Transfusion最新文献_第9页

Novel RHD allele with c.487-2A>G (IVS3-2A>G) variant causing RhD negative phenotype. c.487-2A>G (IVS3-2A>G)变异的新型 RHD 等位基因导致 RhD 阴性表型。

IF 2.5 3区医学

Transfusion Pub Date : 2024-09-01 Epub Date: 2024-08-02 DOI: 10.1111/trf.17979

Yuli Zhu, Lihong Jiang, Zhihui Feng, Aiying Wang

引用次数: 0

Four novel ABO*B alleles associated with reduced B antigen expression. 四种与 B 抗原表达减少有关的新型 ABO*B 等位基因。

IF 2.5 3区医学

Transfusion Pub Date : 2024-09-01 Epub Date: 2024-08-08 DOI: 10.1111/trf.17969

Yan Li, Liling Zhou, Wei Han, Zhaoze Ma, Chenlong Wang

引用次数: 0

2024 Poster Information. 2024 年海报信息。

IF 2.5 3区医学

Transfusion Pub Date : 2024-09-01 DOI: 10.1111/trf.18002

引用次数: 0

2024 Abstract Reviewers. 2024 摘要审阅人。

IF 2.5 3区医学

Transfusion Pub Date : 2024-09-01 DOI: 10.1111/trf.17999

引用次数: 0

Characterization of the alcohol biomarker phosphatidylethanol in donor whole blood and apheresis red blood cells: Implications for transfusion recipients. 供体全血和无细胞红细胞中酒精生物标志物磷脂酰乙醇的特征：对输血者的影响。

IF 2.5 3区医学

Transfusion Pub Date : 2024-09-01 Epub Date: 2024-07-09 DOI: 10.1111/trf.17942

Theresa N Kinard, Pragya Sharma, Kathy N Alegria, Loralie J Langman, Paul J Jannetto, Christine L H Snozek

{"title":"Characterization of the alcohol biomarker phosphatidylethanol in donor whole blood and apheresis red blood cells: Implications for transfusion recipients.","authors":"Theresa N Kinard, Pragya Sharma, Kathy N Alegria, Loralie J Langman, Paul J Jannetto, Christine L H Snozek","doi":"10.1111/trf.17942","DOIUrl":"10.1111/trf.17942","url":null,"abstract":"Introduction: Phosphatidylethanol (PEth) is a long-term marker of alcohol consumption used frequently in clinical scenarios such as liver transplant evaluation. Recent cases have demonstrated that packed red blood cell (pRBC) transfusion creates the potential for artificial elevation or decrease of observed PEth concentrations in recipients. Very little is known about the prevalence or stability of PEth in pRBCs.Methods: Apheresis and whole-blood (WB) donations were tested for PEth using liquid chromatography - tandem mass spectrometry with limit of quantitation 10 ng/mL. Units were stored under routine blood bank conditions to evaluate the stability of PEth and the impact of irradiation.Results: Over 40% of apheresis and WB donors had PEth ≥10 ng/mL (maximum observed 587 ng/mL). As WB units were processed into component pRBCs, PEth concentrations increased and were higher than donor WB levels (EDTA sample) prior to collection (maximum observed 711 ng/mL). Storage for up to 5 weeks post donation resulted in mean 17.3% decrease in PEth-positive units; in contrast to a prior report, we observed no PEth formation in units with negative (<10 ng/mL) baseline concentrations. Irradiation of pRBCs did not substantially affect PEth concentrations in either PEth-positive or PEth-negative units.Discussion: PEth concentrations in healthy blood donors may potentially confound alcohol use or abstinence assessment in pRBC recipients. Transfusion medicine services and clinical practices such as transplantation and behavioral medicine should recognize this phenomenon and collaborate on testing protocols to appropriately interpret PEth in pRBC recipients.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fatal posterior reversible encephalopathy syndrome after blood transfusion in a patient with myelodysplastic syndromes. 骨髓增生异常综合征患者输血后出现致命的后可逆性脑病综合征。

IF 2.5 3区医学

Transfusion Pub Date : 2024-09-01 Epub Date: 2024-07-23 DOI: 10.1111/trf.17968

Ken Takigawa, Takahiro Shima, Chiaki Kubara, Shun Akamine, Sae Utsumi, Teruhiko Yoshino, Mariko Minami, Masayasu Hayashi, Yayoi Matsuo, Takuro Kuriyama, Reiko Yoneda, Shuichi Taniguchi, Tetsuya Eto

