Travel Medicine and Infectious Disease最新文献

{"title":"Preliminary screening of ESBL-producing Escherichia coli and Klebsiella pneumoniae carriage among migrant communities in Klang Valley, Malaysia","authors":"Muhammad Azreen Mat Husin ,&nbsp;Adrian Anthony Peirera ,&nbsp;Thana Seelan ,&nbsp;Ramliza Ramli ,&nbsp;Ilana Lopes Baratella da Cunha Camargo ,&nbsp;Sheila Nathan ,&nbsp;Hui-min Neoh","doi":"10.1016/j.tmaid.2025.102894","DOIUrl":"10.1016/j.tmaid.2025.102894","url":null,"abstract":"<div><div>Economic migrant workers are crucial for a country's development but may also contribute to transboundary transmission of antimicrobial resistance (AMR). This study aimed to investigate the silent carriage of ESBL-producing <em>Escherichia coli</em> (ESBLEC) and <em>Klebsiella pneumoniae</em> (ESBLKP) among economic migrants from Indonesia, Bangladesh and Nepal residing in Klang Valley, Malaysia. Between December 2023 and May 2024, 263 study participants of Indonesian, Bangladeshi, and Nepalese migrant communities were recruited and rectal swabs collected. Swabs were then cultured on CHROMagar™ ESBL; presumptive ESBL-positive strains were confirmed and antimicrobial susceptibility-tested using a VITEK 2 system. ESBL genotyping was also performed on confirmed isolates. A total of 67 and five strains were confirmed as ESBLEC and ESBLKP, respectively. Both ESBLEC and ESBLKP strains showed similar resistance to penicillin and 3rd generation cephalosporins, though more ESBLKP strains were resistant to 4th generation cephalosporins. More ESBLEC strains were resistant to ciprofloxacin. No carbapenem-resistant strains were detected. The <em>bla</em>_CTX-M-1 gene family was predominantly found in ESBLEC strains from all three nationalities, while ESBLKP strains frequently harboured <em>bla</em>_TEM, <em>bla</em>_CTX-M, and <em>bla</em>_SHV genes. The prevalence of ESBL-producing strains was highest among Bangladeshi participants (n = 16, 31.4 %), followed by Indonesians (n = 47, 29.7 %) and Nepalis (n = 9, 19.1 %) working in domestic or manufacturing sectors. These findings highlight the public health risks of high ESBLEC and ESBLKP carriage in healthy migrant workers, which may impact recruitment and retention, leading to labour shortages and higher costs. Screening and increased awareness are crucial to limit the spread of these pathogens.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102894"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A decade of dengue disease burden in Africa (2013–2023): a systematic review","authors":"Gaspary O. Mwanyika ,&nbsp;Monika Moir ,&nbsp;Abdualmoniem O. Musa ,&nbsp;Jenicca Poongavanan ,&nbsp;Graeme Dor ,&nbsp;Eduan Wilkinson ,&nbsp;Cheryl Baxter ,&nbsp;Tulio de Oliveira ,&nbsp;Houriiyah Tegally","doi":"10.1016/j.tmaid.2025.102897","DOIUrl":"10.1016/j.tmaid.2025.102897","url":null,"abstract":"<div><h3>Background</h3><div>Dengue is a major mosquito-borne disease worldwide. The epidemiological trends of the disease in Africa over the past decade remain unclear. This review aims to provide insight into the epidemiological trends of dengue in Africa from 2013 to 2023.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed/MEDLINE and Scopus for studies published between January 2013 and December 2023. Additionally, we collected official records from the World Health Organization for Africa and African Centre for Disease Control. We included studies that reported dengue cases in humans in Africa and excluded publications prior to 2013, review articles and non-human studies. For specific countries, the suspected cases per 100,000 population and fatality rates were estimated and the trend predicted using a negative binomial model. The statistical analyses and visualisations were performed using R programming.</div></div><div><h3>Results</h3><div>Of the 453 reports screened, 87 from 25 African countries were selected for systematic review. Of which 55.2 % (48/87) were indicator-based, 40.2 % (35/87) research and 4.6 % (4/87) event-based reports. Between 2013 and 2023, approximately 200,000 suspected dengue cases, 90,000 confirmed cases and 900 deaths were reported in Africa. Over 80 % of confirmed cases originated from West Africa, with Burkina Faso reporting over 500 cases per 100,000 population. DENV1 and DENV2 predominated at different times with transmission closely linked to rainy seasons.