Transfusion最新文献_第7页

Optimizing damage control resuscitation through early patient identification and real-time performance improvement. 通过早期患者识别和实时性能改进，优化损伤控制复苏。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-01 Epub Date: 2024-07-29 DOI: 10.1111/trf.17806

Daniela Schmulevich, Allyson M Hynes, Shyam Murali, Andrew J Benjamin, Jeremy W Cannon

引用次数: 0

Associations between transfusion reactions and thromboembolism development in blood-transfused patients: A retrospective cohort study. 输血反应与输血患者血栓栓塞症发生之间的关系：一项回顾性队列研究。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-01 Epub Date: 2024-06-09 DOI: 10.1111/trf.17907

Hsin-Yu Chen, Chun-Hao Yin, Shih-Hsiang Ou, Ming-Yun Hsieh, Yao-Shen Chen, Jin-Shuen Chen

{"title":"Associations between transfusion reactions and thromboembolism development in blood-transfused patients: A retrospective cohort study.","authors":"Hsin-Yu Chen, Chun-Hao Yin, Shih-Hsiang Ou, Ming-Yun Hsieh, Yao-Shen Chen, Jin-Shuen Chen","doi":"10.1111/trf.17907","DOIUrl":"10.1111/trf.17907","url":null,"abstract":"Background: Blood transfusion (BT) may be associated with an increased risk of thromboembolism. The associations between transfusion reactions (TRs) during BTs and potential risk factors for the development of thromboembolism in patients underwent blood transfusion have not been analyzed. Therefore, this study aimed to compare risk factors associated with the development of venous thromboembolism (VTE) or pulmonary embolism (PE) between patients underwent blood transfusion with and without TRs.Study designs and methods: The retrospective study was conducted between April 1, 2017, and March 31, 2020, at a medical center in Taiwan. Blood-transfused patients were grouped into two cohorts as follows: those who experienced TRs and those who did not experience TRs. Both cohorts were subjected to follow-up until March 31, 2021. The endpoints for both groups were the occurrence of VTE or PE or the date of March 31, 2021. To investigate between-cohort risk differences, a Kaplan-Meier survival analysis and multiple Cox proportional hazard model was used.Results: A total of 10,759 patients underwent 59,385 transfusion procedures, with 703 patients in the TR group, and 10,056 patients in the non-TR group. The risk of VTE or PE was twice as high in the TR group than in the non-TR group (adjusted hazard ratio 2.53, 95% confidence interval 1.49-4.29, p = .001). Meanwhile, age, female sex, transfusion frequency increment, and being nondiabetic was associated with an increased risk of developing thromboembolism.Conclusion: TRs are associated with increased long-term thromboembolism risk in patients underwent blood transfusion. It is imperative for clinicians to acknowledge this and maintain rigorous follow-up.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel FUT1*932A allele associated with the para-Bombay A phenotype in a Chinese individual. 一个与中国人副孟买A表型相关的新型 FUT1*932A 等位基因。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-01 Epub Date: 2024-06-20 DOI: 10.1111/trf.17923

Lili Shi, Ling Ma, Chenchen Feng, Qinping Yang

引用次数: 0

The c.254C>A change (p.Ala85Glu) in RHD causing a weak D phenotype. RHD 中的 c.254C>A 变化（p.Ala85Glu）会导致弱 D 表型。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-01 Epub Date: 2024-06-10 DOI: 10.1111/trf.17919

Yuli Zhu, Caixia Qiu, Yulin Wang, Zhihui Feng

引用次数: 0

Modeling US blood donor deferrals under a policy of individual risk assessment for HIV risk sexual behavior. 对美国献血者推迟献血的情况进行建模，并对 HIV 风险性行为进行个人风险评估。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-01 Epub Date: 2024-06-12 DOI: 10.1111/trf.17916

Barbee I Whitaker, Yin Huang, Diane Gubernot, Anne F Eder, Debby Herbenick, Tsung-Chieh Fu, Richard A Forshee, Steven A Anderson

{"title":"Modeling US blood donor deferrals under a policy of individual risk assessment for HIV risk sexual behavior.","authors":"Barbee I Whitaker, Yin Huang, Diane Gubernot, Anne F Eder, Debby Herbenick, Tsung-Chieh Fu, Richard A Forshee, Steven A Anderson","doi":"10.1111/trf.17916","DOIUrl":"10.1111/trf.17916","url":null,"abstract":"Background: In May 2023, the Food and Drug Administration (FDA) released final guidance for blood donor eligibility that recommended the elimination of 3-month deferral for men who have sex with men (MSM) and the related deferral for women who have sex with MSM. In its place, FDA introduced an individual risk assessment policy of asking all presenting blood donors, regardless of sex or gender, if they have had a new partner or more than one sexual partner in the last 3 months and deferring those who also report anal sex (penile-anal intercourse) during this period. We modeled the possible impact of this policy on the US blood donor base.Study design and methods: We developed a computational model to estimate the percentage of blood donors who would be deferred under a policy of individual HIV risk assessment. The model incorporated demographic information about donors and national survey data on HIV risk behaviors and included age and sex distributions and dependencies.Results: Our model estimates that approximately 1.2% of US blood donors would be deferred under the individual HIV risk assessment paradigm.Discussion: The model predicts a relatively minor effect of replacing the time-based deferral for MSM with individual risk-based deferral for sexual behavior. As US blood centers implement this new policy, the effect may be mitigated by donor gains, which warrant further study. The new policy is unlikely to adversely affect the availability of blood and blood components.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11328673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to Transfusion management and hemoglobin-based oxygen carrier treatment in a patient with anti-Rh17 antibody. 更正 "一名抗 Rh17 抗体患者的输血管理和基于血红蛋白的氧载体治疗"。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1111/trf.17948

