Travel Medicine and Infectious Disease最新文献

{"title":"Commemorating Carlos Chagas: A legacy of comprehensive disease discovery and public health advancement","authors":"Jaime David Acosta-España , Jenny Belén Altamirano-Jara , Hugo Monteiro Faver , Thiago Areas Lisboa Netto","doi":"10.1016/j.tmaid.2025.102816","DOIUrl":"10.1016/j.tmaid.2025.102816","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102816"},"PeriodicalIF":6.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rabies in humans: A treatment approach","authors":"Cornelis A. De Pijper ,&nbsp;Pieter P.A.M. van Thiel ,&nbsp;Diederik van de Beek ,&nbsp;Matthijs C. Brouwer ,&nbsp;Eleonora Aronica ,&nbsp;Nicole P. Juffermans ,&nbsp;Ron A.A. Mathôt ,&nbsp;Corine H. GeurtsvanKessel ,&nbsp;Janke Schinkel ,&nbsp;Menno D. de Jong ,&nbsp;Martin P. Grobusch ,&nbsp;Abraham Goorhuis","doi":"10.1016/j.tmaid.2025.102813","DOIUrl":"10.1016/j.tmaid.2025.102813","url":null,"abstract":"<div><h3>Background</h3><div>Only few rabies survivors have been described in the medical literature, of whom most suffered severe neurological sequelae. Published treatment protocols have not been applied successfully. Yet, experimental treatments may be of benefit when factors associated with survival are present. Here, we describe two patients who were hospitalised at Amsterdam UMC with clinical rabies and who died despite experimental treatments.</div></div><div><h3>Methods</h3><div>We describe the clinical course and medical decisions in the treatment of two rabies patients at our hospital and compared this approach with published data on the treatment of clinical rabies, depending on the presence or absence of prognostic factors associated with survival, and regarded this information in the context of clinical practice.</div></div><div><h3>Results</h3><div>The most important factor associated with survival - the presence of high antibody titres in serum or cerebrospinal fluid (CSF) at the time of diagnosis - was not present in either of the two cases at our hospital. In addition to supportive treatment, both of our patients were treated unsuccesfully with a novel treatment approach with intrathecal and intravenous monoclonal rabies antibodies, which barely increased serum and CSF antibody levels.</div></div><div><h3>Conclusions</h3><div>Higher-dosed treatments with monoclonal antibodies in serum may be needed to yield an effect. Any experimental treatment may be most promising in patients who have other factors associated with survival. In the absence of these, initiation of palliative care still seems to remain the most rational strategy.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102813"},"PeriodicalIF":6.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of imported Plasmodium malariae infection after treated Plasmodium falciparum malaria: Possible explanations and a review of the literature","authors":"R. Paggi ,&nbsp;A. Lanari ,&nbsp;C. Malcontenti ,&nbsp;D. Boccolini ,&nbsp;A. Aiello ,&nbsp;M. L'Episcopia ,&nbsp;C. Severini ,&nbsp;C. Nencioni ,&nbsp;M. Lapini ,&nbsp;G.M. Rossolini ,&nbsp;J. Richter ,&nbsp;A. Bartoloni ,&nbsp;L. Zammarchi","doi":"10.1016/j.tmaid.2025.102810","DOIUrl":"10.1016/j.tmaid.2025.102810","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102810"},"PeriodicalIF":6.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crimean-Congo haemorrhagic fever virus screening among African individuals in Spain: Lessons to learn","authors":"Helena Miriam Lorenzo Juanes ,&nbsp;Amparo López-Bernus ,&nbsp;Belen Vicente ,&nbsp;Montserrat Alonso-Sardón ,&nbsp;Beatriz Rodríguez Alonso ,&nbsp;Josue Pendones Ulerio ,&nbsp;Pedro Fernandez Soto ,&nbsp;Juan Luis Muñoz Bellido ,&nbsp;Antonio Muro ,&nbsp;Moncef Belhassen-García","doi":"10.1016/j.tmaid.2025.102814","DOIUrl":"10.1016/j.tmaid.2025.102814","url":null,"abstract":"<div><h3>Background</h3><div>Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne viral disease. CCHF is an emerging infectious disease given the expanding distribution of its main vector. This study aimed to evaluate the importance of CCHFV infection in migrants from Africa who attended a tertiary health care centre in Spain.</div></div><div><h3>Methodology</h3><div>A seroepidemiological study was conducted among African patients referred to the University Hospital of Salamanca, Spain. Patients were retrospectively recruited from 2005 to 2023.