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Surveillance cystoscopy for atypical Schistosoma haematobium infection associated with recurrent UTIs 监测膀胱镜检查与复发性尿毒症相关的非典型血吸虫感染。
IF 12 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-05-01 DOI: 10.1016/j.tmaid.2024.102702
Case Keltner, Jacqueline Causbie, Robert Haynes, Jeremy Mandia, Hisham Imad, Wasin Matsee
{"title":"Surveillance cystoscopy for atypical Schistosoma haematobium infection associated with recurrent UTIs","authors":"Case Keltner, Jacqueline Causbie, Robert Haynes, Jeremy Mandia, Hisham Imad, Wasin Matsee","doi":"10.1016/j.tmaid.2024.102702","DOIUrl":"10.1016/j.tmaid.2024.102702","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"59 ","pages":"Article 102702"},"PeriodicalIF":12.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000164/pdfft?md5=4759608b52a3cb75fda4084167d714bf&pid=1-s2.0-S1477893924000164-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139997541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The never-ending story of mpox epidemic: Tracing a new cluster in Florence, Italy 水痘疫情的故事永无止境:追踪意大利佛罗伦萨的新疫情群。
IF 12 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-05-01 DOI: 10.1016/j.tmaid.2024.102704
Luigi Pisano, Manfredi Magliulo, Martina Turco, Jacopo Farini, Anna Lisa Rapaccini, Filippo Lagi, Alessandro Bartoloni, Nicola Pimpinelli
{"title":"The never-ending story of mpox epidemic: Tracing a new cluster in Florence, Italy","authors":"Luigi Pisano, Manfredi Magliulo, Martina Turco, Jacopo Farini, Anna Lisa Rapaccini, Filippo Lagi, Alessandro Bartoloni, Nicola Pimpinelli","doi":"10.1016/j.tmaid.2024.102704","DOIUrl":"10.1016/j.tmaid.2024.102704","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"59 ","pages":"Article 102704"},"PeriodicalIF":12.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000188/pdfft?md5=c2e395e05db9667e58916fee07724803&pid=1-s2.0-S1477893924000188-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in temporal and spatial changes of Japanese encephalitis in Chinese mainland, 2004–2019: A population-based surveillance study 2004-2019年中国大陆日本脑炎的时空变化趋势:一项基于人群的监测研究。
IF 12 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-04-29 DOI: 10.1016/j.tmaid.2024.102724
Chang-Qing Sun , Yun-Qiang Fu , Xuan Ma , Jun-Ru Shen , Bo Hu , Qiang Zhang , Lian-Ke Wang , Rui Hu , Jia-Jun Chen
{"title":"Trends in temporal and spatial changes of Japanese encephalitis in Chinese mainland, 2004–2019: A population-based surveillance study","authors":"Chang-Qing Sun ,&nbsp;Yun-Qiang Fu ,&nbsp;Xuan Ma ,&nbsp;Jun-Ru Shen ,&nbsp;Bo Hu ,&nbsp;Qiang Zhang ,&nbsp;Lian-Ke Wang ,&nbsp;Rui Hu ,&nbsp;Jia-Jun Chen","doi":"10.1016/j.tmaid.2024.102724","DOIUrl":"10.1016/j.tmaid.2024.102724","url":null,"abstract":"<div><h3>Background</h3><p>Japanese encephalitis (JE) is a serious health concern in China, with approximately 80 % of global infections occurring in China. To develop effective prevention and control strategies, this study explored the epidemiological characteristics of JE in China based on spatiotemporal data, to understand the patterns and trends of JE incidence in different regions and time periods.</p></div><div><h3>Method</h3><p>The incidence and mortality rates of JE were extracted from the Public Health Data Center, the official website of the National Health Commission of the People's Republic of China, and the National Notifiable Infectious Disease Surveillance System from 2004 to 2019. Joinpoint regression was applied to examine the spatiotemporal patterns and annual percentage change in incidence and mortality of the JE.</p></div><div><h3>Results</h3><p>From 2004 to 2019, a total of 43,569 cases of JE were diagnosed, including 2081 deaths. The annual incidence rate of JE decreased from 0.4171/100,000 in 2004 to 0.0298/100,000 in 2019, with an annual percentage change (APC) of −13.5 % (<em>P</em> &lt; 0.001). The annual mortality rate of JE showed three stages of change, with inflection points in 2006 and 2014. The incidence and mortality rates of JE have declined in all provinces of China, and more cases were reported in 0–14 years of age, accounting for nearly 80 % of all patients.