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From carrion to soil: microbial recycling of animal carcasses. 从腐肉到土壤：动物尸体的微生物循环。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-01 DOI: 10.1016/j.tim.2024.09.003
Jennifer M DeBruyn, Sarah W Keenan, Lois S Taylor
{"title":"From carrion to soil: microbial recycling of animal carcasses.","authors":"Jennifer M DeBruyn, Sarah W Keenan, Lois S Taylor","doi":"10.1016/j.tim.2024.09.003","DOIUrl":"https://doi.org/10.1016/j.tim.2024.09.003","url":null,"abstract":"<p><p>Decomposer microbial communities are gatekeepers in the redistribution of carbon and nutrients from dead animals (carrion) to terrestrial ecosystems. The flush of decomposition products from a carcass creates a hot spot of microbial activity in the soil below, and the animal's microbiome is released into the environment, mixing with soil communities. Changes in soil physicochemistry, especially reduced oxygen, temporarily constrain microbial nutrient cycling, and influence the timing of these processes and the fate of carrion resources. Carcass-related factors, such as mass, tissue composition, or even microbiome composition may also influence the functional assembly and succession of decomposer communities. Understanding these local scale microbially mediated processes is important for predicting consequences of carrion decomposition beyond the hot spot and hot moment.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring emerging drug responses in Cryptococcus. 探索隐球菌中新出现的药物反应。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-01 Epub Date: 2024-07-19 DOI: 10.1016/j.tim.2024.07.002
Wei Liu, Yiru Gao, Chen Ding
{"title":"Exploring emerging drug responses in Cryptococcus.","authors":"Wei Liu, Yiru Gao, Chen Ding","doi":"10.1016/j.tim.2024.07.002","DOIUrl":"10.1016/j.tim.2024.07.002","url":null,"abstract":"<p><p>Cryptococcosis imposes a considerable burden on public health, and emerging drug responses to anticryptococcal drugs remain to be addressed. In this forum article we discuss the emerging drug responses of Cryptococcus, focusing on the critical nature of understanding such responses in order to improve the effectiveness of anticryptococcal therapeutics.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The macrophage-bacterium mismatch in persister formation. 宿主形成过程中的巨噬细胞-细菌错配。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-01 Epub Date: 2024-03-04 DOI: 10.1016/j.tim.2024.02.009
Iris Dadole, Didier Blaha, Nicolas Personnic
{"title":"The macrophage-bacterium mismatch in persister formation.","authors":"Iris Dadole, Didier Blaha, Nicolas Personnic","doi":"10.1016/j.tim.2024.02.009","DOIUrl":"10.1016/j.tim.2024.02.009","url":null,"abstract":"<p><p>Many pathogens are hard to eradicate, even in the absence of genetically detectable antimicrobial resistance mechanisms and despite proven antibiotic susceptibility. The fraction of clonal bacteria that temporarily elude effective antibiotic treatments is commonly known as 'antibiotic persisters.' Over the past decade, there has been a growing body of research highlighting the pivotal role played by the cellular host in the development of persisters. In parallel, this research has also sought to elucidate the molecular mechanisms underlying the formation of intracellular antibiotic persisters and has demonstrated a prominent role for the bacterial stress response. However, questions remain regarding the conditions leading to the formation of stress-induced persisters among a clonal population of intracellular bacteria and despite an ostensibly uniform environment. In this opinion, following a brief review of the current state of knowledge regarding intracellular antibiotic persisters, we explore the ways in which macrophage functional heterogeneity and bacterial phenotypic heterogeneity may contribute to the emergence of these persisters. We propose that the degree of mismatch between the macrophage permissiveness and the bacterial preparedness to invade and thrive intracellularly may explain the formation of stress-induced nonreplicating intracellular persisters.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small intestinal microbiota: from taxonomic composition to metabolism. 小肠微生物群：从分类组成到新陈代谢。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-01 Epub Date: 2024-03-19 DOI: 10.1016/j.tim.2024.02.013
Simon Yersin, Pascale Vonaesch
{"title":"Small intestinal microbiota: from taxonomic composition to metabolism.","authors":"Simon Yersin, Pascale Vonaesch","doi":"10.1016/j.tim.2024.02.013","DOIUrl":"10.1016/j.tim.2024.02.013","url":null,"abstract":"<p><p>The small intestinal microbiota (SIM) is essential for gastrointestinal health, influencing digestion, immune modulation, and nutrient metabolism. Unlike the colonic microbiota, the SIM has been poorly characterized due to sampling challenges and ethical considerations. Current evidence suggests that the SIM consists of five core genera and additional segment-specific taxa. These bacteria closely interact with the human host, regulating nutrient absorption and metabolism. Recent work suggests the presence of two forms of small intestinal bacterial overgrowth, one dominated by oral bacteria (SIOBO) and a second dominated by coliform bacteria. Less invasive sampling techniques, omics approaches, and mechanistic studies will allow a more comprehensive understanding of the SIM, paving the way for interventions engineering the SIM towards better health.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the shared pathogenic strategies of independently evolved effectors across distinct plant viruses. 探索不同植物病毒中独立进化的效应器的共同致病策略。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-01 Epub Date: 2024-03-22 DOI: 10.1016/j.tim.2024.03.001
Lulu Li, Jianping Chen, Zongtao Sun