引用次数: 0

Making blood immediately available in emergencies. 在紧急情况下立即提供血液。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-01 Epub Date: 2024-07-19 DOI: 10.1111/trf.17929

John B Holcomb, Frank K Butler, Martin A Schreiber, Audra L Taylor, Leslie E Riggs, Jon R Krohmer, Warren C Dorlac, Donald H Jenkins, Daniel B Cox, Andrew N Beckett, Kevin C O'Connor, Jennifer M Gurney

引用次数: 0

Stored platelet hemostatic phenotype and function is not altered when donors are on testosterone replacement therapy. 当捐献者接受睾酮替代治疗时，储存的血小板止血表型和功能不会发生改变。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-01 Epub Date: 2024-07-12 DOI: 10.1111/trf.17926

Alisha Chitrakar, Scott-Wesley M Bean, Tamir Kanias, Kimberly A Thomas

{"title":"Stored platelet hemostatic phenotype and function is not altered when donors are on testosterone replacement therapy.","authors":"Alisha Chitrakar, Scott-Wesley M Bean, Tamir Kanias, Kimberly A Thomas","doi":"10.1111/trf.17926","DOIUrl":"10.1111/trf.17926","url":null,"abstract":"Background: Critical shortages in the national blood supply have led to a re-evaluation of previously overlooked donor sources for blood products. As a part of that effort, red blood cells collected from therapeutic phlebotomy of donors on testosterone replacement therapy (TRT) have been conditionally approved for transfusion. However, platelets from TRT donors are not currently approved for use due to limited data on effects of supraphysiologic testosterone on recipient safety and platelet function. The objective of this study was to provide a comprehensive profile of phenotype and function in platelets from TRT and control donors.Study design and methods: Platelets in plasma were collected from TRT and control donors (N = 10 per group; age- and sex-matched) and stored at room temperature for 7 days. On storage Day 1 (D1) and Day 7 (D7), platelet products were analyzed for platelet count, metabolic parameters (i.e., glucose, lactate, mitochondrial function), surface receptor expression, aggregation, thrombin generation, and thrombus formation under physiological flow conditions.Results: TRT donor platelets were not significantly different than control donor platelets in terms of count, surface phenotype, metabolic function, ability to aggregate, thrombin generation, or ability to form occlusive thrombus under arterial flow regimes. Both groups were similar to each other by D7, but had significantly lost hemostatic function compared to D1.Discussion: Platelets derived from donors undergoing TRT have similar phenotypic and functional profiles compared to those derived from control donors. This suggests that therapeutic phlebotomy of TRT donors may provide a useful source for platelet products.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11326535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new platelet alloantigen (Efs^2a) on glycoprotein GPIIIa leading to neonatal alloimmune thrombocytopenia. 糖蛋白 GPIIIa 上的一种新的血小板同种抗原（Efs2a）导致新生儿同种免疫血小板减少症。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-01 Epub Date: 2024-06-25 DOI: 10.1111/trf.17933

Gérald Bertrand, Yannic Danger, Franck Verite, Mireille Sarpentier Guibourg, Justine Coombs, Virginie Renac

引用次数: 0

The impact of simulation-based training on medical students' whole blood transfusion abilities. 模拟训练对医学生全血输注能力的影响。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-01 Epub Date: 2024-05-23 DOI: 10.1111/trf.17906

Rebekah Cole, Cynthia Shen, Jonathan Shumaker, Kevin J Matthews, Zachery L Brown, Joshua Cuestas, Sherri L Rudinsky

{"title":"The impact of simulation-based training on medical students' whole blood transfusion abilities.","authors":"Rebekah Cole, Cynthia Shen, Jonathan Shumaker, Kevin J Matthews, Zachery L Brown, Joshua Cuestas, Sherri L Rudinsky","doi":"10.1111/trf.17906","DOIUrl":"10.1111/trf.17906","url":null,"abstract":"Background: Whole blood transfusion has been found to increase the likelihood of patient survival within both military and civilian medicine contexts. However, no whole blood transfusion training curriculum currently exists within undergraduate or graduate medical education in the United States. The purpose of our study was to: (1) determine the impact of simulation-based training on medical students' abilities to conduct whole blood transfusions; and (2) determine the impact of simulation-based training on medical students' confidence in conducting whole blood transfusions.Study design and methods: We assessed 157 third-year military medical students' ability to conduct whole blood transfusion before and after Operation Gunpowder, a 2-day high-fidelity prolonged casualty care simulation. We conducted a paired samples t-test to compare the students' pre- and post-simulation performance scores as well as self-reported confidence and stress ratings.Results: There was a significant difference in students' scores at the beginning of the course (M = 20.469, SD 6.40675) compared to their scores at the end of the course (M = 30.361, SD = 2.10053); t(155) = -18.833, p < .001. The effect size for this analysis (d = 6.56) was large. There was a significant difference (p < .001) between the pre- and post-ratings for all self-reported confidence and stress survey items.Discussion: Our results suggest that simulation-based training is an effective means of training medical students to conduct whole blood transfusiontraining in a limited resource simulated environment where blood inventories may be limited.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0