发布求助
文献互助 智能选刊 最新文献

Trends in Microbiology最新文献

筛选
英文 中文
Balancing act: counteracting adverse drug effects on the microbiome. 平衡之术：抵消药物对微生物群的不良影响。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-11 DOI: 10.1016/j.tim.2024.09.011
Jacobo de la Cuesta-Zuluaga, Patrick Müller, Lisa Maier
{"title":"Balancing act: counteracting adverse drug effects on the microbiome.","authors":"Jacobo de la Cuesta-Zuluaga, Patrick Müller, Lisa Maier","doi":"10.1016/j.tim.2024.09.011","DOIUrl":"https://doi.org/10.1016/j.tim.2024.09.011","url":null,"abstract":"<p><p>The human gut microbiome, a community of microbes that plays a crucial role in our wellbeing, is highly adaptable but also vulnerable to drug treatments. This vulnerability can have serious consequences for the host, for example, increasing susceptibility to infections, immune, metabolic, and cognitive disorders. However, the microbiome's adaptability also provides opportunities to prevent, protect, or even reverse drug-induced damage. Recently, several innovative approaches have emerged aimed at minimizing the collateral damage of drugs on the microbiome. Here, we outline these approaches, discuss their applicability in different treatment scenarios, highlight current challenges, and suggest avenues that may lead to an effective protection of the microbiome.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Loading and unloading plasmid cargoes. 装载和卸载质粒货物。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-10 DOI: 10.1016/j.tim.2024.09.012
James P J Hall
{"title":"Loading and unloading plasmid cargoes.","authors":"James P J Hall","doi":"10.1016/j.tim.2024.09.012","DOIUrl":"https://doi.org/10.1016/j.tim.2024.09.012","url":null,"abstract":"<p><p>Plasmids are vehicles for horizontal gene transfer between cells, but they also exchange genes with associated chromosomes in a process termed 'intracellular mobility'. I discuss a recent article by Kadibalban et al. mapping such plasmid-chromosomal sequence similarities across diverse bacteria.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diverse molecular mechanisms underpinning Staphylococcus aureus small colony variants. 金黄色葡萄球菌小菌落变异的多种分子机制。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-10 DOI: 10.1016/j.tim.2024.09.007
Maryam Mapar, Thomas Rydzak, Josefien W Hommes, Bas G J Surewaard, Ian A Lewis
{"title":"Diverse molecular mechanisms underpinning Staphylococcus aureus small colony variants.","authors":"Maryam Mapar, Thomas Rydzak, Josefien W Hommes, Bas G J Surewaard, Ian A Lewis","doi":"10.1016/j.tim.2024.09.007","DOIUrl":"https://doi.org/10.1016/j.tim.2024.09.007","url":null,"abstract":"<p><p>Small colony variants (SCVs) of Staphylococcus aureus are a relatively rare but clinically significant growth morphotype. Infections with SCVs are frequently difficult to treat, inherently antibiotic-resistant, and can lead to persistent infections. Despite a long history of research, the molecular underpinnings of this morphotype and their impact on the clinical trajectory of infections remain unclear. However, a growing body of literature indicates that SCVs are caused by a diverse range of molecular factors. These recent findings suggest that SCVs should be thought of as an ensemble collection of loosely related phenotypes, and not as a single phenomenon. This review describes the diverse mechanisms currently known to contribute to SCVs and proposes an ensemble model for conceptualizing this morphotype.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Azotobacter vinelandii. 醋兰氮杆菌
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI: 10.1016/j.tim.2024.07.006
Brett M Barney
{"title":"Azotobacter vinelandii.","authors":"Brett M Barney","doi":"10.1016/j.tim.2024.07.006","DOIUrl":"10.1016/j.tim.2024.07.006","url":null,"abstract":"","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"1034-1035"},"PeriodicalIF":14.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From carrion to soil: microbial recycling of animal carcasses. 从腐肉到土壤：动物尸体的微生物循环。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-01 DOI: 10.1016/j.tim.2024.09.003
Jennifer M DeBruyn, Sarah W Keenan, Lois S Taylor
{"title":"From carrion to soil: microbial recycling of animal carcasses.","authors":"Jennifer M DeBruyn, Sarah W Keenan, Lois S Taylor","doi":"10.1016/j.tim.2024.09.003","DOIUrl":"https://doi.org/10.1016/j.tim.2024.09.003","url":null,"abstract":"<p><p>Decomposer microbial communities are gatekeepers in the redistribution of carbon and nutrients from dead animals (carrion) to terrestrial ecosystems. The flush of decomposition products from a carcass creates a hot spot of microbial activity in the soil below, and the animal's microbiome is released into the environment, mixing with soil communities. Changes in soil physicochemistry, especially reduced oxygen, temporarily constrain microbial nutrient cycling, and influence the timing of these processes and the fate of carrion resources. Carcass-related factors, such as mass, tissue composition, or even microbiome composition may also influence the functional assembly and succession of decomposer communities. Understanding these local scale microbially mediated processes is important for predicting consequences of carrion decomposition beyond the hot spot and hot moment.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring emerging drug responses in Cryptococcus. 探索隐球菌中新出现的药物反应。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-01 Epub Date: 2024-07-19 DOI: 10.1016/j.tim.2024.07.002
Wei Liu, Yiru Gao, Chen Ding
{"title":"Exploring emerging drug responses in Cryptococcus.","authors":"Wei Liu, Yiru Gao, Chen Ding","doi":"10.1016/j.tim.2024.07.002","DOIUrl":"10.1016/j.tim.2024.07.002","url":null,"abstract":"<p><p>Cryptococcosis imposes a considerable burden on public health, and emerging drug responses to anticryptococcal drugs remain to be addressed. In this forum article we discuss the emerging drug responses of Cryptococcus, focusing on the critical nature of understanding such responses in order to improve the effectiveness of anticryptococcal therapeutics.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"940-943"},"PeriodicalIF":14.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small intestinal microbiota: from taxonomic composition to metabolism. 小肠微生物群：从分类组成到新陈代谢。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-01 Epub Date: 2024-03-19 DOI: 10.1016/j.tim.2024.02.013