</div></div><div><h3>Conclusions</h3><div>The rising dengue cases across Africa, highlight the need to strengthen surveillance and implement effective regional-specific interventions against future dengue outbreaks. Further research is necessary to improve our understanding on dengue transmission dynamics and suitability of regions in Africa.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102897"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144906919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scabies: An updated review from epidemiology to current controversies and future perspectives","authors":"Gianluca Tavoletti ,&nbsp;Gianluca Avallone ,&nbsp;Andrea Sechi ,&nbsp;Elisa Cinotti ,&nbsp;Stefano Veraldi ,&nbsp;Giuseppe Micali ,&nbsp;Francesco Lacarrubba ,&nbsp;Angelo Valerio Marzano ,&nbsp;Gianluca Nazzaro","doi":"10.1016/j.tmaid.2025.102878","DOIUrl":"10.1016/j.tmaid.2025.102878","url":null,"abstract":"<div><div>Scabies is a highly contagious parasitic dermatosis caused by the mite <em>Sarcoptes scabiei</em> var. <em>hominis</em>, affecting over 200 million individuals globally and imposing a significant health burden. Traditionally linked to low socioeconomic status and overcrowding, its prevalence is rising globally, especially among urban and institutional settings. Beyond its cutaneous manifestations, secondary bacterial complications contribute to significant morbidity, particularly in endemic areas.</div><div>Advances in non-invasive imaging techniques including ultraviolet dermoscopy, reflectance confocal microscopy and line-field confocal optical coherence tomography, have improved diagnostic accuracy, while molecular assays show promise for enhanced sensitivity. Conventional diagnostics remain dependent on clinical evaluation and microscopic identification of mites, eggs, or scybala.</div><div>First-line treatment involves topical and systemic therapies, and topical permethrin, benzyl benzoate, and oral ivermectin are commonly recommended in international guidelines. Emerging drug resistance has prompted research toward optimizing drug regimens and novel therapies, including moxidectin and combination treatments. Outbreaks of scabies in institutional settings, as well as endemic disease in those with limited resources, demonstrate the importance of coordinated public health efforts in the form of early case detection, simultaneous treatment of contacts and other environmental control measures.</div><div>In this review, we present an updated and thorough description of scabies, covering the relevant epidemiology, clinical picture and the new diagnostic methods. In summary, by combining new updates and essential unanswered questions, this review describes the current dilemma and covers the latest data in the field.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102878"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and transmission dynamics of tuberculosis among internal migrants in Hangzhou: A retrospective analysis from 2013 to 2022","authors":"Qingchun Li ,&nbsp;Zike Cheng ,&nbsp;Qinglin Cheng ,&nbsp;Ruoqi Dai ,&nbsp;Yifei Wu ,&nbsp;Liyun Ai ,&nbsp;Yinyan Huang ,&nbsp;Qingjun Jia ,&nbsp;Nan jiang ,&nbsp;Xuexin Bai ,&nbsp;Zijian Fang ,&nbsp;Xu Song ,&nbsp;Xin Lv","doi":"10.1016/j.tmaid.2025.102875","DOIUrl":"10.1016/j.tmaid.2025.102875","url":null,"abstract":"<div><h3>Background</h3><div>Tuberculosis (TB) remains a critical public health challenge in China, particularly amid rapid urbanization and internal migration. This retrospective study analyzed the epidemiology and transmission dynamics of TB among internal migrants (IMTB) versus local residents (LRTB) in Hangzhou, China, from 2013 to 2022.</div></div><div><h3>Methods</h3><div>Data from 47,659 pulmonary TB cases were extracted from the national Tuberculosis Information Management System.</div></div><div><h3>Results</h3><div>IMTB accounted for 21.88 % of cases, with patients significantly younger (mean age 33.45 vs. 51.50 years, P &lt; 0.0001) and fewer bacteriologically confirmed diagnoses (34.9 % vs. 41.8 %, P &lt; 0.0001) compared to LRTB. Treatment success rates were higher among IMTB (95.0 % vs. 89.7 %, P &lt; 0.0001). Spatial clustering of IMTB occurred in industrial districts, primarily originating from Anhui, Guizhou, and Jiangxi provinces.