Travel Medicine and Infectious Disease最新文献

{"title":"Malaria risk perceptions and barriers for effective prophylaxis among sub-Saharan African 'visiting friends and relatives' travellers in Hamburg, Germany","authors":"Marabelle N. Essandoh ,&nbsp;Maria S. Mackroth ,&nbsp;Thomas Theo Brehm ,&nbsp;Pia Michelitsch ,&nbsp;Franck Ekoka Mbassi ,&nbsp;Maximilian Rakotonirinalalao ,&nbsp;Kayode Ijagbemi ,&nbsp;Michael Ramharter","doi":"10.1016/j.tmaid.2025.102858","DOIUrl":"10.1016/j.tmaid.2025.102858","url":null,"abstract":"<div><h3>Background</h3><div>The African visiting friends and relatives (VFR) community in the Global North is at high risk of contracting preventable travel-associated infections including malaria when travelling to sub-Saharan Africa. This study aimed to assess barriers to effective prevention and to develop tailored travel counselling.</div></div><div><h3>Methods</h3><div>A questionnaire-based survey was conducted from January to August 2023 at the Hamburg Airport among adult sub-Saharan African VFR travellers returning from malaria-endemic destinations in Africa to assess malaria risk perceptions, attitudes towards prophylaxis and counselling and their experiences with travel medicine and malaria prophylaxis.</div></div><div><h3>Results</h3><div>A total of 389 participants completed the survey. Of these, 67 % (n = 261) demonstrated adequate knowledge of malaria transmission. Fifty-one percent (n = 198) perceived minimal risk of contracting malaria in the malaria-endemic country leading to lower uptake of prophylaxis. Ten percent (n = 37) mistakenly believed they were vaccinated against malaria. Approximately half of the respondents did not seek medical travel advice prior to departure or take antimalarial prophylaxis due to perceived minimal risk of disease. Of those who took antimalarial drugs, 77 % (n = 149) completed the full course. On return, 5 % (n = 20) of the respondents had malaria-like symptoms and of these, 55 % (n = 11) either self-medicated or did not seek medical treatment.</div></div><div><h3>Conclusions</h3><div>VFR travellers mistakenly perceive a low risk of malaria, resulting in low uptake of travel medical advice and chemoprophylaxis. Mistrust of advice from healthcare providers was found. Insights from this survey are valuable for practitioners and travel medicine clinics to provide more tailored and culturally sensitive travel advice to VFR travellers.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102858"},"PeriodicalIF":6.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olinda María Delgado Silva, PhD: A trailblazer in Venezuelan parasitology and a beloved mentor to generations","authors":"Alfonso J. Rodriguez-Morales ,&nbsp;Vanessa Aguilera-Volkman","doi":"10.1016/j.tmaid.2025.102844","DOIUrl":"10.1016/j.tmaid.2025.102844","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102844"},"PeriodicalIF":6.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe mpox clade II infection in an immunocompromised HIV patient: Case report and therapeutic approach","authors":"Serena Vita ,&nbsp;Dimitra Kontogiannis ,&nbsp;Francesca Faraglia ,&nbsp;Alessandra D'Abramo ,&nbsp;Valentina Mazzotta ,&nbsp;Alessandra Scarabello ,&nbsp;Claudia Palazzolo ,&nbsp;Angela Corpolongo ,&nbsp;Andrea Antinori ,&nbsp;Emanuele Nicastri","doi":"10.1016/j.tmaid.2025.102860","DOIUrl":"10.1016/j.tmaid.2025.102860","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102860"},"PeriodicalIF":6.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fever in travelers returning from tropical and subtropical areas: a hospital-based study of factors affecting investigations and diagnoses in children and adults","authors":"Klara Sondén ,&nbsp;Donya Satarvandi ,&nbsp;Helena Hildenwall ,&nbsp;Sara Falck-Jones ,&nbsp;Victor Yman ,&nbsp;Niclas Johansson ,&nbsp;Katja Wyss ,&nbsp;Elin Folkesson ,&nbsp;Hilmir Asgeirsson ,&nbsp;Irene Nordling ,&nbsp;Anna Löwhagen Welander ,&nbsp;Anna Färnert","doi":"10.1016/j.tmaid.2025.102861","DOIUrl":"10.1016/j.tmaid.2025.102861","url":null,"abstract":"<div><h3>Background</h3><div>As global travel surges in the post-pandemic era, healthcare systems must prepare for proper management of diseases encountered by returning travelers.