Transfusion最新文献_第2页

Transfusion-transmissible coinfections among US blood donors. 美国献血者中的输血传播合并感染。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-21 DOI: 10.1111/trf.18050

Galen Conti, Edward P Notari, Roger Y Dodd, Jed Gorlin, Brian Custer, Rita Reik, Benyam Hailu, Barbee I Whitaker, Susan L Stramer

{"title":"Transfusion-transmissible coinfections among US blood donors.","authors":"Galen Conti, Edward P Notari, Roger Y Dodd, Jed Gorlin, Brian Custer, Rita Reik, Benyam Hailu, Barbee I Whitaker, Susan L Stramer","doi":"10.1111/trf.18050","DOIUrl":"https://doi.org/10.1111/trf.18050","url":null,"abstract":"Background: Transfusion-transmissible infection (TTI) prevalence among US blood donors has been widely documented. Here we estimate the prevalence of donors presenting with ≥2 TTIs (multiple infections past or present referred to as coinfections) and describe their demographics and associations.Methods: Data from the Transfusion-Transmissible Infections Monitoring System were compiled for October 2020-September 2023 (3 years). Prevalence per million donations (pmd) was calculated for each TTI coinfection combination with demographic characteristics summarized. The odds of each TTI coinfection combination were estimated using logistic regression. Reactivity by NAT and/or serology (HIV, HBV, and HCV) defined donors as consensus positive (CP) for each infection while serology-based algorithms defined syphilis CP and the subset with active syphilis infections (ASIs).Results: About 22 million donations were included, with 212 coinfections (9.7 pmd). Around 2% of donations positive for any TTI (n = 10,516) were coinfections. Coinfection prevalence per TTI combination ranged from 0.3 pmd for HIV CP and HCV CP, to 4.3 pmd for HIV CP and syphilis CP. There were high proportions of coinfections from donors who were male, aged 25-54 years, white or black, first time, and residing in the southern US Census Region. The odds of a second TTI occurring in an individual donor with a TTI ranged from 23 (95% CI: 13, 41) times more likely for HBV CP and ASI to 395 (95% CI: 298, 524) times more likely for HIV CP and ASI.Conclusions: Coinfections are relatively uncommon among blood donors in the United States; however, associations exist among HIV, HBV, HCV, and syphilis infections.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adherence to COVID-19 vaccination recommendations and vaccine hesitancy in US blood donors. 美国献血者对 COVID-19 疫苗接种建议的遵守情况和疫苗接种犹豫不决的情况。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-21 DOI: 10.1111/trf.18051

Vivian I Avelino-Silva, Roberta Bruhn, Karla G Zurita, Eduard Grebe, Mars Stone, Michael P Busch, Brian Custer

{"title":"Adherence to COVID-19 vaccination recommendations and vaccine hesitancy in US blood donors.","authors":"Vivian I Avelino-Silva, Roberta Bruhn, Karla G Zurita, Eduard Grebe, Mars Stone, Michael P Busch, Brian Custer","doi":"10.1111/trf.18051","DOIUrl":"https://doi.org/10.1111/trf.18051","url":null,"abstract":"Background: General vaccination rates have been falling globally despite unequivocal health benefits. Noncompliance can result from access barriers and/or hesitant attitudes. Few studies have investigated the prevalence and determinants of noncompliance with COVID-19 vaccination in blood donors.Methods: We surveyed blood donors on COVID-19 infection and vaccination history, barriers and motivations for COVID-19 vaccination, and comorbidities. We estimate the prevalence of noncompliance, the prevalence of hesitancy toward COVID-19 vaccines, and investigate associated factors using multivariable models.Results: From December 2021 to December 2022, 33,610 survey respondents were included. Of these, 24% had not been vaccinated for COVID-19 or had missing vaccination information, and 99% of those who reported reasons for being unvaccinated declared at least one of three hesitant attitudes presented in the survey (safety concerns; personal/cultural/religious beliefs; being young and not worrying about being vaccinated). Among noncompliant donors, <2% reported access barriers. In the multivariable model addressing factors associated with vaccine noncompliance, younger age, male gender, White/Caucasian race, absence of comorbidities, residency in a State with less restrictive COVID-19 policies, and living in micropolitan or rural areas were identified as significant predictors. Younger age and White/Caucasian race were independently associated with vaccine hesitancy among noncompliant donors.Conclusions: We found high rates of noncompliance with COVID-19 vaccination in blood donors, mostly driven by vaccine hesitancy. Understanding vaccine adherence among blood donors-a relatively highly educated and healthy population, with good healthcare access and usually motivated by altruism-could provide key information on determinants of vaccine noncompliance that may be harder to overcome.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

