Travel Medicine and Infectious Disease最新文献

{"title":"Marburg virus disease outbreak in Tanzania, 2023–2025","authors":"Ranjana Rohilla , Aroop Mohanty , Rachana Mehta , Shriyansh Srivastava , Sakshi Sharma , Sanjit Sah , Vini Mehta , Vasso Apostolopoulos","doi":"10.1016/j.tmaid.2025.102857","DOIUrl":"10.1016/j.tmaid.2025.102857","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102857"},"PeriodicalIF":6.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis and mortality risk in elderly patients with dengue virus infection: Excess fatality and the urgent need for revising current WHO criteria for elderly patients","authors":"Min-Jia Jeng ,&nbsp;Nan-Yao Lee ,&nbsp;Ing-Kit Lee ,&nbsp;Yi-Chun Chen ,&nbsp;Wen-Chi Huang ,&nbsp;Jui-Chi Hsu ,&nbsp;Chien-Hsiang Tai ,&nbsp;Hao-Min Lan","doi":"10.1016/j.tmaid.2025.102855","DOIUrl":"10.1016/j.tmaid.2025.102855","url":null,"abstract":"<div><h3>Background</h3><div>The World Health Organization (WHO) reports a rising global incidence of dengue and severe outcomes among the elderly. This study investigates the differences in dengue characteristics between elderly and non-elderly patients and identifies mortality risk factors among elderly dengue patients.</div></div><div><h3>Methods</h3><div>We conducted a retrospective study of adults (≥20 years) with dengue virus (DENV) infection at two medical centers from 2002 to 2018. Participants were divided into non-elderly (20–64 years) and elderly (≥65 years) groups.</div></div><div><h3>Results</h3><div>A total of 1274 patients with laboratory-confirmed dengue were included in the study, of whom 373 (29.3 %) were classified as elderly. The majority of patients (67.5 %) were infected with DENV-2. In the overall cohort, age ≥65 years was identified as an independent predictor of mortality. Compared with non-elderly patients, elderly individuals exhibited significantly lower frequencies of classical dengue symptoms (e.g., fever, myalgia, bone pain, rash), but experienced higher rates of severe dengue, longer hospital stays, and more frequent complications, including acute kidney injury, severe hepatitis, bacteremia, pneumonia, and acute respiratory failure. The mortality rate was significantly higher among elderly patients (18 %) compared to non-elderly patients (2.7 %). Multivariate analysis among the elderly subgroup identified altered consciousness and pleural effusion at presentation, along with the development of acute kidney injury, severe hepatitis, and pneumonia during hospitalization, as independent predictors of mortality.</div></div><div><h3>Conclusions</h3><div>The current WHO criteria may be insufficient for the timely identification of dengue in the elderly population. Excess mortality in this group underscores the urgent need for updated guidelines. Neurological symptoms, pleural effusion at presentation, and organ impairment during hospitalization are key predictors of mortality in elderly dengue patients.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102855"},"PeriodicalIF":6.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccine uptake and adherence to non-pharmaceutical interventions at a youth mass gathering event: A longitudinal field cohort study","authors":"Laura J. Ferris ,&nbsp;Jemima Kang ,&nbsp;Joanne A. Rathbone ,&nbsp;Tegan Cruwys ,&nbsp;Mark Stevens ,&nbsp;Jessica L. Donaldson ,&nbsp;Jamie Ranse ,&nbsp;Fiona Kate Barlow","doi":"10.1016/j.tmaid.2025.102853","DOIUrl":"10.1016/j.tmaid.2025.102853","url":null,"abstract":"<div><h3>Background</h3><div>Youth mass gathering events attract thousands of travellers and produce high-exposure conditions for respiratory pathogens and other communicable diseases. Adolescents and young adults have high social circulation and show higher infection rates for viral threats like SARS-CoV2 than other age groups. How young people self-manage their elevated communicable disease risk in high-exposure travel settings such as mass events is under-researched. This study examined vaccination rates, attitudes, and adherence to non-pharmaceutical interventions (e.g., mask-wearing, physical distancing) at a youth mass event during the global COVID-19 pandemic (Oct–Dec 2021).