</div></div><div><h3>Method</h3><div>A retrospective study of the management of returning travelers from tropical or subtropical regions, with fever at the adult and paediatric emergency departments of Karolinska University Hospital, Stockholm Sweden. Demographics, travel history, clinical and microbiology data were extracted from health records. Multivariate regression analyses identified factors affecting investigations and diagnoses.</div></div><div><h3>Results</h3><div>A total of 2441 patients (2197 adults, 244 children) were included. An etiological diagnosis was confirmed in 63.3 % (n = 1546) of patients; with malaria (5.6 %, n = 138), dengue (4.0 %, n = 98) and typhoid fever (0.9 %, n = 22) being the most common tropical infections. Patients with fever &gt;38 °C (aOR 1.48, 95 % CI 1.20–1.84) or hospitalization (aOR 4.68, 95 % CI 3.23–6.80) had higher odds of etiological diagnosis. Children were less likely than adults to have a cause of fever diagnosed (OR 0.64, 95 % CI 0.49–0.84). Malaria testing was lower in children than adults who had visited Sub-Sahara Africa (80.6 % vs 90.4 %). Overall, a lower proportion of children underwent blood cultures, compared to adults (29.5 % vs 68.7 %). VFR travelers and migrants had lower probability of other microbiological investigations when malaria testing was negative (aOR 0.69, 95 % CI 0.54–0.90; aOR 0.67, 95 % CI 0.50–0.90).</div></div><div><h3>Conclusion</h3><div>The management of febrile patients following tropical travel varied significantly across different patient groups. Children, migrants and VFR travelers often receive less thoroughly investigations. This highlights the need for equitable management and investigation, especially for these vulnerable populations.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102861"},"PeriodicalIF":6.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Operational challenges and lessons learned from conducting febrile surveillance in a long-term randomized dengue vaccine trial in Latin America and Asia-Pacific","authors":"Harald Pfaar ,&nbsp;Eduardo López-Medina ,&nbsp;Ian Escudero ,&nbsp;Yanee Hutagalung ,&nbsp;Nicholas Roubinis ,&nbsp;Seloni Thakrar ,&nbsp;Charissa Fay Corazon Borja-Tabora ,&nbsp;Vianney Tricou ,&nbsp;Suely Tuboi","doi":"10.1016/j.tmaid.2025.102840","DOIUrl":"10.1016/j.tmaid.2025.102840","url":null,"abstract":"<div><h3>Background</h3><div>In trials, dengue vaccine efficacy evaluation relies on participants presenting with febrile illness/clinically suspected dengue contacting the study site for sample collection and clinical assessment within a short timeframe. Here, we present key considerations to maintain high compliance with the febrile surveillance procedures in a trial that assessed TAK-003 efficacy.</div></div><div><h3>Methods</h3><div>DEN-301 (NCT02747927) is a randomized phase 3 trial in children/adolescents from eight dengue-endemic countries in Latin America (LATAM) and Asia-Pacific (APAC). Febrile surveillance consisted of weekly contact with the participant to identify cases of fever (≥38 °C; two of three consecutive days). Blood samples were collected for molecular testing, preferably ≤5 days of fever onset, together with thorough clinical assessment by the investigators. The data are presented descriptively.</div></div><div><h3>Results</h3><div>Of the 20,071 (LATAM, 11,080; APAC, 8991) participants who received TAK-003/placebo, 18,260 (91.0 %) completed 4.5 years of follow-up. The overall incidence of febrile illness was 30 (LATAM, 26.0; APAC, 35.1) cases per 100 person-years. The rate samples collected during the acute phase was 98.1 %. The overall rate of samples collected after 5 days of fever onset (missed/out-of-window) was 6 % (LATAM, 10 %; APAC, 2 %). A trend toward reduced missed/out-of-window samples was observed after implementing measures, such as transportation, engagement, and healthcare aid tailored per study site in 2017, which appeared to increase during the COVID-19 pandemic.</div></div><div><h3>Conclusion</h3><div>The design of the febrile surveillance protocol ensured high compliance in the trial. Maintaining engagement and access to healthcare beyond the protocol was important in improving febrile case evaluation ≤5 days of fever onset.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102840"},"PeriodicalIF":6.