Travel Medicine and Infectious Disease最新文献

{"title":"Collapse on a flight to Paris returning from Bangalore: A sentinel cholera case in a man visiting friends and relatives in India","authors":"Marin Caumartin , Sophie Nagle , Racha Eid , Caroline Rouard , Jean Baptiste Destival , Marie Christine Bouton , Lou Macaux , Vladimir Adrien , Olivier Bouchaud , Fatma el Alaoui , Nicolas Vignier","doi":"10.1016/j.tmaid.2025.102824","DOIUrl":"10.1016/j.tmaid.2025.102824","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102824"},"PeriodicalIF":6.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Travel Patterns, Pretravel Preparation, and Travel-associated Morbidity in Travelers with Diabetes in Taiwan.","authors":"Yi-Chen Lee, Yi-Hsuan Lee, Chia-Wen Lu, Kuo-Chin Huang","doi":"10.1016/j.tmaid.2025.102828","DOIUrl":"https://doi.org/10.1016/j.tmaid.2025.102828","url":null,"abstract":"<p><strong>Background: </strong>International travel poses unique health risks for individuals with diabetes. This study explored their travel patterns, preparations, and morbidity, as well as identify factors influencing pre-travel health-seeking behavior from primary healthcare providers.</p><p><strong>Methods: </strong>This cross-sectional, questionnaire-based study recruited adults with diabetes who had traveled internationally within the past 12 months. Data on sociodemographic and clinical characteristics, travel patterns, preparations, and travel-associated morbidity were collected via questionnaires and electronic medical records. Multivariate logistic regression analyses were conducted to identify predictors of patients informing physicians about travel plans.</p><p><strong>Results: </strong>Among 250 participants (median age: 65 years [57-69]; median HbA1c: 7.1 % [6.6-7.9]), 16.4% were on insulin therapy. The median travel duration was 6 days (5-10), with a median of one time zone crossed. Insulin-treated individuals tended to plan shorter trips to closer destinations than their non-insulin-treated counterparts. While 70.8% of participants carried medicines for acute illness, only 10.8% informed their primary care physicians about travel plans, and 11.2% experienced travel-associated morbidity, including acute illness, falls, and hypoglycemia. Predictors of informing physicians about travel plans included travel duration exceeding ten days (OR: 4.87, 95% CI: 1.34-17.63), insulin therapy (OR: 4.37, 95% CI: 1.21-15.80), taking preventive measures against hypoglycemia during travel (OR: 3.40, 95% CI: 1.26-9.14), and good antidiabetic medication adherence (OR: 2.96, 95% CI: 1.10-7.96).</p><p><strong>Conclusions: </strong>This study underscored the impact of diabetes self-care practices on pre-travel health-seeking behavior and demonstrated how insulin therapy shapes travel patterns, highlighting the need for reinforced self-management skills and targeted pre-travel guidance, especially for insulin-treated patients.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102828"},"PeriodicalIF":6.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avian Influenza - The next travel-associated pandemic? Proactive One Health surveillance is required to reduce the risk of the spread.","authors":"Alfonso J Rodriguez-Morales, David S Hui, Giuseppe Ippolito, Tieble Traore, Giovanni Satta, Dean B Everett, Alimuddin Zumla","doi":"10.1016/j.tmaid.2025.102829","DOIUrl":"https://doi.org/10.1016/j.tmaid.2025.102829","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102829"},"PeriodicalIF":6.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemorrhagic Fevers Caused by South American Mammarenaviruses: A Comprehensive Review of Epidemiological and Environmental Factors Related to Potential Emergence.","authors":"Esteban Ortiz-Prado, Jorge Vasconez-Gonzalez, D A Becerra-Cardona, María José Farfán-Bajaña, Susana García-Cañarte, Andrés López-Cortés, Juan S Izquierdo-Condoy","doi":"10.1016/j.tmaid.2025.102827","DOIUrl":"https://doi.org/10.1016/j.tmaid.2025.102827","url":null,"abstract":"<p><p>South American hemorrhagic fevers (SHF), a group of zoonotic diseases caused by various virus families including Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae, are primarily confined to geographic areas where their host species