Transfusion最新文献_第10页

Supplemental findings of the 2023 National Blood Collection and Utilization Survey. 2023年全国血液采集和利用调查的补充结果。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 DOI: 10.1111/trf.18336

Isabel S Griffin, Ian Kracalik, Kelsey McDavid, Tatiana Bradley, Joel Chavez Ortiz, James J Berger, Sridhar V Basavaraju, Rebecca Lien

{"title":"Supplemental findings of the 2023 National Blood Collection and Utilization Survey.","authors":"Isabel S Griffin, Ian Kracalik, Kelsey McDavid, Tatiana Bradley, Joel Chavez Ortiz, James J Berger, Sridhar V Basavaraju, Rebecca Lien","doi":"10.1111/trf.18336","DOIUrl":"10.1111/trf.18336","url":null,"abstract":"Background: The National Blood Collection and Utilization Survey (NBCUS) is conducted biennially to estimate US blood collection and utilization. Supplemental data from the 2023 NBCUS not presented elsewhere are described here.Methods: Data on blood donor characteristics, donation deferrals, component costs, transfusion-associated adverse reactions, and use of pathogen-reduced platelets during 2023 were collected from US blood collecting and transfusing facilities. National estimates were produced using weighting and imputation methods.Results: Compared with 2021, successful blood donations from donors aged 45-64 decreased (11%) in 2023 but still accounted for most donations overall (39%). Donations from donors aged 16-18 years, Black or African American, and Hispanic donors increased by 66%, 38%, and 9%, respectively, since 2021. Donation deferrals for travel increased since 2021 (+162%). From 2021 to 2023, the median price hospitals paid per unit of leukoreduced red blood cells, fresh frozen plasma, and leukoreduced and pathogen-reduced apheresis platelets increased. Apheresis platelets experienced the largest price increase per unit (+$65). Compared with 2021, the proportion of transfusing facilities using pathogen-reduced platelets increased in 2023 (60% vs. 64%). The overall rate of transfusion-associated adverse reactions per 100,000 components transfused was higher in 2023 than in 2021 (312.3 vs. 273.8), although the rate of transfusion-transmitted infections (bacterial, viral, and parasitic) declined in 2023 (0.25 vs. 0.43).Conclusion: From 2021 to 2023, blood donations among older donors decreased, while donations from younger and Black or African American donors increased. Adoption of pathogen-reduced platelets and cost of all blood products increased.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healthy volunteer stem cell donors followed up 10 years after stimulation with biosimilar filgrastim. 健康志愿者干细胞供体在生物仿制药非格昔汀刺激后随访10年。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-07-09 DOI: 10.1111/trf.18317

Jens Heyn, Susanne Bräuninger, Petra Becker, Niklas Stoeckmann, Christian Seidl, Sebastian Howe, Simon Daubert, Daniel Fürst, Hubert Schrezenmeier, Halvard Bonig

{"title":"Healthy volunteer stem cell donors followed up 10 years after stimulation with biosimilar filgrastim.","authors":"Jens Heyn, Susanne Bräuninger, Petra Becker, Niklas Stoeckmann, Christian Seidl, Sebastian Howe, Simon Daubert, Daniel Fürst, Hubert Schrezenmeier, Halvard Bonig","doi":"10.1111/trf.18317","DOIUrl":"10.1111/trf.18317","url":null,"abstract":"Background: The application of granulocyte colony-stimulating factors (G-CSF) for mobilizing hematopoietic stem and progenitor cells in healthy donors is considered safe. However, only limited safety information is available about long-term adverse events (AEs) in this setting. To determine the long-term effect of health consequences to stem cell donors, 244 G-CSF-mobilized donors were tracked prospectively for 10 years.Study design and methods: A total of 244 adult healthy unrelated stem cell donors who received at least one dose of Sandoz biosimilar filgrastim were enrolled in this prospective long-term surveillance study. Safety, mental health, and physical health were followed up over a period of 10 years.Results: Ninety-five percent of the donors experience at least one AE during the stem mobilization period; beyond this period, the onset of the first AE was 3.86 [3.45-4.27] years in females and 4.02 [3.68-4.35] years in males. The risk of reporting an AE was significantly lower in the youngest tertile of donors, when compared to the oldest (p = 0.026). Females were more likely to report AEs than males (0.40 vs. 0.21 AEs/year, rate ratio: 1.87 [CI: 1.32-2.64]; <0.001). No clinically relevant permanent changes occurred up to 10 years from mobilization in physical or mental health.Discussion: No new or excessive AEs were identified during a 10-year follow-up of mobilized stem cell donors and therefore reassure about the overall safety of stem cell mobilization with G-CSF in healthy volunteers.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1418-1426"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Cryobit" aggregates in liquid plasma units. “Cryobit”聚集在液体等离子体单位中。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-06-09 DOI: 10.1111/trf.18308