</div></div><div><h3>Conclusion</h3><div>Migration-driven TB transmission highlights the need for adaptive control strategies in urbanizing settings.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102875"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate change and dengue Fever: A 14-year study of mortality trends during 2010–2023 in Indonesia","authors":"Kurnia Ardiansyah Akbar ,&nbsp;Rosa Kumala Fatma ,&nbsp;Fauzi Elamouri ,&nbsp;Jürgen Kurt Rockstroh","doi":"10.1016/j.tmaid.2025.102893","DOIUrl":"10.1016/j.tmaid.2025.102893","url":null,"abstract":"<div><h3>Background</h3><div>Dengue fever remains a critical public health issue in Indonesia, with a significant increase in mortality cases in recent years. As a vector-borne disease, dengue fever is highly influenced by environmental conditions, making it particularly sensitive to the impacts of climate change. Indonesia, being heavily affected by global climate change, faces increasing challenges in managing dengue fever. This study aims to investigate the association between dengue fever mortality and climate variables, specifically annual rainfall, and temperature, in Indonesia from 2010 to 2023.</div></div><div><h3>Methods</h3><div>Secondary data on dengue fever cases from 2010 to 2023 were collected from the Ministry of Health of Indonesia. Data on annual rainfall and annual temperature were obtained from the Indonesia Meteorology, Climatology, and Geophysics Council, with information gathered from 116 stations across Indonesia. Linear regression analysis was used to determine the association between these variables and dengue fever mortality.</div></div><div><h3>Results</h3><div>The analysis revealed a significant association between annual temperature (p = 0.049; R² = 0.212; 95 % CI: 710.85–2.233) and dengue fever mortality. Additionally, annual dengue fever cases were significantly associated with mortality (p &lt; 0.001; R² = 1.075; 95 % CI: 0.007–0.010). However, annual rainfall was not found to be significant in this study.</div></div><div><h3>Conclusion</h3><div>These findings underscore the importance of monitoring climatic changes and their impact on public health, particularly concerning vector-borne diseases. Enhanced surveillance and targeted interventions could mitigate the adverse effects of these climatic variables on dengue fever mortality in Indonesia.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102893"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yellow fever in South America – A plea for action and call for prevention also in travelers from SLAMVI, ESGITM, EVASG, ALEIMC, GEPI-SEIMC, SEMEVI, and CMTZMV-ACIN","authors":"Alfonso J. Rodriguez-Morales ,&nbsp;Abdulaziz H. Alhazmi ,&nbsp;Abraham Katime ,&nbsp;Ahneez Abdul Hameed ,&nbsp;Alejandra Morales ,&nbsp;Alejandro Claudio Lepetic ,&nbsp;Alejandro Risquez ,&nbsp;Alex Julián Forero-Delgadillo ,&nbsp;Alexis Holguin ,&nbsp;Álvaro A. Faccini-Martínez ,&nbsp;Amanda Guerrero ,&nbsp;Ana Ribeiro ,&nbsp;Asma Al Balushi ,&nbsp;Aysegul Taylan Ozkan ,&nbsp;Balram Rathish ,&nbsp;Baruch Diaz ,&nbsp;Beatriz Elena Porras-Pedroza ,&nbsp;Bhanasut Hunsajarupan ,&nbsp;Botond Lakatos ,&nbsp;Carlos Álvarez-Moreno ,&nbsp;Zitta Barrella Harboe","doi":"10.1016/j.tmaid.2025.102871","DOIUrl":"10.1016/j.tmaid.2025.102871","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102871"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended Lake Louise Score: a novel standard evaluation of cognitive impairment for immigrants' rapid ascent to high altitude","authors":"Tao Xu ,&nbsp;Wen Li ,&nbsp;Chun-Yan Zhang ,&nbsp;Bo Dong ,&nbsp;Tao Luo ,&nbsp;Jian-Guo Huang ,&nbsp;Jin-Long Shi ,&nbsp;Jun Tang ,&nbsp;Shi-Jun Li","doi":"10.1016/j.tmaid.2025.102907","DOIUrl":"10.1016/j.tmaid.2025.102907","url":null,"abstract":"<div><h3>Objective</h3><div>To extend the Lake Louise Scoring (LLS) system to better assess cognitive impairment, and investigate the early changes of hematological indicators for subjects of rapid ascent to high altitude.</div></div><div><h3>Methods</h3><div>One hundred and eighty-nine subjects underwent routine hematology, urine and psychological examination at the altitude of 1500 m in February, and did that again after they had ascended to 3860 m in 2 days. Subjects were evaluated with eLLS using a combination of self-reported cognitive assessment and a diagnosis of AMS based on 4-item Lake Louise Score (LLS) of Acute Mountain Sickness (AMS). Next year, a follow-up validation was conducted in the same area.