{"title":"Fatal posterior reversible encephalopathy syndrome after blood transfusion in a patient with myelodysplastic syndromes.","authors":"Ken Takigawa, Takahiro Shima, Chiaki Kubara, Shun Akamine, Sae Utsumi, Teruhiko Yoshino, Mariko Minami, Masayasu Hayashi, Yayoi Matsuo, Takuro Kuriyama, Reiko Yoneda, Shuichi Taniguchi, Tetsuya Eto","doi":"10.1111/trf.17968","DOIUrl":"10.1111/trf.17968","url":null,"abstract":"Background: Posterior reversible encephalopathy syndrome (PRES) is known as a transfusion-related complication with typically favorable prognosis and no report fatalities. Pathological evaluation of PRES is also scarce.Case report: An 88-year-old female with myelodysplastic syndromes (MDS) attended our hospital because of a compression fracture and chronic heart failure with chronic anemia. While her hemoglobin levels improved from 4.6 to 8.0 g/dL and the pleural effusions substantially decreased following six units of red blood cell transfusion and diuretic therapy, a gradual decline in cognitive function and speech reduction was noted. PRES was diagnosed by magnetic resonance imaging of the head. Despite treatment of intensive supportive care, the patient fell into a coma by the 20th day and passed away on the 22nd day. Although the pathophysiological link between blood-transfusion-related PRES and its impact on survival is not fully understood, autopsy findings confirmed the diagnosis of PRES and revealed multiple cerebral hemorrhages that were not detected in earlier imaging studies.Conclusion: This case highlights the importance of vigilant monitoring and management of PRES, especially in high-risk populations such as elderly patients with multiple comorbidities or those with thrombocytopenia. Further studies are needed to elucidate the mechanisms of PRES in patients with hematologic diseases.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three novel Er blood group system alleles and insights from protein modeling. 三种新型 Er 血型系统等位基因和蛋白质建模的启示。

IF 2.5 3区医学

Transfusion Pub Date : 2024-09-01 Epub Date: 2024-07-25 DOI: 10.1111/trf.17965

William J Lane, Sunitha Vege, Helen H Mah, Gorka Ochoa-Garay, Christine Lomas-Francis, Connie M Westhoff

{"title":"Three novel Er blood group system alleles and insights from protein modeling.","authors":"William J Lane, Sunitha Vege, Helen H Mah, Gorka Ochoa-Garay, Christine Lomas-Francis, Connie M Westhoff","doi":"10.1111/trf.17965","DOIUrl":"10.1111/trf.17965","url":null,"abstract":"Background: The Er blood group system was recently shown to be defined by PIEZO1. The system consists of high prevalence antigens Era, Er3, ERSA, and ERAMA; and low prevalence antigen Erb. Era/Erb are antithetical with Er(a-b+) defined by the ER*B allele [c.7180G>A p.(Gly2394Ser)]. A nonsense variant c.5289C>G p.(Tyr1763*) is associated with a predicted Ernull phenotype, and a missense variant c.7174G>A p.(Glu2392Lys) in close proximity to p.2394 causes loss of both Era and Erb expression.Study design and methods: We investigated PIEZO1 in four Er(a-) individuals who presented with anti-Era. Whole genome sequencing (WGS) and Sanger sequencing were performed. The location and structural differences of predicted protein changes were visualized using the predicted 3-D structure of Piezo1 created using AlphaFold2.Results: One individual was homozygous for the reported ER*B. A second had a novel heterozygous nonsense variant c.3331C>T p.(Gln1111*), but a second allelic variant was not found. In the remaining two individuals, two different heterozygous novel missense variants, c.7184C>T p.(Ala2395Val) or c.7195G>A p.(Gly2399Ser), were in trans to the reported c.7180G>A variant, ER*B. AlphaFold2 protein modeling showed that each of the missense variants is predicted to encode an altered structural conformation near Era and Erb.Conclusions: Investigation of archived samples resulted in the identification of three novel PIEZO1 alleles including a predicted Ernull and two missense variants. Structural modeling suggests that the missense changes potentially alter Era/Erb epitope expression with p.2399Ser resulting in a small increase in the negative electrostatic potential.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Estimating Waiting Time for Compatible Blood: A Negative Binomial Approach". 对 "估计兼容血液的等待时间：负二项法"。

IF 2.5 3区医学

Transfusion Pub Date : 2024-09-01 Epub Date: 2024-08-17 DOI: 10.1111/trf.17976

引用次数: 0

Efficacy and safety of novel freeze-dried plasma products in a porcine combat casualty model. 新型冻干血浆产品在猪战伤模型中的有效性和安全性。

