Travel Medicine and Infectious Disease最新文献

{"title":"Transcriptomic analysis of chronic chikungunya in the Reunionese CHIKGene cohort uncovers a shift in gene expression more than 10 years after infection","authors":"Patrick Gérardin ,&nbsp;Raissa Medina-Santos ,&nbsp;Sigrid Le Clerc ,&nbsp;Léa Bruneau ,&nbsp;Adrien Maillot ,&nbsp;Taoufik Labib ,&nbsp;Myriam Rahmouni ,&nbsp;Jean-Louis Spadoni ,&nbsp;Jean-Philippe Meyniel ,&nbsp;Clémence Cornet ,&nbsp;Cécile Lefebvre ,&nbsp;Nora El Jahrani ,&nbsp;Jakub Savara ,&nbsp;Mano Joseph Mathew ,&nbsp;Christine Fontaine ,&nbsp;Christine Payet ,&nbsp;Nathalie Ah-You ,&nbsp;Cécile Chabert ,&nbsp;Corinne Mussard ,&nbsp;Sylvaine Porcherat ,&nbsp;Jean-François Zagury","doi":"10.1016/j.tmaid.2025.102825","DOIUrl":"10.1016/j.tmaid.2025.102825","url":null,"abstract":"<div><h3>Aim</h3><div>In 2005–2006, a chikungunya epidemic of unprecedented magnitude hit Reunion Island, which raised a public health concern through the substantial proportions of long-lasting manifestations. To understand the pathophysiology underlying chronic chikungunya (CC), we designed the CHIKGene cohort study and collected blood samples from 133 subjects diagnosed with CC and from 86 control individuals that had recovered within 3 months, 12-to-15 years after exposure.</div></div><div><h3>Methods</h3><div>We conducted bulk RNAseq analysis on peripheral blood mononuclear cells to find differentially expressed genes (DEGs), gene set enrichment analysis (GSEA) and gene ontologies to uncover top-level enriched terms associated with DEGs, and weighted gene correlation network analysis (WGCNA) to elucidate underlying cellular processes.</div></div><div><h3>Results</h3><div>Among 1549 DEGs, gene expression analysis identified 10 top genes including <em>NR4A2</em> and <em>TRIM58</em> (upregulated in CC), <em>IGHG3</em> and <em>IGHV3-49</em> (downregulated in CC) linked to immune regulation, <em>OSBP2</em> (upregulated in CC) and <em>SEMA6B</em> (downregulated in CC) linked to neuronal homeostasis and axon guidance, respectively. GSEA and WGCNA unveiled cellular processes such as \"Metabolism of RNA\" and \"Cell Cycle”.</div></div><div><h3>Conclusions</h3><div>This study uncovers a shift in gene expression of CC subjects. <em>IGHG3</em> and <em>IGHV3-49</em> gene shut-offs spotlight the importance of neutralizing antibodies against chikungunya virus in the progression to chronic disease. Human diseases associations highlight connections to rheumatoid arthritis, nervous and cardiac systems. GSEA and WGCNA bounce the hypotheses of a persistent viral reservoir or an increased susceptibility to RNA viral pathogens with new onset infections. Together, our findings might offer potential targets for therapeutic options aimed at alleviating chronic chikungunya.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"65 ","pages":"Article 102825"},"PeriodicalIF":6.3,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malaria in Turkey: A comprehensive analysis of diagnosis, treatment, and the impact of COVID-19, ten years after malaria elimination (2012–2023)","authors":"Özgün Ekin Şahin ,&nbsp;Zeynepgül Kalay ,&nbsp;Nagehan Didem Sarı ,&nbsp;Ayşe Batırel ,&nbsp;Gülden Ersöz ,&nbsp;Günay Tuncer Ertem ,&nbsp;Tuba Turunç ,&nbsp;Ramazan Gözüküçük ,&nbsp;Funda Şimşek Çelener ,&nbsp;Arzu Kantürk ,&nbsp;Kaya Süer ,&nbsp;Şafak Özer Balın ,&nbsp;Ayşe Sağmak Tartar ,&nbsp;Güven Çelebi ,&nbsp;Hülya Kuşoğlu ,&nbsp;Selma Ateş ,&nbsp;Sevil Alkan ,&nbsp;Duru Mıstanoğlu Özatağ ,&nbsp;Hande Berk ,&nbsp;Cengiz Uzun ,&nbsp;Önder Ergönül","doi":"10.1016/j.tmaid.2025.102819","DOIUrl":"10.1016/j.tmaid.2025.102819","url":null,"abstract":"<div><h3>Background</h3><div>The characteristics, diagnosis, and treatment stages of malaria in Turkey in the last ten years are not known except few case reports. We aimed to describe the details of the diagnosis and treatment practices of malaria cases in various hospitals across Turkey between 2012 and 2023 after the declaration of the elimination of malaria.</div></div><div><h3>Methods</h3><div>We collected the patient data from 30 centers by using Qualtrics Survey Software. The patients were categorized according to the WHO Malaria Severe Disease Symptoms guidelines.