Travel Medicine and Infectious Disease最新文献

{"title":"Changes in the epidemiology of Crimean-Congo Hemorrhagic Fever: impact of travel and a OneHealth approach in the European region.","authors":"Francesca F Norman, Octavio A Arce, Marta Díaz-Menéndez, Moncef Belhassen-García, Marta González-Sanz","doi":"10.1016/j.tmaid.2025.102806","DOIUrl":"https://doi.org/10.1016/j.tmaid.2025.102806","url":null,"abstract":"<p><strong>Background: </strong>The World Health Organization has identified Crimean-Congo hemorrhagic fever (CCHF) as a priority disease for research and development in emergency contexts. The epidemiology of CCHF is evolving and this review highlights travel-associated cases and focuses on the need for a One Health approach in Europe.</p><p><strong>Methods: </strong>For this narrative review, two searches were performed in PubMed and Google Scholar for the period 1980-October 2024. The first search identified travel-associated CCHF cases globally, additional cases were identified in the ProMED mail database and through healthmap.org. The second search, with a focus on the European region, aimed to analyse reports of CCHF virus (CCHFV) detected in ticks, CCHF seroprevalence studies in animals and/or humans, and autochthonous CCHF cases.</p><p><strong>Results: </strong>Seventeen cases of imported CCHF, the majority acquired in Africa, were identified. Importation to European countries accounted for eight of the cases. Most patients presented with fever and hemorrhagic manifestations and the estimated case fatality rate was 35%. In the WHO European region, 13 countries have reported ticks infected with different genotypes of CCHFV; 17 countries were found to have animals/humans with positive CCHF serology. Finally, 16 countries in the WHO European region have notified human cases of CCHF. The Russian Federation, Turkey, and several former USSR countries are considered highly endemic, followed by the Balkanic region, with sporadic cases emerging in Bulgaria, Greece, Spain, and recently Portugal.</p><p><strong>Conclusions: </strong>Travel-associated CCHF is infrequent. However, given the recently reported increased geographical distribution in ticks and animals in the European region, additional human cases may be anticipated in the near future. Europe receives over half of all international tourist arrivals annually, so healthcare professionals should be aware of risk factors and current protocols for the management of suspected and confirmed cases.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102806"},"PeriodicalIF":6.3,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for schistosomiasis in a non-endemic setting: accuracy of a rapid antibody test using finger prick blood.","authors":"Margherita Ortalli, Bianca Granozzi, Michele Bacchiega, Concettina Di Lillo, Greta Roncarati, Silvia Stefania Longoni, Cristina Mazzi, Elisa Vanino, Zeno Bisoffi, Stefania Varani","doi":"10.1016/j.tmaid.2025.102807","DOIUrl":"https://doi.org/10.1016/j.tmaid.2025.102807","url":null,"abstract":"<p><p>Human schistosomiasis is a chronic neglected tropical disease caused by blood flukes of the genus Schistosoma, infecting 250 million people worldwide, mostly in sub-Saharan Africa. Recently, thousands of cases have been reported in immigrants to non-endemic countries, including Italy. Serological screening is recommended but so far, no accurate point-of-care (POC) and lab-free test is available. We carried out a prospective evaluation of the accuracy of a new immunochromatographic test (Black- ICT, IgG-IgM) using finger prick blood for screening of schistosomiasis at the University Hospital of Bologna. Eligible immigrants were recruited regardless the presence of symptoms. The other tests used were microscopy on stools and urine, a serum-ICT (SCHISTOSOMA ICT IgG-IgM, LDBIO Diagnostics), an ELISA (NovaLisa Schistosoma mansoni IgG, Novatec) and a Western Blot (SCHISTO II Western Blot IgG, LDBIO Diagnostics). Statistical analysis was performed using a Bayesian latent class model. We enrolled 198 subjects in the study. Black-ICT had a sensitivity of 86.6% (95% credible interval 76.9-94.7) and a specificity of 88.4% (82.0-94.3). At the estimated prevalence level for the study sample, 32.6% (25.5-40.0), the positive and negative predictive values were 78.2% (66.4-89.4) and 93.2% (87.7-97.6), respectively. Good agreement was found with the other antibody tests, with the highest sensitivity being observed for serum-ICT (91.0%, 84.7-96.4) and the highest specificity for ELISA (92.6%, 87.5-96.7). The novel POC test for schistosomiasis showed satisfactory results and could improve the detection of this parasitic infection in non-endemic settings, as the lab-free approach could greatly expand the target group.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102807"},"PeriodicalIF":6.