reside. Transmission to humans occurs through direct contact with infected animals, especially rodents, and when infected, humans can transmit diseases to other humans through person-to-person interactions and other means, leading to illnesses that range from mild to life-threatening conditions. Diseases such as Argentine hemorrhagic fever, caused by the Junin virus, Brazilian hemorrhagic fever, caused by the Sabia virus, Venezuelan hemorrhagic fever, caused by the Guanarito virus, and Chapare hemorrhagic fever, are responsible for most hemorrhagic fevers excluding hemorrhagic consequences of diseases such as those caused by dengue. These diseases were first described in the late 1950s, coinciding with environmental and agricultural changes that led to increased rodent populations and the expansion of urban areas into rural zones. Pathogenically, these viruses typically initiate infection in the lungs and subsequently disseminate to regional lymphatic vessels and other organs, resulting in severe vascular and coagulation dysfunction. Clinical manifestations start with a prodromal phase characterized by general malaise and fever, progressing to more severe neurological and hemorrhagic symptoms, and concluding with a convalescent phase that may result in long-term neurological conditions. We comprehensively reviewed the literature on these South American hemorrhagic fevers. The dynamics of these diseases highlight the complex interactions between environmental factors, human behavior, and viral pathogenicity that drive the epidemiology of hemorrhagic fevers in South America.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102827"},"PeriodicalIF":6.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic analysis of chronic chikungunya in the Reunionese CHIKGene cohort uncovers a shift in gene expression more than 10 years after infection.","authors":"Patrick Gérardin, Raissa Medina-Santos, Sigrid Le Clerc, Léa Bruneau, Adrien Maillot, Taoufik Labib, Myriam Rahmouni, Jean-Louis Spadoni, Jean-Philippe Meyniel, Clémence Cornet, Cécile Lefebvre, Nora El Jahrani, Jakub Savara, Mano Joseph Mathew, Christine Fontaine, Christine Payet, Nathalie Ah-You, Cécile Chabert, Corinne Mussard, Sylvaine Porcherat, Samir Medjane, Josselin Noirel, Catherine Marimoutou, Hakim Hocini, Jean-François Zagury","doi":"10.1016/j.tmaid.2025.102825","DOIUrl":"https://doi.org/10.1016/j.tmaid.2025.102825","url":null,"abstract":"<p><strong>Aim: </strong>In 2005-2006, a chikungunya epidemic of unprecedented magnitude hit Reunion Island, which raised a public health concern through the substantial proportions of long-lasting manifestations. To understand the pathophysiology underlying chronic chikungunya (CC), we designed the CHIKGene cohort study and collected blood samples from 133 subjects diagnosed with CC and from 86 control individuals that had recovered within 3 months, 12-to-15 years after exposure.</p><p><strong>Methods: </strong>We conducted bulk RNAseq analysis on peripheral blood mononuclear cells to find differentially expressed genes (DEGs), gene set enrichment analysis (GSEA) and gene ontologies to uncover top-level enriched terms associated with DEGs, and weighted gene correlation network analysis (WGCNA) to elucidate underlying cellular processes.</p><p><strong>Results: </strong>Among 1549 DEGs, gene expression analysis identified 10 top genes including NR4A2 and TRIM58 (upregulated in CC), IGHG3 and IGHV3-49 (downregulated in CC) linked to immune regulation, OSBP2 (upregulated in CC) and SEMA6B (downregulated in CC) linked to neuronal homeostasis and axon guidance, respectively. GSEA and WGCNA unveiled cellular processes such as \"Metabolism of RNA\" and \"Cell Cycle\".</p><p><strong>Conclusions: </strong>This study uncovers a shift in gene expression of CC subjects. IGHG3 and IGHV3-49 gene shut-offs spotlight the importance of neutralizing antibodies against chikungunya virus in the progression to chronic disease. Human diseases associations highlight connections to rheumatoid arthritis, nervous and cardiac systems. GSEA and WGCNA bounce the hypotheses of a persistent viral reservoir or an increased susceptibility to RNA viral pathogens with new onset infections. Together, our findings might offer potential targets for therapeutic options aimed at alleviating chronic chikungunya.