IF 2.5 3区医学

Transfusion Pub Date : 2024-09-01 Epub Date: 2024-08-09 DOI: 10.1111/trf.17971

Frédérique Dufour-Gaume, Vénétia Cardona, Audrey Bordone, Florent Montespan, Philippe Vest, Anne-Margaux Legland, Nadira Frescaline, Nicolas Prat

{"title":"Efficacy and safety of novel freeze-dried plasma products in a porcine combat casualty model.","authors":"Frédérique Dufour-Gaume, Vénétia Cardona, Audrey Bordone, Florent Montespan, Philippe Vest, Anne-Margaux Legland, Nadira Frescaline, Nicolas Prat","doi":"10.1111/trf.17971","DOIUrl":"10.1111/trf.17971","url":null,"abstract":"Background: Hemorrhagic shock is well documented as a leading cause of preventable fatalities among military casualties. During military operations plasma can be transfused while waiting for whole blood. This study was conducted to assess the safety and efficacy of two new freeze-dried plasma formulations in a porcine model of traumatic hemorrhagic shock.Study design and methods: In the face of species-specific transfusion, transfusible blood products were derived from porcine sources. The efficacy of three lyophilized plasma (LP) formulations was evaluated: lyophilized plasma (LP), concentrated lyophilized plasma (CLP), and platelet-rich concentrated lyophilized plasma (PCLP). Pigs were subjected to multi-trauma and hemorrhagic shock. Ninety minutes post-shock induction, the animals were treated with one of the three lyophilized products. Monitoring included systolic blood pressure and cardiac output. Point-of-care and laboratory diagnostic tests were used to assess renal function, real-time hemostasis (ROTEM), and coagulation. Histological examinations of kidney, lung, and muscle tissues were conducted 4 h after shock induction.Results: CLP and PCLP significantly improved systolic blood pressure and cardiac output and positively influenced base excess, creatinine, various ROTEM, and coagulation markers compared with standard LP without histologic modification. No adverse effect was associated with the transfusion of any of the plasma products throughout the experimental procedures.Conclusion: Both CLP and PCLP exhibit promising therapeutic potential for managing hemorrhagic shock in scenario where whole blood supplies are limited. However, the distinct physiological and coagulation characteristics of the swine model necessitate further investigation using humanized preclinical models to fully understand their clinical applicability and constraints.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141910134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expired blood transfusion and mortality outcomes in combat trauma patients. 战斗创伤患者的过期输血和死亡结果。

IF 2.5 3区医学

Transfusion Pub Date : 2024-09-01 Epub Date: 2024-07-05 DOI: 10.1111/trf.17943

Brian C Riley, Jimmy Phuong, Rida A Hasan, Lynn G Stansbury, John R Hess, Daniel J Roubik

{"title":"Expired blood transfusion and mortality outcomes in combat trauma patients.","authors":"Brian C Riley, Jimmy Phuong, Rida A Hasan, Lynn G Stansbury, John R Hess, Daniel J Roubik","doi":"10.1111/trf.17943","DOIUrl":"10.1111/trf.17943","url":null,"abstract":"Background: Expired blood can be transfused if clinically indicated but outcome data do not exist. We hypothesized that modestly outdated blood can effectively support a hemorrhaging patient until surgical control is achieved. This study assessed whether expired blood was associated with mortality in combat trauma patients.Study design and methods: A retrospective analysis of Armed Services Blood Program and Department of Defense Trauma Registry databases evaluated combat casualty records (2001-2023). The intervention of interest was transfusion of at least one unit of whole blood (WB), red blood cells (RBC), or platelets within one week past expiration. The outcome of interest was mortality at discharge. A control cohort that only received in-date blood was matched to the treatment cohort for logistic regression analysis.Results: One hundred patients received expired RBCs (86), WB (11), and platelets (3). Mortality at discharge was 11.6% for expired RBC recipients and 13.4% for the control cohort (p = .97). After adjustment for injury severity, expired RBCs were not associated with mortality (OR = 0.40 [95% CI, 0.14-1.16]; p = .09). Of 10 patients who received the most expired RBCs by volume or storage duration, two were deceased at discharge. All 14 expired WB and platelet recipients were alive at discharge, but sample sizes were underpowered for regression analysis.Discussion: Transfusion of modestly outdated RBCs was not associated with mortality in combat trauma patients. Expired WB and platelet recipients did well, but sample sizes were too small to draw significant conclusions. Expired blood should be further investigated for possible use in extenuating circumstances.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0