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical care and initial health status of French children returnees from Jihadist Group Operation Areas: a cross-sectional study from 2017 to 2020 in one referral French hospital.","authors":"J Goutines, L L Pham, N Lucidarme, C Briand, A Malka, C Baker, M Veyret-Morau, A Mapelli, A Klein, T Baubet, L De Pontual","doi":"10.1016/j.tmaid.2025.102805","DOIUrl":"https://doi.org/10.1016/j.tmaid.2025.102805","url":null,"abstract":"<p><strong>Introduction: </strong>The return of foreign fighters's children whose parents joined the so called « islamic state » in the Iraq-Syrian area, had been a very controversial topic. Since 2017, a national procedure in France has been designed to coordinate their care, including a systematic pediatric medical assessment.</p><p><strong>Methods: </strong>The aim of this cross-sectional study was to assess the prevalence rate of diseases diagnosed at their arrival in France. Demographic characteristics and clinical assessment of all the children included in this procedure in one paediatric center between 2017 and 2020 were retrospectively collected.</p><p><strong>Findings: </strong>We included 70 children (44M, 26F ; mean age : 4.9 years old (±3.8)). In average, they crossed two countries, mainly Syria (n=55), Turkey (n=53) and Iraq (n=18). At least one parent was deceased or incarcerated in respectively 25 (36%) and 50 cases (71%). Main pathologies were infectious diseases (n=14, 20%), including one lymph node tuberculosis. Mild nutritional impairment (n=55, 78%-95%), stunting (n=13, 19%- 95%), psychomotor troubles (n=18, 26%) and psychological or behavior troubles (n=36, 51%) were also reported. Nutritional impairment was associated with a longer stay abroad (aOR 4.34, 95% CI [1.21-18.24], p=0.03) whereas no significant association was found between the other diseases and age, birth country or length of stay abroad.</p><p><strong>Conclusions: </strong>Nutritional impairment and psychomotor or behaviour troubles were more frequent than other diseases in our cohort. These results emphasize the importance of considering the developmental aspects of these young children who experimented multiple potentially psychic traumatic events.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102805"},"PeriodicalIF":6.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarification of factors associated with post-artesunate delayed hemolysis (PADH): analysis of 327 patients with severe imported Plasmodium falciparum malaria in France.","authors":"Pierre-Louis Conan, Marc Thellier, Eric Kendjo, Sandrine Houzé, Rémonie Seng, Stéphane Jauréguiberry","doi":"10.1016/j.tmaid.2025.102801","DOIUrl":"https://doi.org/10.1016/j.tmaid.2025.102801","url":null,"abstract":"<p><strong>Background: </strong>Post-Artesunate delayed hemolysis (PADH) occurs in approximately 15% of treated patients 2 to 3 weeks after artesunate administration. Identifying risk markers for PADH would help predict which patients are at higher risk.</p><p><strong>Methods: </strong>In this prospective national cohort study conducted in a non-malaria endemic area from 2011 to 2016, a Cox proportional hazards model was used to assess the association between clinical and biological data available at Day 0 and the occurrence of PADH within 30 days of artesunate administration.</p><p><strong>Results: </strong>In the analyzed population (n=327), 49 PADH events occurred after a median time of 14 days (IQR, 13-17) after artesunate initiation. Higher initial parasitemia was associated with an increased risk of PADH, with a significant interaction found with patient origin. The cumulative probability of PADH event at Day 30 post-artesunate was 65% (95% confidence interval [CI], 44-79) for European patients vs. 14% (95% CI, 0-26) for those with recent African ancestry [RAA] when the initial parasitemia was > 10%. After adjustment for weight, history of malaria, initial hemoglobin, very severe malaria and residence in an endemic area, compared to recent African ancestry with initial parasitemia < 4%, the adjusted hazard ratio for PADH occurrence was 18.8 (95% CI, 4-89) for Europeans and 4.77 (95% CI, 0.8-29.2) for recent African ancestry with initial parasitemia > 10%.</p><p><strong>Conclusions: </strong>This study showed that initial parasitemia and patient origin were the main predictors of developing PADH, with the highest risk observed in Europeans with an initial parasitemia > 10%.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102801"},"PeriodicalIF":6.3,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of consular assistance provided to Irish citizens abroad, 2014-2023.","authors":"Alan Alby, Aoife Power, Gerard T Flaherty","doi":"10.1016/j.tmaid.2025.102803","DOIUrl":"10.1016/j.tmaid.2025.102803","url":null,"abstract":"<p><strong>Introduction: </strong>There has been limited literature reporting the nature of the consular assistance provided to travellers. This study aimed to describe the consular assistance activity of the Irish Department of Foreign Affairs.