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102825"},"PeriodicalIF":6.3,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rabies exposure in international travellers: Experience from a single travel clinic in Paris, France, 2018-2022.","authors":"Patrick Hochedez, Kaoutar Jidar, Fabien Taieb, Oula Itani, Ghania Benabdelmoumen, Perrine Parize, Hervé Bourhy, Paul-Henri Consigny, Philippe Poujol","doi":"10.1016/j.tmaid.2025.102821","DOIUrl":"https://doi.org/10.1016/j.tmaid.2025.102821","url":null,"abstract":"<p><strong>Background: </strong>Rabies is a vaccine-preventable zoonotic disease which causes thousands of deaths every year, mainly in Asia and Africa, and dogs are the main source of human cases. Although rabies is rare in international travellers, rabies exposure is relatively frequent and the number of travellers seeking post-exposure treatment may rise as international travel continues to increase. We aimed to better understand the characteristics of travellers exposed to rabies abroad, in order to deliver targeted advice and rabies vaccination during pre-travel clinics.</p><p><strong>Methods: </strong>During 2018-2022, we studied all returning travellers who attended a single travel clinic in Paris, France, for animal exposures abroad and requiring rabies post-exposure prophylaxis (n=2,916).</p><p><strong>Results: </strong>During the study period, 2,916 returning travellers were included, and 59.7% of exposures occurred in Southeast Asia (mainly Thailand and Indonesia) and North-Africa. Dogs were predominantly responsible for exposures, but the animals involved varied significantly according to the region visited and the age of the traveller. Monkey exposures were more frequently reported in Asia, and cat exposures in North Africa and among children. Exposures were reported as unprovoked in 22.9% of cases, and 91% of travellers had not received anti-rabies vaccines before travelling.</p><p><strong>Conclusions: </strong>Travellers to rabies endemic countries should benefit from more targeted information based on the region visited, the animals they are likely to encounter, and the age of the travellers. Critically, they should be counselled on the importance of avoiding contact with animals, the long-lasting benefit of pre-travel rabies vaccination, and the need for adequate post-exposure prophylaxis.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102821"},"PeriodicalIF":6.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malaria in Turkey: A comprehensive analysis of diagnosis, treatment, and the impact of COVID-19, ten years after malaria elimination (2012–2023)","authors":"Özgün Ekin Şahin ,&nbsp;Zeynepgül Kalay ,&nbsp;Nagehan Didem Sarı ,&nbsp;Ayşe Batırel ,&nbsp;Gülden Ersöz ,&nbsp;Günay Tuncer Ertem ,&nbsp;Tuba Turunç ,&nbsp;Ramazan Gözüküçük ,&nbsp;Funda Şimşek Çelener ,&nbsp;Arzu Kantürk ,&nbsp;Kaya Süer ,&nbsp;Şafak Özer Balın ,&nbsp;Ayşe Sağmak Tartar ,&nbsp;Güven Çelebi ,&nbsp;Hülya Kuşoğlu ,&nbsp;Selma Ateş ,&nbsp;Sevil Alkan ,&nbsp;Duru Mıstanoğlu Özatağ ,&nbsp;Hande Berk ,&nbsp;Cengiz Uzun ,&nbsp;Önder Ergönül","doi":"10.1016/j.tmaid.2025.102819","DOIUrl":"10.1016/j.tmaid.2025.102819","url":null,"abstract":"<div><h3>Background</h3><div>The characteristics, diagnosis, and treatment stages of malaria in Turkey in the last ten years are not known except few case reports. We aimed to describe the details of the diagnosis and treatment practices of malaria cases in various hospitals across Turkey between 2012 and 2023 after the declaration of the elimination of malaria.</div></div><div><h3>Methods</h3><div>We collected the patient data from 30 centers by using Qualtrics Survey Software. The patients were categorized according to the WHO Malaria Severe Disease Symptoms guidelines.