination and malaria prevention. To address these gaps, increased awareness among families, improved training for pediatricians and GPs, and clear and accessible pediatric-specific guidelines are urgently needed.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"69 ","pages":"Article 102946"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145744175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dengue serotypes and epidemic dynamics in Brazil: a spatiotemporal perspective","authors":"Camila Lorenz ,&nbsp;Philippe Lemey ,&nbsp;Simon Dellicour","doi":"10.1016/j.tmaid.2025.102948","DOIUrl":"10.1016/j.tmaid.2025.102948","url":null,"abstract":"<div><div>Changes in the geographic distribution and territorial expansion of <em>Aedes aegypti,</em> the main dengue vector in the Americas, coupled with the concurrent circulation of multiple DENV serotypes, have driven the overall rise in dengue incidence in Brazil. Here, we investigate the spatiotemporal distribution of dengue virus serotypes across Brazil, focusing on dengue epidemiology over the last decade (2014–2025). We examine the temporal dynamics of these serotypes and discuss the main strategies to mitigate the public health impact of their co-circulation.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"69 ","pages":"Article 102948"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining the clinical utility of dengue RT-iiPCR: stratification by days post-onset and primary vs. secondary infection during the 2023 Taiwan outbreak","authors":"Li-Teh Liu ,&nbsp;Po-Chih Chen ,&nbsp;Ping-Chang Lin ,&nbsp;Ching-Yi Tsai ,&nbsp;Chun-Hong Chen ,&nbsp;Chen-Hsuan Lin ,&nbsp;Jih-Jin Tsai","doi":"10.1016/j.tmaid.2025.102945","DOIUrl":"10.1016/j.tmaid.2025.102945","url":null,"abstract":"<div><h3>Background</h3><div>Rapid molecular diagnostics are critical for timely dengue virus (DENV) detection, especially in resource-limited settings. Reverse transcription-insulated isothermal polymerase chain reaction (RT-iiPCR) enables sample-to-answer amplification without thermocyclers. While this platform was previously validated, its diagnostic performance against contemporary viral genotypes and, critically, across different host immune statuses (primary vs. secondary infection) remains largely undefined. We assessed a DENV iiPCR assay against quantitative real-time reverse transcription PCR (qRT-PCR) during the 2023 outbreak in southern Taiwan.</div></div><div><h3>Methods</h3><div>Acute-phase sera (n = 185) from febrile patients were tested by qRT-PCR, pan-DENV iiPCR, IgM/IgG ELISAs, and serotype-specific RT-PCR/iiPCR. Diagnostic performance was evaluated with qRT-PCR as a reference. Subgroup analyses examined effects of days post-symptom onset (PSO), immune status (primary vs secondary infection), and serotype on iiPCR sensitivity.</div></div><div><h3>Results</h3><div>Pan-iiPCR achieved 88.4 % sensitivity and 100 % specificity versus qRT-PCR. Sensitivity peaked within 3 days PSO (96.8 %) and in primary infections (95.0 %) but declined after day 3 (53.3 %) and in secondary infections (82.2 %). Combining pan-iiPCR with IgM testing raised sensitivity to ≥99 % beyond the viremic window. iiPCR correctly typed 83.5 % (71/85) of DENV-1 and 94.3 % (66/70) of DENV-2. Because pan-iiPCR served as the screening step, 18 RT-PCR–positive specimens were pan-iiPCR negative and therefore did not proceed to iiPCR serotyping.</div></div><div><h3>Conclusions</h3><div>iiPCR enables rapid early-phase detection and is useful when paired with serology. However, reduced sensitivity in low-viremia and secondary infections, as well as incomplete serotyping, limit standalone use. Primer optimization and integration with IgM testing may enhance outbreak utility.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"69 ","pages":"Article 102945"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recrudescence of Plasmodium falciparum malaria imported from Sub-Saharan Africa: a report of two cases and the first detection of artemisinin resistance in Italy","authors":"Mariangela L'Episcopia ,&nbsp;Andrea Poloni ,&nbsp;Mario Corbellino ,&nbsp;Daniela Boccolini ,&nbsp;Anna Gigantiello ,&nbsp;Alice Covizzi ,&nbsp;Davide Bernasconi ,&nbsp;Valeria Colombo ,&nbsp;Carlo Severini ,&nbsp;Spinello Antinori","doi":"10.1016/j.tmaid.2025.102950","DOIUrl":"10.1016/j.tmaid.2025.102950","url":null,"abstract":"<div><h3>Background</h3><div>Artemisinin-based combination therapy for <em>Plasmodium falciparum</em> malaria is threatened by the emergence of partial resistance.</div></div><div><h3>Methods</h3><div>Molecular characterization of antimalarial resistance-associated genes <em>Pfk13, Pfcrt, Pfmdr1, Pfdhfr, Pfdhps</em> and <em>PfCytB</em> was performed on blood samples collected from two patients with recurrent episodes of <em>P. falciparum</em> malaria.</div></div><div><h3>Results</h3><div>Two severe <em>P. falciparum</em> malaria in Italian travelers from sub-Saharan Africa showed recrudescence after standard treatment with intravenous artesunate and oral dihydroartemisinin-piperaquine. In one case, the validated marker R561H of artemisinin partial resistance was identified. In the second patient, no <em>Pfkelch13</em> mutations were detected, and the recrudescent episode was probably the consequence of low blood drug concentration administered by nasogastric tube, although the possible role of <em>Pfkelch13</em>-independent pathways or reduced artemisinin susceptibility cannot be ruled out.