IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-06-23 DOI: 10.1111/trf.18313

Vivian I Avelino-Silva, Roberta L Bruhn, Zhanna Kaidarova, Daniel Hindes, Edward Notari, Donna Burke, Debra A Kessler, Carlos Delvalle, Rita Reik, Vilson Ortiz, Sheri Fallon, Marion C Lanteri, Susan L Stramer, Benyam Hailu, James J Berger, Hong Yang, Barbee Whitaker, Brian Custer

{"title":"Factors associated with active syphilis infection in US blood donors.","authors":"Vivian I Avelino-Silva, Roberta L Bruhn, Zhanna Kaidarova, Daniel Hindes, Edward Notari, Donna Burke, Debra A Kessler, Carlos Delvalle, Rita Reik, Vilson Ortiz, Sheri Fallon, Marion C Lanteri, Susan L Stramer, Benyam Hailu, James J Berger, Hong Yang, Barbee Whitaker, Brian Custer","doi":"10.1111/trf.18313","DOIUrl":"10.1111/trf.18313","url":null,"abstract":"Background: Syphilis is increasing globally, with limited monitoring of risk factors in asymptomatic, low-risk populations. Here, we investigate contemporary demographic and behavioral risk factors associated with active syphilis infection (ASI) in US blood donors.Study design and methods: Beginning with donations in October 2020, four US blood centers implemented standardized risk factor interviews for ASI in blood donors as part of a larger case-control study. Logistic regression models were used to assess ASI associations with demographics and behaviors within 12 months before donation. A conceptual framework explored causal ASI pathways.Results: Responses were obtained from 369 ASI cases and 868 controls; from all eligible cases, the enrollment rate was 16%. Risk factors in the multivariable-adjusted model included age between 40 and 54 years old (compared to 55+), Black race (compared to White), lower income, single/never married and separated/divorced or widowed status (compared to married or living together), first-time donation, gay/homosexual sexual orientation, having ≥2 male or ≥2 female sexual partners in the 12 months before donation, and a history of sexually transmitted infection. The conceptual risk framework suggests that important determinants of ASI include complex variables and mediators that may have not been fully captured by the questionnaire and regression analyses.Discussion: Although not fully defining causal relationships with ASI, our findings establish a baseline for factors associated with ASI among US blood donors, which can be used to refine the donor history questionnaire following the implementation of individual risk assessment and further surveillance efforts.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1460-1471"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How do we improve massive transfusion protocol adherence among anesthesia providers? 我们如何提高麻醉提供者对大规模输血方案的依从性？

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-07-03 DOI: 10.1111/trf.18315

Ana Julia H Parks, Susan G Silva, Jessica L Poisson, Virginia C Simmons, Nicole R Guinn, Adam M Flowe, Valerie K Sabol

{"title":"How do we improve massive transfusion protocol adherence among anesthesia providers?","authors":"Ana Julia H Parks, Susan G Silva, Jessica L Poisson, Virginia C Simmons, Nicole R Guinn, Adam M Flowe, Valerie K Sabol","doi":"10.1111/trf.18315","DOIUrl":"10.1111/trf.18315","url":null,"abstract":"Background: Previous studies have called for the implementation of provider reeducation efforts to improve massive transfusion protocol adherence.Objective: This quality improvement project implemented an educational module designed to increase anesthesia provider adherence to the hospital's massive transfusion protocol during the intraoperative massive transfusion of trauma patients. It also aimed to increase survival rates for trauma patients in the operating room for whom a massive transfusion protocol had been activated.Methods: An educational intervention was developed and disseminated to anesthesia providers. The intervention consisted of a PowerPoint presentation, an expert question-and-answer session, and the distribution of a badge card. Provider knowledge of and confidence in utilizing the protocol was evaluated before and after the intervention, while provider adherence to the packed red blood cell:fresh frozen plasma and packed red blood cell:platelet ratios outlined in the massive transfusion protocol and patient survival were assessed for 4 months pre- and post-implementation of the intervention.Results: The knowledge test scores of the 18 anesthesia providers participating in the education significantly improved after the intervention (p = .0005). Provider confidence in utilizing the massive transfusion protocol also substantially improved. Provider adherence to the massive transfusion protocol was determined for 20 trauma cases (11 pre-and 9 post-intervention). Although the adherence to the packed red blood cell:fresh frozen plasma ratio and packed red blood cell:platelet ratios improved, patient survival rates did not increase.Conclusion: Project findings suggest that provider massive transfusion protocol reeducation efforts improve provider protocol knowledge, confidence, and adherence.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1387-1394"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supplemental findings of the 2023 National Blood Collection and Utilization Survey. 2023年全国血液采集和利用调查的补充结果。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 DOI: 10.1111/trf.18336

Isabel S Griffin, Ian Kracalik, Kelsey McDavid, Tatiana Bradley, Joel Chavez Ortiz, James J Berger, Sridhar V Basavaraju, Rebecca Lien

