Transfusion最新文献_第9页

Pediatric autologous peripheral blood stem cell collection without heparin using a highly concentrated sodium citrate anticoagulant: A retrospective comparison with standard ACD-A. 使用高浓度柠檬酸钠抗凝剂收集不使用肝素的儿童自体外周血干细胞：与标准ACD-A的回顾性比较。

IF 2 3区医学

Transfusion Pub Date : 2026-04-01 Epub Date: 2026-02-02 DOI: 10.1111/trf.70102

Keiko Fujii, Wataru Kitamura, Kana Washio, Kazuhiro Ikeuchi, Joji Shimono, Hiroyuki Murakami, Fumio Otsuka, Yoshinobu Maeda, Nobuharu Fujii

{"title":"Pediatric autologous peripheral blood stem cell collection without heparin using a highly concentrated sodium citrate anticoagulant: A retrospective comparison with standard ACD-A.","authors":"Keiko Fujii, Wataru Kitamura, Kana Washio, Kazuhiro Ikeuchi, Joji Shimono, Hiroyuki Murakami, Fumio Otsuka, Yoshinobu Maeda, Nobuharu Fujii","doi":"10.1111/trf.70102","DOIUrl":"10.1111/trf.70102","url":null,"abstract":"Background: Heparin combined with sodium citrate has been used in leukocytapheresis for pediatric patients. Since 2022, we have performed leukocytapheresis using a highly concentrated sodium citrate solution (HSC, 5.32%) instead of acid citrate dextrose solution A (ACD-A). We conducted this study to determine whether HSC use reduces run time and the total amount of anticoagulant solution in children.Study design and methods: We retrospectively analyzed data from consecutive autologous peripheral blood stem cell harvests (auto-PBSCHs) between June 2012 and May 2025, including patient characteristics, mobilization methods, protocol used, anticoagulant type, run time, total anticoagulant solution volume, and collection efficiency.Results: Auto-PBSCH was performed using the mononuclear cell collection (MNC) protocol in 28 procedures and the continuous MNC protocol in 20 procedures. ACD-A was used in 35 procedures and HSC in 13. The run time was significantly shorter (204 [range, 117-302] vs. 157 min [range, 103-227], p = .02) in the HSC group and also confirmed in multivariable regression analysis (coefficient, -55.6; 95% confidence interval, -106.2 to -5.04; p = .03). In a subgroup analysis of cMNC procedures, CD34+ collection efficiency showed a strong negative correlation with the proportion of run time devoted to establishing the initial interface (r = -.73, p = .0003).Conclusion: Delays in establishing the initial interface can reduce the duration of the effective MNC collection phase and may negatively affect collection efficiency. Careful attention to the initial interface phase is therefore warranted when using HSC.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"677-688"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13049261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuing Medical Education. 继续医学教育。

IF 2 3区医学

Transfusion Pub Date : 2026-04-01 DOI: 10.1111/trf.70177

引用次数: 0

Equivalent and resource-saving: Whole blood versus component therapy for trauma resuscitation. 等效和节省资源：全血与成分治疗在创伤复苏中的应用。

IF 2 3区医学

Transfusion Pub Date : 2026-04-01 Epub Date: 2026-01-28 DOI: 10.1111/trf.70100

Jacob W Roden-Foreman, Michael E Johnston, Nicole Lunardi, Pamela J Jensen, Tanya Robohm, Michael Cheung, Philip Edmundson, Brian Tibbs