</div></div><div><h3>Conclusion</h3><div>The first imported case of artemisinin-resistant <em>P. falciparum</em> in Italy from sub-Saharan Africa underscores the need for continuous surveillance and eventually adapting treatment protocols.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"69 ","pages":"Article 102950"},"PeriodicalIF":4.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemophagocytic lymphohistiocytosis secondary to typhoid fever: a diagnostic challenge","authors":"Jorge A. Morcillo Muñoz ,&nbsp;Diego Andrés Rodríguez Lugo ,&nbsp;Abraham Katime Zuñiga ,&nbsp;Daniela Miranda Paz ,&nbsp;Álvaro A. Faccini-Martínez","doi":"10.1016/j.tmaid.2025.102941","DOIUrl":"10.1016/j.tmaid.2025.102941","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"68 ","pages":"Article 102941"},"PeriodicalIF":4.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145517082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leptospirosis in the United Kingdom: a decade of experience from a large regional hospital","authors":"Andrew Taylor ,&nbsp;Paul N. Newton ,&nbsp;Ivo Elliott","doi":"10.1016/j.tmaid.2025.102920","DOIUrl":"10.1016/j.tmaid.2025.102920","url":null,"abstract":"<div><h3>Background</h3><div>Leptospirosis is one of the most common bacterial zoonoses worldwide, with a broad spectrum of illness from mild and self-resolving to multi-organ failure and death. There have been few reports of the epidemiology, clinical features and outcomes of the disease in the United Kingdom.</div></div><div><h3>Methods</h3><div>We present experience of 29 patients with confirmed leptospirosis from 924 tested patients over a 10-year period at a large tertiary hospital in the UK.</div></div><div><h3>Results</h3><div>All patients reported a fever and eit travel overseas in the 6 weeks prior to illness, or documented exposure to water or animals in the UK. Acute kidney injury occurred in 18/29 (62 %), 6 patients (20 %) required admission to the intensive care unit and 1 died. There were no recorded acquired UK cases during winter when water temperatures are usually below 10 °C.</div></div><div><h3>Conclusions</h3><div>Epidemiological awareness and documented exposure history may increase the proportion of positive tests and offer potential laboratory cost savings.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"68 ","pages":"Article 102920"},"PeriodicalIF":4.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESBL-producing and colistin-resistant Enterobacterales among Czech international travellers: genomic relatedness to community and environmental isolates","authors":"Suhanya Prasad ,&nbsp;Barbora Dratvova ,&nbsp;Milena Antuskova ,&nbsp;Marie Brajerova ,&nbsp;Elka Nycova ,&nbsp;Eva Adamova ,&nbsp;Milan Trojanek ,&nbsp;Jan Tkadlec ,&nbsp;Pavel Drevinek ,&nbsp;Marcela Krutova","doi":"10.1016/j.tmaid.2025.102930","DOIUrl":"10.1016/j.tmaid.2025.102930","url":null,"abstract":"<div><h3>Background</h3><div>While antimicrobial resistance in Enterobacterales is closely monitored in healthcare settings, much less is known about the circulation of these bacteria in the community, particularly in high-risk groups such as travellers. This study aimed to determine the prevalence of intestinal carriage of extended-spectrum β-lactamase (ESBL)-producing, carbapenem- and colistin-resistant Enterobacterales in returning symptomatic Czech travellers, and to investigate whether travel contributes to colonisation with resistant strains distinct from those circulating in the Czech Republic.</div></div><div><h3>Methods</h3><div>Stool samples were cultured using a selective chromogenic medium following enrichment. Isolates with phenotypic resistance were characterised by short and long-read whole-genome sequencing. Genomes of ESBL and <em>mcr-1</em>-carrying <em>E. coli</em> isolates from travellers were compared with available genomes from various Czech sources, including wastewater treatment plants, hospital sewage, river water, patients with urinary tract infections, rectal swabs from medical students, and meat samples.</div></div><div><h3>Results</h3><div>Between September 2019 and October 2021, 165 stool samples (male = 91, 55.2 %, average age 41 years) were analysed. Thirty-two travellers (19.4 %) were culture-positive on the ESBL screening media, with ESBL genes identified in 17.6 % (29/165). The <em>bla</em>_CTX-M-15 gene was dominant (59 %, 17/29), located either on the plasmid or the chromosome. Three non-ESBL <em>E. coli</em> isolates carried the <em>mcr-1</em> gene (1.8 %, 3/165). No carbapenem-resistant isolates were recovered. No clonal relatedness was observed between ESBL-carrying <em>E. coli</em> isolates or their plasmids from travellers and other sources.</div></div><div><h3>Conclusion</h3><div>Czech travellers frequently carried diverse ESBL-producing Enterobacterales, suggesting that travel contributes to the dissemination of bacterial strains and mobile genetic elements harbouring antimicrobial resistance genes.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"68 ","pages":"Article 102930"},"PeriodicalIF":4.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145483002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}