Travel Medicine and Infectious Disease最新文献

{"title":"Travellers’ adherence to atovaquone/proguanil malaria chemoprophylaxis after return from endemic areas","authors":"Jenny Lea Schnyder ,&nbsp;David Cornelis Birkhoff ,&nbsp;Myrthe Celine Jarings ,&nbsp;Sabine Margot Hermans ,&nbsp;Martin Peter Grobusch ,&nbsp;Hanna Katrien de Jong","doi":"10.1016/j.tmaid.2025.102812","DOIUrl":"10.1016/j.tmaid.2025.102812","url":null,"abstract":"<div><h3>Background</h3><div>According to current guidelines, atovaquone/proguanil (AP) malaria chemoprophylaxis is taken once daily during travel, and continued for seven days after return from malaria-endemic areas. However, pharmacokinetic data and studies on drug-sparing AP regimens suggest that AP could possibly be discontinued upon return without loss of protection. Besides being more cost-effective, shorter AP regimens may enhance adherence. We aimed to investigate adherence to the current AP chemoprophylaxis regimen during the seven days post-travel, and travellers’ preferences for potential drug-sparing AP regimens.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, adult travellers, who were prescribed AP chemoprophylaxis during a pre-travel consultation between 01-12-2022 and 01-12-2023 at the Amsterdam UMC travel clinic, were send a post-travel online questionnaire. The primary outcome was the proportion of travellers non-adherent to AP during the seven days post-travel, defined as missing one tablet or more. Secondary outcomes were non-adherence during travel, reasons for non-adherence, and AP regimen preferences.</div></div><div><h3>Results</h3><div>The questionnaire was completed by 62 % (382/614) of contacted travellers. Of the participants, 31 % (117/382) reported non-adherence during the seven days post-travel; during stay this was 16 % (58/382). Frequently reported reasons for non-adherence were: forgetfulness, low self-perceived malaria risk, and adverse effects. An alternative AP regimen discontinuing AP upon return was deemed most appealing and easy to adhere by 73 % (276/376) of participants.</div></div><div><h3>Conclusions</h3><div>Non-adherence was high during the seven days after return. Travellers preferred an alternative AP chemoprophylaxis regimen, allowing them to discontinue upon return. Future research shall be conducted to investigate whether AP could be discontinued upon return.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102812"},"PeriodicalIF":6.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leukemoid-like eosinophilia in a splenectomised traveler returning from Brazil","authors":"Anna Barbiero ,&nbsp;Laura Povolo ,&nbsp;Michele Spinicci ,&nbsp;Costanza Fiorelli ,&nbsp;Sara De Chiara ,&nbsp;Alessandro Bartoloni ,&nbsp;Lorenzo Zammarchi","doi":"10.1016/j.tmaid.2025.102809","DOIUrl":"10.1016/j.tmaid.2025.102809","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102809"},"PeriodicalIF":6.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The EP3622 clone of CD1a for diagnosing intestinal leishmaniasis in an acquired immunodeficiency syndrome patient in Colombia","authors":"Diego Andrés Rodríguez-Lugo ,&nbsp;Jorge Alfredo Morcillo Muñoz ,&nbsp;Javier Hernández Moreno ,&nbsp;Carolina Moreno Reyes ,&nbsp;Luz Helena Patiño ,&nbsp;David F. Martínez ,&nbsp;Juan Fernando Contreras-Valero ,&nbsp;Juan David Ramírez ,&nbsp;Álvaro A. Faccini-Martínez","doi":"10.1016/j.tmaid.2025.102808","DOIUrl":"10.1016/j.tmaid.2025.102808","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102808"},"PeriodicalIF":6.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenging therapeutic management of visceral leishmaniasis (L. Infantum) in a patient with thymoma: Case report with literature review","authors":"Serena Vita ,&nbsp;Tommaso Ascoli Bartoli ,&nbsp;Andrea Mariano ,&nbsp;Gaetano Maffongelli ,&nbsp;Laura Scorzolini ,&nbsp;Angela Corpolongo ,&nbsp;Maria Virginia Tomassi ,&nbsp;Silvia Rosati ,&nbsp;Francesca Faraglia ,&nbsp;Claudia Palazzolo ,&nbsp;Nazario Bevilacqua ,&nbsp;Maria Letizia Giancola ,&nbsp;Antonella Vulcano ,&nbsp;Lorenzo Zammarchi ,&nbsp;Alessandra D'Abramo ,&nbsp;Emanuele Nicastri","doi":"10.1016/j.tmaid.2025.102804","DOIUrl":"10.1016/j.tmaid.2025.102804","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102804"},"PeriodicalIF":6.3,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the epidemiology of Crimean-Congo hemorrhagic fever: Impact of travel and a One Health approach in the European region","authors":"Francesca F. Norman ,&nbsp;Octavio A. Arce ,&nbsp;Marta Díaz-Menéndez ,&nbsp;Moncef Belhassen-García ,&nbsp;Marta González-Sanz","doi":"10.1016/j.tmaid.2025.102806","DOIUrl":"10.1016/j.tmaid.2025.102806","url":null,"abstract":"<div><h3>Background</h3><div>The World Health Organization has identified Crimean-Congo hemorrhagic fever (CCHF) as a priority disease for research and development in emergency contexts. The epidemiology of CCHF is evolving and this review highlights travel-associated cases and focuses on the need for a One Health approach in Europe.