</div></div><div><h3>Results</h3><div>Sixty-eight subjects were diagnosed AMS with LLS and 92 subjects met the diagnostic criteria of eLLS among 189 subjects. The difference in hematological indicators calculated by the eLLS criteria was more significant than that calculated by the LLS criteria, which including red blood cells (P &lt; 0.01), white blood cells (P &lt; 0.05), hemoglobin (P &lt; 0.01), platelets (P &lt; 0.01) and neutrophils (P &lt; 0.01). The eLLS identified additional risk factors comparing with LLS, which included higher white blood cells (OR 1.660, 95 % CI 1.032–2.670, P &lt; 0.05), neutrophils (OR 1.312, 95 % CI 1.002–1.718, P &lt; 0.05). Follow-up results showed that there were more significant differences in psychological scale scores between the groups identified using the eLLS criteria. (P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>We proposed eLLS standard for individuals rapidly ascending to high altitude, which is more sensitive to hematological changes and can better reflect the cognitive mental state than the LLS.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102907"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First trial of recycling used insecticide treated nets by pyrolysis for safer environment: The RINSE project","authors":"Guillaume Carnevale ,&nbsp;Sinclair Andrew ,&nbsp;Florence Fouque ,&nbsp;Pierre Carnevale","doi":"10.1016/j.tmaid.2025.102835","DOIUrl":"10.1016/j.tmaid.2025.102835","url":null,"abstract":"<div><h3>Background</h3><div>Thanks to the large-scale distribution of long-lasting insecticide-treated nets (LLINs), several hundreds of millions of cases, and malaria related mortality, were averted these last decades.</div><div>However, disposing of the used, and discarded nets, made of non-biodegradable plastics, and impregnated with insecticides, and usually burned or buried, raises significant, physical and chemical, environmental and health concerns. This study explores the first application of pyrolysis to recycle, and repurpose, discarded LLINs, with tests conducted in Lombok, Indonesia.</div></div><div><h3>Method</h3><div>Pyrolysis was tested on Royal Sentry® LLINs, made from polyethylene and impregnated with alpha-cypermethrin. A special equipment was prepared to make this pyrolysis, following the same protocol as the one currently used for treating plastic waste at large-scale in the factory Geo Trash Management (Lombok).</div></div><div><h3>Results</h3><div>The pyrolysis yielded 81.3 % high-quality oil, 5.65 % oil residue, and 5 % carbon residue. Gas Chromatography–Mass Spectrometry (GC-MS) analysis identified 36 hydrocarbons, 7 alcohols, and 1 acid, without harmful chemicals like polychlorinated biphenyls (PCBs). Unexpectedly, the nets contained Nonacosane, a mosquito attractant, and Citronellol, a natural repellent, raising questions about their effects on mosquito behaviour.</div></div><div><h3>Conclusions</h3><div>Polyethylene LLINs are suitable for pyrolysis, offering an innovative solution to the environmental impact of discarded nets. The Recycling used Insecticide-Treated Nets for Safer Environment (RINSE) project plans to transfer this technology to malaria-endemic countries, establishing recycling structures and promoting sustainability. This approach supports global efforts to combat plastic pollution, create a circular economy, and sustainably manage LLIN disposal. Further research is recommended to explore the behavioural implications of detected compounds.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102835"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serodiagnosis of strongyloidiasis in a low-endemic setting – a two-tiered test approach","authors":"Sebastian Albermann ,&nbsp;Anne Vischer ,&nbsp;Xuan Lan Vu ,&nbsp;Anja Horat ,&nbsp;Felix Grimm ,&nbsp;Beatrice Nickel ,&nbsp;Bruno Gottstein ,&nbsp;Cédric Hirzel ,&nbsp;Alexander Oberli","doi":"10.1016/j.tmaid.2025.102890","DOIUrl":"10.1016/j.tmaid.2025.102890","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have demonstrated that <em>Strongyloides</em> ELISAs frequently exhibit cross-reactivity with infections caused by other helminths. This may result in false-positive results, especially in low-endemic areas, potentially leading to unwarranted treatment. This study aimed to present a new Western blot for the detection of anti-<em>Strongyloides</em> antibodies such as to enhance the accuracy of distinguishing true-positive from false-positive ELISA results.