</div></div><div><h3>Results</h3><div>We detected 299 malaria cases. Of these patients, 23.7 % experienced misdiagnosis, with 77.5 % of misdiagnosed cases receiving antibiotics. Among the patients, 9 (3 %) had no travel history. Additionally, 28 (9.4 %) patients required admission to the intensive care unit (ICU) during hospitalization. There is a significant association between misdiagnosis and subsequent ICU admissions. Additionally, the duration between malaria diagnosis and the initiation of treatment significantly affected ICU admissions. Furthermore, the number of cases with severe malaria (according to WHO criteria) and ICU admissions increased after the COVID-19 period. In multivariate analysis, initial misdiagnosis was found to be associated with ICU admission (OR: 2.8, p &lt; 0.05), while each day's treatment delays post-diagnosis increased ICU admissions (OR: 1.26, p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Misdiagnosis is common which delays the treatment and is correlated with higher admissions to ICUs. Post-COVID-19, there was a notable increase in both ICU admissions and cases of severe malaria, suggesting an escalation in disease severity that warrants further investigation. The resurgence of rare malaria cases with no travel history to abroad highlights the necessity of continued vigilance for new malaria cases. Efforts to promptly treat upon diagnosis and improve diagnostic accuracy in Turkey, where malaria is uncommon, are crucial. Enhancing diagnostic methods and treatment strategies remains essential, especially in significant events like COVID-19.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102819"},"PeriodicalIF":6.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Landscape of guidance documents used at TropNet and GeoSentinel centres for the clinical management of schistosomiasis outside endemic areas: A systematic appraisal","authors":"Francesca Tamarozzi ,&nbsp;Cristina Mazzi ,&nbsp;Spinello Antinori ,&nbsp;Marta Arsuaga ,&nbsp;Sören L. Becker ,&nbsp;Cristina Bocanegra ,&nbsp;Emmanuel Bottieau ,&nbsp;Dora Buonfrate ,&nbsp;Amaya L. Bustinduy ,&nbsp;Daniel Camprubí-Ferrer ,&nbsp;Eric Caumes ,&nbsp;Alexandre Duvignaud ,&nbsp;Martin P. Grobusch ,&nbsp;Ralph Huits ,&nbsp;Stephane Jaureguiberry ,&nbsp;Sabine Jordan ,&nbsp;Andreas Mueller ,&nbsp;Momar Ndao ,&nbsp;Andreas Neumayr ,&nbsp;Jose A. Perez-Molina ,&nbsp;Federico G. Gobbi","doi":"10.1016/j.tmaid.2025.102822","DOIUrl":"10.1016/j.tmaid.2025.102822","url":null,"abstract":"<div><h3>Background</h3><div>The diagnostic and treatment approaches for schistosomiasis in individual patients, outside endemic areas, are not standardised. This study aimed to appraise the reference documents that the experts from the TropNet and GeoSentinel networks use in practice as guidance for the clinical management of their patients with (suspect) schistosomiasis.</div></div><div><h3>Methods</h3><div>We systematically appraised the following data from the referenced guidance documents: i) document type, ii) case definitions, iii) diagnostic techniques envisaged; iv) treatment recommendations; v) follow-up recommendations; vi) screening recommendations, and vii) symptom-based diagnostic suspicion.</div></div><div><h3>Results</h3><div>Twenty-two of the 30 responders (73.3 %) indicated 19 reference documents, three of which were WHO material not intended for individual clinical management. Only 4/19 (21.1 %) documents were national recommendations; no international guideline was indicated. Case definitions were explicitly presented in only one document (1/19; 5.3 %). Diagnostic tools were detailed in 11/16 (68.8 %) and follow-up guidance in 8/16 (50 %) documents. Treatment guidance was provided in 14/16 (87.5 %) documents.</div></div><div><h3>Conclusions</h3><div>Heterogeneity in clinical guidance was evident, although with noticeable overlap at least for chronic schistosomiasis. This confirms the need to formalise case definitions, which should be used to design trials to rigorously assess diagnostic tools and treatment schemes, and eventually come to harmonization of clinical management guidance.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102822"},"PeriodicalIF":6.