Catherine Gereg, Christopher A Tormey, F Bernadette West, Nalan Yurtsever

引用次数: 0

One versus two: How much does it matter? A single-center retrospective study evaluating 1-day extracorporeal photopheresis schedule for treating patients with chronic lung allograft rejection. 一对二：有多重要？一项单中心回顾性研究评估1天体外光移植术治疗慢性同种异体肺移植排斥患者的方案。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-07-14 DOI: 10.1111/trf.18318

Claudia Del Fante, Valentina Vertui, Catherine Klersy, Cristina Mortellaro, Domenica Federica Briganti, Letizia Corinna Morlacchi, Marianna Russo, Cesare Perotti, Federica Meloni

{"title":"One versus two: How much does it matter? A single-center retrospective study evaluating 1-day extracorporeal photopheresis schedule for treating patients with chronic lung allograft rejection.","authors":"Claudia Del Fante, Valentina Vertui, Catherine Klersy, Cristina Mortellaro, Domenica Federica Briganti, Letizia Corinna Morlacchi, Marianna Russo, Cesare Perotti, Federica Meloni","doi":"10.1111/trf.18318","DOIUrl":"10.1111/trf.18318","url":null,"abstract":"Background: Several studies show that extracorporeal photopheresis (ECP) might benefit chronic lung allograft dysfunction (CLAD). A standard ECP cycle consists of two consecutive procedures regardless of the technique employed.Study design and methods: Evaluation of ECP cycle (from two to one procedure) modification due to pandemic restrictions in 25 patients with CLAD under chronic treatment by off-line ECP in the 6 months preceding cycle modification (one procedure processing 1.5 patients blood volumes [1.5 ECP]). Assessment of any significant change in lung function decline and the relationship with product characteristics compared to pre-ECP cycle modification.Results: ECP patients (23 obstructive and two mixed) were enrolled in 2020 during the COVID pandemic. Two hundred and thirty five ECP procedures followed the standard protocol and 121 the 1.5 ECP. There was little or no variation in lung function during the study period. The mean number of mononuclear cells (MNC) per kg administered over time was higher in the 1.5 ECP than in the standard ECP protocol (p = .014). No association was found between respiratory function and MNC infused. Persistent Forced Expiratory Volume in 1 s decline >10% was observed in two patients over the 6 months preceding 1.5 ECP (due to CLAD progression) and in three patients after 1.5 ECP initiation (one for CLAD progression, two for bronchial colonization).Conclusion: Our study shows that respiratory function is maintained over time and is comparable between both ECP strategies in responders. The shift from two to one procedure per cycle may be reasonable in CLAD patients treated by off-line ECP.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1490-1501"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rising transfusion rates amidst stable blood supply: A Canadian perspective on emerging challenges for blood operators. 在稳定的血液供应中不断上升的输血率：加拿大对血液运营商面临的新挑战的看法。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-06-27 DOI: 10.1111/trf.18325

An Duong, Sheharyar Raza, Marianne Waito, Tanya Petraszko, Asim Q Alam

引用次数: 0

Duffy-null associated count: Perspectives from the blood Bank. 达菲相关计数：来自血库的观点。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-06-23 DOI: 10.1111/trf.18323

Heather M Ross, Zhen Mei, Andrea McGonigle, Alyssa Ziman, Dawn C Ward

引用次数: 0

Continuing Medical Education. 继续医学教育。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 DOI: 10.1111/trf.18359

引用次数: 0

West Nile Virus positivity amongst Canadian blood donors and effectiveness of off-season screening. 西尼罗病毒在加拿大献血者中的阳性和淡季筛查的有效性。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-06-28 DOI: 10.1111/trf.18326

Carmen L Charlton, Steven J Drews, Kai Makowski, Gordon Hawes, Cynthia Cranney, Alyssia Robinson, Heidi Wood, Mark Bigham, Sheila F O'Brien

{"title":"West Nile Virus positivity amongst Canadian blood donors and effectiveness of off-season screening.","authors":"Carmen L Charlton, Steven J Drews, Kai Makowski, Gordon Hawes, Cynthia Cranney, Alyssia Robinson, Heidi Wood, Mark Bigham, Sheila F O'Brien","doi":"10.1111/trf.18326","DOIUrl":"10.1111/trf.18326","url":null,"abstract":"Background: We sought to examine the prevalence of West Nile Virus (WNV) nucleic acid test (NAT) positivity over time in Canadian blood donors, examine the level of false-positive NAT screening, and understand the effectiveness of travel-related testing outside of WNV seasonality in Canada.Study design and methods: All blood donations in Canada (except Québec) between 2018 and 2023 were tested by the Roche Cobas WNV-NAT assay during the summer-fall season by Canadian Blood Services. Testing for recent travel outside Canada was performed in the winter-spring season. All 2023 WNV-NAT-positives were confirmed by two independent WNV-specific polymerase chain reaction (PCRs).Results: While WNV positivity varied by location and time, no increasing trend of positivity was observed over the 6-year study period. No WNV-NAT-positive donors with a history of recent travel outside of Canada in the winter-spring season were identified by donor screening (2018-2023). In total, 2,454,102 samples were tested during summer months and 267,988 in winter months. In 2023, WNV-specific PCR confirmed 10 of 13 (76.9%) screening WNV-NATs. Recent Japanese Encephalitis Virus (JEV) vaccination was identified as a potential false positive for initial WNV screening results.Discussion: Between 2018 and 2023, WNV-NAT positivity amongst Canadian blood donors remained stable, with no evidence of an increasing positivity trend. The utility of off-season travel-related testing may be limited, as no donors were identified during the six-year study timeframe. Finally, confirmation testing using WNV-specific PCR is recommended to identify true cases and to limit misidentification of other genetically similar viruses, such as JEV.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1484-1489"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current red blood cell and platelet transfusion practices in Canadian neonatal intensive care units. 目前加拿大新生儿重症监护病房的红细胞和血小板输注实践。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-06-09 DOI: 10.1111/trf.18305

