Transfusion最新文献_第10页

Prehospital central venous catheters. 院前中心静脉导管。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-08-30 DOI: 10.1111/trf.17949

Nicholas M Studer, Jason R Pickett, C J Winckler, William R Smith, Andrew P Cap, Cord W Cunningham

引用次数: 0

Iron deficiency-related symptoms in non-anemic whole blood donors. 非贫血全血献血者中与缺铁有关的症状。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-08-14 DOI: 10.1111/trf.17983

J Karregat, A Meulenbeld, J Abubakar, F A Quee, K van den Hurk

{"title":"Iron deficiency-related symptoms in non-anemic whole blood donors.","authors":"J Karregat, A Meulenbeld, J Abubakar, F A Quee, K van den Hurk","doi":"10.1111/trf.17983","DOIUrl":"10.1111/trf.17983","url":null,"abstract":"Introduction: Whole blood donors are at increased risk for iron deficiency (ID). ID anemia is associated with several symptoms, such as fatigue, cognitive dysfunction, pica, and restless leg syndrome (RLS). However, it is unclear if these symptoms also occur when a donor has developed ID without anemia. This study aims to determine whether non-anemic ID (NAID) is associated with the occurrence of ID-related symptoms.Study designs and methods: We combined data from three studies in whole blood donors (i.e., Donor Insight-III, FIND'EM, and FORTE) to create a substantial sample size (N = 12,143). The self-reported occurrence and severity of ID-related symptoms, such as physical and mental health, fatigue, cognitive functioning, pica, and RLS, was measured using validated questionnaires. Associations were studied using logistic regression modeling with ID-related symptoms derived from the questionnaires as the dependent variable and ferritin level group (0-15 μg/L, 15-30 μg/L, and >30 μg/L) as explanatory variable.Results: After applying inclusion and exclusion criteria, 9829 donors were eligible for analysis. In the models corrected for age, body mass index, Hb level, and cohort, only fatigue was shown to be associated with ferritin levels in men, showing lower odds (OR 1.41, 95% CI 1.11-1.79) for fatigue with higher ferritin levels.Conclusion: In these studies, NAID was only associated with self-reported fatigue in male donors. Although selection bias may have led to underestimated associations, ferritin measurements in donors should be primarily considered as a measure to prevent anemia, rather than to prevent or mitigate NAID-related symptoms.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1920-1930"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Massive fetomaternal hemorrhage from placental abruption presenting as weak-D expression. 胎盘早剥引起的大面积母体出血，表现为弱D。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-08-19 DOI: 10.1111/trf.17988

Lindsey K Durowoju, Rida A Hasan, John R Hess, Daniel E Sabath, Andrew Bryan, Monica B Pagano, Hamilton C Tsang

引用次数: 0

Prediction of CD34+ hematopoietic stem cells in healthy allogeneic stem cell donors on the Optia cell separator based on CE2: Which formula is more correlated with actual CD34+? 基于 CE2 预测 Optia 细胞分离器上健康异体干细胞捐献者的 CD34+ 造血干细胞：哪个公式与实际 CD34+ 更相关？

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-08-17 DOI: 10.1111/trf.17990

Sıdıka Gülkan Özkan, Ali Kimiaei, Seyedehtina Safaei, Tarık Ercan, Meral Sönmezoğlu, Gülderen Yanıkkaya Demirel, Sema Aktaş, Sinem Özdemir, Helin Serda Özalp, Hasan Atilla Özkan