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143465497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical evaluation of the RBD-Trimeric vaccine: A novel approach to strengthening biotechnological sovereignty in developing countries against SARS-CoV-2 variants","authors":"Luis Flórez ,&nbsp;Daniel Echeverri-De la Hoz ,&nbsp;Alfonso Calderón ,&nbsp;Hector Serrano-Coll ,&nbsp;Caty Martinez ,&nbsp;Camilo Guzmán ,&nbsp;Bertha Gastelbondo ,&nbsp;German Arrieta ,&nbsp;Ariel Arteta ,&nbsp;Tania Márquez ,&nbsp;Ricardo Rivero ,&nbsp;Salim Máttar","doi":"10.1016/j.tmaid.2025.102820","DOIUrl":"10.1016/j.tmaid.2025.102820","url":null,"abstract":"<div><div>New immunogens against emerging new virus variants are essential for controlling new variants.</div></div><div><h3>Methods</h3><div>A preclinical study in which a receptor-binding domain (RBD) trimer was designed in silico with information from the Beta (B.1.351), Omicron (BA.5), and Wuhan 1 variant. A three-dimensional model of the RBD-trimer was made, and the synthesis of the trimer was based on the RBD domain of the S protein of Beta and Omicron. For the experimental trials, 63 BALB/c mice were immunized and divided into three groups: control (n = 15), adjuvant (n = 15), and RBD-trimer (n = 33).</div></div><div><h3>Results</h3><div>81 % (13/16), 90 % (9/10), and 85 % (6/7) of BALB/c mice that received one dose, two doses, and three doses, respectively, seroconverted. Significant statistical differences (p &lt; 0.001) were found between the experimental group vaccinated with the RBD-trimer, the group with adjuvant, and the control group. The booster did not show significant differences (p &gt; 0.05. No inflammatory or cellular changes were observed, highlighting the safety of the RBD vaccine candidate. Kinetics and seroconversion of 75 % were obtained in the mice with two doses of tri-RBD. (P &lt; 0.0001).</div></div><div><h3>Conclusions</h3><div>Applying two doses of the RBD vaccine candidate in BALB/c mice was safe and immunogenic against SARS-CoV-2. This study provides support for the country's biotechnological sovereignty and its potential contribution to public health in Colombia.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102820"},"PeriodicalIF":6.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The next arbovirus epidemic in Latin America and beyond: A question of when, not if – Mayaro, Oropouche, Usutu or Disease X?","authors":"Salim Mattar ,&nbsp;Yesica López ,&nbsp;German Arrieta ,&nbsp;Ameth Salim Mattar ,&nbsp;Antonio Carlos Bandeira ,&nbsp;Alberto Paniz-Mondolfi ,&nbsp;Jan Felix Drexler ,&nbsp;Alfonso J. Rodriguez-Morales","doi":"10.1016/j.tmaid.2025.102818","DOIUrl":"10.1016/j.tmaid.2025.102818","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102818"},"PeriodicalIF":6.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commemorating Carlos Chagas: A legacy of comprehensive disease discovery and public health advancement","authors":"Jaime David Acosta-España ,&nbsp;Jenny Belén Altamirano-Jara ,&nbsp;Hugo Monteiro Faver ,&nbsp;Thiago Areas Lisboa Netto","doi":"10.1016/j.tmaid.2025.102816","DOIUrl":"10.1016/j.tmaid.2025.102816","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102816"},"PeriodicalIF":6.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rabies in humans: A treatment approach","authors":"Cornelis A. De Pijper ,&nbsp;Pieter P.A.M. van Thiel ,&nbsp;Diederik van de Beek ,&nbsp;Matthijs C. Brouwer ,&nbsp;Eleonora Aronica ,&nbsp;Nicole P. Juffermans ,&nbsp;Ron A.A. Mathôt ,&nbsp;Corine H. GeurtsvanKessel ,&nbsp;Janke Schinkel ,&nbsp;Menno D. de Jong ,&nbsp;Martin P. Grobusch ,&nbsp;Abraham Goorhuis","doi":"10.1016/j.tmaid.2025.102813","DOIUrl":"10.1016/j.tmaid.2025.102813","url":null,"abstract":"<div><h3>Background</h3><div>Only few rabies survivors have been described in the medical literature, of whom most suffered severe neurological sequelae. Published treatment protocols have not been applied successfully. Yet, experimental treatments may be of benefit when factors associated with survival are present. Here, we describe two patients who were hospitalised at Amsterdam UMC with clinical rabies and who died despite experimental treatments.</div></div><div><h3>Methods</h3><div>We describe the clinical course and medical decisions in the treatment of two rabies patients at our hospital and compared this approach with published data on the treatment of clinical rabies, depending on the presence or absence of prognostic factors associated with survival, and regarded this information in the context of clinical practice.