Travel Medicine and Infectious Disease最新文献

{"title":"Mapping the global risk of chikungunya virus endemicity and autochthonous transmission following importation","authors":"Yu-Feng Yang ,&nbsp;Yun-Bo Qiu ,&nbsp;Qiang Xu ,&nbsp;Rui-Cheng Gao ,&nbsp;Tian Tang ,&nbsp;Yao Tian ,&nbsp;Yan-He Wang ,&nbsp;Sheng-Hong Lin ,&nbsp;Yun-Dong Shi ,&nbsp;Long-Tao Chen ,&nbsp;Yan Zhang ,&nbsp;Jun Ma ,&nbsp;Chen-Long Lv ,&nbsp;Guo-Lin Wang ,&nbsp;Hai-Feng Pan ,&nbsp;Wei Liu ,&nbsp;Li-Qun Fang","doi":"10.1016/j.tmaid.2025.102892","DOIUrl":"10.1016/j.tmaid.2025.102892","url":null,"abstract":"<div><h3>Background</h3><div>Chikungunya virus, emerging as an increasingly significant global health threat, poses significant uncertainty regarding the global risk of its endemicity and autochthonous transmission following importation.</div></div><div><h3>Methods</h3><div>In this study, we established a multi-source database spanning 70 years (1953–2023), synthesizing 4515 geolocated records of human, vector, and animal infections alongside clinical metadata. Three machine learning algorithms were utilized to analyze the ecological factors associated with CHIKV occurrences in regions characterized by endemic or autochthonous transmission following importation. Subsequently, the respective risk distributions of CHIKV occurrences were projected and used the SHAP method to rank feature importance and interpret model predictions.</div></div><div><h3>Results</h3><div>Machine learning frameworks that stratifying endemic zones and importation-transmission prone regions have revealed consistent ecological drivers, albeit with significantly discrepant rankings of feature importance. The habitat suitability indices of <em>Aedes aegypti</em> and <em>Aedes albopictus</em>, as indicated by the Shapley values analysis, were identified as the most significant contributing factors for endemic occurrence and autochthonous transmission following importation, respectively. Population density, human footprint index, precipitation, thermal conditions, and the habitat suitability indices of other mosquito vectors also play crucial roles in the transmission within the two regions. Notably, temperate regions with established <em>Ae. albopictus</em> populations, including southern United States, most parts of Western Europe, East Asia, West Asia and Australia, emerged as high-risk hotspots for autochthonous transmission following importation.</div></div><div><h3>Conclusions</h3><div>This study assesses the potential risks of endemic occurrence and post-import autochthonous transmission of CHIKV, respectively. The frameworks provide insights for informing vaccine deployment strategies and mitigating globalization-driven arboviral threats.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102892"},"PeriodicalIF":4.7,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144879035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunisation in pregnancy - Weighing the unknown to balance benefits and risks impacting women, offspring, and development.","authors":"Stephen Toovey, Jessica A Hellings","doi":"10.1016/j.tmaid.2025.102889","DOIUrl":"10.1016/j.tmaid.2025.102889","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102889"},"PeriodicalIF":4.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serodiagnosis of strongyloidiasis in a low-endemic setting – a two-tiered test approach","authors":"Sebastian Albermann ,&nbsp;Anne Vischer ,&nbsp;Xuan Lan Vu ,&nbsp;Anja Horat ,&nbsp;Felix Grimm ,&nbsp;Beatrice Nickel ,&nbsp;Bruno Gottstein ,&nbsp;Cédric Hirzel ,&nbsp;Alexander Oberli","doi":"10.1016/j.tmaid.2025.102890","DOIUrl":"10.1016/j.tmaid.2025.102890","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have demonstrated that <em>Strongyloides</em> ELISAs frequently exhibit cross-reactivity with infections caused by other helminths. This may result in false-positive results, especially in low-endemic areas, potentially leading to unwarranted treatment. This study aimed to present a new Western blot for the detection of anti-<em>Strongyloides</em> antibodies such as to enhance the accuracy of distinguishing true-positive from false-positive ELISA results.