{"title":"Prediction of CD34+ hematopoietic stem cells in healthy allogeneic stem cell donors on the Optia cell separator based on CE2: Which formula is more correlated with actual CD34+?","authors":"Sıdıka Gülkan Özkan, Ali Kimiaei, Seyedehtina Safaei, Tarık Ercan, Meral Sönmezoğlu, Gülderen Yanıkkaya Demirel, Sema Aktaş, Sinem Özdemir, Helin Serda Özalp, Hasan Atilla Özkan","doi":"10.1111/trf.17990","DOIUrl":"10.1111/trf.17990","url":null,"abstract":"Background: Peripheral blood-derived hematopoietic stem cells (HSCs) are widely used for various adult stem cell transplants. To obtain sufficient HSCs from healthy volunteer donors during the apheresis process and ensure that the donors are exposed to fewer apheresis-related side effects, calculation methods have been developed for the prediction of processed blood volume or CD34+ count. However, there is no consensus on a formula to predict the volume of blood to be processed or the number of stem cells to be obtained.Objective: This study aimed to estimate the predicted blood volume and CD34+ cell counts using collection efficiency (CE)-based formulas and evaluate their accuracy compared to the actual CD34+ cell counts. It also seeks to identify the factors that affect CE.Methods: Data from 397 healthy, unrelated stem cell donors were retrospectively analyzed. An algorithm using four different CE2 metrics (1st quartile, mean, 3rd quartile, and median) was developed to predict the volume of blood to be processed using the Spectra Optia continuous mononuclear cell collection procedure.Results: When employing the mean CE2 algorithm, the results revealed a strong correlation (r = .894, p < .001) between predicted and actual CD34+ values. The study also identified strong associations between pre-apheresis CD34+, pre-apheresis leukocyte count, the use of two doses of G-CSF, and low CE2.Conclusion: These findings suggest that the mean CE2 algorithm could be a potent, straightforward, and accurate tool for predicting CD34+ stem cell counts in healthy allogeneic stem cell donors and potentially optimizing stem cell collection procedures.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1959-1967"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CONTINUING MEDICAL EDUCATION. 继续医学教育。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 DOI: 10.1111/trf.18015

引用次数: 0

Addressing platelet insecurity - A national call to action. 解决血小板不安全问题--全国行动呼吁。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-08-12 DOI: 10.1111/trf.17987

Eric A Gehrie, Pampee P Young, Sridhar V Basavaraju, Arthur W Bracey, Andrew P Cap, Liz Culler, Nancy M Dunbar, Mary Homer, Iris Isufi, Rob Macedo, Tanya Petraszko, Glenn Ramsey, Christopher A Tormey, Richard M Kaufman, Edward L Snyder

引用次数: 0

Simple formula for adjusted performance parameters in evaluation of diagnostic methods. 诊断方法评估中调整性能参数的简单公式。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-08-15 DOI: 10.1111/trf.17989

Frederik Banch Clausen, Alberte Aspaas Lundquist, Emil Urhammer, Leif Kofoed Nielsen, Klaus Rieneck

引用次数: 0

The effectiveness of telephone surveys on the return of first-time donors: A randomized controlled trial. 电话调查对首次捐献者回归的有效性：随机对照试验。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI: 10.1111/trf.17974

Vanessa C Marsano, Dirk Hasenclever, Reinhard Henschler

{"title":"The effectiveness of telephone surveys on the return of first-time donors: A randomized controlled trial.","authors":"Vanessa C Marsano, Dirk Hasenclever, Reinhard Henschler","doi":"10.1111/trf.17974","DOIUrl":"10.1111/trf.17974","url":null,"abstract":"Background: The management of blood supply depends, among other factors, on the effective remobilization of first-time donors (FTDs). This study investigates the efficacy of telephone calls to increase second donation rates.Study design and methods: A randomized controlled trial was conducted on 418 first-time blood donors. In the telephone group (TG, n = 206), men were contacted 9-10 and women 13-14 weeks after their first donation. They were asked about satisfaction and intention to return, and offered an appointment. The primary outcome was the return rate within 6 months after the first donation.Results: The mean age was 28.8 ± 10.0 years and 59.9% of FTDs were female. In the TG, 89.3% were reached. Approximately 50% of each group had donated a second time by 24.2 weeks for the control group (CG) and 14.8 weeks for the TG. The six-month return rate was 65.0% in the TG and 54.3% in the CG (95%-CI [0.9%; 20.6%]; p = .033). The restricted mean time to return within 6 months was 19.4 weeks in the CG compared to 17.2 weeks in the TG (95%-CI [0.7; 3.7]; p = .004). The intervention effect tended to be larger in men than in women.Discussion: Contacting FTDs by phone after their first donation increases the six-month return rate and reduces the interval to a second donation. Male donors appear to be more receptive to this intervention. Whether the effect of the intervention helps to establish a donor identity in the long term should be the subject of further studies.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1931-1939"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Providing red blood cells to facilitate organ transplant via normothermic perfusion techniques: A single-center experience. 通过常温灌注技术提供红细胞以促进器官移植：单中心经验。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-08-24 DOI: 10.1111/trf.17994

Elizabeth S Allen, Laura D Stephens, Nesinee Weber, Aleah L Brubaker, Ken Hudson, Victor Pretorius, Gabriel Schnickel, Patricia M Kopko

