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Primaquine-induced hemolysis in a Colombian patient with glucose-6-phosphate dehydrogenase deficiency 一名患有葡萄糖-6-磷酸脱氢酶缺乏症的哥伦比亚患者因普利马喹引起的溶血。
IF 6.3 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-07-30 DOI: 10.1016/j.tmaid.2024.102748
Daniel Celis-Giraldo, María Alejandra Fajardo, Diana Camila Romo Arteaga, Álvaro A. Faccini-Martínez
{"title":"Primaquine-induced hemolysis in a Colombian patient with glucose-6-phosphate dehydrogenase deficiency","authors":"Daniel Celis-Giraldo, María Alejandra Fajardo, Diana Camila Romo Arteaga, Álvaro A. Faccini-Martínez","doi":"10.1016/j.tmaid.2024.102748","DOIUrl":"10.1016/j.tmaid.2024.102748","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102748"},"PeriodicalIF":6.3,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000644/pdfft?md5=4e3c5f2ceb640fbbd38d59d2c5ab4a44&pid=1-s2.0-S1477893924000644-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of species hybridization on the clinical management of schistosomiasis: A prospective study 物种杂交对血吸虫病临床治疗的影响:一项前瞻性研究。
IF 6.3 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-07-23 DOI: 10.1016/j.tmaid.2024.102744
Joaquín Salas-Coronas , M. Dolores Bargues , Pedro Fernández-Soto , Manuel J. Soriano-Pérez , Patricio Artigas , José Vázquez-Villegas , Antonio Villarejo-Ordoñez , José C. Sánchez-Sánchez , María I. Cabeza-Barrera , Begoña Febrer-Sendra , Alejandra De Elías-Escribano , Beatriz Crego-Vicente , María C. Fantozzi , Juan García-Bernalt Diego , Nerea Castillo-Fernández , Jaime Borrego-Jiménez , Antonio Muro , María P. Luzón-García
{"title":"Impact of species hybridization on the clinical management of schistosomiasis: A prospective study","authors":"Joaquín Salas-Coronas ,&nbsp;M. Dolores Bargues ,&nbsp;Pedro Fernández-Soto ,&nbsp;Manuel J. Soriano-Pérez ,&nbsp;Patricio Artigas ,&nbsp;José Vázquez-Villegas ,&nbsp;Antonio Villarejo-Ordoñez ,&nbsp;José C. Sánchez-Sánchez ,&nbsp;María I. Cabeza-Barrera ,&nbsp;Begoña Febrer-Sendra ,&nbsp;Alejandra De Elías-Escribano ,&nbsp;Beatriz Crego-Vicente ,&nbsp;María C. Fantozzi ,&nbsp;Juan García-Bernalt Diego ,&nbsp;Nerea Castillo-Fernández ,&nbsp;Jaime Borrego-Jiménez ,&nbsp;Antonio Muro ,&nbsp;María P. Luzón-García","doi":"10.1016/j.tmaid.2024.102744","DOIUrl":"10.1016/j.tmaid.2024.102744","url":null,"abstract":"<div><h3>Background</h3><p>Species hybridization represents a real concern in terms of parasite transmission, epidemiology and morbidity of schistosomiasis. It is greatly important to better understand the impact of species hybridization for the clinical management.</p></div><div><h3>Methods</h3><p>A prospective observational study was carried out in sub-Saharan migrants who were diagnosed with confirmed genitourinary schistosomiasis. A tailored protocol was applied, including <em>Schistosoma</em> serology, a specific urine LAMP tests for schistosomiasis and an ultrasound examination before treatment with praziquantel. A scheduled follow-up was performed at 3, 6 and 12 months to monitor treatment response, comparing patients carriers of <em>Schistosoma</em> hybrids with carriers of only genetically pure forms.</p></div><div><h3>Results</h3><p>A total of 31 male patients from West Africa were included in the study with a mean age of 26.5 years. Twelve (38.7 %) of the patients were carriers of <em>Schistosoma</em> hybrids. As compared with patients infected with <em>S. haematobium</em> alone, hybrid carriers had lower haemoglobin levels (13.8 g/dL [SD 1.8] vs 14.8 g/dL [SD 1.4], p = 0.04), a greater frequency of hematuria (100 % <em>vs</em> 52.6 %, p = 0.005), a higher ultrasound score (2.64, SD 2.20 vs 0.89, SD 0.99; p = 0.02). However, the presence of hybrids did not result in differences in clinical and analytical responses after treatment.