</div></div><div><h3>Methods</h3><div>We developed and validated a Western blot to detect anti-<em>S. stercoralis</em> specific antibodies using reference sera from confirmed cases (n = 55), non-infected control patients (n = 20), and patients with other helminth infections (n = 50). Using this sample set, we evaluated the analytical performance of three serologic approaches: an in-house ELISA, the commercially available Bordier-ELISA, and a two-tiered testing procedure combining the in-house ELISA with a confirmatory Western blot. Using receiver operating characteristics (ROC) analysis, setting-specific cut-offs values were determined for both ELISA assays. Further, we conducted a retrospective cohort study using serum samples from solid organ transplant (SOT) candidates (n = 310) tested by ELISA during pre-transplant evaluations at Bern University Hospital (2018–2022).</div></div><div><h3>Results</h3><div>The Western blot specifically detected human IgG antibodies against <em>S. stercoralis</em>. A two-tier test algorithm (in-house ELISA, followed by confirmatory Western blot) showed a diagnostic sensitivity of 96.4 % (95 %CI:87.5 %–99.6 %) and a diagnostic specificity of 98.6 % (95 %CI:92.3 %–100 %). Out of 310 SOT candidates’ serum samples, 9.3 % (n = 29) exhibited positive, and 5.2 % (n = 16) equivocal ELISA results. Testing by Western blot revealed positive <em>S. stercoralis</em> findings for 11.1 % (n = 5) of these patients. Two of those were initially positive and 3 were equivocal by ELISA.</div></div><div><h3>Conclusions</h3><div>The new Western blot is a promising tool for clarifying equivocal <em>S. stercoralis</em> ELISA results, and therefore predisposed to reduce false positive <em>Strongyloides</em> ELISA results, especially in low-endemic regions.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102890"},"PeriodicalIF":4.7,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An imported case of Haplorchis taichui infection diagnosed with molecular genomics in France.","authors":"Victor Luzarraga, Maxime Moniot, Patricia Combes, Mathilde Legay, Philippe Poirier, Céline Nourrisson","doi":"10.1016/j.tmaid.2025.102888","DOIUrl":"10.1016/j.tmaid.2025.102888","url":null,"abstract":"<p><strong>Purpose: </strong>We report here on an imported case of Haplorchis taichui infection in a Western country. Given their rarity in these countries, such diagnoses of heterophyid flukes can be particularly difficult.</p><p><strong>Methods: </strong>The stool of a 70-year-old Laotian woman with eosinophilia was sent to the laboratory for examination. Microscopic observations based on direct examination and two concentration methods were performed on the fecal sample. After extraction of DNA from the sample, Sanger sequencing of the internal transcribed spacer 2 (ITS2) region and the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene was carried out.</p><p><strong>Results: </strong>Ellipsoid eggs with a convex operculum and abopercular knob were observed on microscopic examination, suggestive of fluke eggs, but there was no morphological criterion to distinguish between opisthorchiid and heterophyid eggs. Results of ITS2 and cox1 sequencing matched the intestinal fluke Haplorchis taichui.</p><p><strong>Conclusion: </strong>This case report points out that small trematode eggs can hardly be used to distinguish between opisthorchiid and heterophyid flukes in fecal examinations, and underlines the need for molecular genomic studies to establish an accurate species diagnosis.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102888"},"PeriodicalIF":4.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious diseases on passenger ships: Port preparedness and response - A narrative systematic review.","authors":"Johannes A Neumann, Jette Zimmermann, Marie Frese, Martin Dirksen-Fischer, Scarlett Kleine-Kampmann, Volker Harth, Jan Heidrich","doi":"10.1016/j.tmaid.2025.102886","DOIUrl":"10.1016/j.tmaid.2025.102886","url":null,"abstract":"<p><strong>Background: </strong>Ships are environments conducive to the spread of infectious diseases among passengers and crew members. In this context, it is essential to establish effective prevention and control measures to protect the health of passengers and crew members while ensuring that shipping minimizes its contribution to the global spread of disease via ship-to-shore interactions. The aim of this review is to provide knowledge on the impact of infectious diseases on board large passenger ships on the port, the port community and other land-based operations.