{"title":"Equivalent and resource-saving: Whole blood versus component therapy for trauma resuscitation.","authors":"Jacob W Roden-Foreman, Michael E Johnston, Nicole Lunardi, Pamela J Jensen, Tanya Robohm, Michael Cheung, Philip Edmundson, Brian Tibbs","doi":"10.1111/trf.70100","DOIUrl":"10.1111/trf.70100","url":null,"abstract":"Background: Use of low-titer O+ whole blood (LTOWB) in civilian trauma has increased in recent years. This project evaluated multiple patient-centered and resource-related outcomes related to the initiation of our facility's LTOWB program in November 2020.Study design and methods: This retrospective cohort study examined patients receiving component therapy versus LTOWB within 4 h of arrival to our trauma center in November 2018 to 2022. Females were excluded due to ineligibility. After 1:1 matching, double-robust estimation was used to model outcomes.Results: A total of 218 patients were included. LTOWB was associated with equivalent or better outcomes for all variables assessed. Overall mortality was similar between groups (hazard ratio = 1.05, 95% CI = 0.65-1.68). Emergency department mortality was lower in patients receiving LTOWB (12.7% vs. 20.9%, p = 0.006). Among survivors, lengths of stay were non-significantly shorter with LTOWB (13 ± 14 days vs. 17 ± 29 days, p = 0.096). Among non-survivors, patients who received LTOWB survived longer before succumbing (1.3 ± 3.1 days vs. 0.2 ± 0.6 days, p = 0.012). Total massive transfusion volumes, including LTOWB, were 40% lower with LTOWB (rate ratio = 0.60, 95% CI = 0.43-0.85).Discussion: This evaluation of our LTOWB program indicates many outcomes are similar with LTOWB and component therapy. However, LTOWB patients survived longer during initial resuscitation and had lower massive transfusion requirements. This represents an opportunity to conserve blood products and provides opportunities for surgical rescue in severely injured patients.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"770-776"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146067287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon monoxide treatment rescues leukofiltration and preserves storage quality of red blood cell concentrates from sickle cell trait donors. 一氧化碳处理挽救了白细胞过滤，并保持了镰状细胞特征供者红细胞浓缩物的储存质量。

IF 2 3区医学

Transfusion Pub Date : 2026-04-01 Epub Date: 2026-01-31 DOI: 10.1111/trf.70103

Sofiane Driouche, Laurent Kiger, Stephane Moutereau, Nadir Mouri, Katy Drémont, Sabine Cléophax, Laura Bencheikh, Vincent Malcor Deydier de Pierrefeu, Remy Tristan, Emmanuel Adu, Sadaf Pakdaman, Pablo Bartolucci, Véronique Baudin-Creuza, France Pirenne, Yves Beuzard, Kim-Anh Nguyen

{"title":"Carbon monoxide treatment rescues leukofiltration and preserves storage quality of red blood cell concentrates from sickle cell trait donors.","authors":"Sofiane Driouche, Laurent Kiger, Stephane Moutereau, Nadir Mouri, Katy Drémont, Sabine Cléophax, Laura Bencheikh, Vincent Malcor Deydier de Pierrefeu, Remy Tristan, Emmanuel Adu, Sadaf Pakdaman, Pablo Bartolucci, Véronique Baudin-Creuza, France Pirenne, Yves Beuzard, Kim-Anh Nguyen","doi":"10.1111/trf.70103","DOIUrl":"10.1111/trf.70103","url":null,"abstract":"Background: Filtration failures in sickle cell trait (SCT, AS) blood donations limit the availability of antigen-matched red blood cell concentrates (RBCCs) for transfusion. Carbon monoxide (CO), by stabilizing hemoglobin in its high-affinity relaxed state, may prevent filter clogging and restore leukofiltration efficiency. However, the storage quality and stability of CO-treated RBCCs remain to be evaluated.Study design and methods: RBCCs from normal (AA) donors and AS donors with prior leukofiltration failure were categorized as AA-NC (untreated AA), AA-CO (CO-treated AA), and AS-CO (CO-treated AS). CO treatment consisted of exposing RBCCs to CO gas under controlled conditions before leukofiltration. Filtration success, hematological parameters, metabolic stability, oxidative stress markers, and hemolysis parameters were analyzed on days 0, 14, 28, and 42.Results: CO treatment reversed filter clogging in AS RBCCs, enabling successful leukofiltration without significant hemolysis. It induced approximately 90% COHb, with a slight increase in MetHb due to the injection technique, which remained stable throughout the 42-day storage period. Hematological and metabolic parameters were preserved across groups. CO also reduced free Hb oxidation in both AA and AS RBCCs and limited storage lesions in AA RBCCs, whereas AS RBCs remained more prone to senescence at the end of storage.Discussion: CO treatment enables successful leukofiltration of previously non-filterable AS RBCCs and helps preserve RBC quality during storage. This strategy could enhance the availability of antigen-matched RBCCs and improve transfusion safety in sickle cell disease.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"729-741"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the concept of novelty in hybrid cord blood banking models. 论混合脐带血银行模式的新颖性概念。