</p><p><strong>Methods: </strong>Publicly available consular assistance data (2014-2023) were analysed descriptively. Consular missions were listed under 16-19 categories.</p><p><strong>Results: </strong>A total of 26,378 consular assistance missions were recorded. The greatest proportion of missions related to COVID-19 repatriations (26.9 %, n = 7097), deaths overseas (10 %, n = 2650), and medical illness/mental health emergency abroad (11.6 %, n = 3047). Forensic incidents (arrests/victims of crime) accounted for 12.9 % (n = 3392) of consular assistance episodes.</p><p><strong>Conclusion: </strong>This study highlights the characteristics and trends of consular assistance requests received by a national governmental agency. Future studies should explore traveller awareness of consular procedures and the extent to which they are addressed in travel medicine consultations.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102803"},"PeriodicalIF":6.3,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effectiveness of dengue surveillance in the tropical and sub-tropical Asian nations through dengue case data from travelers returning to the five Western Pacific countries and territories.","authors":"Jong-Hun Kim, Ah-Young Lim, Sung Hye Kim","doi":"10.1016/j.tmaid.2025.102802","DOIUrl":"10.1016/j.tmaid.2025.102802","url":null,"abstract":"<p><strong>Introduction: </strong>Dengue, affecting over 3.9 billion people, is a significant health threat globally. Despite a tenfold increase in reported cases from 2000 to 2020, underreporting remains an issue. Our study utilized traveler data from the five Western Pacific countries and territories as sentinel sites, to examine dengue surveillance in Southeast and South Asia.</p><p><strong>Methods: </strong>We reported dengue cases among returning travelers (2010-2018) and computed dengue incidence per 100,000 travelers for each destination country. We compared officially reported dengue incidence per 100,000 inhabitants of the destination country with estimated incidence per 100,000 travelers, using Pearson's correlation coefficient.</p><p><strong>Results: </strong>Key findings revealed eight Southeast and South Asia countries as popular destinations for our sentinel sites, with Australia exhibiting the highest incidence (40.7 per 100,000 travelers). Dengue incidence variations were evident, with Malaysia showing a sharp increase over time. Correlation analysis showed strong links in Malaysia (r = 0.66-0.92) and weaker connections in India (r = -0.54-0.76) between dengue incidence among inhabitants and travelers.</p><p><strong>Conclusion: </strong>Systematically collected dengue surveillance data from returning travelers can serve as a proxy for dengue incidence in the destination country and can be used to assess the robustness of the country's dengue surveillance.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102802"},"PeriodicalIF":6.3,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hantavirus and Leptospira are important causes of nonspecific acute febrile syndrome, Meta, Colombia.","authors":"Liliana Sánchez-Lerma, Salim Mattar, Verónica Contreras, Jorge Miranda, Vaneza Tique, Virginia Rodríguez, Derly Rodriguez, Sonia Lopez, Andrés Rojas-Gulloso","doi":"10.1016/j.tmaid.2025.102800","DOIUrl":"10.1016/j.tmaid.2025.102800","url":null,"abstract":"<p><strong>Introduction: </strong>Acute undifferentiated febrile illnesses are fevers lasting less than fourteen days without an evident focus of infection on the initial physical examination or with inconclusive laboratory tests.</p><p><strong>Objective: </strong>Carry out epidemiological surveillance of the etiology of acute undifferentiated febrile syndrome in the Meta department.</p><p><strong>Methods: </strong>A descriptive, prospective cross-sectional study was carried out between February 2021 and June 2023 in a first-level hospital in the department of Meta, Colombia. All enrolled patients underwent routine hematology and blood biochemistry examinations. RT-qPCR was performed for Dengue and serology for laboratory diagnoses using ELISA and MAT for Hantavirus and Leptospirosis, respectively. A descriptive and bivariate analysis was performed using SPSS vr 23.0.</p><p><strong>Results: </strong>Of the study's total of one hundred patients, 14 % showed antibodies against hantavirus IgG, of which two were seroconverted. In addition, a risk factor OR = 8.3 (CI = 1.8-38.4) for Hantavirus was found in those patients who had contact with farm animals. Regarding leptospirosis, 3 % of the sera agglutinated with titers greater than 1:400, resulting in a primary infection; 11 % of the sera presented agglutination with titers no greater than 1:200 as exposure to leptospirosis. The bivariate analysis showed an OR = 2.4; CI = 0.75-7.4 with water recreational activities in the last 30 days before the onset of symptoms.