</div></div><div><h3>Results</h3><div>We detected 299 malaria cases. Of these patients, 23.7 % experienced misdiagnosis, with 77.5 % of misdiagnosed cases receiving antibiotics. Among the patients, 9 (3 %) had no travel history. Additionally, 28 (9.4 %) patients required admission to the intensive care unit (ICU) during hospitalization. There is a significant association between misdiagnosis and subsequent ICU admissions. Additionally, the duration between malaria diagnosis and the initiation of treatment significantly affected ICU admissions. Furthermore, the number of cases with severe malaria (according to WHO criteria) and ICU admissions increased after the COVID-19 period. In multivariate analysis, initial misdiagnosis was found to be associated with ICU admission (OR: 2.8, p &lt; 0.05), while each day's treatment delays post-diagnosis increased ICU admissions (OR: 1.26, p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Misdiagnosis is common which delays the treatment and is correlated with higher admissions to ICUs. Post-COVID-19, there was a notable increase in both ICU admissions and cases of severe malaria, suggesting an escalation in disease severity that warrants further investigation. The resurgence of rare malaria cases with no travel history to abroad highlights the necessity of continued vigilance for new malaria cases. Efforts to promptly treat upon diagnosis and improve diagnostic accuracy in Turkey, where malaria is uncommon, are crucial. Enhancing diagnostic methods and treatment strategies remains essential, especially in significant events like COVID-19.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102819"},"PeriodicalIF":6.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of neglected tropical diseases among migrants living in Europe: a systematic review and meta-analysis.","authors":"Guido G, Frallonardo L, Cotugno S, De Vita E, Patti G, De Santis L, Segala Fv, Nicastri E, Gobbi F, Morea A, Francesca Indraccolo, Domenico Otranto, A Requena-Mendez, Veronese N, Saracino A, Di Gennaro F, Iatta R","doi":"10.1016/j.tmaid.2025.102823","DOIUrl":"https://doi.org/10.1016/j.tmaid.2025.102823","url":null,"abstract":"<p><strong>Background: </strong>Migration to Europe has intensified due to recent political conflicts, economic crises, and climate change, introducing an increased risk of neglected tropical diseases (NTDs) within this population. While NTDs typically impact tropical regions, their presence among migrants in Europe presents a growing challenge, compounded by limited research in this area. This study provides the first meta-analysis on the prevalence of NTDs in migrants across European nations.</p><p><strong>Methods: </strong>A systematic review and meta-analysis was conducted focusing on studies that included NTD prevalence among migrant populations in Europe, with data sourced until July 2024. Cross-sectional and longitudinal studies were eligible, with bias assessed using the Newcastle-Ottawa Scale. Prevalence rates for various NTDs were calculated using a random-effects model, and meta-regressions were performed to assess potential moderators like sample size, age, and gender.</p><p><strong>Results: </strong>A total of 148 studies comprising 228,798 migrants were analyzed. The most prevalent NTDs were strongyloidiasis (11.53%) and schistosomiasis (10.8%), with American trypanosomiasis also present. Dengue and lymphatic filariasis showed significant rates, though high heterogeneity was noted. Data quality was frequently low, with most studies at a high risk of bias.</p><p><strong>Conclusions: </strong>This study underscores the need for robust screening and diagnostic protocols in Europe for NTDs, particularly as clinician familiarity with these diseases is limited. Test-and-treat strategies appear promising, yet more comprehensive efforts are necessary. Establishing a European NTD registry could improve monitoring and management. Future studies should prioritize higher-quality data and address the barriers migrants face in accessing health services.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102823"},"PeriodicalIF":6.