</div></div><div><h3>Methods</h3><div>We developed and validated a Western blot to detect anti-<em>S. stercoralis</em> specific antibodies using reference sera from confirmed cases (n = 55), non-infected control patients (n = 20), and patients with other helminth infections (n = 50). Using this sample set, we evaluated the analytical performance of three serologic approaches: an in-house ELISA, the commercially available Bordier-ELISA, and a two-tiered testing procedure combining the in-house ELISA with a confirmatory Western blot. Using receiver operating characteristics (ROC) analysis, setting-specific cut-offs values were determined for both ELISA assays. Further, we conducted a retrospective cohort study using serum samples from solid organ transplant (SOT) candidates (n = 310) tested by ELISA during pre-transplant evaluations at Bern University Hospital (2018–2022).</div></div><div><h3>Results</h3><div>The Western blot specifically detected human IgG antibodies against <em>S. stercoralis</em>. A two-tier test algorithm (in-house ELISA, followed by confirmatory Western blot) showed a diagnostic sensitivity of 96.4 % (95 %CI:87.5 %–99.6 %) and a diagnostic specificity of 98.6 % (95 %CI:92.3 %–100 %). Out of 310 SOT candidates’ serum samples, 9.3 % (n = 29) exhibited positive, and 5.2 % (n = 16) equivocal ELISA results. Testing by Western blot revealed positive <em>S. stercoralis</em> findings for 11.1 % (n = 5) of these patients. Two of those were initially positive and 3 were equivocal by ELISA.</div></div><div><h3>Conclusions</h3><div>The new Western blot is a promising tool for clarifying equivocal <em>S. stercoralis</em> ELISA results, and therefore predisposed to reduce false positive <em>Strongyloides</em> ELISA results, especially in low-endemic regions.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102890"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imported fascioliasis in non-endemic countries: a case series and review of the literature","authors":"Paola Rodari,&nbsp;Maria Luca D'Errico,&nbsp;Andrea Angheben,&nbsp;Leonardo Motta,&nbsp;Veronica Andrea Fittipaldo,&nbsp;Dora Buonfrate,&nbsp;Federico Giovanni Gobbi","doi":"10.1016/j.tmaid.2025.102883","DOIUrl":"10.1016/j.tmaid.2025.102883","url":null,"abstract":"<div><h3>Background</h3><div>Fascioliasis is one of the most neglected foodborne zoonotic infectious disease, caused by the trematodes <em>Fasciola hepatica</em> and <em>Fasciola gigantica</em>. In last decades, it emerged as a public health problem worldwide, due to the substantial number of human infections. Fascioliasis has also been described in travellers and migrants, with relevance in Travel Medicine.</div></div><div><h3>Methods</h3><div>We reported four cases of imported human fascioliasis diagnosed in our Department between 2011 and 2023. Literature search was performed on MEDLINE and Embase. We included case reports and case series on patients diagnosed with imported fascioliasis in non-endemic countries to summarize diagnostic and therapeutic approaches.</div></div><div><h3>Results</h3><div>We retrieved 46 cases of imported fascioliasis, mostly acquired after stay in countries of South East Asia (41.3 %) and Africa (34.8 %). Forty patients (86.9 %) presented with symptoms, particularly low-grade fever and abdominal pain. Eosinophilia was found in 94.4 %. When performed, serology was positive in almost all patients (36/37, 97.3 %), while parasitological stool examination was positive only in a few cases (5/32, 15.6 %). In 12 cases, adult worm was removed by endoscopic technique, while in six cases fascioliasis was diagnosed after liver biopsy or resection. Triclabendazole was administered 33 cases, with excellent outcome.</div></div><div><h3>Discussion</h3><div>Diagnosis of fascioliasis is complex in non-endemic settings, and a high index of suspicion is crucial. The presence of eosinophilia, fever and hepatic lesions in travellers or migrants should rise suspicion, and serological tests may confirm the diagnosis. Triclabendazole remains the drug of choice, despite unavailability in many countries.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102883"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}