Prevalence of neglected tropical diseases among migrants living in Europe: A systematic review and meta-analysis

IF 6.3 3区 医学 Q1 INFECTIOUS DISEASES
Giacomo Guido , Luisa Frallonardo , Sergio Cotugno , Elda De Vita , Giulia Patti , Laura De Santis , Francesco Vladimiro Segala , Emanuele Nicastri , Federico Gobbi , Anna Morea , Francesca Indraccolo , Domenico Otranto , Ana Requena-Mendez , Nicola Veronese , Annalisa Saracino , Francesco Di Gennaro , Roberta Iatta
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引用次数: 0

Abstract

Background

Migration to Europe has intensified due to recent political conflicts, economic crises, and climate change, introducing an increased risk of neglected tropical diseases (NTDs) within this population. While NTDs typically impact tropical regions, their presence among migrants in Europe presents a growing challenge, compounded by limited research in this area. This study provides the first meta-analysis on the prevalence of NTDs in migrants across European nations.

Methods

A systematic review and meta-analysis was conducted focusing on studies that included NTD prevalence among migrant populations in Europe, with data sourced until July 2024. Cross-sectional and longitudinal studies were eligible, with bias assessed using the Newcastle-Ottawa Scale. Prevalence rates for various NTDs were calculated using a random-effects model, and meta-regressions were performed to assess potential moderators like sample size, age, and gender.

Results

A total of 148 studies comprising 228,798 migrants were analyzed. The most prevalent NTDs were strongyloidiasis (11.53 %) and schistosomiasis (10.8 %), with American trypanosomiasis also present. Dengue and lymphatic filariasis showed significant rates, though high heterogeneity was noted. Data quality was frequently low, with most studies at a high risk of bias.

Conclusions

This study underscores the need for robust screening and diagnostic protocols in Europe for NTDs, particularly as clinician familiarity with these diseases is limited. Test-and-treat strategies appear promising, yet more comprehensive efforts are necessary. Establishing a European NTD registry could improve monitoring and management. Future studies should prioritize higher-quality data and address the barriers migrants face in accessing health services.
生活在欧洲的移民中被忽视的热带病的流行:系统回顾和荟萃分析。
背景:由于最近的政治冲突、经济危机和气候变化,向欧洲的移民加剧,这一人群中被忽视的热带病(NTDs)风险增加。虽然被忽视的热带病通常影响热带地区,但它们在欧洲移徙者中的存在带来了越来越大的挑战,加上这方面的研究有限。本研究首次对欧洲各国移民中被忽视热带病的患病率进行了荟萃分析。方法:对欧洲移民人口中NTD患病率的研究进行了系统回顾和荟萃分析,数据来源截止到2024年7月。横断面和纵向研究是合格的,使用纽卡斯尔-渥太华量表评估偏倚。使用随机效应模型计算各种被忽视热带病的患病率,并进行meta回归以评估样本量、年龄和性别等潜在调节因素。结果:共分析了148项研究,包括228,798名移民。最常见的被忽视热带病是圆线虫病(11.53%)和血吸虫病(10.8%),美洲锥虫病也存在。登革热和淋巴丝虫病的发病率显著,但异质性较高。数据质量往往较低,大多数研究存在高偏倚风险。结论:这项研究强调了在欧洲对被忽视热带病进行强有力的筛查和诊断方案的必要性,特别是在临床医生对这些疾病的熟悉程度有限的情况下。测试和治疗策略看起来很有希望,但更全面的努力是必要的。建立一个欧洲NTD登记处可以改善监测和管理。今后的研究应优先考虑高质量的数据,并解决移徙者在获得保健服务方面面临的障碍。
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来源期刊
Travel Medicine and Infectious Disease
Travel Medicine and Infectious Disease PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-INFECTIOUS DISEASES
CiteScore
19.40
自引率
1.70%
发文量
211
审稿时长
49 days
期刊介绍: Travel Medicine and Infectious Disease Publication Scope: Publishes original papers, reviews, and consensus papers Primary theme: infectious disease in the context of travel medicine Focus Areas: Epidemiology and surveillance of travel-related illness Prevention and treatment of travel-associated infections Malaria prevention and treatment Travellers' diarrhoea Infections associated with mass gatherings Migration-related infections Vaccines and vaccine-preventable disease Global policy/regulations for disease prevention and control Practical clinical issues for travel and tropical medicine practitioners Coverage: Addresses areas of controversy and debate in travel medicine Aims to inform guidelines and policy pertinent to travel medicine and the prevention of infectious disease Publication Features: Offers a fast peer-review process Provides early online publication of accepted manuscripts Aims to publish cutting-edge papers
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