Transfusion最新文献

{"title":"Budget impact of implementing universal Plasmodium NAT screening in the blood transfusion system in the US.","authors":"Cristina Coll-Ortega, Elisabet Viayna, Jiani Zhou, Susan L Stramer","doi":"10.1111/trf.70396","DOIUrl":"https://doi.org/10.1111/trf.70396","url":null,"abstract":"<p><strong>Background: </strong>Blood donor deferral for malaria risk relies exclusively on responses to self-reported questionnaires. This study evaluated the economic impact of introducing Plasmodium nucleic acid testing (NAT) as a universal screening strategy in the United States.</p><p><strong>Study design and methods: </strong>A budget impact analysis comparing scenarios with and without universal Plasmodium NAT screening was conducted. In the testing scenario, question (Q) 29 on malaria risk was removed from the donor questionnaire. NAT was performed on mini-pools of 16 donations, followed by individual testing of reactive pools. Clinical, epidemiological, and cost inputs were obtained through a targeted literature review. The analysis adopted the perspective of blood suppliers and included a 1-to-3-year projection with a one-way sensitivity analysis. Costs were adjusted to 2021 USD.</p><p><strong>Results: </strong>Universal Plasmodium NAT screening is estimated to yield a net cost saving of 13,628,616 USD for US blood suppliers in the first year. While implementing NAT would add 4,443,286 USD in expenses, these costs would be offset by additional donations from donors previously deferred due to malaria risk identified by Q29 (266,438 extra blood products, resulting in 15,037,737 USD additional revenue), and labor savings of 3,034,165 USD from removing Q29, which is time-consuming, labor-intensive, and error-prone. Assuming an annual average increase of 2.4% in donations, projected savings are 13,865,670 USD in year 2 and 14,108,893 USD in year 3.</p><p><strong>Conclusion: </strong>Implementing universal Plasmodium NAT screening could enhance the availability and safety of blood products in the United States while reducing labor costs and losses from collections from deferred donors.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pneumothorax discovered following central venous catheter placement for apheresis.","authors":"Tracy Ruska, Elizabeth M Cappello, Tanya Sommers, Reuben Jacob","doi":"10.1111/trf.70328","DOIUrl":"10.1111/trf.70328","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1891-1892"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148621441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"From environmental impact to implementation pathways: Advancing life-cycle thinking for transfusion systems in a warming and unequal world\".","authors":"","doi":"10.1111/trf.70217","DOIUrl":"10.1111/trf.70217","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"2066"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rise of AI slop in transfusion medicine: Urgent need for oversight.","authors":"Sheharyar Raza, Garrett S Booth, Jeremy W Jacobs","doi":"10.1111/trf.70347","DOIUrl":"10.1111/trf.70347","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"2042-2044"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel c.145C>G variation in ABO*B.01 allele is associated with a B₃ phenotype.","authors":"Yan Li, Wei Han, Wenwen Kou, Zhaoze Ma, Hongmei Yang, Liling Zhou, Chenlong Wang","doi":"10.1111/trf.70387","DOIUrl":"10.1111/trf.70387","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"2061-2065"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148921126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel c.586dup frameshift variant in A4GALT associated with the p phenotype in a Chinese blood donor.","authors":"Xue Tian, Xiaoyue Chu, Dong Xiang, Liangzi Zhang, Hua Xu","doi":"10.1111/trf.70335","DOIUrl":"10.1111/trf.70335","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"2052-2054"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A global survey of blood transfusion practices for patients with sickle cell disease.","authors":"Jeremy W Jacobs, Arwa Z Al-Riyami, Jeannie Callum, Meghan Delaney, David Daniel, Jenny White, Christopher Bocquet, Mohammed Farouk, Claude Tayou, Chinelo P Onyenekwu, Kristina Prus, Divjot Singh Lamba, Julie Makani, Quentin Eichbaum, Luiz Amorim, Silvano Wendel, France Pirenne, Vernon Louw, Evan M Bloch","doi":"10.1111/trf.70331","DOIUrl":"10.1111/trf.70331","url":null,"abstract":"<p><strong>Background: </strong>Sickle cell disease (SCD) affects over 7 million people globally, with blood transfusion remaining a cornerstone of management. However, contemporary transfusion practices across diverse settings remain poorly characterized. We evaluated global transfusion practices for patients with SCD to identify gaps and inform resource prioritization.