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Landscape of guidance documents used at TropNet and GeoSentinel centres for the clinical management of schistosomiasis outside endemic areas: A systematic appraisal","authors":"Francesca Tamarozzi ,&nbsp;Cristina Mazzi ,&nbsp;Spinello Antinori ,&nbsp;Marta Arsuaga ,&nbsp;Sören L. Becker ,&nbsp;Cristina Bocanegra ,&nbsp;Emmanuel Bottieau ,&nbsp;Dora Buonfrate ,&nbsp;Amaya L. Bustinduy ,&nbsp;Daniel Camprubí-Ferrer ,&nbsp;Eric Caumes ,&nbsp;Alexandre Duvignaud ,&nbsp;Martin P. Grobusch ,&nbsp;Ralph Huits ,&nbsp;Stephane Jaureguiberry ,&nbsp;Sabine Jordan ,&nbsp;Andreas Mueller ,&nbsp;Momar Ndao ,&nbsp;Andreas Neumayr ,&nbsp;Jose A. Perez-Molina ,&nbsp;Federico G. Gobbi","doi":"10.1016/j.tmaid.2025.102822","DOIUrl":"10.1016/j.tmaid.2025.102822","url":null,"abstract":"<div><h3>Background</h3><div>The diagnostic and treatment approaches for schistosomiasis in individual patients, outside endemic areas, are not standardised. This study aimed to appraise the reference documents that the experts from the TropNet and GeoSentinel networks use in practice as guidance for the clinical management of their patients with (suspect) schistosomiasis.</div></div><div><h3>Methods</h3><div>We systematically appraised the following data from the referenced guidance documents: i) document type, ii) case definitions, iii) diagnostic techniques envisaged; iv) treatment recommendations; v) follow-up recommendations; vi) screening recommendations, and vii) symptom-based diagnostic suspicion.</div></div><div><h3>Results</h3><div>Twenty-two of the 30 responders (73.3 %) indicated 19 reference documents, three of which were WHO material not intended for individual clinical management. Only 4/19 (21.1 %) documents were national recommendations; no international guideline was indicated. Case definitions were explicitly presented in only one document (1/19; 5.3 %). Diagnostic tools were detailed in 11/16 (68.8 %) and follow-up guidance in 8/16 (50 %) documents. Treatment guidance was provided in 14/16 (87.5 %) documents.</div></div><div><h3>Conclusions</h3><div>Heterogeneity in clinical guidance was evident, although with noticeable overlap at least for chronic schistosomiasis. This confirms the need to formalise case definitions, which should be used to design trials to rigorously assess diagnostic tools and treatment schemes, and eventually come to harmonization of clinical management guidance.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102822"},"PeriodicalIF":6.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143465497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical evaluation of the RBD-Trimeric vaccine: A novel approach to strengthening biotechnological sovereignty in developing countries against SARS-CoV-2 variants","authors":"Luis Flórez ,&nbsp;Daniel Echeverri-De la Hoz ,&nbsp;Alfonso Calderón ,&nbsp;Hector Serrano-Coll ,&nbsp;Caty Martinez ,&nbsp;Camilo Guzmán ,&nbsp;Bertha Gastelbondo ,&nbsp;German Arrieta ,&nbsp;Ariel Arteta ,&nbsp;Tania Márquez ,&nbsp;Ricardo Rivero ,&nbsp;Salim Máttar","doi":"10.1016/j.tmaid.2025.102820","DOIUrl":"10.1016/j.tmaid.2025.102820","url":null,"abstract":"<div><div>New immunogens against emerging new virus variants are essential for controlling new variants.</div></div><div><h3>Methods</h3><div>A preclinical study in which a receptor-binding domain (RBD) trimer was designed in silico with information from the Beta (B.1.351), Omicron (BA.5), and Wuhan 1 variant. A three-dimensional model of the RBD-trimer was made, and the synthesis of the trimer was based on the RBD domain of the S protein of Beta and Omicron. For the experimental trials, 63 BALB/c mice were immunized and divided into three groups: control (n = 15), adjuvant (n = 15), and RBD-trimer (n = 33).</div></div><div><h3>Results</h3><div>81 % (13/16), 90 % (9/10), and 85 % (6/7) of BALB/c mice that received one dose, two doses, and three doses, respectively, seroconverted. Significant statistical differences (p &lt; 0.001) were found between the experimental group vaccinated with the RBD-trimer, the group with adjuvant, and the control group. The booster did not show significant differences (p &gt; 0.05. No inflammatory or cellular changes were observed, highlighting the safety of the RBD vaccine candidate. Kinetics and seroconversion of 75 % were obtained in the mice with two doses of tri-RBD. (P &lt; 0.0001).</div></div><div><h3>Conclusions</h3><div>Applying two doses of the RBD vaccine candidate in BALB/c mice was safe and immunogenic against SARS-CoV-2. This study provides support for the country's biotechnological sovereignty and its potential contribution to public health in Colombia.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102820"},"PeriodicalIF":6.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}