</p><p><strong>Methods: </strong>A systematic literature review was conducted, searching the PubMed, Scopus and Cochrane Library databases and including additional articles from hand searches up to July 2024. Peer-reviewed studies of infectious disease outbreaks related to large passenger ship travel that described ship-shore interaction, port preparedness and impact on the port community were included. Article selection and data extraction were conducted by two independent reviewers.</p><p><strong>Results: </strong>A total of 593 publications were initially identified, with 23 articles included in the analysis. Most studies reported COVID-19 outbreaks on cruise ships; other communicable diseases reported were influenza, gastroenteritis, and varicella. The articles highlighted the importance of comprehensive management plans and proactive risk assessment during infectious disease outbreaks that impact ship-to-shore interactions.</p><p><strong>Conclusions: </strong>Effective stakeholder collaboration, ship-to-shore communication, coordination of diagnostic testing and medical transport, isolation, and quarantine measures are essential components of infectious disease prevention, mitigation, and management in passenger shipping within the port environment.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102886"},"PeriodicalIF":4.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scabies: An updated review from epidemiology to current controversies and future perspectives","authors":"Gianluca Tavoletti ,&nbsp;Gianluca Avallone ,&nbsp;Andrea Sechi ,&nbsp;Elisa Cinotti ,&nbsp;Stefano Veraldi ,&nbsp;Giuseppe Micali ,&nbsp;Francesco Lacarrubba ,&nbsp;Angelo Valerio Marzano ,&nbsp;Gianluca Nazzaro","doi":"10.1016/j.tmaid.2025.102878","DOIUrl":"10.1016/j.tmaid.2025.102878","url":null,"abstract":"<div><div>Scabies is a highly contagious parasitic dermatosis caused by the mite <em>Sarcoptes scabiei</em> var. <em>hominis</em>, affecting over 200 million individuals globally and imposing a significant health burden. Traditionally linked to low socioeconomic status and overcrowding, its prevalence is rising globally, especially among urban and institutional settings. Beyond its cutaneous manifestations, secondary bacterial complications contribute to significant morbidity, particularly in endemic areas.</div><div>Advances in non-invasive imaging techniques including ultraviolet dermoscopy, reflectance confocal microscopy and line-field confocal optical coherence tomography, have improved diagnostic accuracy, while molecular assays show promise for enhanced sensitivity. Conventional diagnostics remain dependent on clinical evaluation and microscopic identification of mites, eggs, or scybala.</div><div>First-line treatment involves topical and systemic therapies, and topical permethrin, benzyl benzoate, and oral ivermectin are commonly recommended in international guidelines. Emerging drug resistance has prompted research toward optimizing drug regimens and novel therapies, including moxidectin and combination treatments. Outbreaks of scabies in institutional settings, as well as endemic disease in those with limited resources, demonstrate the importance of coordinated public health efforts in the form of early case detection, simultaneous treatment of contacts and other environmental control measures.</div><div>In this review, we present an updated and thorough description of scabies, covering the relevant epidemiology, clinical picture and the new diagnostic methods. In summary, by combining new updates and essential unanswered questions, this review describes the current dilemma and covers the latest data in the field.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102878"},"PeriodicalIF":4.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Content analysis of malaria-related health information published in online travel blogs","authors":"Shayan Din ,&nbsp;Ramy Bishay ,&nbsp;Usama Asad ,&nbsp;Gerard T. Flaherty","doi":"10.1016/j.tmaid.2025.102879","DOIUrl":"10.1016/j.tmaid.2025.102879","url":null,"abstract":"<div><h3>Introduction</h3><div>It is not known whether travellers consult travel blogs for malaria preventive advice. This study aimed to characterise information about travellers’ malaria across a sample of online travel blogs.</div></div><div><h3>Methods</h3><div>A search of online travel blogs was conducted using the Google search engine for reference to malaria. Blogs were analysed across 35 variables and usage statistics were recorded.