Simon Yersin, Pascale Vonaesch
{"title":"Small intestinal microbiota: from taxonomic composition to metabolism.","authors":"Simon Yersin, Pascale Vonaesch","doi":"10.1016/j.tim.2024.02.013","DOIUrl":"10.1016/j.tim.2024.02.013","url":null,"abstract":"<p><p>The small intestinal microbiota (SIM) is essential for gastrointestinal health, influencing digestion, immune modulation, and nutrient metabolism. Unlike the colonic microbiota, the SIM has been poorly characterized due to sampling challenges and ethical considerations. Current evidence suggests that the SIM consists of five core genera and additional segment-specific taxa. These bacteria closely interact with the human host, regulating nutrient absorption and metabolism. Recent work suggests the presence of two forms of small intestinal bacterial overgrowth, one dominated by oral bacteria (SIOBO) and a second dominated by coliform bacteria. Less invasive sampling techniques, omics approaches, and mechanistic studies will allow a more comprehensive understanding of the SIM, paving the way for interventions engineering the SIM towards better health.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"970-983"},"PeriodicalIF":14.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the shared pathogenic strategies of independently evolved effectors across distinct plant viruses. 探索不同植物病毒中独立进化的效应器的共同致病策略。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-01 Epub Date: 2024-03-22 DOI: 10.1016/j.tim.2024.03.001
Lulu Li, Jianping Chen, Zongtao Sun
{"title":"Exploring the shared pathogenic strategies of independently evolved effectors across distinct plant viruses.","authors":"Lulu Li, Jianping Chen, Zongtao Sun","doi":"10.1016/j.tim.2024.03.001","DOIUrl":"10.1016/j.tim.2024.03.001","url":null,"abstract":"<p><p>Plants have developed very diverse strategies to defend themselves against viral pathogens, among which plant hormones play pivotal roles. In response, some viruses have also deployed multifunctional viral effectors that effectively hijack key component hubs to counter or evade plant immune surveillance. Although significant progress has been made toward understanding counter-defense strategies that manipulate plant hormone regulatory molecules, these efforts have often been limited to an individual virus or specific host target/pathway. This review provides new insights into broad-spectrum antiviral responses in rice triggered by key components of phytohormone signaling, and highlights the common features of counter-defense strategies employed by distinct rice-infecting RNA viruses. These strategies involve the secretion of multifunctional virulence effectors that target the sophisticated phytohormone system, dampening immune responses by engaging with the same host targets. Additionally, the review provides an in-depth exploration of various viral effectors, emphasizing tertiary structure-based research and shared host targets. Understanding these conserved characteristics in detail may pave the way for molecular drug design, opening new opportunities to enhance broad-spectrum antiviral trials through precise engineering.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"1021-1033"},"PeriodicalIF":14.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140194640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The macrophage-bacterium mismatch in persister formation. 宿主形成过程中的巨噬细胞-细菌错配。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-01 Epub Date: 2024-03-04 DOI: 10.1016/j.tim.2024.02.009
Iris Dadole, Didier Blaha, Nicolas Personnic
{"title":"The macrophage-bacterium mismatch in persister formation.","authors":"Iris Dadole, Didier Blaha, Nicolas Personnic","doi":"10.1016/j.tim.2024.02.009","DOIUrl":"10.1016/j.tim.2024.02.009","url":null,"abstract":"<p><p>Many pathogens are hard to eradicate, even in the absence of genetically detectable antimicrobial resistance mechanisms and despite proven antibiotic susceptibility. The fraction of clonal bacteria that temporarily elude effective antibiotic treatments is commonly known as 'antibiotic persisters.' Over the past decade, there has been a growing body of research highlighting the pivotal role played by the cellular host in the development of persisters. In parallel, this research has also sought to elucidate the molecular mechanisms underlying the formation of intracellular antibiotic persisters and has demonstrated a prominent role for the bacterial stress response. However, questions remain regarding the conditions leading to the formation of stress-induced persisters among a clonal population of intracellular bacteria and despite an ostensibly uniform environment. In this opinion, following a brief review of the current state of knowledge regarding intracellular antibiotic persisters, we explore the ways in which macrophage functional heterogeneity and bacterial phenotypic heterogeneity may contribute to the emergence of these persisters. We propose that the degree of mismatch between the macrophage permissiveness and the bacterial preparedness to invade and thrive intracellularly may explain the formation of stress-induced nonreplicating intracellular persisters.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"944-956"},"PeriodicalIF":14.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The HIPS 2024 symposium: highlighting advances in pharmaceutical sciences in infection research. HIPS 2024 专题讨论会：强调感染研究中的制药科学进展。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-01 Epub Date: 2024-08-23 DOI: 10.1016/j.tim.2024.07.007
Godfrey Mayoka, Daniel Krug, Brigitta Loretz, Kenan Bozhüyük, Martin Empting, Anna K H Hirsch, Rolf Müller
{"title":"The HIPS 2024 symposium: highlighting advances in pharmaceutical sciences in infection research.","authors":"Godfrey Mayoka, Daniel Krug, Brigitta Loretz, Kenan Bozhüyük, Martin Empting, Anna K H Hirsch, Rolf Müller","doi":"10.1016/j.tim.2024.07.007","DOIUrl":"10.1016/j.tim.2024.07.007","url":null,"abstract":"","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"927-930"},"PeriodicalIF":14.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信