</div></div><div><h3>Results</h3><div>The most important factor associated with survival - the presence of high antibody titres in serum or cerebrospinal fluid (CSF) at the time of diagnosis - was not present in either of the two cases at our hospital. In addition to supportive treatment, both of our patients were treated unsuccesfully with a novel treatment approach with intrathecal and intravenous monoclonal rabies antibodies, which barely increased serum and CSF antibody levels.</div></div><div><h3>Conclusions</h3><div>Higher-dosed treatments with monoclonal antibodies in serum may be needed to yield an effect. Any experimental treatment may be most promising in patients who have other factors associated with survival. In the absence of these, initiation of palliative care still seems to remain the most rational strategy.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102813"},"PeriodicalIF":6.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of imported Plasmodium malariae infection after treated Plasmodium falciparum malaria: Possible explanations and a review of the literature","authors":"R. Paggi ,&nbsp;A. Lanari ,&nbsp;C. Malcontenti ,&nbsp;D. Boccolini ,&nbsp;A. Aiello ,&nbsp;M. L'Episcopia ,&nbsp;C. Severini ,&nbsp;C. Nencioni ,&nbsp;M. Lapini ,&nbsp;G.M. Rossolini ,&nbsp;J. Richter ,&nbsp;A. Bartoloni ,&nbsp;L. Zammarchi","doi":"10.1016/j.tmaid.2025.102810","DOIUrl":"10.1016/j.tmaid.2025.102810","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102810"},"PeriodicalIF":6.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crimean-Congo haemorrhagic fever virus screening among African individuals in Spain: Lessons to learn","authors":"Helena Miriam Lorenzo Juanes ,&nbsp;Amparo López-Bernus ,&nbsp;Belen Vicente ,&nbsp;Montserrat Alonso-Sardón ,&nbsp;Beatriz Rodríguez Alonso ,&nbsp;Josue Pendones Ulerio ,&nbsp;Pedro Fernandez Soto ,&nbsp;Juan Luis Muñoz Bellido ,&nbsp;Antonio Muro ,&nbsp;Moncef Belhassen-García","doi":"10.1016/j.tmaid.2025.102814","DOIUrl":"10.1016/j.tmaid.2025.102814","url":null,"abstract":"<div><h3>Background</h3><div>Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne viral disease. CCHF is an emerging infectious disease given the expanding distribution of its main vector. This study aimed to evaluate the importance of CCHFV infection in migrants from Africa who attended a tertiary health care centre in Spain.</div></div><div><h3>Methodology</h3><div>A seroepidemiological study was conducted among African patients referred to the University Hospital of Salamanca, Spain. Patients were retrospectively recruited from 2005 to 2023.</div></div><div><h3>Principal findings</h3><div>We screened 485 serum samples, with a mean (±SD) age of 17 years (±9.9). Among these individuals, 18 were IgG positive and 9 were IgM positive, resulting in an IgG seroprevalence against CCHFV of 3.71 % and an IgM seroprevalence of 1.85 %. Most IgG-positive samples were collected in 2010 (14/316), representing a seroprevalence of 4.43 %. Forty-seven percent of the immigrant participants were from Equatorial Guinea; thus, the IgG seroprevalence among the Equatorial Guinean immigrant population (13/228) was 5.70 %. All patients were negative according to RT‒PCR.</div></div><div><h3>Conclusions</h3><div>This is the first serosurvey conducted in Spain to suggest possible active circulation of the virus in Africans. Our results suggest the need for more extensive clinical and epidemiological studies in Africans to determine the epidemiology and transmission of CCHFV in Spain and to evaluate the relevance of control measures for clinical interventions in situations with a potential risk of transmission. Although the risk is considered very low in these collectives, clinicians should be alert to the possibility of new CCHF cases, given the high pathogenicity of CCHFV and the risk of transmission.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102814"},"PeriodicalIF":6.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences between Influenza H5N1, A/H1N1 2009, and SARS-CoV-2 in a pandemic risk scenario","authors":"Pablo I. Plaza,&nbsp;Sergio A. Lambertucci","doi":"10.1016/j.tmaid.2025.102811","DOIUrl":"10.1016/j.tmaid.2025.102811","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102811"},"PeriodicalIF":6.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}