Transfusion最新文献

{"title":"Continuing Medical Education.","authors":"","doi":"10.1111/trf.18196","DOIUrl":"https://doi.org/10.1111/trf.18196","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":"65 4","pages":"684"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do we implement a prehospital whole blood administration program for shock trauma patients on a statewide basis?","authors":"Robert A Rosenbaum, Mollee Dworkin, Justin Eisenman, Paul Cowan, Kyle Burch, Jordan Dattoli, David Aber, Kelli Starr-Leach, John Wright, Robert Mauch, Michael Nichols, Mark Logemann, Christopher Johnson, Britany Huss, Michelle E Jones, Dawn Shane, Sydney Kappers, Bruce S Sachais, Kristin M Frederick","doi":"10.1111/trf.18160","DOIUrl":"10.1111/trf.18160","url":null,"abstract":"<p><strong>Background: </strong>Since bleeding is a major cause of early mortality in trauma, there is continued interest in providing transfusion support as early as possible to trauma patients. Various approaches have been taken to accomplish this, including the rapid provision of blood products upon arrival at the hospital, as well as a variety of prehospital approaches. However, implementing prehospital blood availability statewide for use in all populations has been limited.</p><p><strong>Study design and methods: </strong>The program described for prehospital transfusion identifies a direct partnership between state EMS providers and the local blood center. Predictive modeling is compared to early outcome data of the first 100 patients who received whole blood from this program. Additional discussion contains key elements of the program, including planning, validation, and implementation.</p><p><strong>Results: </strong>Between May 2023 and July 2024, an average of 11 prehospital whole blood units were transfused per month against the projected average of 10-16 units administered per month, with the median time to transfusion of 29.2 min. The leading reason for blood administration was due to blunt trauma. Of the patients who were not in prehospital cardiac arrest prior to paramedic arrival or excluded for other reasons, approximately 95% survived to hospital discharge.</p><p><strong>Discussion: </strong>Implementation of prehospital whole blood across the state has demonstrated effectiveness early within the first year of the program. Continued process improvements will be implemented with statewide ground paramedic agency utilization of whole blood as well as expansion into aviation divisions for more expedient whole blood administration times.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"654-663"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a novel variant (c.1-111A>G) located in GATA-1 motif of RHCE proximal promoter in two Chinese patients with the rare D-- phenotype.","authors":"Ran Zhang, Jizhi Wen, Changjiu Tang, Shuangshuang Jia, Qi Chen, Yanli Ji","doi":"10.1111/trf.18223","DOIUrl":"10.1111/trf.18223","url":null,"abstract":"<p><strong>Background: </strong>D-- is a rare phenotype lacking the expression of the C, c, E, and e antigens and several high-frequency antigens on the red cells. Anti-Rh17 (Hr0) could be developed in individuals with the D-- phenotype to cause hemolytic transfusion reactions (HTR) and hemolytic disease of the fetus and newborn (HDFN). Nuleotide(s) change of the RHCE gene and RHCE-D-CE hybrid alleles are the common molecular basis of the D-- phenotype.</p><p><strong>Study design and methods: </strong>One D-- Chinese patient detected in routine RhD and RhCE serologic testing and another D-- Chinese patient identified with anti-Rh17 were recruited. Further RHD, RHCE, and RHAG whole gene sequences were analyzed using the PacBio sequencing. A dual-luciferase reporter assay was performed to verify the effect of the variant identified in the promoter of the RHCE gene on the transcriptional activity of the reporter gene in vitro.</p><p><strong>Results: </strong>A homozygous RHCE*Ce(1-111G)/Ce(1-111G) genotype and a heterozygous RHCE*CeN.08/Ce(1-111G) genotype carried one novel variant (c.1-111A>G) located in the GATA-1 motif of the RHCE proximal promoter was identified in two D-- patients, respectively. In the reporter assay, the luciferase transcriptional activity of the mutant RHCE promoter [c.1-111G] construct reduced from ~1.0 to 0.28 relative luciferase activity normalized to RHCE wild-type, with a ~72% reduction rate.