</div></div><div><h3>Results</h3><div>Of 100 blogs retrieved, 92 contained malaria-related information. Ten different drugs were mentioned in this series, five of which were not appropriate for prevention of falciparum malaria. Pre-travel consultation was recommended by almost a third of blogs. Most blogs were supported by commercial sponsors, related to either the travel industry or travel health products.</div></div><div><h3>Conclusion</h3><div>Given the inconsistency of the malaria preventive advice provided, there is scope for the travel medicine community to produce reliable material suitable for the lay traveller to be shared with prominent bloggers.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102879"},"PeriodicalIF":4.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining outpatient dengue management 18 years on: lessons from a national tertiary centre","authors":"Jinghao Nicholas Ngiam ,&nbsp;Matthew Chung Yi Koh ,&nbsp;Brenda Mae Alferez Salada ,&nbsp;Dale Fisher ,&nbsp;Sophia Archuleta ,&nbsp;Jolene Ee Ling Oon","doi":"10.1016/j.tmaid.2025.102882","DOIUrl":"10.1016/j.tmaid.2025.102882","url":null,"abstract":"<div><h3>Background</h3><div>Dengue fever places a substantial burden on healthcare systems in endemic areas. Traditional inpatient management places strain on hospital capacity during seasonal surges. This study evaluates an expanded nurse-led Dengue Outpatient Management (DOM) program at a tertiary centre in Singapore.</div></div><div><h3>Methods</h3><div>A prospective observational study was conducted from January 2023 to August 2024. DOM inclusion criteria were broadened to include older adults and patients with comorbidities, if clinically stable. Patients received physician evaluation, a nurse-led symptom-based assessment and vital signs monitoring.</div></div><div><h3>Results</h3><div>There were 167 patients managed in DOM in the study period. The model saved an average of 3.3 bed-days per patient, amounting to approximately 231 bed-days saved in 2023.</div></div><div><h3>Conclusion</h3><div>This expanded nurse-led outpatient dengue management model demonstrates safety, feasibility, and resource efficiency. With structured patient selection and monitoring protocols, DOM significantly reduces hospital bed occupancy while offering a scalable solution for dengue-endemic regions<strong>.</strong></div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102882"},"PeriodicalIF":4.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measles importations by international travelers, GeoSentinel 2019–2025","authors":"Ralph Huits ,&nbsp;Dora Buonfrate ,&nbsp;Kevin O'Laughlin ,&nbsp;Davidson H. Hamer ,&nbsp;Michael Libman","doi":"10.1016/j.tmaid.2025.102885","DOIUrl":"10.1016/j.tmaid.2025.102885","url":null,"abstract":"<div><h3>Background</h3><div>The global resurgence of measles is a threat to measles elimination campaigns. Measles importations by international travelers have been identified as a risk factor for outbreaks.</div></div><div><h3>Methods</h3><div>We reviewed measles cases among international travelers and migrants reported to the GeoSentinel network.</div></div><div><h3>Results</h3><div>From May 2019 through June 2025, GeoSentinel recorded 53 measles cases among travelers imported into 15 different countries. Travelers of all age groups were affected, and 74 % were 21 years or older. Thirty-three travelers (61 %) were hospitalized. Seventy-nine percent of cases reported no or unknown history of vaccination against measles.</div></div><div><h3>Conclusions</h3><div>Against a background of increasing numbers of measles cases and outbreaks globally, GeoSentinel observed a stable trend of measles importations by international travelers. Measles caused considerable morbidity among travelers. Immunization effectively prevents measles in more than 97 % of individuals. Pretravel consultations provide an important opportunity to promote vaccination coverage for all vaccine-preventable diseases, including measles.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102885"},"PeriodicalIF":4.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing yellow fever and arboviral risks during the 2025 jubilee in Rome: A mass gathering and global mobility perspective","authors":"Giancarlo Ceccarelli ,&nbsp;Francesco Branda ,&nbsp;Fabio Scarpa ,&nbsp;Marta Giovanetti ,&nbsp;Massimo Ciccozzi","doi":"10.1016/j.tmaid.2025.102884","DOIUrl":"10.1016/j.tmaid.2025.102884","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102884"},"PeriodicalIF":4.7,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}