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marburg virus disease outbreak in Tanzania, 2023–2025","authors":"Ranjana Rohilla ,&nbsp;Aroop Mohanty ,&nbsp;Rachana Mehta ,&nbsp;Shriyansh Srivastava ,&nbsp;Sakshi Sharma ,&nbsp;Sanjit Sah ,&nbsp;Vini Mehta ,&nbsp;Vasso Apostolopoulos","doi":"10.1016/j.tmaid.2025.102857","DOIUrl":"10.1016/j.tmaid.2025.102857","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102857"},"PeriodicalIF":6.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis and mortality risk in elderly patients with dengue virus infection: Excess fatality and the urgent need for revising current WHO criteria for elderly patients","authors":"Min-Jia Jeng ,&nbsp;Nan-Yao Lee ,&nbsp;Ing-Kit Lee ,&nbsp;Yi-Chun Chen ,&nbsp;Wen-Chi Huang ,&nbsp;Jui-Chi Hsu ,&nbsp;Chien-Hsiang Tai ,&nbsp;Hao-Min Lan","doi":"10.1016/j.tmaid.2025.102855","DOIUrl":"10.1016/j.tmaid.2025.102855","url":null,"abstract":"<div><h3>Background</h3><div>The World Health Organization (WHO) reports a rising global incidence of dengue and severe outcomes among the elderly. This study investigates the differences in dengue characteristics between elderly and non-elderly patients and identifies mortality risk factors among elderly dengue patients.</div></div><div><h3>Methods</h3><div>We conducted a retrospective study of adults (≥20 years) with dengue virus (DENV) infection at two medical centers from 2002 to 2018. Participants were divided into non-elderly (20–64 years) and elderly (≥65 years) groups.</div></div><div><h3>Results</h3><div>A total of 1274 patients with laboratory-confirmed dengue were included in the study, of whom 373 (29.3 %) were classified as elderly. The majority of patients (67.5 %) were infected with DENV-2. In the overall cohort, age ≥65 years was identified as an independent predictor of mortality. Compared with non-elderly patients, elderly individuals exhibited significantly lower frequencies of classical dengue symptoms (e.g., fever, myalgia, bone pain, rash), but experienced higher rates of severe dengue, longer hospital stays, and more frequent complications, including acute kidney injury, severe hepatitis, bacteremia, pneumonia, and acute respiratory failure. The mortality rate was significantly higher among elderly patients (18 %) compared to non-elderly patients (2.7 %). Multivariate analysis among the elderly subgroup identified altered consciousness and pleural effusion at presentation, along with the development of acute kidney injury, severe hepatitis, and pneumonia during hospitalization, as independent predictors of mortality.</div></div><div><h3>Conclusions</h3><div>The current WHO criteria may be insufficient for the timely identification of dengue in the elderly population. Excess mortality in this group underscores the urgent need for updated guidelines. Neurological symptoms, pleural effusion at presentation, and organ impairment during hospitalization are key predictors of mortality in elderly dengue patients.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102855"},"PeriodicalIF":6.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccine uptake and adherence to non-pharmaceutical interventions at a youth mass gathering event: A longitudinal field cohort study","authors":"Laura J. Ferris ,&nbsp;Jemima Kang ,&nbsp;Joanne A. Rathbone ,&nbsp;Tegan Cruwys ,&nbsp;Mark Stevens ,&nbsp;Jessica L. Donaldson ,&nbsp;Jamie Ranse ,&nbsp;Fiona Kate Barlow","doi":"10.1016/j.tmaid.2025.102853","DOIUrl":"10.1016/j.tmaid.2025.102853","url":null,"abstract":"<div><h3>Background</h3><div>Youth mass gathering events attract thousands of travellers and produce high-exposure conditions for respiratory pathogens and other communicable diseases. Adolescents and young adults have high social circulation and show higher infection rates for viral threats like SARS-CoV2 than other age groups. How young people self-manage their elevated communicable disease risk in high-exposure travel settings such as mass events is under-researched. This study examined vaccination rates, attitudes, and adherence to non-pharmaceutical interventions (e.g., mask-wearing, physical distancing) at a youth mass event during the global COVID-19 pandemic (Oct–Dec 2021).