</p></div><div><h3>Conclusions</h3><p>The presence of <em>Schistosoma</em> hybrids seems to cause increased morbidity in infected individuals. However, it does not appear to result in differences in diagnostic tests or in clinical and analytical responses after treatment.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102744"},"PeriodicalIF":6.3,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000607/pdfft?md5=4ec115016baa650e8c87d491a5132279&pid=1-s2.0-S1477893924000607-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Necrotizing mpox with persistent microbiological positivity despite the use of tecovirimat: A case report 尽管使用了替考韦利马特,但微生物呈持续阳性的坏死性麻疹:一份病例报告。
IF 6.3 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-07-22 DOI: 10.1016/j.tmaid.2024.102746
Pierluigi Francesco Salvo, Gianmaria Baldin, Elena Visconti, Simona Di Giambenedetto
{"title":"Necrotizing mpox with persistent microbiological positivity despite the use of tecovirimat: A case report","authors":"Pierluigi Francesco Salvo,&nbsp;Gianmaria Baldin,&nbsp;Elena Visconti,&nbsp;Simona Di Giambenedetto","doi":"10.1016/j.tmaid.2024.102746","DOIUrl":"10.1016/j.tmaid.2024.102746","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102746"},"PeriodicalIF":6.3,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000620/pdfft?md5=08d5d947215ca3b3272a25ae86577697&pid=1-s2.0-S1477893924000620-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between positive serology for COVID-19 and chagas cardiomyopathy progression: The SaMi-Trop project COVID-19 血清学阳性与南美锥虫病心肌病进展之间的关系:SaMi-Trop项目。
IF 6.3 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-07-22 DOI: 10.1016/j.tmaid.2024.102745
Ariela Mota Ferreira , Léa Campos Oliveira-da Silva , Clareci Silva Cardoso , Cláudia Di Lorenzo Oliveira , Bruno Oliveira de Figueiredo Brito , Ana Luiza Bierrenbach , Ana Clara de Jesus Santos , Dardiane Santos Cruz , Sâmara Fernandes Leite , Andréia Brito Jesus , Renata Fiúza Damasceno , Maria Carmo Pereira Nunes , Israel Molina , Desirée Sant’ Anna Haikal , Ester Cerdeira Sabino , Antonio Luiz Pinho Ribeiro
{"title":"Association between positive serology for COVID-19 and chagas cardiomyopathy progression: The SaMi-Trop project","authors":"Ariela Mota Ferreira ,&nbsp;Léa Campos Oliveira-da Silva ,&nbsp;Clareci Silva Cardoso ,&nbsp;Cláudia Di Lorenzo Oliveira ,&nbsp;Bruno Oliveira de Figueiredo Brito ,&nbsp;Ana Luiza Bierrenbach ,&nbsp;Ana Clara de Jesus Santos ,&nbsp;Dardiane Santos Cruz ,&nbsp;Sâmara Fernandes Leite ,&nbsp;Andréia Brito Jesus ,&nbsp;Renata Fiúza Damasceno ,&nbsp;Maria Carmo Pereira Nunes ,&nbsp;Israel Molina ,&nbsp;Desirée Sant’ Anna Haikal ,&nbsp;Ester Cerdeira Sabino ,&nbsp;Antonio Luiz Pinho Ribeiro","doi":"10.1016/j.tmaid.2024.102745","DOIUrl":"10.1016/j.tmaid.2024.102745","url":null,"abstract":"<div><h3>Background</h3><p>Chagas Disease (CD) can cause Chagas cardiomyopathy. The new coronavirus disease (COVID-19) also affects the cardiovascular system and may worsen Chagas cardiomyopathy. However, the cardiac evolution of patients with CD infected by COVID-19 is not known. Thus, the objective of this study is to assess, within one year, whether there was cardiac progression after COVID-19 in CD.</p></div><div><h3>Methods</h3><p>Longitudinal study with CD patients. The outcome was cardiac progression, defined as the appearance of new major changes in the current ECG compared to the previous ECG considered from the comparison of electrocardiograms (ECGs) performed with an interval of one year. Positive Anti-SARS-CoV2 Serology was the independent variable of interest. For each analysis, a final multiple model was constructed, adjusted for sociodemographic, clinical, and pandemic-related characteristics.