IF 2 3区医学

Transfusion Pub Date : 2026-04-01 Epub Date: 2026-02-24 DOI: 10.1111/trf.70142

Durmus Burgucu, Ali Imran Dastan

引用次数: 0

Transfusion requirements in recipients of plasma units from blood donors with recent SARS-CoV-2 infection. 近期感染SARS-CoV-2的献血者血浆单位接受者的输血需求

IF 2 3区医学

Transfusion Pub Date : 2026-04-01 Epub Date: 2026-02-04 DOI: 10.1111/trf.70118

Nareg H Roubinian, Colleen Plimier, Bryan R Spencer, Marjorie Bravo, Brian Custer, Angelo D'Alessandro, Steve Kleinman, Philip J Norris, Michael P Busch

{"title":"Transfusion requirements in recipients of plasma units from blood donors with recent SARS-CoV-2 infection.","authors":"Nareg H Roubinian, Colleen Plimier, Bryan R Spencer, Marjorie Bravo, Brian Custer, Angelo D'Alessandro, Steve Kleinman, Philip J Norris, Michael P Busch","doi":"10.1111/trf.70118","DOIUrl":"10.1111/trf.70118","url":null,"abstract":"Introduction: SARS-CoV-2 infection is associated with hypercoagulability in patients with Coronavirus disease (COVID-19). We used a vein-to-vein database to examine the impact of transfusion of plasma units from blood donors with recent SARS-CoV-2 infection.Study design and methods: We linked donor SARS-CoV-2 serology data with plasma transfusions occurring between 6/1/2020 and 3/31/2022. Using multivariable regression, we examined changes in the international normalized ratio (INR) and subsequent transfusion requirements following plasma transfusion relative to the timing of donor SARS-CoV-2 nucleocapsid antibody (anti-N Ab) positivity.Results: We identified 2350 adults who received 5397 plasma units with donor SARS-CoV-2 serology data as part of 3721 plasma transfusion events. 8.1% (436/5397) of plasma units were from anti-N Ab positive donors, and median time from index seropositivity to donation was 89 days (interquartile range [IQR] 0-210). In recipients of plasma units from recently SARS-CoV-2 infected donors (<120 days), the adjusted odds of a 0.25 per unit lowering of the INR were increased (aOR 1.6 [1.1-2.5]; p = .03) and the odds of additional plasma transfusions within 24 h were decreased (aOR 0.6 [0.4-0.9]; p = .04).Conclusion: Recipients of plasma units from blood donors with recent SARS-CoV-2 infection were more likely to have post-transfusion reductions in the INR and less likely to require additional plasma transfusions.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"651-655"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146120299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum-derived albumin as a cryoprotective agent for the long-term storage of red blood cells: A preliminary examination. 血清来源的白蛋白作为长期储存红细胞的冷冻保护剂：初步研究。

IF 2 3区医学

Transfusion Pub Date : 2026-03-30 DOI: 10.1111/trf.70192

Thomas Bailey-Schmidt, Christine V Saunders, Chloë E George, Thomas G Scorer, Lynn M R McCallum, Tracey E Madgett

