Transfusion最新文献

{"title":"Adherence to local rotational thromboelastometry recommendations in the care of trauma patients: A retrospective cohort study.","authors":"Vinyas Harish, Gemma Postill, Fayad Al-Haimus, Melissa McGowan, Katerina Pavenski, Andrew Beckett, Michelle Sholzberg, Brodie Nolan","doi":"10.1111/trf.18349","DOIUrl":"10.1111/trf.18349","url":null,"abstract":"<p><strong>Background: </strong>Rotational thromboelastometry (ROTEM) is a blood test that measures hemostatic parameters to guide hemostatic therapy. ROTEM outputs can be cognitively challenging to interpret, which may limit adherence in trauma care. Our objective was to assess hemostatic therapy administration adherence to local ROTEM recommendations.</p><p><strong>Study design and methods: </strong>We conducted a retrospective cohort study of trauma patients receiving ROTEM testing at a level 1 trauma center between January 1st 2017, and December 31st 2021. Adherence to local ROTEM best practices was determined by comparing the blood products patients received after a patient's first ROTEM test to those that should have been administered based on their ROTEM results. Multivariable logistic regression models were used to determine the association between clinical and patient covariates with ROTEM adherence and between ROTEM adherence and in-hospital mortality.</p><p><strong>Results: </strong>Only 46.6% (n = 208/446) of patients had complete adherence to ROTEM recommendations. Product-specific adherence was lower when product initiation was recommended (vs. not) by ROTEM. A greater number of ROTEM abnormalities (odds ratio [OR]: 0.11, 95% confidence interval [CI]: 0.05-0.19) and a higher injury severity score (OR: 0.96, 95% CI: 0.94-0.98) reduced adherence. Adherence to ROTEM did not reduce in-hospital mortality (OR: 0.71, 95% CI: 0.35-1.41). The number of ROTEM abnormalities was associated with in-hospital mortality (OR: 3.07, 95% CI: 2.01-4.77).</p><p><strong>Discussion: </strong>We found moderate adherence to admission ROTEM recommendations with lower adherence for more severely injured patients. The number of ROTEM abnormalities increased the odds of in-hospital mortality. Quantifying adherence is valuable for understanding ROTEM implementations in trauma care.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1716-1727"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modernizing iron screening: The case for reticulocyte hemoglobin.","authors":"Jesse Qiao, Gagan Mathur","doi":"10.1111/trf.18335","DOIUrl":"10.1111/trf.18335","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1564-1566"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood deserts in a universal health system: Addressing structural inequities in northern Canada.","authors":"Boaz Laor, Shreenik Kundu","doi":"10.1111/trf.18347","DOIUrl":"10.1111/trf.18347","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1746-1750"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare case of warm IgM autoimmune hemolytic anemia.","authors":"Bryan Tordon, Nour Alhomsi, Ali Iqbal, Azim Gangji, Gwen Clarke, Shuoyan Ning","doi":"10.1111/trf.18353","DOIUrl":"10.1111/trf.18353","url":null,"abstract":"<p><p>Cold agglutinins are IgM-mediated autoimmune hemolytic processes that most often cause destruction of red blood cells at colder temperatures. Here we describe a case of a patient with history of living donor renal transplantation that developed an atypical autoantibody causing profound anemia and hemolysis which, although IgM in nature, reacted best at warmer temperatures and was caused by a lymphoproliferative disorder. The investigations and serological findings here raise awareness to less common forms of autoimmune hemolytic disorders and describe specialized tests that can help uncover these antibodies. This case also highlights a rare presentation of post-transplant lymphoproliferative disorder manifesting clinically as hemolytic anemia.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1756-1760"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of cellular composition and T-cell senescence of mononuclear cell concentrates on the manufacturing process of chimeric antigen receptor (CAR) T-cells.","authors":"Vladan Vučinić, Theresa Tumewu, Mandy Brückner, Janine Kirchberg, Madlen Jentzsch, Raymund Buhmann, Yvonne Remane, Sandra Hoffmann, Florian Ramdohr, Maximilian Merz, Klaus H Metzeler, Sebastian Schwind, Carmen Herling, Simon M Krauß, Marco Herling, Georg-Nikolaus Franke, Nora Grieb, Georg Stachel, Martin Janz, Olaf Penack, Lars Bullinger, Ulrich Keller, Michael Cross, Reinhard Henschler, Enrica Bach, Uwe Platzbecker","doi":"10.1111/trf.18354","DOIUrl":"10.1111/trf.18354","url":null,"abstract":"<p><strong>Background: </strong>Apheresis procedure of autologous lymphocytes competent for proliferation and expansion is a crucial step in the production of chimeric antigen receptor (CAR) T-cells. Previous therapies or disease status prior to collection may negatively impact the collections.