</div></div><div><h3>Principal findings</h3><div>We screened 485 serum samples, with a mean (±SD) age of 17 years (±9.9). Among these individuals, 18 were IgG positive and 9 were IgM positive, resulting in an IgG seroprevalence against CCHFV of 3.71 % and an IgM seroprevalence of 1.85 %. Most IgG-positive samples were collected in 2010 (14/316), representing a seroprevalence of 4.43 %. Forty-seven percent of the immigrant participants were from Equatorial Guinea; thus, the IgG seroprevalence among the Equatorial Guinean immigrant population (13/228) was 5.70 %. All patients were negative according to RT‒PCR.</div></div><div><h3>Conclusions</h3><div>This is the first serosurvey conducted in Spain to suggest possible active circulation of the virus in Africans. Our results suggest the need for more extensive clinical and epidemiological studies in Africans to determine the epidemiology and transmission of CCHFV in Spain and to evaluate the relevance of control measures for clinical interventions in situations with a potential risk of transmission. Although the risk is considered very low in these collectives, clinicians should be alert to the possibility of new CCHF cases, given the high pathogenicity of CCHFV and the risk of transmission.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102814"},"PeriodicalIF":6.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences between Influenza H5N1, A/H1N1 2009, and SARS-CoV-2 in a pandemic risk scenario","authors":"Pablo I. Plaza,&nbsp;Sergio A. Lambertucci","doi":"10.1016/j.tmaid.2025.102811","DOIUrl":"10.1016/j.tmaid.2025.102811","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102811"},"PeriodicalIF":6.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Travellers’ adherence to atovaquone/proguanil malaria chemoprophylaxis after return from endemic areas","authors":"Jenny Lea Schnyder ,&nbsp;David Cornelis Birkhoff ,&nbsp;Myrthe Celine Jarings ,&nbsp;Sabine Margot Hermans ,&nbsp;Martin Peter Grobusch ,&nbsp;Hanna Katrien de Jong","doi":"10.1016/j.tmaid.2025.102812","DOIUrl":"10.1016/j.tmaid.2025.102812","url":null,"abstract":"<div><h3>Background</h3><div>According to current guidelines, atovaquone/proguanil (AP) malaria chemoprophylaxis is taken once daily during travel, and continued for seven days after return from malaria-endemic areas. However, pharmacokinetic data and studies on drug-sparing AP regimens suggest that AP could possibly be discontinued upon return without loss of protection. Besides being more cost-effective, shorter AP regimens may enhance adherence. We aimed to investigate adherence to the current AP chemoprophylaxis regimen during the seven days post-travel, and travellers’ preferences for potential drug-sparing AP regimens.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, adult travellers, who were prescribed AP chemoprophylaxis during a pre-travel consultation between 01-12-2022 and 01-12-2023 at the Amsterdam UMC travel clinic, were send a post-travel online questionnaire. The primary outcome was the proportion of travellers non-adherent to AP during the seven days post-travel, defined as missing one tablet or more. Secondary outcomes were non-adherence during travel, reasons for non-adherence, and AP regimen preferences.</div></div><div><h3>Results</h3><div>The questionnaire was completed by 62 % (382/614) of contacted travellers. Of the participants, 31 % (117/382) reported non-adherence during the seven days post-travel; during stay this was 16 % (58/382). Frequently reported reasons for non-adherence were: forgetfulness, low self-perceived malaria risk, and adverse effects. An alternative AP regimen discontinuing AP upon return was deemed most appealing and easy to adhere by 73 % (276/376) of participants.</div></div><div><h3>Conclusions</h3><div>Non-adherence was high during the seven days after return. Travellers preferred an alternative AP chemoprophylaxis regimen, allowing them to discontinue upon return. Future research shall be conducted to investigate whether AP could be discontinued upon return.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102812"},"PeriodicalIF":6.