{"title":"Serum-derived albumin as a cryoprotective agent for the long-term storage of red blood cells: A preliminary examination.","authors":"Thomas Bailey-Schmidt, Christine V Saunders, Chloë E George, Thomas G Scorer, Lynn M R McCallum, Tracey E Madgett","doi":"10.1111/trf.70192","DOIUrl":"https://doi.org/10.1111/trf.70192","url":null,"abstract":"Background: Cryopreservation extends the shelf life of red blood cells (RBC) from weeks to years, offering major advantages for blood banking logistics, especially in remote environments. However, current glycerol-based methods, though effective, are limited in scope due to complex post-thaw washing and incompatibility with routine clinical workflows. This study evaluated plasma-derived albumin as a potential alternative cryoprotective agent (CPA) for human RBC.Study design and methods: Donor-derived RBC were suspended in 25% w/v bovine serum albumin (BSA) prepared in various diluents and tested for biocompatibility and cryoprotective efficacy under rapid freezing (immersion in liquid nitrogen) and gradual freezing with storage at -80°C. Post-thaw recovery was quantified by measuring hemolysis after resuscitation of frozen cells to 37°C.Results: Albumin-based media were non-toxic, maintaining >99% RBC recovery prior to freezing. When rapidly frozen, albumin conferred strong cryoprotection (≥95% recovery) in salt-rich diluents such as SAG-M, Hartmann's, and Alsever's solutions, exceeding that of glycerol-based CPA (77 ± 25%). Albumin's cryopreservative efficacy was enhanced in ionic media of neutral pH but was absent entirely under gradual freezing (<20% recovery).Discussion: The cryoprotective effect of albumin appears dependent on rapid cooling and ionic co-solutes, suggesting a mechanism rooted in colloid-ion interactions rather than direct inhibition of ice formation. The dependence on freeze rate and ionic environment suggests that multiple solution properties contribute to its efficacy. While further work is required to clarify underlying mechanisms, albumin-based methods may provide a basis for a simplified method of cryopreservation.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping ionized calcium levels and evaluating the outcome of prehospital calcium supplementation in acute trauma and hemorrhagic shock. 急性创伤和失血性休克患者院前补钙的结果及离子钙水平测定

IF 2 3区医学

Transfusion Pub Date : 2026-03-29 DOI: 10.1111/trf.70176

Richard W Walsh, Michael A Meledeo, Susannah E Nicolson, Antonio O Sanchez, Hernandez Rivera Orlando, Xiaowu Wu

{"title":"Mapping ionized calcium levels and evaluating the outcome of prehospital calcium supplementation in acute trauma and hemorrhagic shock.","authors":"Richard W Walsh, Michael A Meledeo, Susannah E Nicolson, Antonio O Sanchez, Hernandez Rivera Orlando, Xiaowu Wu","doi":"10.1111/trf.70176","DOIUrl":"https://doi.org/10.1111/trf.70176","url":null,"abstract":"Background: Hypocalcemia is correlated with poor outcomes in trauma patients and is considered the fourth component in the \"diamond of death\" alongside acidosis, coagulopathy, and hypothermia.Study design and methods: We characterized the kinetics of ionized calcium (iCa) at the point of injury and evaluated the efficacy of prehospital calcium supplementation in a rat model of lethal decompensated hemorrhagic shock. iCa and parathyroid hormone (PTH) were measured in models of hemorrhage-alone (H) or blunt trauma with hemorrhage (TH). Linear regression was used to analyze the correlation between iCa and key laboratory parameters.Results: Both the H and TH models demonstrated a significant decrease in iCa shortly after the onset of injury. iCa levels were negatively correlated with heart rate, lactate, and sodium. A compensatory increase in PTH was observed in both models. In the H model, a single 20 mg/kg dose of calcium gluconate (CG) alone failed to improve survival. Plasma administration improved survival; however, concurrent administration of CG failed to fully correct hypocalcemia or provide additional benefit.Conclusion: This study demonstrates that while hypocalcemia occurs early and consistently in both models of trauma-hemorrhage, simple calcium repletion is insufficient to improve survival. The lack of additional benefit from calcium supplementation when combined with life-saving plasma suggests that the underlying pathophysiology is more complex than a simple calcium deficit. Future strategies must look beyond mere repletion, investigate other primary drivers of trauma-induced hypocalcemia, and optimize the dosing of calcium supplementation.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transfusion reactions after whole blood transfusion in Norway, 2021-2024: A report from the Norwegian Hemovigilance program. 挪威全血输血后的输血反应，2021-2024：来自挪威血液警戒计划的报告。

IF 2 3区医学

Transfusion Pub Date : 2026-03-29 DOI: 10.1111/trf.70193

Bjarte Skoe Erikstein, Thomas Larsen Titze, Barbora Jacobsen, Tor Hervig, Are Engum, Torunn Oveland Apelseth, Øystein Flesland