</p><p><strong>Study design and methods: </strong>We performed a retrospective analysis with the aim to determine cellular factors in association with the collection of autologous T-cells and subsequent CAR T manufacturing toward tisagenlecleucel (tisa-cel). Between February 2019 and February 2022, 63 collections of 54 patients were performed for subsequent therapy with tisa-cel.</p><p><strong>Results: </strong>We observed no difference in median CD3+ cell yields according to the number of prior therapy lines (>3 vs. ≤3, p = .335), prior treatment with bendamustine (p = .954) or marrow infiltration (p = .634). Fifty-six collections were sent for manufacturing, of which 22 (39%) resulted in manufacturing failures, namely terminations (n = 12) or out-of-specification events (n = 10). Collections resulting in manufacturing failures yielded significantly lower CD3+ (p = .005), CD3+CD4+ (p = .044), and non-senescent CD3+CD27+CD28+ (p = .003) counts. Multivariable analysis identified the absolute number of CD3+CD27+CD28+ cells as relevant, with a calculated cut-off of ≥34.58 × 10⁸ CD3+CD27+CD28+ cells for 89.5% probability of successful CAR T-cell production.</p><p><strong>Discussion: </strong>In summary, we report a positive influence of a higher number of non-senescent Τ-cells on successful manufacturing. Further analyses are required to determine measures for further optimization of collection outcomes.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1650-1661"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using geographic information system (GIS) technology to evaluate a hospital-based mobile blood donation program.","authors":"Kristen N Ruby, Walter H Dzik, Julia J Collins, Hongying Tang, Shawn Ela, Robert S Makar","doi":"10.1111/trf.18332","DOIUrl":"10.1111/trf.18332","url":null,"abstract":"<p><strong>Background: </strong>Geographic information system (GIS) technology is widely used in public health to track disease patterns, though its application in transfusion medicine is limited. We report the use of GIS software by a hospital-based blood donor program to examine patterns of blood drive activity.</p><p><strong>Study design and methods: </strong>We performed a 3-year retrospective study examining our donor program's mobile drives. Esri ArcGIS Pro™ software and ArcGIS Online™ were used to create vector and choropleth maps reflecting activity by town.</p><p><strong>Results: </strong>Sixteen thousand nine mobile whole blood donations were identified in 2021-2023. Four hundred and fifty-five mobile blood drives were hosted at 189 unique locations. Seventeen towns within or intersecting a 15-mile radius of our donation center had never been visited by our bloodmobile during the study period, with adult population sizes ranging from approximately 3000 to 53,000 representing donation opportunities. Untapped blood mobile opportunities were also identified in 33 Massachusetts towns (>700,000 adults) with nearby healthcare facilities in our hospital network.</p><p><strong>Discussion: </strong>GIS-generated maps serve as an effective tool to identify previously successful blood donation locations and locations not yet visited by our donor program. Blood collection centers may benefit from future application of ArcGIS analysis tools to identify optimal locations for future mobile blood drives.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1630-1639"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current advances 2024: A critical review of selected topics by the Association for the Advancement of Blood and Biotherapies (AABB) Clinical Transfusion Medicine Committee.","authors":"Elizabeth P Crowe, Jennifer Andrews, Stella T Chou, Claudia S Cohn, Mischa L Covington, Ruchika Goel, Aaron S Hess, Tina S Ipe, Jessica Jacobson, Cyril Jacquot, Jenna Khan, Michael F Murphy, Kerry O'Brien, Monica B Pagano, Anil K Panigrahi, Jacqueline N Poston, Eric Salazar, Nabiha H Saifee, Moritz Stolla, Nicole D Zantek, Alyssa Ziman, Ryan A Metcalf","doi":"10.1111/trf.18330","DOIUrl":"10.1111/trf.18330","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1728-1737"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Openness about sexuality predicts deferral policy noncompliance among recent MSM (men who have sex with men) blood donors: An exploratory analysis.","authors":"Koson Tony Sriamporn, Nathan S Consedine, Peter J W Saxton","doi":"10.1111/trf.18352","DOIUrl":"10.1111/trf.18352","url":null,"abstract":"<p><strong>Background: </strong>Blood service providers use deferral policies to reduce the risk of transfusion-transmitted infections, but policy effectiveness depends on donors' honesty in disclosing risk behaviors. Identifying specific social factors within men who have sex with men (MSM) may provide insight into noncompliance with sexual behavioral deferral criteria.