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leukemoid-like eosinophilia in a splenectomised traveler returning from Brazil","authors":"Anna Barbiero ,&nbsp;Laura Povolo ,&nbsp;Michele Spinicci ,&nbsp;Costanza Fiorelli ,&nbsp;Sara De Chiara ,&nbsp;Alessandro Bartoloni ,&nbsp;Lorenzo Zammarchi","doi":"10.1016/j.tmaid.2025.102809","DOIUrl":"10.1016/j.tmaid.2025.102809","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102809"},"PeriodicalIF":6.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The EP3622 clone of CD1a for diagnosing intestinal leishmaniasis in an acquired immunodeficiency syndrome patient in Colombia","authors":"Diego Andrés Rodríguez-Lugo ,&nbsp;Jorge Alfredo Morcillo Muñoz ,&nbsp;Javier Hernández Moreno ,&nbsp;Carolina Moreno Reyes ,&nbsp;Luz Helena Patiño ,&nbsp;David F. Martínez ,&nbsp;Juan Fernando Contreras-Valero ,&nbsp;Juan David Ramírez ,&nbsp;Álvaro A. Faccini-Martínez","doi":"10.1016/j.tmaid.2025.102808","DOIUrl":"10.1016/j.tmaid.2025.102808","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102808"},"PeriodicalIF":6.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenging therapeutic management of visceral leishmaniasis (L. Infantum) in a patient with thymoma: Case report with literature review","authors":"Serena Vita ,&nbsp;Tommaso Ascoli Bartoli ,&nbsp;Andrea Mariano ,&nbsp;Gaetano Maffongelli ,&nbsp;Laura Scorzolini ,&nbsp;Angela Corpolongo ,&nbsp;Maria Virginia Tomassi ,&nbsp;Silvia Rosati ,&nbsp;Francesca Faraglia ,&nbsp;Claudia Palazzolo ,&nbsp;Nazario Bevilacqua ,&nbsp;Maria Letizia Giancola ,&nbsp;Antonella Vulcano ,&nbsp;Lorenzo Zammarchi ,&nbsp;Alessandra D'Abramo ,&nbsp;Emanuele Nicastri","doi":"10.1016/j.tmaid.2025.102804","DOIUrl":"10.1016/j.tmaid.2025.102804","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102804"},"PeriodicalIF":6.3,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the epidemiology of Crimean-Congo hemorrhagic fever: Impact of travel and a One Health approach in the European region","authors":"Francesca F. Norman ,&nbsp;Octavio A. Arce ,&nbsp;Marta Díaz-Menéndez ,&nbsp;Moncef Belhassen-García ,&nbsp;Marta González-Sanz","doi":"10.1016/j.tmaid.2025.102806","DOIUrl":"10.1016/j.tmaid.2025.102806","url":null,"abstract":"<div><h3>Background</h3><div>The World Health Organization has identified Crimean-Congo hemorrhagic fever (CCHF) as a priority disease for research and development in emergency contexts. The epidemiology of CCHF is evolving and this review highlights travel-associated cases and focuses on the need for a One Health approach in Europe.</div></div><div><h3>Methods</h3><div>For this narrative review, two searches were performed in PubMed and Google Scholar for the period 1980–October 2024. The first search identified travel-associated CCHF cases globally, additional cases were identified in the ProMED mail database and through healthmap.org. The second search, with a focus on the European region, aimed to analyse reports of CCHF virus (CCHFV) detected in ticks, CCHF seroprevalence studies in animals and/or humans, and autochthonous CCHF cases.</div></div><div><h3>Results</h3><div>Seventeen cases of imported CCHF, the majority acquired in Africa, were identified. Importation to European countries accounted for eight of the cases. Most patients presented with fever and hemorrhagic manifestations and the estimated case fatality rate was 35 %. In the WHO European region, at least 13 countries have reported ticks infected with different genotypes of CCHFV; 17 countries were found to have animals/humans with positive CCHF serology. Finally, 16 countries in the WHO European region have notified human cases of CCHF. The Russian Federation, Turkey, and several former USSR countries are considered highly endemic, followed by the Balkanic region, with sporadic cases emerging in Bulgaria, Greece, Spain, and recently Portugal.</div></div><div><h3>Conclusions</h3><div>Travel-associated CCHF is infrequent. However, given the recently reported increased geographical distribution in ticks and animals in the European region, additional human cases may be anticipated in the near future. Europe receives over half of all international tourist arrivals annually, so healthcare professionals should be aware of risk factors and current protocols for the management of suspected and confirmed cases.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102806"},"PeriodicalIF":6.3,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}