Mathilde Lamothe, Marc Beltempo, Anie Lapointe, Andréanne Villeneuve

{"title":"Current red blood cell and platelet transfusion practices in Canadian neonatal intensive care units.","authors":"Mathilde Lamothe, Marc Beltempo, Anie Lapointe, Andréanne Villeneuve","doi":"10.1111/trf.18305","DOIUrl":"10.1111/trf.18305","url":null,"abstract":"Background: Red blood cell and platelet transfusions are often prescribed in preterm infants. Consensus on the best transfusion practices in this population has still not been reached, causing disparities in neonatal care. The objective of this study is to provide updated data on current red blood cell and platelet transfusion practices in preterm neonates regarding thresholds and justifications associated with the decision to transfuse.Study design and methods: An electronic survey was sent to one neonatology representative of each center of the Canadian Neonatal Network (31 sites). Descriptive data from each center was collected from the Network's work database.Results: More than half of the respondents (54.8%) have a red blood cell transfusion protocol, while only 32.3% of centers have a platelet transfusion protocol. The most commonly reported justification for red blood cell transfusion is low levels of hemoglobin (100%), while the severity of illness and hemodynamic instability were also frequently mentioned (58.1% and 35.5%). For platelet transfusion justifications, the most reported is low platelet count (96.8%), followed by significant bleeding (93.6%) and severity of illness (35.5%). The reported thresholds also vary greatly depending on the presence of oxygen support for red blood cell transfusions and the occurrence of bleeding or invasive procedures for platelets.Discussion: There is great variability between Canadian centers concerning red blood cells and platelet transfusions in preterm neonates. Practice guidelines should be established for better oversight of transfusion practices in preterm infants to support more judicious use of blood products.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1427-1443"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Segmenting military blood donors: A targeted marketing approach to increase expeditionary blood availability. 分割军事献血者：一个有针对性的营销方法，以增加远征血液供应。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-05-27 DOI: 10.1111/trf.18300

Michael Carrillo, Daniel Roman, Ryan Comes, Chih Huang, Frederick Lumzy, Matthew Hanson, Ramey Wilson, Peter Kulis, Andrew Hall

{"title":"Segmenting military blood donors: A targeted marketing approach to increase expeditionary blood availability.","authors":"Michael Carrillo, Daniel Roman, Ryan Comes, Chih Huang, Frederick Lumzy, Matthew Hanson, Ramey Wilson, Peter Kulis, Andrew Hall","doi":"10.1111/trf.18300","DOIUrl":"10.1111/trf.18300","url":null,"abstract":"Background: The Armed Services Blood Program (ASBP) manages blood collection and distribution for the Department of Defense in support of global military and interagency operations. Despite its critical role, there is limited research exploring what motivates ASBP blood donors. This study identifies intrinsic and extrinsic motivations to inform targeted marketing strategies aimed at increasing ASBP blood donations.Study design and methods: A survey was conducted among blood donors at the Keesler Blood Donor Center (BDC). Participants ranked intrinsic and extrinsic motivational factors on a 5-point Likert scale, and demographic data were collected. Exploratory factor analysis was performed, and demographic variations were assessed through analysis of variance.Results: A total of 376 surveys were included. Intrinsic motivations, notably altruism (\"Desire to Help Others\") and military-specific support (\"Supporting Military Personnel\"), were ranked highest among respondents. Higher-value extrinsic motivation items (such as uniform patches and gift cards) were preferred, although exemption from physical training emerged as an unexpectedly popular and low-cost incentive. While statistically significant motivational differences existed between genders and military branches, the practical impact of these differences was minimal.Discussion: Identified intrinsic motivations provide clear guidance for targeted marketing campaigns emphasizing altruism and service. Additionally, low-cost incentives, such as physical training exemptions, complement more costly extrinsic rewards. Although demographic differences were statistically significant, their practical implications are limited, suggesting broadly appealing marketing messages may be sufficient across military populations.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1444-1450"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0