</p><p><strong>Methods: </strong>We identified a sample of 136 recent blood donors from a large behavioral surveillance survey of MSM in New Zealand. Univariate analyses were used to identify factors associated with self-reported noncompliance before a two-step hierarchical regression assessed whether MSM-related social factors added to the prediction of noncompliance, compared to only considering background characteristics.</p><p><strong>Results: </strong>Incorporating the MSM-related social factors significantly enhanced the model fit, explaining 23.2% additional variance in noncompliance (Nagelkerke R² = 0.331, p = .002). Only MSM who were more open about their sexuality had increased odds of noncompliance (Odds ratio 5.25, 95% Confidence Interval 1.78-15.48, p = .003). Full-time employment remained a predictor of lower noncompliance in the final model (OR 0.19, 95% CI 0.05-0.69, p = .012).</p><p><strong>Conclusion: </strong>This exploratory evidence suggests that blood service providers should consider the broader social context, particularly openness about sexuality, in understanding noncompliance with time-based sexual behavior donor deferral criteria. This \"outness\" in MSM donors likely reflects confidence in making disclosure decisions based on their perceived HIV risk, challenging the notion that noncompliance necessarily arises from discomfort or lack of knowledge about policies. Future research should explore the gap between perceived risk and policy understanding to better address MSM donors' complex decision-making processes.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":"65 9","pages":"1586-1591"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Epitope-based matching for platelet transfusion overview: Is it time?\"-Insights and future directions from the 2024 American Red Cross symposium on platelet component selection.","authors":"Neng Yu, Sandhya Panch, Kirti Mepani, Simon Stanworth, Carolina Bonet-Bub, Loren Gragert, Vanessa Menard, Massimo Mangiola, Martin Maiers, Noureddine Berka","doi":"10.1111/trf.18392","DOIUrl":"https://doi.org/10.1111/trf.18392","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How we implement a prehospital transfusion program.","authors":"Emily Coberly, John Barry, Bethany Brown, Tracy Cameron, Joyisa Deb, Justine Garza, Divjot Singh Lamba, Janine Shepherd, Erin Tuott, Barbara Swanson, Jed Gorlin, Yvette Tanhehco","doi":"10.1111/trf.18389","DOIUrl":"https://doi.org/10.1111/trf.18389","url":null,"abstract":"<p><strong>Background: </strong>Prehospital blood transfusions are necessary in certain situations that involve significant bleeding to prevent fatality.</p><p><strong>Study design and methods: </strong>Members of the AABB Donor and Blood Component Management Prehospital working group collaborated to provide a consensus review of best practices in the implementation of a prehospital transfusion program.</p><p><strong>Results: </strong>Several logistic paradigms exist in terms of how blood products are provided to emergency medical services (EMS). Each paradigm has pros and cons and should be adopted according to the specific environmental and operational needs of the states, regions, and agencies they serve. Low titer group O whole blood (LTOWB) has been successfully used in prehospital programs, but blood components such as packed red blood cells (pRBCs) and liquid plasma may also be used. All blood products carried by EMS must be transported and stored according to the same regulatory requirements set by the United States Food and Drug Administration. Processes must be in place to minimize wastage of blood products carried by EMS due to product expiration to preserve this limited resource. Barriers to the implementation of a prehospital transfusion program include scope of practice limitations, program costs, blood product reimbursement, cost of wastage, and collaboration between prehospital agencies, blood suppliers, and hospital transfusion services.</p><p><strong>Discussion: </strong>Program implementation requires significant collaboration among different business entities with a carefully written and executed agreement. Despite the barriers, prehospital transfusion programs are worthy endeavors with the potential to save lives.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}