</p></div><div><h3>Conclusions</h3><p>The morbidity and mortality rates of JE in China are generally on a downward trend, and emphasis should be placed on strengthening disease surveillance in special areas and populations, popularizing vaccination, and increasing publicity.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"60 ","pages":"Article 102724"},"PeriodicalIF":12.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000383/pdfft?md5=e5f8b4749a818d1f02f7a2e72667a5ea&pid=1-s2.0-S1477893924000383-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of crimean Congo hemorrhagic fever in Khyber Pakhtunkhwa, Pakistan 巴基斯坦开伯尔巴图克瓦省的刚果出血热流行情况
IF 12 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-04-18 DOI: 10.1016/j.tmaid.2024.102722
Asad Zia , Ali Talha Khalil , Naz Alam , Abdul Qadoos Khan , Mubarak Ali Khan , Yasar Yosafzai , Asif Ali , Ihsan Ullah , Ali Rehman Wazir
{"title":"Prevalence of crimean Congo hemorrhagic fever in Khyber Pakhtunkhwa, Pakistan","authors":"Asad Zia ,&nbsp;Ali Talha Khalil ,&nbsp;Naz Alam ,&nbsp;Abdul Qadoos Khan ,&nbsp;Mubarak Ali Khan ,&nbsp;Yasar Yosafzai ,&nbsp;Asif Ali ,&nbsp;Ihsan Ullah ,&nbsp;Ali Rehman Wazir","doi":"10.1016/j.tmaid.2024.102722","DOIUrl":"https://doi.org/10.1016/j.tmaid.2024.102722","url":null,"abstract":"<div><h3>Background</h3><p>CCHFV is well recognized as a major public health threat and its prevalence and epidemiological distribution in Pakistan and specifically in KP province is not well documented.</p></div><div><h3>Methods</h3><p>We used a gold-standard PCR-based diagnostic assay for confirmation of CCHFV among suspected patients. A total of 150 patients were enrolled from June 2022 to September 2022 and their blood samples were collected for PCR confirmation.</p></div><div><h3>Results</h3><p>The overall positivity rate for CCHFV was 26.67 %, with the virus mostly prevalent in the middle-aged group (21–40 years). In the July of 2022, a significant spike in the prevalence of CCHFV was observed in provincial capital Peshawar with the highest burden (31.57 %).</p></div><div><h3>Conclusion</h3><p>Our findings indicate the necessity of strengthening CCHFV monitoring programs and intensifying efforts to identify hotspot regions for effective surveillance and control of CCHFV. The months before the Eid-ul-Adha are crucial in the context of CCHFV control.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"59 ","pages":"Article 102722"},"PeriodicalIF":12.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S147789392400036X/pdfft?md5=a579dde5635a4b4c9e163773ff9aed68&pid=1-s2.0-S147789392400036X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140620907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mosquito-borne ross river virus: A raising concern in Queensland 蚊子传播的罗斯河病毒:昆士兰州日益令人担忧的问题
IF 12 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-04-18 DOI: 10.1016/j.tmaid.2024.102723
Shriyansh Srivastava, Sachin Kumar, Sampath Chinnam, Naina Srivastava, Rachana Mehta, Aroop Mohanty, Sanjit Sah, Jack Feehan, Maximilian de Courten, Vasso Apostolopoulos , Ranjit Sah
{"title":"Mosquito-borne ross river virus: A raising concern in Queensland","authors":"Shriyansh Srivastava,&nbsp;Sachin Kumar,&nbsp;Sampath Chinnam,&nbsp;Naina Srivastava,&nbsp;Rachana Mehta,&nbsp;Aroop Mohanty,&nbsp;Sanjit Sah,&nbsp;Jack Feehan,&nbsp;Maximilian de Courten,&nbsp;Vasso Apostolopoulos ,&nbsp;Ranjit Sah","doi":"10.1016/j.tmaid.2024.102723","DOIUrl":"https://doi.org/10.1016/j.tmaid.2024.102723","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"59 ","pages":"Article 102723"},"PeriodicalIF":12.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000371/pdfft?md5=c20ed9568603272bfedecab74c5bdc1f&pid=1-s2.0-S1477893924000371-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140638008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging threats: Is highly pathogenic avian influenza A(H5N1) in dairy herds a prelude to a new pandemic? 新出现的威胁:奶牛场中的高致病性禽流感 A(H5N1)是新的大流行的前奏吗?