</div></div><div><h3>Methods</h3><div>For this narrative review, two searches were performed in PubMed and Google Scholar for the period 1980–October 2024. The first search identified travel-associated CCHF cases globally, additional cases were identified in the ProMED mail database and through healthmap.org. The second search, with a focus on the European region, aimed to analyse reports of CCHF virus (CCHFV) detected in ticks, CCHF seroprevalence studies in animals and/or humans, and autochthonous CCHF cases.</div></div><div><h3>Results</h3><div>Seventeen cases of imported CCHF, the majority acquired in Africa, were identified. Importation to European countries accounted for eight of the cases. Most patients presented with fever and hemorrhagic manifestations and the estimated case fatality rate was 35 %. In the WHO European region, at least 13 countries have reported ticks infected with different genotypes of CCHFV; 17 countries were found to have animals/humans with positive CCHF serology. Finally, 16 countries in the WHO European region have notified human cases of CCHF. The Russian Federation, Turkey, and several former USSR countries are considered highly endemic, followed by the Balkanic region, with sporadic cases emerging in Bulgaria, Greece, Spain, and recently Portugal.</div></div><div><h3>Conclusions</h3><div>Travel-associated CCHF is infrequent. However, given the recently reported increased geographical distribution in ticks and animals in the European region, additional human cases may be anticipated in the near future. Europe receives over half of all international tourist arrivals annually, so healthcare professionals should be aware of risk factors and current protocols for the management of suspected and confirmed cases.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102806"},"PeriodicalIF":6.3,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for schistosomiasis in a non-endemic setting: Accuracy of a rapid antibody test using finger prick blood","authors":"Margherita Ortalli ,&nbsp;Bianca Granozzi ,&nbsp;Michele Bacchiega ,&nbsp;Concettina Di Lillo ,&nbsp;Greta Roncarati ,&nbsp;Silvia Stefania Longoni ,&nbsp;Cristina Mazzi ,&nbsp;Elisa Vanino ,&nbsp;Zeno Bisoffi ,&nbsp;Stefania Varani","doi":"10.1016/j.tmaid.2025.102807","DOIUrl":"10.1016/j.tmaid.2025.102807","url":null,"abstract":"<div><div>Human schistosomiasis is a chronic neglected tropical disease caused by blood flukes of the genus <em>Schistosoma,</em> infecting 250 million people worldwide, mostly in sub-Saharan Africa. Recently, thousands of cases have been reported in immigrants to non-endemic countries, including Italy. Serological screening is recommended but so far, no accurate point-of-care (POC) and lab-free test is available.</div><div>We carried out a prospective evaluation of the accuracy of a new immunochromatographic test (Black- ICT, IgG-IgM) using finger prick blood for screening of schistosomiasis at the University Hospital of Bologna. Eligible immigrants were recruited regardless the presence of symptoms. The other tests used were microscopy on stools and urine, a serum-ICT (SCHISTOSOMA ICT IgG-IgM, LDBIO Diagnostics), an ELISA (NovaLisa Schistosoma mansoni IgG, Novatec) and a Western Blot (SCHISTO II Western Blot IgG, LDBIO Diagnostics). Statistical analysis was performed using a Bayesian latent class model.</div><div>We enrolled 198 subjects in the study. Black-ICT had a sensitivity of 86.6 % (95 % credible interval 76.9–94.7) and a specificity of 88.4 % (82.0–94.3). At the estimated prevalence level for the study sample, 32.6 % (25.5–40.0), the positive and negative predictive values were 78.2 % (66.4–89.4) and 93.2 % (87.7–97.6), respectively. Good agreement was found with the other antibody tests, with the highest sensitivity being observed for serum-ICT (91.0 %, 84.7–96.4) and the highest specificity for ELISA (92.6 %, 87.5–96.7).