</div></div><div><h3>Methods</h3><div>Longitudinal cohort design with online surveys 1 month pre- (T0), during (T1-T3) and 1 month post- (T4) event. Participants were <em>N</em> = 291 Australian school-leavers (16–19 years) during end-of-school mass celebrations called ‘Schoolies’. Participants reported travel origin and whether they attended an official Schoolies festival (primary site), or elsewhere (secondary sites). Surveys measured COVID-19 vaccine uptake, vaccine-related attitudes, and adherence to non-pharmaceutical interventions.</div></div><div><h3>Results</h3><div>At T0, 88% were vaccinated. Pro-vaccine attitudes were a strong positive correlate of vaccination. Primary site (versus secondary site) attendees held more favourable attitudes toward COVID-19 vaccination, perceiving higher vaccine safety, effectiveness, and importance, and lower risk. Vaccine uptake at T0 was associated with poorer subsequent physical distancing. Adherence to non-pharmaceutical interventions declined during the event; but ‘rebounded’ post-event corresponding with Australia's first omicron wave.</div></div><div><h3>Conclusions</h3><div>Findings provide the first longitudinal picture of non-mandated COVID-19 vaccination rates and adherence to non-pharmaceutical interventions at a youth mass event, with insights for prospective management of health risks after travel vaccinations.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102853"},"PeriodicalIF":6.3,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The epidemiology and identification of risk factors associated with severe dengue during the 2023 dengue outbreak in Kaohsiung City, Taiwan","authors":"Li-Teh Liu ,&nbsp;Shi-Ya Huang ,&nbsp;Chen-Hsuan Lin ,&nbsp;Chun-Hong Chen ,&nbsp;Ching-Yi Tsai ,&nbsp;Ping-Chang Lin ,&nbsp;Jih-Jin Tsai","doi":"10.1016/j.tmaid.2025.102852","DOIUrl":"10.1016/j.tmaid.2025.102852","url":null,"abstract":"<div><div>After the previous major dengue fever (DF) outbreaks in 2014 and 2015 in Taiwan, the second-largest DF outbreak re-emerged in 2023. A total of 178 patients with laboratory-confirmed dengue virus (DENV) infection, including 92 DENV-1 and 86 DENV-2 cases, were enrolled in this study conducted during the 2023 dengue outbreak in Kaohsiung City, Taiwan. This study aimed to analyze epidemiological characteristics, clinical severity, and risk factors for severe dengue (SD), as well as the diagnostic implications of the non-structural protein 1 (NS1) antigen rapid test. Patients infected with DENV-2 exhibited significantly older age, higher incidence of secondary infections, diabetes mellitus (DM), hypertension (HT), and longer hospital stays than patients infected with DENV-1. Multivariate analysis revealed that older age (age ≥65), secondary dengue infection, DM, and HT were significant independent predictors of SD. Compared with non-SD cases, SD patients were significantly more likely to be older (age ≥65), to exhibit a higher incidence of secondary infections and a greater prevalence of chronic diseases, including DM and HT. Notably, dengue-confirmed patients with negative NS1 results had a shorter duration since symptom onset (<em>p</em> &lt; 0.001). Our DENV-1 and DENV-2 isolates are related to strains from neighboring Asian countries. Our findings emphasize the important factors of old age, secondary infections, and chronic diseases that contributed to dengue severity. We should meticulously manage these high-risk groups to prevent dengue progression. Screening incoming travelers for DF during the epidemic season will be an important measure to prevent the introduction of DENV into Taiwan.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102852"},"PeriodicalIF":6.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous leishmaniasis presenting as dactylitis and paronychia in an immunocompetent individual: Case report of a rare condition from Tuscany region, Italy","authors":"Roberta Maria Antonello ,&nbsp;Anna Barbiero ,&nbsp;Michele Spinicci ,&nbsp;Costanza Fiorelli ,&nbsp;Alessandro Bartoloni ,&nbsp;Lorenzo Zammarchi","doi":"10.1016/j.tmaid.2025.102851","DOIUrl":"10.1016/j.tmaid.2025.102851","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102851"},"PeriodicalIF":6.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}