IF 12 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-04-07 DOI: 10.1016/j.tmaid.2024.102721
Francesco Branda, Chiara Romano, Marta Giovanetti, Alessandra Ciccozzi, Massimo Ciccozzi, Fabio Scarpa
{"title":"Emerging threats: Is highly pathogenic avian influenza A(H5N1) in dairy herds a prelude to a new pandemic?","authors":"Francesco Branda,&nbsp;Chiara Romano,&nbsp;Marta Giovanetti,&nbsp;Alessandra Ciccozzi,&nbsp;Massimo Ciccozzi,&nbsp;Fabio Scarpa","doi":"10.1016/j.tmaid.2024.102721","DOIUrl":"https://doi.org/10.1016/j.tmaid.2024.102721","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"59 ","pages":"Article 102721"},"PeriodicalIF":12.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000358/pdfft?md5=621b5ca8533a8a923ef225ece845c088&pid=1-s2.0-S1477893924000358-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140542732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrointestinal syndrome encountered during a train voyage to high altitudes: A 14-day survey of 69 passengers in China 高海拔地区火车旅行中遇到的胃肠道综合征:对中国 69 名乘客进行的为期 14 天的调查
IF 12 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-04-04 DOI: 10.1016/j.tmaid.2024.102718
Yihui Chen , Xiaoqi Tang , Xiong Zeng , Ben Han , Huichao Xie , Wei Wang , Lihua Sun , Mingdong Hu , Yuqi Gao , Weidong Xiao
{"title":"Gastrointestinal syndrome encountered during a train voyage to high altitudes: A 14-day survey of 69 passengers in China","authors":"Yihui Chen ,&nbsp;Xiaoqi Tang ,&nbsp;Xiong Zeng ,&nbsp;Ben Han ,&nbsp;Huichao Xie ,&nbsp;Wei Wang ,&nbsp;Lihua Sun ,&nbsp;Mingdong Hu ,&nbsp;Yuqi Gao ,&nbsp;Weidong Xiao","doi":"10.1016/j.tmaid.2024.102718","DOIUrl":"https://doi.org/10.1016/j.tmaid.2024.102718","url":null,"abstract":"<div><h3>Background</h3><p>The diagnosis and evaluation of the severity of acute mountain sickness (AMS) continue to be problematic due to a lack of consensus on the inclusion of symptoms in a scoring system. Recent investigations highlight the significance of gastrointestinal symptoms in identifying this condition. However, the specific gastrointestinal symptoms associated with AMS have not been thoroughly elucidated in previous studies, and the underlying risk factors remain inadequately comprehended.</p></div><div><h3>Methods</h3><p>This study aimed to investigate the characteristics, trends, and risk factors related to gastrointestinal symptoms encountered during train travel to high altitude. A total of 69 passengers, specifically all with medical backgrounds, were surveyed 6 times over a period of 14 days.</p></div><div><h3>Results</h3><p>The daily incidence of abdominal discomfort was higher than non-gastrointestinal symptoms within 14 days. Gastrointestinal symptoms demonstrated a greater prevalence, longer duration, and increased risk compared to non-gastrointestinal symptoms, such as headaches. The symptoms of abdominal distension and bowel sound hyperaction were found to be prevalent and persistent among patients diagnosed with AMS, exhibiting a high incidence rate. Gender, age, body mass index (BMI), smoking habits, and alcohol consumption were identified as risk factors associated with the occurrence and duration of gastrointestinal symptoms.</p></div><div><h3>Conclusion</h3><p>This study suggests that gastrointestinal symptoms are more common and persistent when traveling to the plateau by train. These symptoms should be taken into consideration in the further diagnosis and prevention of AMS. Therefore, this study provides a significant theoretical foundation for the prevention and treatment of AMS.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"59 ","pages":"Article 102718"},"PeriodicalIF":12.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000322/pdfft?md5=ff8c3c86052e358f220d0566bb34855d&pid=1-s2.0-S1477893924000322-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140535954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Travel medicine in Basel - 450 years before CISTM18 巴塞尔的旅行医学--比 CISTM 早 450 年18