</div></div><div><h3>Methods</h3><div>Longitudinal cohort design with online surveys 1 month pre- (T0), during (T1-T3) and 1 month post- (T4) event. Participants were <em>N</em> = 291 Australian school-leavers (16–19 years) during end-of-school mass celebrations called ‘Schoolies’. Participants reported travel origin and whether they attended an official Schoolies festival (primary site), or elsewhere (secondary sites). Surveys measured COVID-19 vaccine uptake, vaccine-related attitudes, and adherence to non-pharmaceutical interventions.</div></div><div><h3>Results</h3><div>At T0, 88% were vaccinated. Pro-vaccine attitudes were a strong positive correlate of vaccination. Primary site (versus secondary site) attendees held more favourable attitudes toward COVID-19 vaccination, perceiving higher vaccine safety, effectiveness, and importance, and lower risk. Vaccine uptake at T0 was associated with poorer subsequent physical distancing. Adherence to non-pharmaceutical interventions declined during the event; but ‘rebounded’ post-event corresponding with Australia's first omicron wave.</div></div><div><h3>Conclusions</h3><div>Findings provide the first longitudinal picture of non-mandated COVID-19 vaccination rates and adherence to non-pharmaceutical interventions at a youth mass event, with insights for prospective management of health risks after travel vaccinations.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102853"},"PeriodicalIF":6.3,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The epidemiology and identification of risk factors associated with severe dengue during the 2023 dengue outbreak in Kaohsiung City, Taiwan","authors":"Li-Teh Liu ,&nbsp;Shi-Ya Huang ,&nbsp;Chen-Hsuan Lin ,&nbsp;Chun-Hong Chen ,&nbsp;Ching-Yi Tsai ,&nbsp;Ping-Chang Lin ,&nbsp;Jih-Jin Tsai","doi":"10.1016/j.tmaid.2025.102852","DOIUrl":"10.1016/j.tmaid.2025.102852","url":null,"abstract":"<div><div>After the previous major dengue fever (DF) outbreaks in 2014 and 2015 in Taiwan, the second-largest DF outbreak re-emerged in 2023. A total of 178 patients with laboratory-confirmed dengue virus (DENV) infection, including 92 DENV-1 and 86 DENV-2 cases, were enrolled in this study conducted during the 2023 dengue outbreak in Kaohsiung City, Taiwan. This study aimed to analyze epidemiological characteristics, clinical severity, and risk factors for severe dengue (SD), as well as the diagnostic implications of the non-structural protein 1 (NS1) antigen rapid test. Patients infected with DENV-2 exhibited significantly older age, higher incidence of secondary infections, diabetes mellitus (DM), hypertension (HT), and longer hospital stays than patients infected with DENV-1. Multivariate analysis revealed that older age (age ≥65), secondary dengue infection, DM, and HT were significant independent predictors of SD. Compared with non-SD cases, SD patients were significantly more likely to be older (age ≥65), to exhibit a higher incidence of secondary infections and a greater prevalence of chronic diseases, including DM and HT. Notably, dengue-confirmed patients with negative NS1 results had a shorter duration since symptom onset (<em>p</em> &lt; 0.001). Our DENV-1 and DENV-2 isolates are related to strains from neighboring Asian countries. Our findings emphasize the important factors of old age, secondary infections, and chronic diseases that contributed to dengue severity. We should meticulously manage these high-risk groups to prevent dengue progression. Screening incoming travelers for DF during the epidemic season will be an important measure to prevent the introduction of DENV into Taiwan.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102852"},"PeriodicalIF":6.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous leishmaniasis presenting as dactylitis and paronychia in an immunocompetent individual: Case report of a rare condition from Tuscany region, Italy","authors":"Roberta Maria Antonello ,&nbsp;Anna Barbiero ,&nbsp;Michele Spinicci ,&nbsp;Costanza Fiorelli ,&nbsp;Alessandro Bartoloni ,&nbsp;Lorenzo Zammarchi","doi":"10.1016/j.tmaid.2025.102851","DOIUrl":"10.1016/j.tmaid.2025.102851","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102851"},"PeriodicalIF":6.