</p><p><strong>Study design and methods: </strong>We conducted a cross-sectional web-based survey of clinicians and laboratory professionals providing transfusion support for SCD, distributed via email using three professional society's membership lists (July-September 2025). Variables included facility characteristics, pre-transfusion testing capabilities, antigen-matching strategies, transfusion modalities, and barriers to care, stratified by World Bank income classification.</p><p><strong>Results: </strong>After excluding incomplete/duplicate responses, 102 facilities from 39 countries were analyzed; 95 actively treated patients with SCD. Facilities were predominantly public (73%), with 46% in lower-middle-income countries (LMICs). Routine newborn screening was performed by 33% overall (48% high-income countries [HICs] vs. 0% low-income). While ABO/RhD typing was nearly universal, antibody screening was available in only 72% of facilities (0% low-income, 47% LMICs, 98% HICs). Prophylactic RBC antigen matching was performed by 46% (18% LMICs vs. 70% HICs), primarily limited to Rh(CcEe) and K. Automated RBC exchange was available in 44% overall (0% low-income, 25% LMICs, 73% HICs); among facilities with exchange capability, 83% of HICs versus 36% of LMICs could provide exchange within 24 h for acute indications.</p><p><strong>Discussion: </strong>Pronounced income-related disparities exist in SCD transfusion support. Facilities in lower-income settings disproportionately lack antibody testing, prophylactic matching, and timely automated exchange. Targeted infrastructure investment and context-appropriate guidelines are essential for equitable care.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1926-1938"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13674188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148449557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Employee motivators and barriers of workplace-supported blood donation.","authors":"Kathleen Chell, Lachie Toms, Barbara Masser, Debbie Haski-Leventhal, Irit Alony","doi":"10.1111/trf.70419","DOIUrl":"https://doi.org/10.1111/trf.70419","url":null,"abstract":"<p><strong>Background: </strong>Workplace-supported blood donation is a promising yet underexamined strategy for donor recruitment and retention. Aligning blood donation with corporate social responsibility goals may improve employee engagement while reducing logistical barriers. Although blood collection agencies worldwide adopt varied models of workplace support, limited research has examined how workplace contexts shape motivators and barriers to blood donation.</p><p><strong>Study design and methods: </strong>An online self-report survey (n = 285) was conducted with employees from four large Australian organizations, each with established blood donation teams (>1000 members) and paid donor leave. Measures included awareness and engagement of workplace donation teams and leave entitlements, as well as general and workplace-specific motivators and barriers, with subgroup comparisons.</p><p><strong>Results: </strong>Altruism and perceived need motivated blood donation, while inconvenience (time, location) was the main barrier, especially among non-donors. Workplace-supported blood donation increased motivation through convenience, social connection, and supportive organizational culture. However, lack of awareness of workplace initiatives was the most common barrier, indicating substantial unrealized potential.</p><p><strong>Discussion: </strong>When effectively embedded and communicated, workplace-supported blood donation could activate latent altruism, reduce barriers, and foster social norms that sustain behavior, as well as strengthen coworker connection and alignment with organizational values. Further research should examine the benefits for employees and employers to build the case for workplaces as effective settings for donor recruitment and retention.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-design with community partners in blood donor recruitment: A global assessment.","authors":"Richard Mills, Arwa Z Al-Riyami, Jeannie Callum, Abiola Okubanjo, Christopher Bocquet, Barbara Masser, Eva-Maria Merz, Eamonn Ferguson","doi":"10.1111/trf.70412","DOIUrl":"https://doi.org/10.1111/trf.70412","url":null,"abstract":"<p><strong>Background: </strong>Blood services need to increase representativeness of donors from ethnically diverse communities, yet evidence-based recruitment strategies remain scarce. Co-design with community partners is a promising approach to developing culturally resonant materials, but the extent of its use globally remains unknown.