{"title":"Providing red blood cells to facilitate organ transplant via normothermic perfusion techniques: A single-center experience.","authors":"Elizabeth S Allen, Laura D Stephens, Nesinee Weber, Aleah L Brubaker, Ken Hudson, Victor Pretorius, Gabriel Schnickel, Patricia M Kopko","doi":"10.1111/trf.17994","DOIUrl":"10.1111/trf.17994","url":null,"abstract":"Background: Normothermic regional perfusion (NRP) and normothermic machine perfusion (NMP) are organ procurement and transport techniques that can improve organ quality, facilitate longer transport, and reduce postoperative complications, increasing organ availability and improving outcomes. NRP and NMP often require allogeneic red blood cells (RBCs). Our academic transfusion service began providing RBCs to support NRP and NMP for adult heart transplant (HT), orthotopic liver transplant (OLT), and multiorgan transplant (MOT) in August 2020.Methods: This single-center, retrospective study describes the implementation process and analyzes the characteristics of RBC support during the first 3 years of the perfusion programs. Timing and quantity of units issued and used, organ recipient demographics, and transplant outcomes were obtained from transfusion service and electronic medical records.Results: From 2020 to 2023, the transfusion service received 233 requests to support NRP and NMP perfusion cases. Of these, 105 cases resulted in RBC use, and units were returned or discarded in 112 cases. A total of 131 patients received perfusion-facilitated transplants (92 HT, 27 OLT, and 12 MOT). The majority of perfusion-facilitated HTs utilized NRP (81/92, 88%), whereas most perfusion-facilitated OLTs utilized NMP (21/27, 78%). Across all 233 requests, a total of 381 RBC units were used to facilitate 131 transplants, averaging 2.91 units/transplant.Discussion: Provision of RBCs for NRP and NMP techniques represents a novel method for transfusion services to support and facilitate life-saving organ transplants with only modest product use, about three RBC units per organ transplant in this single-center study.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1899-1908"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of blood bank and transfusion medicine practices for pregnant individuals with fetuses at risk of hemolytic disease in the United States. 美国针对有溶血病风险胎儿的孕妇的血库和输血医学实践特点。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-09-09 DOI: 10.1111/trf.18011

Jeremy W Jacobs, Garrett S Booth, Kenneth J Moise, Brian D Adkins, Sara Bakhtary, Ross M Fasano, Ruchika Goel, Hannah D Hinton, Sadia A Laghari, Laura D Stephens, Christopher A Tormey, Elizabeth P Crowe, Evan M Bloch, Elizabeth A Abels

{"title":"Characterization of blood bank and transfusion medicine practices for pregnant individuals with fetuses at risk of hemolytic disease in the United States.","authors":"Jeremy W Jacobs, Garrett S Booth, Kenneth J Moise, Brian D Adkins, Sara Bakhtary, Ross M Fasano, Ruchika Goel, Hannah D Hinton, Sadia A Laghari, Laura D Stephens, Christopher A Tormey, Elizabeth P Crowe, Evan M Bloch, Elizabeth A Abels","doi":"10.1111/trf.18011","DOIUrl":"10.1111/trf.18011","url":null,"abstract":"Background: Hemolytic disease of the fetus and newborn (HDFN) is caused by maternal alloantibody-mediated destruction of fetal/neonatal red blood cells (RBCs). While the pathophysiology has been well-characterized, the clinical and laboratory monitoring practices are inconsistent.Methods: We surveyed 103 US institutions to characterize laboratory testing practices for individuals with fetuses at risk of HDFN. Questions included antibody testing and titration methodologies, the use of critical titers, paternal and cell-free fetal DNA testing, and result reporting and documentation practices.Results: The response rate was 44% (45/103). Most respondents (96%, 43/45) assess maternal antibody titers, primarily using conventional tube-based methods only (79%, 34/43). Among respondents, 51% (23/45) rescreen all individuals for antibodies in the third trimester, and 60% (27/45) perform paternal RBC antigen testing. A minority (27%, 12/45) utilize cell-free fetal DNA (cffDNA) testing to predict fetal antigen status. Maternal antibody titers are performed even when the fetus is not considered to be at risk of HDFN based on cffDNA or paternal RBC antigen testing at 23% (10/43) of sites that assess titers.Discussion: There is heterogeneity across US institutions regarding the testing, monitoring, and reporting practices for pregnant individuals with fetuses at risk of HDFN, including the use of antibody titers in screening and monitoring programs, the use of paternal RBC antigen testing and cffDNA, and documentation of fetal antigen results. Standardization of laboratory testing protocols and closer collaboration between the blood bank and transfusion medicine service and the obstetric/maternal-fetal medicine service are needed.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1870-1880"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142155040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0