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IF 2.9 3区医学

Transfusion Pub Date : 2024-09-09 DOI: 10.1111/trf.17439

引用次数: 0

Survey of pediatric massive transfusion protocol practice at United States level I trauma centers: An AABB Pediatric Transfusion Medicine Subsection study. 美国一级创伤中心儿科大量输血方案实践调查：美国医学会儿科输血医学分会的一项研究。

IF 2.5 3区医学

Transfusion Pub Date : 2024-09-08 DOI: 10.1111/trf.17997

Brian D Adkins, Daniel K Noland, Jeremy W Jacobs, Garrett S Booth, Denise Malicki, Louise Helander, Cyril Jacquot, Gina Buscema, Ruchika Goel, Jennifer Andrews, Lani Lieberman

{"title":"Survey of pediatric massive transfusion protocol practice at United States level I trauma centers: An AABB Pediatric Transfusion Medicine Subsection study.","authors":"Brian D Adkins, Daniel K Noland, Jeremy W Jacobs, Garrett S Booth, Denise Malicki, Louise Helander, Cyril Jacquot, Gina Buscema, Ruchika Goel, Jennifer Andrews, Lani Lieberman","doi":"10.1111/trf.17997","DOIUrl":"https://doi.org/10.1111/trf.17997","url":null,"abstract":"Background: Trauma remains the leading cause of pediatric mortality in the United States. Although use of massive transfusion protocols (MTPs) in this population is widespread, optimal pediatric resuscitation is not well established. We sought to assess contemporary pediatric MTP practice in the United States.Study design and methods: A web-based survey was designed by the Association for the Advancement of Blood & Biotherapies (AABB) Pediatric Transfusion Medicine Subsection and distributed to select American College of Surgeons (ACS) Level I Verified pediatric trauma centers. The survey assessed current MTP policy, implementation, and recent changes in practice.Results: Response rate was 55% (22/40). Almost half of the respondents were from the South. The median RBC:plasma ratio was 1 (interquartile range 1-1.5). Protocolized fibrinogen supplementation was common while integration of antifibrinolytic therapy into MTPs was infrequent. Viscoelastic testing (VET) was available at most sites, 71% (15/21, one site did not respond), and was generally utilized on an ad-hoc basis. Roughly, a third of sites had changed their MTP in the past 3 years due to blood supply issues, and about a third reported having group O Whole Blood on-site.Conclusion: MTP practice is similar throughout the United States. Though fibrinogen supplementation is common-other emerging interventions such as antifibrinolytic therapy or utilization of routine viscoelastic testing-are not widespread. Pediatric transfusion medicine experts must continue to follow practice change, as contemporary large trials begin to characterize new supportive modalities to optimize resuscitation in pediatric trauma patients.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142155041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keep ahead: A monthly roundup of key articles in other journals 保持领先：每月综述其他期刊的重要文章

IF 2.9 3区医学

Transfusion Pub Date : 2024-09-06 DOI: 10.1111/trf.18005

Caitlin McOmish

引用次数: 0

Prehospital central venous catheters. 院前中心静脉导管。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-30 DOI: 10.1111/trf.17949

Nicholas M Studer, Jason R Pickett, C J Winckler, William R Smith, Andrew P Cap, Cord W Cunningham

引用次数: 0

Life-threatening hemorrhage as defined by the critical administration threshold in nontraumatic critical bleeding: A descriptive observational study. 根据非创伤性危重出血的临界管理阈值定义的危及生命的出血：一项描述性观察研究。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-29 DOI: 10.1111/trf.17996

Luke J Matzek, Andrew C Hanson, Phillip J Schulte, Kimberly D Cureton, Daryl J Kor, Matthew A Warner