</p><p><strong>Conclusion: </strong>The novel variant of the GATA-1 motif of the RHCE proximal promoter was identified to diminish the binding of the GATA-1 transcription factor and markedly down-regulate the transcription activity of the RHCE gene to abolish the expression of RhCE antigens, causing the rare D-- phenotype.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"669-675"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfusion service staff and anesthesiologists prefer pathogen-reduced cryoprecipitate over conventional cryoprecipitated antihemophilic factor.","authors":"Robert A DeSimone, Pooja Desai, Jordan Brown, Sidney Ong, Denden Benabdessadek, Tobias Cohen, Alexandra Jimenez, Christine Lennon, Meghann M Fitzgerald, Melissa M Cushing","doi":"10.1111/trf.18212","DOIUrl":"https://doi.org/10.1111/trf.18212","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":"65 4","pages":"788-790"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking the role of older donors in a sustainable blood supply.","authors":"Melissa K Hyde, Barbara M Masser, Rachel Thorpe, Aaron Akpu Philip, Amanda Salmon, Theresa L Scott, Tanya E Davison","doi":"10.1111/trf.18190","DOIUrl":"10.1111/trf.18190","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"758-766"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engaging blood donors as advocates: Social media preferences and associations with marketing stimuli.","authors":"Tzadok Moshe, Iryna Rudyk, Racheli Magnezi","doi":"10.1111/trf.18166","DOIUrl":"10.1111/trf.18166","url":null,"abstract":"<p><strong>Background: </strong>Various critical medical procedures would become impossible without blood donations-saving lives in emergencies, surgeries, and chronic conditions like thalassemia. Therefore, it seems crucial to enhance donor recruitment and ensure blood supply. For this, we rate donor motivations and explore associations between donors' engagement with marketing stimuli and willingness to participate in donor recruitment. To help design tailored marketing strategies, this study examines age-specific social media preferences for promoting blood donation.</p><p><strong>Study design and methods: </strong>To reach these objectives, we conducted a cross-sectional survey with 907 donors at Israeli blood-donation centers. Data on donation motivations, social media preferences, and willingness to recruit others were collected through a structured questionnaire.</p><p><strong>Results: </strong>The leading motivators for blood donation were solidarity and marketing stimuli. The results also revealed a significant association between donors' engagement with marketing stimuli and willingness to encourage others to donate blood. The channel preferred by donors of all age groups for promoting blood donation content was WhatsApp. The choice of other social media varied significantly by age. While younger donors (18-30) favored Instagram, other donor age groups (31-50; 51+) preferred Facebook. Based on average values, the most popular social media for promoting blood donation content were WhatsApp, Facebook, and Instagram.</p><p><strong>Discussion: </strong>Insights from this research can support blood collection agencies in refining marketing strategies for donor recruitment. For maximizing the reach of recruitment efforts, it seems essential to use various social media based on donors' age groups.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"708-718"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of a Duffy antigen screening test order with interpretation guide to help optimize resource allocation at an urban safety-net hospital.","authors":"Adeyemi Sofoluwe, Grace Ferri, J Mark Sloan, James Caron, Reggie R Thomasson","doi":"10.1111/trf.18205","DOIUrl":"10.1111/trf.18205","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"652-653"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deglycerolization of manually glycerolized, frozen red cell concentrates using a closed system cell processor.","authors":"Anita Howell, Jayme Kurach, Nishaka William, Angela Hill, Brandie Dennis, Jason P Acker","doi":"10.1111/trf.18156","DOIUrl":"10.1111/trf.18156","url":null,"abstract":"<p><strong>Background: </strong>Historically, red cell concentrates (RCCs) have been manually glycerolized and deglycerolized using an open system (COBE 2991, Terumo). Implementation of a closed system cell processor (ACP-215, Haemonetics) for glycerolization and deglycerolization of RCCs creates a challenge for management of the historic cryopreserved RCC inventory. A study was undertaken to determine whether manually glycerolized frozen RCCs could be deglycerolized using the closed system processor, as the open system processors are being discontinued.