IF 12 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-04-03 DOI: 10.1016/j.tmaid.2024.102720
Irmgard L. Bauer
{"title":"Travel medicine in Basel - 450 years before CISTM18","authors":"Irmgard L. Bauer","doi":"10.1016/j.tmaid.2024.102720","DOIUrl":"https://doi.org/10.1016/j.tmaid.2024.102720","url":null,"abstract":"<div><p>Concern for travellers' wellbeing and safety is as old as humankind. Historic documents offer insights into how a safe journey was prepared or travel ailments treated based on the prevailing knowledge of body and (dys)function. In 1561, Guilhelmo Gratarolo published a comprehensive book on what we call today ‘travel medicine’. Many then problems are still today's travel malaises. How they were dealt with 450 years ago is uncovered in his fascinating publication.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"59 ","pages":"Article 102720"},"PeriodicalIF":12.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000346/pdfft?md5=12c00a9ce0f4f5c6fcf542499e3f3953&pid=1-s2.0-S1477893924000346-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140535955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mpox across countries from Central and Eastern Europe - 2022 outbreak 中欧和东欧各国的麻风病--2022 年爆发
IF 12 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-04-02 DOI: 10.1016/j.tmaid.2024.102719
Irina Ianache , Agata Skrzat-Klapaczynska , David Jilich , Lukas Fleischhans , Ivana Gmizic , Jovan Ranin , Antonios Papadopoulos , Konstantinos Protopapas , Velida Mulabdic , Botond Lakatos , Eva Livia Nagy , Josip Begovac , Tiberiu Holban , Dilek Yildiz Sevgi , Alma Cicic , Nina Yancheva , Lubomir Sojak , Nino Rukhadze , Justyna Kowalska , Cristiana Oprea
{"title":"Mpox across countries from Central and Eastern Europe - 2022 outbreak","authors":"Irina Ianache ,&nbsp;Agata Skrzat-Klapaczynska ,&nbsp;David Jilich ,&nbsp;Lukas Fleischhans ,&nbsp;Ivana Gmizic ,&nbsp;Jovan Ranin ,&nbsp;Antonios Papadopoulos ,&nbsp;Konstantinos Protopapas ,&nbsp;Velida Mulabdic ,&nbsp;Botond Lakatos ,&nbsp;Eva Livia Nagy ,&nbsp;Josip Begovac ,&nbsp;Tiberiu Holban ,&nbsp;Dilek Yildiz Sevgi ,&nbsp;Alma Cicic ,&nbsp;Nina Yancheva ,&nbsp;Lubomir Sojak ,&nbsp;Nino Rukhadze ,&nbsp;Justyna Kowalska ,&nbsp;Cristiana Oprea","doi":"10.1016/j.tmaid.2024.102719","DOIUrl":"https://doi.org/10.1016/j.tmaid.2024.102719","url":null,"abstract":"<div><h3>Background</h3><p>The aim of the study was to assess socio-demographical characteristics, clinical presentation, and outcomes in patients diagnosed with mpox.</p></div><div><h3>Methods</h3><p>A survey on patients diagnosed with mpox was performed in 14 countries from Central and Eastern Europe. Data was compared according to HIV status and country of origin (EU vs. non-EU). Mpox diagnosis was confirmed by RT-PCR from oropharyngeal swabs, skin lesions, and other body fluids.</p></div><div><h3>Results</h3><p>Out of 154 patients confirmed with mpox in 2022, 99.3% were males, with a median age (years) of 35 (IQR 30–39), 90.2% MSM and 48.7% PLWH. Compared to HIV-negative subjects, PLWH had more frequent high-risk behaviours:chemsex (p = 0.015), group sex (p = 0.027), and a history of sexually transmitted infections (STIs) (p = 0.004). Persons from EU were more often PLWH (p = 0.042), MSM (p &lt; 0.0001), had multiple sexual partners (p = 0.025), practiced chemsex (p = 0.008) or group-sex (p = 0.005) and had more often history of STIs (p &lt; 0.0001). The median CD4 cell count/mL at mpox diagnosis was 713 (IQR 486–996) and 73.5% had undetectable HIV VL. The commonest clinical features were fever (108 cases), lymphadenopathy (78), and vesiculo-pustular rash: penile (76), perianal (48), limbs (67). Fifty-one (31%) persons were hospitalized due to complications or epidemiological reasons. Three patients received tecovirimat or cidofovir. The outcome was favorable for all patients, including 4 with severe forms.