{"title":"Life-threatening hemorrhage as defined by the critical administration threshold in nontraumatic critical bleeding: A descriptive observational study.","authors":"Luke J Matzek, Andrew C Hanson, Phillip J Schulte, Kimberly D Cureton, Daryl J Kor, Matthew A Warner","doi":"10.1111/trf.17996","DOIUrl":"https://doi.org/10.1111/trf.17996","url":null,"abstract":"Background: Evaluations of critical bleeding and massive transfusion have focused on traumatic hemorrhage. However, most critical bleeding in hospitalized patients occurs outside trauma. The purpose of this study was to provide an in-depth description examining the critical administration threshold (CAT; ≥3 units red blood cells (RBCs) in a 1-h period) occurrences in nontraumatic hemorrhage. This will assist in establishing the framework for future investigations in nontraumatic hemorrhage.Methods: This is an observational cohort study of adults experiencing critical bleeding defined as being CAT+ during hospitalization from 2016 to 2021 at a single academic institution. A CAT episode started with administration of the first qualifying RBC unit and ended at the time of completion of the last allogeneic unit prior to a ≥4-h gap without subsequent transfusion. The primary goal was to describe demographic, clinical and transfusion characteristics of participants with nontraumatic critical bleeding.Results: 2433 patients suffered critical bleeding, most often occurring in the operating room (71.1%) followed by the intensive care unit (20.8%). 57% occurred on the initial day of hospitalization, with a median duration of 138 (36, 303) minutes. The median number of RBCs transfused during the episode was 5 (4, 8), with median total allogeneic units of 9 (4, 9). Hospital mortality was 19.2%. The most common cause of death was multi-organ failure (50.3%), however death within 24 h was due to exsanguination (72.7%).Discussion: The critical administration threshold may be employed to identify critical bleeding in non-trauma settings of life-threatening hemorrhage, with a mortality rate of approximately 20%.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional biomarkers for sickle cell disease. 镰状细胞病的功能性生物标志物。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-27 DOI: 10.1111/trf.17992

Yvette C Tanhehco

引用次数: 0

Acceptability of sexual history questions in a gender-neutral risk assessment for blood donation. 在献血性别中性风险评估中性史问题的可接受性。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-27 DOI: 10.1111/trf.17993

Yasmin Mowat, Bridget Haire, Barbara Masser, Veronica Hoad, Anita Heywood, Rachel Thorpe, Hamish McManus, John Kaldor, Skye McGregor

{"title":"Acceptability of sexual history questions in a gender-neutral risk assessment for blood donation.","authors":"Yasmin Mowat, Bridget Haire, Barbara Masser, Veronica Hoad, Anita Heywood, Rachel Thorpe, Hamish McManus, John Kaldor, Skye McGregor","doi":"10.1111/trf.17993","DOIUrl":"https://doi.org/10.1111/trf.17993","url":null,"abstract":"Background: Currently in Australia, men are deferred from donating blood if they have had sex with another man within the past 3 months. However, a proposed gender-neutral assessment (GNA) process will ask all donors questions about sex with new or multiple recent partners, with deferral based on responses to a question about anal sex. Understanding the acceptability of such questions among existing and potential blood donors is paramount for successful implementation of GNA.Study design and methods: We used data from a nationally representative survey to estimate the levels of comfort with the proposed GNA questions among the Australian population and subgroups, defined by self-reported ethnicity and religion. Respondents were aged over 18 and living in Australia. Results were weighted to represent the population.Results: Most of the 5178 respondents described themselves as comfortable with answering questions about new partners (73.1%) or anal sex (64.0%) to donate blood. However, 2.2% and 4.5% indicated that questions about new sex partners and anal sex, respectively, would stop them from donating, and 4.4% and 7.7% respectively, said they were \"completely uncomfortable.\" By religion, the least comfortable were Muslim or Eastern Orthodox respondents, and by country of birth, the least comfortable were those born in the Middle East, followed by those born in Southern Europe and Asia.Discussion: GNA appears to be broadly acceptable in the Australian context, but our findings suggest that key GNA questions are less acceptable in some population subgroups, indicating a need for targeted campaigns that consider cultural sensitivities.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Providing red blood cells to facilitate organ transplant via normothermic perfusion techniques: A single-center experience. 通过常温灌注技术提供红细胞以促进器官移植：单中心经验。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-24 DOI: 10.1111/trf.17994

Elizabeth S Allen, Laura D Stephens, Nesinee Weber, Aleah L Brubaker, Ken Hudson, Victor Pretorius, Gabriel Schnickel, Patricia M Kopko