{"title":"Supplemental findings of the 2023 National Blood Collection and Utilization Survey.","authors":"Isabel S Griffin, Ian Kracalik, Kelsey McDavid, Tatiana Bradley, Joel Chavez Ortiz, James J Berger, Sridhar V Basavaraju, Rebecca Lien","doi":"10.1111/trf.18336","DOIUrl":"https://doi.org/10.1111/trf.18336","url":null,"abstract":"Background: The National Blood Collection and Utilization Survey (NBCUS) is conducted biennially to estimate US blood collection and utilization. Supplemental data from the 2023 NBCUS not presented elsewhere are described here.Methods: Data on blood donor characteristics, donation deferrals, component costs, transfusion-associated adverse reactions, and use of pathogen-reduced platelets during 2023 were collected from US blood collecting and transfusing facilities. National estimates were produced using weighting and imputation methods.Results: Compared with 2021, successful blood donations from donors aged 45-64 decreased (11%) in 2023 but still accounted for most donations overall (39%). Donations from donors aged 16-18 years, Black or African American, and Hispanic donors increased by 66%, 38%, and 9%, respectively, since 2021. Donation deferrals for travel increased since 2021 (+162%). From 2021 to 2023, the median price hospitals paid per unit of leukoreduced red blood cells, fresh frozen plasma, and leukoreduced and pathogen-reduced apheresis platelets increased. Apheresis platelets experienced the largest price increase per unit (+$65). Compared with 2021, the proportion of transfusing facilities using pathogen-reduced platelets increased in 2023 (60% vs. 64%). The overall rate of transfusion-associated adverse reactions per 100,000 components transfused was higher in 2023 than in 2021 (312.3 vs. 273.8), although the rate of transfusion-transmitted infections (bacterial, viral, and parasitic) declined in 2023 (0.25 vs. 0.43).Conclusion: From 2021 to 2023, blood donations among older donors decreased, while donations from younger and Black or African American donors increased. Adoption of pathogen-reduced platelets and cost of all blood products increased.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Cryobit" aggregates in liquid plasma units. “Cryobit”聚集在液体等离子体单位中。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-06-09 DOI: 10.1111/trf.18308

Catherine Gereg, Christopher A Tormey, F Bernadette West, Nalan Yurtsever

引用次数: 0

Healthy volunteer stem cell donors followed up 10 years after stimulation with biosimilar filgrastim. 健康志愿者干细胞供体在生物仿制药非格昔汀刺激后随访10年。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-07-09 DOI: 10.1111/trf.18317

Jens Heyn, Susanne Bräuninger, Petra Becker, Niklas Stoeckmann, Christian Seidl, Sebastian Howe, Simon Daubert, Daniel Fürst, Hubert Schrezenmeier, Halvard Bonig

{"title":"Healthy volunteer stem cell donors followed up 10 years after stimulation with biosimilar filgrastim.","authors":"Jens Heyn, Susanne Bräuninger, Petra Becker, Niklas Stoeckmann, Christian Seidl, Sebastian Howe, Simon Daubert, Daniel Fürst, Hubert Schrezenmeier, Halvard Bonig","doi":"10.1111/trf.18317","DOIUrl":"10.1111/trf.18317","url":null,"abstract":"Background: The application of granulocyte colony-stimulating factors (G-CSF) for mobilizing hematopoietic stem and progenitor cells in healthy donors is considered safe. However, only limited safety information is available about long-term adverse events (AEs) in this setting. To determine the long-term effect of health consequences to stem cell donors, 244 G-CSF-mobilized donors were tracked prospectively for 10 years.Study design and methods: A total of 244 adult healthy unrelated stem cell donors who received at least one dose of Sandoz biosimilar filgrastim were enrolled in this prospective long-term surveillance study. Safety, mental health, and physical health were followed up over a period of 10 years.Results: Ninety-five percent of the donors experience at least one AE during the stem mobilization period; beyond this period, the onset of the first AE was 3.86 [3.45-4.27] years in females and 4.02 [3.68-4.35] years in males. The risk of reporting an AE was significantly lower in the youngest tertile of donors, when compared to the oldest (p = 0.026). Females were more likely to report AEs than males (0.40 vs. 0.21 AEs/year, rate ratio: 1.87 [CI: 1.32-2.64]; <0.001). No clinically relevant permanent changes occurred up to 10 years from mobilization in physical or mental health.Discussion: No new or excessive AEs were identified during a 10-year follow-up of mobilized stem cell donors and therefore reassure about the overall safety of stem cell mobilization with G-CSF in healthy volunteers.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1418-1426"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One versus two: How much does it matter? A single-center retrospective study evaluating 1-day extracorporeal photopheresis schedule for treating patients with chronic lung allograft rejection. 一对二：有多重要？一项单中心回顾性研究评估1天体外光移植术治疗慢性同种异体肺移植排斥患者的方案。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-07-14 DOI: 10.1111/trf.18318

Claudia Del Fante, Valentina Vertui, Catherine Klersy, Cristina Mortellaro, Domenica Federica Briganti, Letizia Corinna Morlacchi, Marianna Russo, Cesare Perotti, Federica Meloni