</div><div>The novel POC test for schistosomiasis showed satisfactory results and could improve the detection of this parasitic infection in non-endemic settings, as the lab-free approach could greatly expand the target group.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102807"},"PeriodicalIF":6.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical care and initial health status of French children returnees from jihadist group operation areas: A cross-sectional study from 2017 to 2020 in one referral French hospital","authors":"J. Goutines ,&nbsp;L.L. Pham ,&nbsp;N. Lucidarme ,&nbsp;C. Briand ,&nbsp;A. Malka ,&nbsp;C. Baker ,&nbsp;M. Veyret-Morau ,&nbsp;A. Mapelli ,&nbsp;A. Klein ,&nbsp;T. Baubet ,&nbsp;L. De Pontual","doi":"10.1016/j.tmaid.2025.102805","DOIUrl":"10.1016/j.tmaid.2025.102805","url":null,"abstract":"<div><h3>Introduction</h3><div>The return of foreign fighters's children whose parents joined the so called « islamic state » in the Iraq-Syrian area, had been a very controversial topic. Since 2017, a national procedure in France has been designed to coordinate their care, including a systematic pediatric medical assessment.</div></div><div><h3>Methods</h3><div>The aim of this cross-sectional study was to assess the prevalence rate of diseases diagnosed at their arrival in France. Demographic characteristics and clinical assessment of all the children included in this procedure in one paediatric center between 2017 and 2020 were retrospectively collected.</div></div><div><h3>Findings</h3><div>We included 70 children (44M, 26F; mean age: 4.9 years old (±3.8)). In average, they crossed two countries, mainly Syria (n = 55), Turkey (n = 53) and Iraq (n = 18). At least one parent was deceased or incarcerated in respectively 25 (36 %) and 50 cases (71 %). Main pathologies were infectious diseases (n = 14, 20 %), including one lymph node tuberculosis. Mild nutritional impairment (n = 55, 78%–95 %), stunting (n = 13, 19%–95 %), psychomotor troubles (n = 18, 26 %) and psychological or behavior troubles (n = 36, 51 %) were also reported. Nutritional impairment was associated with a longer stay abroad (aOR 4.34, 95 % CI [1.21–18.24], p = 0.03) whereas no significant association was found between the other diseases and age, birth country or length of stay abroad.</div></div><div><h3>Conclusions</h3><div>Nutritional impairment and psychomotor or behaviour troubles were more frequent than other diseases in our cohort. These results emphasize the importance of considering the developmental aspects of these young children who experimented multiple potentially psychic traumatic events.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102805"},"PeriodicalIF":6.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarification of factors associated with post-artesunate delayed hemolysis (PADH): Analysis of 327 patients with severe imported Plasmodium falciparum malaria in France","authors":"Pierre-Louis Conan ,&nbsp;Marc Thellier ,&nbsp;Eric Kendjo ,&nbsp;Sandrine Houzé ,&nbsp;Rémonie Seng ,&nbsp;Stéphane Jauréguiberry","doi":"10.1016/j.tmaid.2025.102801","DOIUrl":"10.1016/j.tmaid.2025.102801","url":null,"abstract":"<div><h3>Background</h3><div>Post-Artesunate delayed hemolysis (PADH) occurs in approximately 15 % of treated patients 2–3 weeks after artesunate administration. Identifying risk markers for PADH would help predict which patients are at higher risk.</div></div><div><h3>Methods</h3><div>In this prospective national cohort study conducted in a non-malaria endemic area from 2011 to 2016, a Cox proportional hazards model was used to assess the association between clinical and biological data available at Day 0 and the occurrence of PADH within 30 days of artesunate administration.