{"title":"Providing red blood cells to facilitate organ transplant via normothermic perfusion techniques: A single-center experience.","authors":"Elizabeth S Allen, Laura D Stephens, Nesinee Weber, Aleah L Brubaker, Ken Hudson, Victor Pretorius, Gabriel Schnickel, Patricia M Kopko","doi":"10.1111/trf.17994","DOIUrl":"https://doi.org/10.1111/trf.17994","url":null,"abstract":"Background: Normothermic regional perfusion (NRP) and normothermic machine perfusion (NMP) are organ procurement and transport techniques that can improve organ quality, facilitate longer transport, and reduce postoperative complications, increasing organ availability and improving outcomes. NRP and NMP often require allogeneic red blood cells (RBCs). Our academic transfusion service began providing RBCs to support NRP and NMP for adult heart transplant (HT), orthotopic liver transplant (OLT), and multiorgan transplant (MOT) in August 2020.Methods: This single-center, retrospective study describes the implementation process and analyzes the characteristics of RBC support during the first 3 years of the perfusion programs. Timing and quantity of units issued and used, organ recipient demographics, and transplant outcomes were obtained from transfusion service and electronic medical records.Results: From 2020 to 2023, the transfusion service received 233 requests to support NRP and NMP perfusion cases. Of these, 105 cases resulted in RBC use, and units were returned or discarded in 112 cases. A total of 131 patients received perfusion-facilitated transplants (92 HT, 27 OLT, and 12 MOT). The majority of perfusion-facilitated HTs utilized NRP (81/92, 88%), whereas most perfusion-facilitated OLTs utilized NMP (21/27, 78%). Across all 233 requests, a total of 381 RBC units were used to facilitate 131 transplants, averaging 2.91 units/transplant.Discussion: Provision of RBCs for NRP and NMP techniques represents a novel method for transfusion services to support and facilitate life-saving organ transplants with only modest product use, about three RBC units per organ transplant in this single-center study.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effectiveness of telephone surveys on the return of first-time donors: A randomized controlled trial. 电话调查对首次捐献者回归的有效性：随机对照试验。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-20 DOI: 10.1111/trf.17974

Vanessa C Marsano, Dirk Hasenclever, Reinhard Henschler

{"title":"The effectiveness of telephone surveys on the return of first-time donors: A randomized controlled trial.","authors":"Vanessa C Marsano, Dirk Hasenclever, Reinhard Henschler","doi":"10.1111/trf.17974","DOIUrl":"https://doi.org/10.1111/trf.17974","url":null,"abstract":"Background: The management of blood supply depends, among other factors, on the effective remobilization of first-time donors (FTDs). This study investigates the efficacy of telephone calls to increase second donation rates.Study design and methods: A randomized controlled trial was conducted on 418 first-time blood donors. In the telephone group (TG, n = 206), men were contacted 9-10 and women 13-14 weeks after their first donation. They were asked about satisfaction and intention to return, and offered an appointment. The primary outcome was the return rate within 6 months after the first donation.Results: The mean age was 28.8 ± 10.0 years and 59.9% of FTDs were female. In the TG, 89.3% were reached. Approximately 50% of each group had donated a second time by 24.2 weeks for the control group (CG) and 14.8 weeks for the TG. The six-month return rate was 65.0% in the TG and 54.3% in the CG (95%-CI [0.9%; 20.6%]; p = .033). The restricted mean time to return within 6 months was 19.4 weeks in the CG compared to 17.2 weeks in the TG (95%-CI [0.7; 3.7]; p = .004). The intervention effect tended to be larger in men than in women.Discussion: Contacting FTDs by phone after their first donation increases the six-month return rate and reduces the interval to a second donation. Male donors appear to be more receptive to this intervention. Whether the effect of the intervention helps to establish a donor identity in the long term should be the subject of further studies.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Massive fetomaternal hemorrhage from placental abruption presenting as weak-D expression. 胎盘早剥引起的大面积母体出血，表现为弱D。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-19 DOI: 10.1111/trf.17988

Lindsey K Durowoju, Rida A Hasan, John R Hess, Daniel E Sabath, Andrew Bryan, Monica B Pagano, Hamilton C Tsang

引用次数: 0