</p><p><strong>Study design and methods: </strong>Thirteen ABO/Rh matched RCCs were pooled and split to produce six large (approximately 354 mL) and six small (approximately 244 mL) RCCs. All units were stored for 14 days post-collection, manually glycerolized and frozen at ≤ -65°C for ≥72 h. Half of the units of each size were deglycerolized using the COBE 2991 and resuspended in 0.9% saline, and the remaining units were centrifuged, deglycerolized on the ACP-215, and resuspended AS-3. RBC quality was tested at 24 ± 2 h post-deglycerolization.</p><p><strong>Results: </strong>All units deglycerolized on the ACP-215 had significantly lower hemolysis (p < .001) levels than those processed on the COBE2991. Large ACP-215 deglycerolized units had lower hematocrits (p < .05), hemoglobin (p < .01), and recovery (p = .001) than did large units deglycerolized on the COBE 2991. All ACP-215 units met the regulatory standards for hemolysis, hematocrit, hemoglobin, and recovery.</p><p><strong>Discussion: </strong>The closed-system ACP-215 processor significantly reduced post-deglycerolization hemolysis in all units, and hemoglobin content in large units. The ACP-215, in combination with a centrifugation step, is suitable for processing cryopreserved RCCs that have been manually glycerolized.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"664-668"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expected outcomes of stratified post-donation testing in whole blood donation in England: A discrete event simulation modeling study.","authors":"Hongchao Qi, Angela M Wood, Stephen Kaptoge, Amy McMahon, Susan Mehenny, Nathalie Kingston, Willem H Ouwehand, John Danesh, David J Roberts, Emanuele Di Angelantonio, Lois G Kim","doi":"10.1111/trf.18165","DOIUrl":"10.1111/trf.18165","url":null,"abstract":"<p><strong>Background: </strong>In England, blood donors with low hemoglobin concentration are deferred following on-session testing to prevent donations below regulatory thresholds, thereby protecting donors' health and blood supply quality. However, deferrals are costly, time-consuming and may discourage donors. Post-donation testing (PDT), where hemoglobin levels are measured after donation, offer potential alternatives as used in some European countries.</p><p><strong>Study design and methods: </strong>We compared four PDT strategies to the current approach: (A) no on-session testing, (B) on-session testing if low hemoglobin at previous visit, (C) on-session testing if low/medium hemoglobin at previous visit, all with delayed reinvitation if low hemoglobin at previous donation, and (D) on-session testing if low/medium hemoglobin at previous visit without delayed reinvitations. We employed discrete event simulation modeling, informed by data collected from 16,941 donors returning under the current strategy in England, to simulate and compare total donations, under-threshold donations, and deferrals for each strategy over 18 months.</p><p><strong>Results: </strong>Strategy A eliminated deferrals but led to increased under-threshold donations compared to the current strategy in men (6.5% vs. 2.3%) and women (11.8% vs. 4.5%). Strategies B-D reduced deferrals rates for men (1.0%-3.7% vs. 5.5%) and women (2.2%-6.3% vs. 8.9%) but showed slightly higher under-threshold donations in men (3.0%-5.1% vs. 2.3%) and women (5.3%-8.8% vs. 4.5%). Strategies with more on-session testing had lower under-threshold donations.</p><p><strong>Discussion: </strong>PDT strategies incorporating on-session testing for low/medium hemoglobin at previous visits could reduce deferrals while maintaining a low proportion of under-threshold donations, thereby balancing donor safety with operational efficiency.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"696-707"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel molecular mechanism underlying the In(Lu) phenotype in Brazilians.","authors":"C P Arnoni, C S R Araújo, B A Machado, A Pasqualotti, N M Silva, A Cortez, F R M Latini, L Castilho","doi":"10.1111/trf.18169","DOIUrl":"10.1111/trf.18169","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"E10-E12"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}