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral shedding in saliva, axillary, rectal and vaginal swabs of an imported case of Dengue - Oropouche virus Co-infection","authors":"Serena Vita,&nbsp;Francesca Colavita,&nbsp;Gaetano Maffongelli,&nbsp;Fabrizio Carletti,&nbsp;Laura Scorzolini,&nbsp;Giulia Matusali,&nbsp;Maria Virginia Tomassi,&nbsp;Silvia Meschi,&nbsp;Alessandra D'Abramo,&nbsp;Enrico Girardi,&nbsp;Francesco Vairo ,&nbsp;Fabrizio Maggi,&nbsp;Emanuele Nicastri ,&nbsp;INMI Arbovirosi Group","doi":"10.1016/j.tmaid.2025.102854","DOIUrl":"10.1016/j.tmaid.2025.102854","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"66 ","pages":"Article 102854"},"PeriodicalIF":6.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forecasting norovirus cases on cruise ships to support outbreak management on board","authors":"Andrea Bizzotto ,&nbsp;Alfredo De Bellis ,&nbsp;Valentina Marziano ,&nbsp;Varvara A. Mouchtouri ,&nbsp;Leonidas Kourentis ,&nbsp;Lemonia Anagnostopoulos ,&nbsp;Christos Hadjichristodoulou ,&nbsp;Stefano Merler ,&nbsp;Giorgio Guzzetta","doi":"10.1016/j.tmaid.2025.102850","DOIUrl":"10.1016/j.tmaid.2025.102850","url":null,"abstract":"<div><h3>Background</h3><div>Norovirus outbreaks on cruise ships are a significant threat to the cruising industry. Mathematical models have the potential to leverage routinely collected syndromic surveillance data on board to provide insight into outbreak evolution.</div></div><div><h3>Methods</h3><div>We used historical data from seven norovirus outbreaks occurred in 2011–2013, totalling 359 diagnosed cases, to assess the performance of automated forecasts in real-time. We compared the performance of a set of alternative models on three endpoints (the number of cases by symptom onset time, by diagnosis date, and the total number of cases until the end of the cruise), using the logarithmic score (logS), the ranked probability score (RPS), and the 95 % coverage.</div></div><div><h3>Results</h3><div>We found that the best forecasting performance was given by a model that includes both superspreading and the effect of case isolation. This model had in most cases a better score than that of a baseline model assuming constant incidence; this happened in 59–70 % of data points when assessed using the logS and 53–57 % with the RPS (depending on the considered endpoint). The best model also had the highest coverage over all endpoints. Its added value was especially evident for longer forecasting horizons, with an improvement in performance for up to 78 % of data points, both according to the logS and the RPS.</div></div><div><h3>Conclusions</h3><div>Simple mathematical models integrating key mechanisms of norovirus transmission can help predict the number of cases on board. This knowledge can be automatized in syndromic surveillance systems to support decision making for the management of outbreaks.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102850"},"PeriodicalIF":6.3,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leishmaniasis in Syria – A call for action of the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) Study Groups for Infections in Travellers and Migrants (ESGITM) and for Clinical Parasitology (ESGCP)","authors":"Aula Abbara ,&nbsp;Marta González-Sanz ,&nbsp;Ayla AlKharrat ,&nbsp;Mohamad Khalife ,&nbsp;Yasir Elferruh ,&nbsp;Naser Almhawish ,&nbsp;Salam Abbara ,&nbsp;Sana Marroush ,&nbsp;Clare Shortall ,&nbsp;Shamsa Hussein Ahmed ,&nbsp;Abdulaziz Alhazmi ,&nbsp;Miriam J. Alvarez-Martinez ,&nbsp;Muhammad Asaduzzaman ,&nbsp;Asma Al Balushi ,&nbsp;Ana Paula Barboza ,&nbsp;Hanne Brekke ,&nbsp;Paola Di Carlo ,&nbsp;Antonio Cascio ,&nbsp;Peter Chiodini ,&nbsp;Agnese Colpani ,&nbsp;Alfonso J. Rodriguez-Morales","doi":"10.1016/j.tmaid.2025.102849","DOIUrl":"10.1016/j.tmaid.2025.102849","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"66 ","pages":"Article 102849"},"PeriodicalIF":6.