</p></div><div><h3>Results</h3><p>Of the 404 individuals included, 22.8 % had positive serology for COVID-19 and 10.9 % had cardiac progression. In the final model, positive serology for COVID-19 was the only factor associated with cardiac progression in the group as a whole (OR = 2.65; 95 % CI = 1.27–5.53) and for new-onset cardiomyopathy in the group with normal previous ECG (OR = 3.50; 95 % CI = 1.21–10.13).</p></div><div><h3>Conclusion</h3><p>Our study shows an association between COVID-19 and progression of Chagas cardiomyopathy, evaluated by repeated ECGs, suggesting that COVID-19 accelerated the natural history of CD.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102745"},"PeriodicalIF":6.3,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000619/pdfft?md5=74b22fe89142b3ac09a91e3deff0995b&pid=1-s2.0-S1477893924000619-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and clinical significance of non-tuberculous mycobacteria among migrants in Denmark: A nationwide register-based cohort study from 1991 through 2021 丹麦移民中非结核分枝杆菌的发病率和临床意义:1991 年至 2021 年基于全国登记的队列研究。
IF 6.3 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-07-10 DOI: 10.1016/j.tmaid.2024.102736
{"title":"Incidence and clinical significance of non-tuberculous mycobacteria among migrants in Denmark: A nationwide register-based cohort study from 1991 through 2021","authors":"","doi":"10.1016/j.tmaid.2024.102736","DOIUrl":"10.1016/j.tmaid.2024.102736","url":null,"abstract":"<div><h3>Background</h3><p>There is limited knowledge about non-tuberculous mycobacteria (NTM) infections in migrants. We aimed to assess the incidence and clinical significance of NTM among migrants in Denmark.</p></div><div><h3>Method</h3><p>Nationwide register-based cohort study of migrants with a positive NTM culture in Denmark from 1991 through 2021, stratified by patient demographics, disease localisation, species, and clinical significance.</p></div><div><h3>Results</h3><p>433 migrants had a positive NTM culture, resulting in an overall incidence rate (IR) of 3.7 (95%CI 3.3–4.0) per 100,000 migrants. Overall NTM IRs for definite disease were 1.0 (95%CI 0.9–1.2), possible disease 1.0 (95%CI 0.8–1.2), and isolation 1.7 (95%CI 1.4–1.9) per 100,000 migrants. Migrants had considerably higher age- and sex-adjusted NTM IRs of positive cultures (incidence rate ratio [IRR] = 2.1, 95%CI 1.9–2.3, p &lt; 0.001), possible disease (IRR = 2.4, 95%CI 2.0–3.0, p &lt; 0.001), and isolation (IRR = 4.6, 95%CI 3.9–5.4, p &lt; 0.001) compared to Danish-born, but not of definite disease (IRR = 1.1, 95%CI 0.9–1.3, p = 0.562). IRs of migrants with positive NTM cultures did not increase over time (−0.8 %/year, p = 0.133).</p></div><div><h3>Conclusions</h3><p>Migrants have a higher, but stable, burden of NTM compared with Danish-born. The higher rates likely reflect that more specimens are examined for <em>Mycobacterium tuberculosis</em>. Microbiologically classified definite NTM disease is not substantially more common among migrants.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102736"},"PeriodicalIF":6.3,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000528/pdfft?md5=83362da17dd22b80c1c5746b94e5919f&pid=1-s2.0-S1477893924000528-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141601879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mosquito-borne Murray Valley encephalitis: Re-emergence in Western Australia 蚊媒墨累山谷脑炎:重新出现在西澳大利亚州。
IF 6.3 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-07-01 DOI: 10.1016/j.tmaid.2024.102734
{"title":"Mosquito-borne Murray Valley encephalitis: Re-emergence in Western Australia","authors":"","doi":"10.1016/j.tmaid.2024.102734","DOIUrl":"10.1016/j.tmaid.2024.102734","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"60 ","pages":"Article 102734"},"PeriodicalIF":6.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000504/pdfft?md5=ef8e8c4135e47d808684c3e048b49b4a&pid=1-s2.0-S1477893924000504-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141601880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zika and Chikungunya in Europe 2100 – A GIS based model for risk estimation 2100 年欧洲的寨卡病毒和基孔肯雅病毒--基于地理信息系统的风险评估模型。
