噬菌体trna：破解谜题。

IF 14 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Microbiology Pub Date : 2025-06-17 DOI:10.1016/j.tim.2025.05.009

Daan F van den Berg, Stan J J Brouns

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引用次数: 0

摘要

自20世纪60年代初发现噬菌体基因组中存在trna以来，科学家们一直对其感兴趣，因为人们认为噬菌体依赖宿主trna进行翻译。多年来，人们探索了许多假设，提供了证据表明不同生活方式的噬菌体以不同的方式利用trna。近年来，一些研究提供了证据，证明噬菌体trna在逃避噬菌体防御系统中起着至关重要的作用。在这篇综述中，我们总结了噬菌体trna领域的现状，强调了它们在噬菌体感染中的不同作用。我们还讨论了宿主对噬菌体trna的反应以及应用这些知识来改进基于噬菌体的治疗方法以对抗细菌感染。

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Phage tRNAs: decoding the enigma.

The presence of tRNAs in bacteriophage genomes has intrigued scientists since their discovery in the early 1960s, as phages were believed to rely on the host tRNAs for their translation. Over the years, a multitude of hypotheses have been explored, providing evidence that phages with different lifestyles utilize tRNAs in distinct ways. In recent years, several studies have provided evidence that phage tRNAs play a crucial role in evading phage defense systems. In this review we summarize the current state of the field of phage tRNAs, highlighting their diverse roles in phage infection. We also discuss the host response to phage tRNAs and the application of this knowledge to improve phage-based therapeutics to combat bacterial infections.

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来源期刊

Trends in Microbiology 生物-生化与分子生物学

CiteScore

25.30

自引率

0.60%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.