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic next-generation sequencing enhances the diagnosis of Q fever: A retrospective observational study","authors":"Lingxiao Sun ,&nbsp;Yuyao Yin ,&nbsp;Yifan Guo,&nbsp;Hongbin Chen,&nbsp;Hui Wang","doi":"10.1016/j.tmaid.2025.102845","DOIUrl":"10.1016/j.tmaid.2025.102845","url":null,"abstract":"<div><h3>Background</h3><div>Q fever, a global zoonosis, poses a significant challenge for public health due to its varied and nonspecific clinical presentations, making diagnosis difficult. Metagenomic next-generation sequencing (mNGS) is a potential tool for diagnosing Q fever.</div></div><div><h3>Methods</h3><div>This retrospective observational study was conducted on patients with Q fever admitted to Peking University People's Hospital, from May 2023 to November 2024. mNGS was performed using the patient's peripheral blood, and the qPCR of <em>Coxiella burnetii</em> was also adopted. Subsequently, the clinical data of patients diagnosed with Q fever were systematically evaluated.</div></div><div><h3>Results</h3><div>Twelve peripheral blood samples of 12 patients were detected <em>Coxiella burnetii</em> positive by mNGS. Most patients were male (10, 83.33 %). Fever (12, 100 %), muscle soreness (8, 66.7 %), and headache (4, 33.3 %) were the most common clinical manifestations. Specific qPCR of <em>Coxiella burnetii</em> was detected positive in 8 patients. Chronic Q fever was diagnosed in two patients, who had aortic valve replacement, and their immunological markers, like anti-nuclear were elevated. Once the diagnosis was clear, proper antibiotics were used, and all patients were discharged in better health.</div></div><div><h3>Conclusion</h3><div>Metagenomic next-generation sequencing enhances the diagnosis of Q fever, especially for patients displaying atypical and various clinical symptoms and having unclear epidemiological data or histories of antibiotic use.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102845"},"PeriodicalIF":6.3,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox knowledge, risk perception, attitudes and willingness to vaccinate in Colombia's LGBTIQ+ communities: Online survey (CoSex)","authors":"Cándida Diaz-Brochero ,&nbsp;Miguel Barriga ,&nbsp;John Fredy Ramirez ,&nbsp;David Santiago Quevedo ,&nbsp;Geraldine Gomez ,&nbsp;Juliana Mateus ,&nbsp;Natalia Nino-Machado ,&nbsp;Juliana Cuervo-Rojas ,&nbsp;Zulma M. Cucunubá","doi":"10.1016/j.tmaid.2025.102848","DOIUrl":"10.1016/j.tmaid.2025.102848","url":null,"abstract":"<div><h3>Background</h3><div>In the 2022-23 global clade IIb mpox outbreak, Colombia was the sixth country with the most reported cases globally and the second in Latin America after Brazil. LGTBIQ + communities, especially those with extensive sexual networks, were particularly affected.</div></div><div><h3>Objective</h3><div>We aim to characterize the knowledge, risk perceptions, attitudes, and willingness to implement preventive measures against mpox among LGBTIQ + communities in Colombia.</div></div><div><h3>Methods</h3><div>This was an anonymized, cross-sectional, observational study based on a population-based online questionnaire using a participatory approach.</div></div><div><h3>Results</h3><div>Among the 784 participants from 66 municipalities, 49.1 % were aged 18–29 years, and 89.3 % were male and assigned at birth. A total of 73.9 % identified as homosexual, whereas 14.9 % reported never using condoms. Casual sexual partners were reported by 45.4 % of the participants in the past year (median: 3; range: 1–100), and 29.3 % engaged in group sex during the same period (median: 4; range: 2–100). Temporary behavioral changes to reduce mpox risk, such as limiting sexual partners and increasing condom use, were reported by 24.1 % of the participants. Suspected or confirmed mpox infection was reported by 4 % of the participants, with 77.4 % attributing potential exposure to sexual contact. Notably, 89.5 % expressed a willingness to receive mpox vaccination if it was offered.</div></div><div><h3>Conclusions</h3><div>Our findings demonstrate the importance of academic and social communities' cross-collaboration to understand the impact of mpox infection in this population and as a basis for planning epidemic responses to future mpox outbreaks in Colombia and Latin America.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102848"},"PeriodicalIF":6.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}