IF 6.3 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-07-01 DOI: 10.1016/j.tmaid.2024.102737
J. Kronen , M. Leuchner , T. Küpper
{"title":"Zika and Chikungunya in Europe 2100 – A GIS based model for risk estimation","authors":"J. Kronen ,&nbsp;M. Leuchner ,&nbsp;T. Küpper","doi":"10.1016/j.tmaid.2024.102737","DOIUrl":"10.1016/j.tmaid.2024.102737","url":null,"abstract":"<div><h3>Background</h3><p>The spread of vector-borne infectious diseases is determined, among other things, by temperature. Thus, climate change will have an influence on their global distribution. In the future, Europe will approach the temperature optimum for the transmission of ZIKV and CHIKV. Climate scenarios and climate models can be used to depict future climatic changes and to draw conclusions about future risk areas for vector-borne infectious diseases.</p></div><div><h3>Methods</h3><p>Based on the RCP 4.5 and RCP 8.5 climate scenarios, a geospatial analysis was carried out for the future temperature suitability of ZIKV and CHIKV in Europe. The results were presented in maps and the percentage of the affected areas calculated.</p></div><div><h3>Results</h3><p>Due to rising temperatures, the risk areas for transmission of ZIKV and CHIKV spread in both RCP scenarios. For CHIKV transmission, Spain, Portugal, the Mediterranean coast and areas near the Black Sea are mainly affected. Due to high temperatures, large areas throughout Europe are at risk for ZIKV and CHIKV transmission.</p></div><div><h3>Conclusion</h3><p>Temperature is only one of many factors influencing the spread of vector-borne infectious diseases. Nevertheless, the representation of risk areas on the basis of climate scenarios allows an assessment of future risk development. Monitoring and adaptation strategies are indispensable for coping with and containing possible future autochthonous transmissions and epidemics in Europe.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"60 ","pages":"Article 102737"},"PeriodicalIF":6.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S147789392400053X/pdfft?md5=884527ce36de6a0fcea841a593afdfe9&pid=1-s2.0-S147789392400053X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141601882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unexpected discovery of Trypanosoma brucei gambiense on CSF in a western country: About a case 在一个西方国家的脑脊液中意外发现布氏锥虫:关于一个病例。
IF 6.3 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-07-01 DOI: 10.1016/j.tmaid.2024.102741
Lou-Ann Francois, Laurent Bret, Jonathan Wong So, Camelia Gubavu, Feriel Touafek, Morgane Vinsonneau, Khaoula Kochbati, Véronique Avettand-Fenoel, Clemence Guillaume, Etienne Carbonnelle, Jérôme Guinard, Gilbert Mchantaf
{"title":"Unexpected discovery of Trypanosoma brucei gambiense on CSF in a western country: About a case","authors":"Lou-Ann Francois,&nbsp;Laurent Bret,&nbsp;Jonathan Wong So,&nbsp;Camelia Gubavu,&nbsp;Feriel Touafek,&nbsp;Morgane Vinsonneau,&nbsp;Khaoula Kochbati,&nbsp;Véronique Avettand-Fenoel,&nbsp;Clemence Guillaume,&nbsp;Etienne Carbonnelle,&nbsp;Jérôme Guinard,&nbsp;Gilbert Mchantaf","doi":"10.1016/j.tmaid.2024.102741","DOIUrl":"10.1016/j.tmaid.2024.102741","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"60 ","pages":"Article 102741"},"PeriodicalIF":6.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000577/pdfft?md5=2cfcc390c73f8a1d45400581db307056&pid=1-s2.0-S1477893924000577-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Not all severe malaria cases are severe: Is it time to redefine severity criteria for malaria in non-endemic regions? 并非所有重症疟疾病例都是重症:现在是重新定义非疟疾流行地区疟疾严重程度标准的时候了吗?