</p><p><strong>Study design and methods: </strong>We surveyed transfusion professionals registered with the Association for the Advancement of Blood and Biotherapies (AABB) and the International Society of Blood Transfusion (ISBT). Respondents reported recruitment methods in general use and ranked their perceived effectiveness. We then examined the adoption of co-design specifically for ethnically diverse donor recruitment, including attitudes, barriers, and evaluation.</p><p><strong>Results: </strong>Of 170 respondents across four regions (Europe, North America, South-East-Asia, Rest-of-the-World), 94% reported that their institution actively recruited blood donors, and 51% identified they had a critical need for ethnically diverse supplies. Co-design was used by 33% of active recruiters, ranking seventh of 11 methods. Among those stating a critical need: 73% had developed ethnically tailored materials, 38% had used co-design, 13% co-designed videos, and 11% evaluated co-designed video effectiveness. Attitudes were favorable regardless of critical-need status, with 82%-89% endorsing bespoke videos as effective. Barriers were predominantly resource-based: funding (54%-57%), media-production expertise (29%-35%), and co-design expertise (24%-36%).</p><p><strong>Discussion: </strong>Co-design for ethnically diverse donor recruitment is underused, revealing a belief-practice gap: attitudes are favorable, but adoption is low. Barriers are resource-based rather than attitudinal, and evaluation is rare. Wider adoption depends on building organizational capacity: funding, co-design expertise, and embedding evaluation from the outset.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping obstetric biobanks: A scoping review highlighting gaps in the study of alloimmunized pregnancies.","authors":"Orlin Chowdhury, Chantal Armali, Catherine Devion, Sasha Kyser-Burke, Akash Gupta, Noor Niyar N Ladhani, Harley Meirovich, Hubert Tsui, Noah Zweig, Yulia Lin, Heather VanderMeulen","doi":"10.1111/trf.70383","DOIUrl":"https://doi.org/10.1111/trf.70383","url":null,"abstract":"<p><strong>Background: </strong>Maternal red cell alloimmunization can cause hemolytic disease of the fetus and newborn (HDFN), yet prediction of disease severity remains limited. Biobanks that link pregnancy biospecimens with clinical and laboratory data could accelerate translational research; however, the landscape of relevant obstetric biobanks has not been mapped.</p><p><strong>Study design and methods: </strong>We conducted a scoping review following Joanna Briggs Institute methodology. MEDLINE, Embase, and CENTRAL were searched from January 2005 to May 20, 2025 for publications describing the establishment, structure, or operation of obstetric biobanks. Abstract screening, text review, and data extraction were conducted in duplicate. Findings were synthesized narratively.</p><p><strong>Results: </strong>Of 2482 records screened, 29 publications met inclusion criteria, representing 21 unique biobanks across 18 countries and 6 continents. Most were conducted in high-income countries (n = 13) and were multicenter (n = 17). Biobanks primarily focused on environmental and genetic influences on development (n = 14) and pregnancy outcomes (n = 7), with no identified biobanks dedicated to alloimmunization. The types of maternal biospecimens collected varied, including whole blood (n = 19), plasma (n = 18), serum (n = 16), and urine (n = 16), with frequent collection of placental tissue (n = 14) and cord blood (n = 16). All biobanks incorporated maternal clinical variables (n = 21), whereas paternal (n = 10) and laboratory (n = 9) variables were less common. Only one biobank explicitly collected immunohematology variables (e.g., RhD status and maternal alloantibodies).</p><p><strong>Conclusion: </strong>Obstetric biobanks have the potential to accelerate discovery in alloimmunized pregnancies, but existing biobanks rarely capture immunohematologic variables. Integrating standardized immunohematology variables and paired maternal-fetal-paternal sampling into future initiatives could facilitate translational research on alloimmunization and HDFN.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}