</p></div><div><h3>Conclusions</h3><p>Mpox was diagnosed predominantly in young MSM, with high-risk behaviors and history of STIs. Effective contact tracing and vaccination are important strategic pillars to control mpox outbreaks.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"59 ","pages":"Article 102719"},"PeriodicalIF":12.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000334/pdfft?md5=9d886ddc4897f3065cabcba454750587&pid=1-s2.0-S1477893924000334-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140350869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamics of viral DNA shedding and culture viral DNA positivity in different clinical samples collected during the 2022 mpox outbreak in Lombardy, Italy 2022 年意大利伦巴第大区流行性腮腺炎爆发期间采集的不同临床样本中病毒 DNA 脱落和培养病毒 DNA 阳性的动态变化。
IF 12 3区 医学
Travel Medicine and Infectious Disease Pub Date : 2024-03-29 DOI: 10.1016/j.tmaid.2024.102698
Antonio Piralla , Davide Mileto , Alberto Rizzo , Guglielmo Ferrari , Federica Giardina , Stefano Gaiarsa , Greta Petazzoni , Micol Bianchi , Federica Salari , Fiorenza Bracchitta , Josè Camilla Sammartino , Alessandro Ferrari , Gloria Gagliardi , Alessandro Mancon , Claudio Fenizia , Mara Biasin , Francesca Rovida , Stefania Paolucci , Elena Percivalle , Alessandra Lombardi , Sara Piccinelli
{"title":"Dynamics of viral DNA shedding and culture viral DNA positivity in different clinical samples collected during the 2022 mpox outbreak in Lombardy, Italy","authors":"Antonio Piralla ,&nbsp;Davide Mileto ,&nbsp;Alberto Rizzo ,&nbsp;Guglielmo Ferrari ,&nbsp;Federica Giardina ,&nbsp;Stefano Gaiarsa ,&nbsp;Greta Petazzoni ,&nbsp;Micol Bianchi ,&nbsp;Federica Salari ,&nbsp;Fiorenza Bracchitta ,&nbsp;Josè Camilla Sammartino ,&nbsp;Alessandro Ferrari ,&nbsp;Gloria Gagliardi ,&nbsp;Alessandro Mancon ,&nbsp;Claudio Fenizia ,&nbsp;Mara Biasin ,&nbsp;Francesca Rovida ,&nbsp;Stefania Paolucci ,&nbsp;Elena Percivalle ,&nbsp;Alessandra Lombardi ,&nbsp;Sara Piccinelli","doi":"10.1016/j.tmaid.2024.102698","DOIUrl":"10.1016/j.tmaid.2024.102698","url":null,"abstract":"<div><h3>Background</h3><p>Mpox virus (MPXV) has recently spread outside of sub-Saharan Africa. This large multicentre study was conducted in Lombardy, the most densely populated Italian region accounting for more than 40% of Italian cases. The present study aims to: i) evaluate the presence and the shedding duration of MPXV DNA in different body compartments correlating the MPXV viability with the time to onset of symptoms; ii) provide evidence of MPXV persistence in different body compartment as a source of infection and iii) characterize the MPXV evolution by whole genome sequencing (WGS) during the outbreak occurred in Italy.</p></div><div><h3>Material and methods</h3><p>The study included 353 patients with a laboratory-confirmed diagnosis of MPXV infection screened in several clinical specimens in the period May 24th - September 1st, 2022. Viral isolation was attempted from different biological matrices and complete genome sequencing was performed for 61 MPXV strains.</p></div><div><h3>Results</h3><p>MPXV DNA detection was more frequent in the skin (94.4%) with the longest median time of viral clearance (16 days). The actively-replicating virus in cell culture was obtained for 123/377 (32.6%) samples with a significant higher viral quantity on isolation positive samples (20 vs 31, p &lt; 0.001). The phylogenetic analysis highlighted the high genetic identity of the MPXV strains collected, both globally and within the Lombardy region.</p></div><div><h3>Conclusion</h3><p>Skin lesion is gold standard material and the high viral load and the actively-replicating virus observed in genital sites confirms that sexual contact plays a key role in the viral transmission.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"59 ","pages":"Article 102698"},"PeriodicalIF":12.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000127/pdfft?md5=7cf5e2d73167e755ec0b01a8ae144bde&pid=1-s2.0-S1477893924000127-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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