IF 6.3 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-07-01 DOI: 10.1016/j.tmaid.2024.102740
Leire Balerdi-Sarasola , Jose Muñoz , Pedro Fleitas , Natalia Rodriguez-Valero , Alex Almuedo-Riera , Alba Antequera , Carme Subirà , Ignacio Grafia-Perez , Maria Ortiz-Fernández , Tessa de Alba , Miriam J. Álvarez-Martínez , M Eugenia Valls , Claudio Parolo , Pedro Castro , Daniel Camprubí-Ferrer
{"title":"Not all severe malaria cases are severe: Is it time to redefine severity criteria for malaria in non-endemic regions?","authors":"Leire Balerdi-Sarasola ,&nbsp;Jose Muñoz ,&nbsp;Pedro Fleitas ,&nbsp;Natalia Rodriguez-Valero ,&nbsp;Alex Almuedo-Riera ,&nbsp;Alba Antequera ,&nbsp;Carme Subirà ,&nbsp;Ignacio Grafia-Perez ,&nbsp;Maria Ortiz-Fernández ,&nbsp;Tessa de Alba ,&nbsp;Miriam J. Álvarez-Martínez ,&nbsp;M Eugenia Valls ,&nbsp;Claudio Parolo ,&nbsp;Pedro Castro ,&nbsp;Daniel Camprubí-Ferrer","doi":"10.1016/j.tmaid.2024.102740","DOIUrl":"10.1016/j.tmaid.2024.102740","url":null,"abstract":"<div><h3>Background</h3><p>The current definition of severe malaria in non-endemic areas follows WHO criteria, which mainly target children in malaria-endemic areas, potentially misclassifying cases in non-endemic regions. We assessed the performance of a modified severe malaria classification criteria within our patient cohort.</p></div><div><h3>Methods</h3><p>A cohort study of patients managed for malaria in a non-endemic setting (2005–2023) was analyzed. We classified patients into severe malaria (SM) using WHO 2013 criteria except for hyperparasitemia, where 2 % threshold was applied. Patients with SM were distinguished as very severe malaria (VSM) when presenting at least one of the following conditions: parasitemia &gt;10 %, pulmonary edema, impaired consciousness, seizures, renal failure, metabolic acidosis or hyperlactatemia, shock or hypoglycemia. In patients with SM and no criteria for VSM, less severe malaria (LSM) was defined by: 2–10 % parasitemia, hyperbilirubinemia, prostration, anemia or minor bleeding. The primary composite outcome was death or the need for a life-saving intervention, as analyzed in the three comparative groups. Secondary outcome was the prevalence of co-infections.</p></div><div><h3>Results</h3><p>Among 506 patients with malaria, 176 (34.8 %) presented with SM. A total of 37 (7.3 %) patients developed a life-threatening condition, namely death (n = 4) and/or the need for life-saving interventions (n = 34). All fatalities and 33 out of the 34 life-saving interventions occurred in the VSM group. Patients in LSM group did not develop any life-threatening conditions. As to co-infections, 28 (5.5 %) patients had a community-acquired co-infection, with no differences between groups (p = 0.763).</p></div><div><h3>Conclusions</h3><p>Severity criteria definitions would benefit from a review when assessing patients with malaria in non-endemic areas. Within the spectrum of SM, patients reclassified as LSM have a low risk of developing a life-threatening condition and present low co-infection incidence and could benefit from management out of intensive care units and a restrictive use of empirical antibiotics.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"60 ","pages":"Article 102740"},"PeriodicalIF":6.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000565/pdfft?md5=d45330cc47982cd68d0c4b9dc1722df4&pid=1-s2.0-S1477893924000565-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Communicable diseases in Ukraine during the period of 2018–2023: Impact of the COVID-19 pandemic and war 2018-2023 年期间乌克兰的传染病:COVID-19 大流行和战争的影响。
IF 6.3 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-07-01 DOI: 10.1016/j.tmaid.2024.102733
Pavlo Petakh , Viktoriia Tymchyk , Oleksandr Kamyshnyi
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