</div></div><div><h3>Results</h3><div>In the analyzed population (n = 327), 49 PADH events occurred after a median time of</div><div>14 days (IQR, 13–17) after artesunate initiation. Higher initial parasitemia was associated with an increased risk of PADH, with a significant interaction found with patient origin. The cumulative probability of PADH event at Day 30 post-artesunate was 65 % (95 % confidence interval [CI], 44–79) for European patients vs. 14 % (95 % CI, 0–26) for those with recent African ancestry [RAA] when the initial parasitemia was &gt;10 %. After adjustment for weight, history of malaria, initial hemoglobin, very severe malaria and residence in an endemic area, compared to recent African ancestry with initial parasitemia &lt;4 %, the adjusted hazard ratio for PADH occurrence was 18.8 (95 % CI, 4–89) for Europeans and 4.77 (95 % CI, 0.8–29.2) for recent African ancestry with initial parasitemia &gt;10 %.</div></div><div><h3>Conclusions</h3><div>This study showed that initial parasitemia and patient origin were the main predictors of developing PADH, with the highest risk observed in Europeans with an initial parasitemia &gt;10 %.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102801"},"PeriodicalIF":6.3,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of consular assistance provided to Irish citizens abroad, 2014–2023","authors":"Alan Alby ,&nbsp;Aoife Power ,&nbsp;Gerard T. Flaherty","doi":"10.1016/j.tmaid.2025.102803","DOIUrl":"10.1016/j.tmaid.2025.102803","url":null,"abstract":"<div><h3>Introduction</h3><div>There has been limited literature reporting the nature of the consular assistance provided to travellers. This study aimed to describe the consular assistance activity of the Irish Department of Foreign Affairs.</div></div><div><h3>Methods</h3><div>Publicly available consular assistance data (2014–2023) were analysed descriptively. Consular missions were listed under 16–19 categories.</div></div><div><h3>Results</h3><div>A total of 26,378 consular assistance missions were recorded. The greatest proportion of missions related to COVID-19 repatriations (26.9 %, n = 7097), deaths overseas (10 %, n = 2650), and medical illness/mental health emergency abroad (11.6 %, n = 3047). Forensic incidents (arrests/victims of crime) accounted for 12.9 % (n = 3392) of consular assistance episodes.</div></div><div><h3>Conclusion</h3><div>This study highlights the characteristics and trends of consular assistance requests received by a national governmental agency. Future studies should explore traveller awareness of consular procedures and the extent to which they are addressed in travel medicine consultations.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102803"},"PeriodicalIF":6.3,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effectiveness of dengue surveillance in the tropical and sub-tropical Asian nations through dengue case data from travelers returning to the five Western Pacific countries and territories","authors":"Jong-Hun Kim ,&nbsp;Ah-Young Lim ,&nbsp;Sung Hye Kim","doi":"10.1016/j.tmaid.2025.102802","DOIUrl":"10.1016/j.tmaid.2025.102802","url":null,"abstract":"<div><h3>Introduction</h3><div>Dengue, affecting over 3.9 billion people, is a significant health threat globally. Despite a tenfold increase in reported cases from 2000 to 2020, underreporting remains an issue. Our study utilized traveler data from the five Western Pacific countries and territories as sentinel sites, to examine dengue surveillance in Southeast and South Asia.</div></div><div><h3>Methods</h3><div>We reported dengue cases among returning travelers (2010–2018) and computed dengue incidence per 100,000 travelers for each destination country. We compared officially reported dengue incidence per 100,000 inhabitants of the destination country with estimated incidence per 100,000 travelers, using Pearson's correlation coefficient.</div></div><div><h3>Results</h3><div>Key findings revealed eight Southeast and South Asia countries as popular destinations for our sentinel sites, with Australia exhibiting the highest incidence (40.7 per 100,000 travelers). Dengue incidence variations were evident, with Malaysia showing a sharp increase over time. Correlation analysis showed strong links in Malaysia (<em>r</em> = 0.66–0.92) and weaker connections in India (<em>r</em> = −0.54–0.76) between dengue incidence among inhabitants and travelers.</div></div><div><h3>Conclusion</h3><div>Systematically collected dengue surveillance data from returning travelers can serve as a proxy for dengue incidence in the destination country and can be used to assess the robustness of the country's dengue surveillance.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102802"},"PeriodicalIF":6.3,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}