</p><p><strong>Conclusions: </strong>Our study demonstrates the importance of Hantavirus, Dengue, and leptospirosis as a cause of acute undifferentiated febrile illnesses. Coinfections are frequent in one of the tropical areas of Colombia, so it is crucial to establish a more precise diagnosis.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102800"},"PeriodicalIF":6.3,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aedes-borne arboviral human infections in Europe from 2000 to 2023: A systematic review and meta-analysis.","authors":"Nadja Hedrich, Maria Bekker-Nielsen Dunbar, Martin P Grobusch, Patricia Schlagenhauf","doi":"10.1016/j.tmaid.2025.102799","DOIUrl":"10.1016/j.tmaid.2025.102799","url":null,"abstract":"<p><strong>Introduction: </strong>Aedes-borne arboviral infections, both imported and autochthonous, are reported in Europe. We evaluated the landscape of these infections in Europe over 23 years and attempted to pre-empt the trajectory of impact of these infections in the climatic context of Aedes mosquito expansion in Europe.</p><p><strong>Methods: </strong>This systematic review was conducted in accordance with PRISMA guidelines and registered in Prospero (CRD42023360259). PubMed, Embase, Web of Science, IEEE Xplore, and Cochrane Central Register of Controlled Trials (CENTRAL) databases and the European Centre for Disease Prevention and Control (ECDC) websites were searched for publications reporting on cases of Aedes-borne infection in Europe between January 1st, 2000, and December 31st, 2023.</p><p><strong>Results: </strong>Some 353 papers were included, covering 59,589 cases of infection in Europe by seven arboviruses: dengue, Zika, chikungunya, yellow fever, Mayaro, Ross River, and Rift Valley. Most cases (55,924) were travel related, while 5 % were autochthonous. There were 59 cases of non-vector-borne transmission, primarily Zika-related sexual transmissions. Nineteen deaths were reported, of which three were associated with chikungunya virus infection, 12 with dengue, and four with yellow fever. Notable sequelae included persistent arthralgia from chikungunya and neurological effects in Zika-infected infants. The meta-analysis of 31 studies revealed a pooled prevalence of 0.047 (95 % CI: 0.03-0.07) in symptomatic returning travelers.</p><p><strong>Conclusion: </strong>The systematic review provides a comprehensive overview of over 20 years of Aedes -borne infections in Europe, highlighting the dynamic nature of virus transmission influenced by global travel patterns, climate change, the expanding spread of Aedes populations, and evolving public health campaigns.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102799"},"PeriodicalIF":6.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Costs of typhoid vaccination for international travelers from the United States.","authors":"Heesoo Joo, Brian A Maskery, Louise K Francois Watkins, Joohyun Park, Kristina M Angelo, Eric S Halsey","doi":"10.1016/j.tmaid.2025.102798","DOIUrl":"10.1016/j.tmaid.2025.102798","url":null,"abstract":"<p><p>In the United States, typhoid vaccination is recommended for international travelers to areas with a recognized risk of typhoid exposure. Using MarketScan® Commercial Database from 2016 through 2022, we estimated typhoid vaccination costs by route (injectable vs. oral) and provider setting (clinic vs. pharmacy). Of 165,930 vaccinated individuals, 99,471 received injectable and 66,459 received oral typhoid vaccines, with 88 % and 17 % respectively administered at clinics. Average costs for injectable vaccination were $132.91 per person [95 % confidence interval (CI): $132.68-$133.13], with clinic and pharmacy costs at $136.38 [95 % CI: $136.14-$136.63] and $107.45 [95 % CI: $107.13-$107.77], respectively. Oral vaccination costs averaged $81.23 per person [95 % CI: $81.14-$81.33], encompassing $86.61 [95 % CI: $86.13-$87.10] at clinics and $80.14 [95 % CI: $80.09-$80.19] at pharmacies. Out-of-pocket costs comprised 21 % and 33 % of total costs for injectable and oral vaccinations. These findings may inform clinical decision-making to protect international travelers' health.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102798"},"PeriodicalIF":6.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of pediatric scrub typhus presenting as acalculous cholecystitis during the non-epidemic season without eschar.","authors":"Ruonan Li, Yanchun Wang, Xiaotao Yang, Yonghan Luo","doi":"10.1016/j.tmaid.2025.102797","DOIUrl":"10.1016/j.tmaid.2025.102797","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102797"},"PeriodicalIF":6.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}