{"title":"Transfusion reactions after whole blood transfusion in Norway, 2021-2024: A report from the Norwegian Hemovigilance program.","authors":"Bjarte Skoe Erikstein, Thomas Larsen Titze, Barbora Jacobsen, Tor Hervig, Are Engum, Torunn Oveland Apelseth, Øystein Flesland","doi":"10.1111/trf.70193","DOIUrl":"https://doi.org/10.1111/trf.70193","url":null,"abstract":"Background: Whole blood (WB) transfusion for major hemorrhage in Western civilian settings has seen a resurgence over the past two decades. This study aims to determine the rate and type of adverse reactions (ARs) following WB transfusion in Norway between 2021 and 2024.Study design and methods: This retrospective quality surveillance study analyzed, validated, and aggregated all digital reports of ARs after WB transfusion submitted to the Norwegian Hemovigilance system.Results: Seven ARs were identified, corresponding to an incidence rate of 2.53 per 1000 WB transfusions (7 per 2766 transfusions) or 0.253% (95% CI: 0.123%-0.521%). Three cases were classified as acute hemolytic transfusion reactions: one due to ABO minor incompatibility, one to anti-Jka, and one associated with an unidentified red blood cell alloantibody. One case involved respiratory distress and was diagnosed as transfusion-associated dyspnea. Two reactions were allergic: one mild and one fulfilling the criteria for transfusion-associated anaphylaxis. The most severe case involved cardiac arrest, probably due to hyperkalemia and hypocalcemia following massive transfusion, but the patient made a full recovery after defibrillation.Discussion: These findings indicate that WB transfusion in Norway is safe. However, there are inherent risks for blood transfusion in general and also risks more specific to WB transfusion. These include the presence of red blood cell alloantibodies anti-A and anti-B combined with approximately 250 mL plasma from a single donor. Accurate and timely hemovigilance work is important to safeguard patient outcomes and provide a foundation for targeted risk mitigation strategies for WB transfusion.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2 3区医学

Transfusion Pub Date : 2026-03-28 DOI: 10.1111/trf.70196

Mackenzie Foster, Miriam Brown, Angela Mueller, Toufik Tahiri, Kaycie Atchison, Deva Sharma, Cosby A Stone, Jonathan Tucci, Garrett S Booth, Jeremy W Jacobs

{"title":"Transfusion-related alpha-gal syndrome: Two new cases expanding the demographic and geographic spectrum, and evidence of a diagnostic gap in allergic transfusion reaction evaluation.","authors":"Mackenzie Foster, Miriam Brown, Angela Mueller, Toufik Tahiri, Kaycie Atchison, Deva Sharma, Cosby A Stone, Jonathan Tucci, Garrett S Booth, Jeremy W Jacobs","doi":"10.1111/trf.70196","DOIUrl":"10.1111/trf.70196","url":null,"abstract":"Background: Transfusion-related alpha-gal syndrome (TRAGS) has recently been proposed as a cause of allergic transfusion reactions (ATRs) in which alpha-gal-specific IgE in sensitized group O (or potentially group A) recipients reacts with epitopes on group B or AB plasma-containing components. Fewer than 10 cases have been reported, all from the Northeast and mid-Atlantic United States, and alpha-gal-specific ATR evaluation practices are unstudied.Study design and methods: Two patients with ATRs consistent with TRAGS at a large academic medical center in Nashville, Tennessee are reported alongside a 5-year retrospective cohort analysis of group O and A recipients experiencing ATRs following transfusion of group B or AB plasma-containing products. Alpha-gal IgE testing, AGS diagnosis documentation, and documented consideration of IgA deficiency were assessed for each qualifying reaction.Results: Both index patients had pre-existing AGS diagnoses unrecognized at component selection; one was a 42-year-old female and the second an 83-year-old male. Among 50 qualifying ATRs in 44 patients, including 13 severe or anaphylactic reactions, alpha-gal IgE testing was not performed for any event, and no patient had a documented AGS diagnosis. IgA deficiency was considered in eight patients (18%), yielding no diagnoses.Conclusion: TRAGS occurs in the tick-endemic southeastern United States across a broader demographic range than previously recognized. IgA deficiency, present in <0.3% of the population, was considered in 18% of qualifying patients while alpha-gal sensitization, affecting 20%-30% in this region, was investigated in none. Integration of AGS history into pre-transfusion risk assessment and ATR evaluation protocols is warranted.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147532282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0