{"title":"One versus two: How much does it matter? A single-center retrospective study evaluating 1-day extracorporeal photopheresis schedule for treating patients with chronic lung allograft rejection.","authors":"Claudia Del Fante, Valentina Vertui, Catherine Klersy, Cristina Mortellaro, Domenica Federica Briganti, Letizia Corinna Morlacchi, Marianna Russo, Cesare Perotti, Federica Meloni","doi":"10.1111/trf.18318","DOIUrl":"10.1111/trf.18318","url":null,"abstract":"Background: Several studies show that extracorporeal photopheresis (ECP) might benefit chronic lung allograft dysfunction (CLAD). A standard ECP cycle consists of two consecutive procedures regardless of the technique employed.Study design and methods: Evaluation of ECP cycle (from two to one procedure) modification due to pandemic restrictions in 25 patients with CLAD under chronic treatment by off-line ECP in the 6 months preceding cycle modification (one procedure processing 1.5 patients blood volumes [1.5 ECP]). Assessment of any significant change in lung function decline and the relationship with product characteristics compared to pre-ECP cycle modification.Results: ECP patients (23 obstructive and two mixed) were enrolled in 2020 during the COVID pandemic. Two hundred and thirty five ECP procedures followed the standard protocol and 121 the 1.5 ECP. There was little or no variation in lung function during the study period. The mean number of mononuclear cells (MNC) per kg administered over time was higher in the 1.5 ECP than in the standard ECP protocol (p = .014). No association was found between respiratory function and MNC infused. Persistent Forced Expiratory Volume in 1 s decline >10% was observed in two patients over the 6 months preceding 1.5 ECP (due to CLAD progression) and in three patients after 1.5 ECP initiation (one for CLAD progression, two for bronchial colonization).Conclusion: Our study shows that respiratory function is maintained over time and is comparable between both ECP strategies in responders. The shift from two to one procedure per cycle may be reasonable in CLAD patients treated by off-line ECP.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1490-1501"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rising transfusion rates amidst stable blood supply: A Canadian perspective on emerging challenges for blood operators. 在稳定的血液供应中不断上升的输血率：加拿大对血液运营商面临的新挑战的看法。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-06-27 DOI: 10.1111/trf.18325

An Duong, Sheharyar Raza, Marianne Waito, Tanya Petraszko, Asim Q Alam

引用次数: 0

Continuing Medical Education. 继续医学教育。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 DOI: 10.1111/trf.18359

引用次数: 0

Duffy-null associated count: Perspectives from the blood Bank. 达菲相关计数：来自血库的观点。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-06-23 DOI: 10.1111/trf.18323

Heather M Ross, Zhen Mei, Andrea McGonigle, Alyssa Ziman, Dawn C Ward

引用次数: 0

West Nile Virus positivity amongst Canadian blood donors and effectiveness of off-season screening. 西尼罗病毒在加拿大献血者中的阳性和淡季筛查的有效性。

IF 2 3区医学

Transfusion Pub Date : 2025-08-01 Epub Date: 2025-06-28 DOI: 10.1111/trf.18326

Carmen L Charlton, Steven J Drews, Kai Makowski, Gordon Hawes, Cynthia Cranney, Alyssia Robinson, Heidi Wood, Mark Bigham, Sheila F O'Brien

{"title":"West Nile Virus positivity amongst Canadian blood donors and effectiveness of off-season screening.","authors":"Carmen L Charlton, Steven J Drews, Kai Makowski, Gordon Hawes, Cynthia Cranney, Alyssia Robinson, Heidi Wood, Mark Bigham, Sheila F O'Brien","doi":"10.1111/trf.18326","DOIUrl":"10.1111/trf.18326","url":null,"abstract":"Background: We sought to examine the prevalence of West Nile Virus (WNV) nucleic acid test (NAT) positivity over time in Canadian blood donors, examine the level of false-positive NAT screening, and understand the effectiveness of travel-related testing outside of WNV seasonality in Canada.Study design and methods: All blood donations in Canada (except Québec) between 2018 and 2023 were tested by the Roche Cobas WNV-NAT assay during the summer-fall season by Canadian Blood Services. Testing for recent travel outside Canada was performed in the winter-spring season. All 2023 WNV-NAT-positives were confirmed by two independent WNV-specific polymerase chain reaction (PCRs).Results: While WNV positivity varied by location and time, no increasing trend of positivity was observed over the 6-year study period. No WNV-NAT-positive donors with a history of recent travel outside of Canada in the winter-spring season were identified by donor screening (2018-2023). In total, 2,454,102 samples were tested during summer months and 267,988 in winter months. In 2023, WNV-specific PCR confirmed 10 of 13 (76.9%) screening WNV-NATs. Recent Japanese Encephalitis Virus (JEV) vaccination was identified as a potential false positive for initial WNV screening results.Discussion: Between 2018 and 2023, WNV-NAT positivity amongst Canadian blood donors remained stable, with no evidence of an increasing positivity trend. The utility of off-season travel-related testing may be limited, as no donors were identified during the six-year study timeframe. Finally, confirmation testing using WNV-specific PCR is recommended to identify true cases and to limit misidentification of other genetically similar viruses, such as JEV.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1484-1489"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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