{"title":"Exploring the shared pathogenic strategies of independently evolved effectors across distinct plant viruses.","authors":"Lulu Li, Jianping Chen, Zongtao Sun","doi":"10.1016/j.tim.2024.03.001","DOIUrl":"10.1016/j.tim.2024.03.001","url":null,"abstract":"<p><p>Plants have developed very diverse strategies to defend themselves against viral pathogens, among which plant hormones play pivotal roles. In response, some viruses have also deployed multifunctional viral effectors that effectively hijack key component hubs to counter or evade plant immune surveillance. Although significant progress has been made toward understanding counter-defense strategies that manipulate plant hormone regulatory molecules, these efforts have often been limited to an individual virus or specific host target/pathway. This review provides new insights into broad-spectrum antiviral responses in rice triggered by key components of phytohormone signaling, and highlights the common features of counter-defense strategies employed by distinct rice-infecting RNA viruses. These strategies involve the secretion of multifunctional virulence effectors that target the sophisticated phytohormone system, dampening immune responses by engaging with the same host targets. Additionally, the review provides an in-depth exploration of various viral effectors, emphasizing tertiary structure-based research and shared host targets. Understanding these conserved characteristics in detail may pave the way for molecular drug design, opening new opportunities to enhance broad-spectrum antiviral trials through precise engineering.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140194640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The HIPS 2024 symposium: highlighting advances in pharmaceutical sciences in infection research. HIPS 2024 专题讨论会：强调感染研究中的制药科学进展。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-01 Epub Date: 2024-08-23 DOI: 10.1016/j.tim.2024.07.007
Godfrey Mayoka, Daniel Krug, Brigitta Loretz, Kenan Bozhüyük, Martin Empting, Anna K H Hirsch, Rolf Müller
{"title":"The HIPS 2024 symposium: highlighting advances in pharmaceutical sciences in infection research.","authors":"Godfrey Mayoka, Daniel Krug, Brigitta Loretz, Kenan Bozhüyük, Martin Empting, Anna K H Hirsch, Rolf Müller","doi":"10.1016/j.tim.2024.07.007","DOIUrl":"10.1016/j.tim.2024.07.007","url":null,"abstract":"","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chitinase-assisted winner: nematodes antagonize symbiotic microbes. 几丁质酶辅助的赢家：线虫与共生微生物对立。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-01 Epub Date: 2024-08-31 DOI: 10.1016/j.tim.2024.08.008
Jingyi Zhang, Heng Sun, Feng Feng, Pengbo Liang
{"title":"Chitinase-assisted winner: nematodes antagonize symbiotic microbes.","authors":"Jingyi Zhang, Heng Sun, Feng Feng, Pengbo Liang","doi":"10.1016/j.tim.2024.08.008","DOIUrl":"10.1016/j.tim.2024.08.008","url":null,"abstract":"<p><p>Nematodes do not merely siphon off plant resources but also sabotage the plant's mutualistic relationships with beneficial microbes. Yang and colleagues elegantly elucidated this generalizable molecular antagonism, revealing how Heterodera glycines, the notorious soybean cyst nematode (SCN), suppresses beneficial microbial symbiosis through a specific chitinase, HgCht2.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cryptococcus neoformans: plant-microbe interactions and ecology. 新生隐球菌：植物与微生物的相互作用和生态学。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-10-01 Epub Date: 2024-03-21 DOI: 10.1016/j.tim.2024.03.002
Magnus Hallas-Møller, Meike Burow, Bernard Henrissat, Katja Salomon Johansen
{"title":"Cryptococcus neoformans: plant-microbe interactions and ecology.","authors":"Magnus Hallas-Møller, Meike Burow, Bernard Henrissat, Katja Salomon Johansen","doi":"10.1016/j.tim.2024.03.002","DOIUrl":"10.1016/j.tim.2024.03.002","url":null,"abstract":"<p><p>While the opportunistic human pathogens Cryptococcus neoformans and Cryptococcus gattii are often isolated from plants and plant-related material, evidence suggests that these Cryptococcus species do not directly infect plants. Studies find that plants are important for Cryptococcus mating and dispersal. However, these studies have not provided enough detail about how plants and these fungi interact, especially in ways that could show the fungi are capable of causing disease. This review synthesizes recent findings from studies utilizing different plant models associated with the ecology of C. neoformans and C. gattii. Unanswered questions about their environmental role are highlighted. Overall, current research indicates that Cryptococcus utilizes plants as a substrate rather than harming them, arguing against Cryptococcus as a genuine plant pathogen. We hypothesize that plants represent reservoirs that aid dispersal, not hosts vulnerable to infection.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Borrelia (Borreliella) burgdorferi. Borrelia (Borreliella) burgdorferi.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-09-27 DOI: 10.1016/j.tim.2024.09.002
Martin Strnad, Marie Vancová, Ryan O M Rego
{"title":"Borrelia (Borreliella) burgdorferi.","authors":"Martin Strnad, Marie Vancová, Ryan O M Rego","doi":"10.1016/j.tim.2024.09.002","DOIUrl":"https://doi.org/10.1016/j.tim.2024.09.002","url":null,"abstract":"","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transitioning ecosystems: how will permafrost cryophiles respond to a changing climate? 过渡生态系统：永冻土嗜冷者将如何应对不断变化的气候？
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-09-20 DOI: 10.1016/j.tim.2024.08.009
Lexi Mollica, Meghan Craughwell, Jackie Goordial
{"title":"Transitioning ecosystems: how will permafrost cryophiles respond to a changing climate?","authors":"Lexi Mollica, Meghan Craughwell, Jackie Goordial","doi":"10.1016/j.tim.2024.08.009","DOIUrl":"https://doi.org/10.1016/j.tim.2024.08.009","url":null,"abstract":"<p><p>Permafrost harbours a diversity of cryophilic microorganisms that can be metabolically active at sub-zero temperatures and likely play a role in global carbon cycling. This forum article explores possible impacts of permafrost warming on cold-adapted microbiota, highlights underexplored areas of research, and suggests future short and long-term research foci.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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