It is time to reconsider leukoreduction of whole blood for use in patients with life-threatening hemorrhage. 现在是时候重新考虑将全血减白用于危及生命的大出血患者了。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-17 DOI: 10.1111/trf.18047

Mark H Yazer, Andrew Beckett, Evan M Bloch, Andrew P Cap, Claudia S Cohn, Jennifer Gurney, Daniela Hermelin, Philip C Spinella

引用次数: 0

The impact of institutional measures on optimal use of intravenous immunoglobulin. 机构措施对静脉注射免疫球蛋白优化使用的影响。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-17 DOI: 10.1111/trf.18031

Jean-Nicolas Champagne, Antoine Desilets, Guillaume Roy, Océane Landon-Cardinal, Hugo Chapdelaine, Geneviève Matte, Claudia Bouchard, Benjamin Rioux-Massé, Anne-Sophie Lemay

{"title":"The impact of institutional measures on optimal use of intravenous immunoglobulin.","authors":"Jean-Nicolas Champagne, Antoine Desilets, Guillaume Roy, Océane Landon-Cardinal, Hugo Chapdelaine, Geneviève Matte, Claudia Bouchard, Benjamin Rioux-Massé, Anne-Sophie Lemay","doi":"10.1111/trf.18031","DOIUrl":"https://doi.org/10.1111/trf.18031","url":null,"abstract":"Background: Intravenous immunoglobulin (IVIG) shortage represents an emerging issue in transfusion medicine. Limited data are available to determine effective strategies for optimal use. The objective of this retrospective observational study was to determine the impact of institutional measures on IVIG use at a large academic center.Methods: IVIG infusions from November 26, 2018 to September 25, 2022 were categorized according to their appropriateness (Recommended, Option of treatment, or Unrecommended), based on provincial guidelines, and separated into three phases: Reference, Transition, and Post-Implementation phases, the latter following the adoption of restrictive measures, including mandatory standardized order forms, a blood bank gatekeeping strategy, and the creation of a stewardship committee.Results: A total of 5431 IVIG infusions were administered to 544 patients, accounting for 295,033 g. The most common indication categories were neurology (30.4%), immunology (29.0%), and hematology (17.4%). From Reference to Post-Implementation phase, IVIG infusions decreased from 2275 to 2000 with unrecommended indications dropping from 9.5% to 7.4% (p = 0.01), and a global reduction of 23.0% (from 131,163 g to 100,936 g of IVIG). Decrease in chronic immunomodulation accounted for 48.3% of total reduction (14,610 g of 30,227 g), whereas single-use immunomodulation, 40.5% (12,237 g of 30,227 g). Moreover, an absolute reduction of 16.9% was observed in orders exceeding the recommended doses (20.8% to 3.9%; p < 0.0001). Together, the unrecommended and excessive IVIG doses decreased from 19,975 g (15.2%) to 6670 g (6.6%).Conclusions: A global reduction in IVIG use and a preferential decrease in the unrecommended orders were observed, most likely attributable to the bundle of restrictive strategies implemented.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-exchange neutrophil count, but not post-hematocrit, predicts endogenous erythropoiesis in patients with sickle cell disease undergoing chronic red cell exchange. 交换后中性粒细胞计数（而非血细胞比容）可预测接受慢性红细胞交换的镰状细胞病患者的内源性红细胞生成。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-15 DOI: 10.1111/trf.18044

Nalan Yurtsever, Nicholas Tong, Saroja Geetha, Vijay Nandi, Patricia A Shi

{"title":"Post-exchange neutrophil count, but not post-hematocrit, predicts endogenous erythropoiesis in patients with sickle cell disease undergoing chronic red cell exchange.","authors":"Nalan Yurtsever, Nicholas Tong, Saroja Geetha, Vijay Nandi, Patricia A Shi","doi":"10.1111/trf.18044","DOIUrl":"https://doi.org/10.1111/trf.18044","url":null,"abstract":"Background: With chronic transfusion in sickle cell disease (SCD), equipoise exists regarding whether increasing the post-procedure hematocrit (Hct) suppresses endogenous erythropoiesis. Reticulocytosis predicts SCD morbidity and mortality, so this study's objective was to clarify the role of the post-procedure Hct in suppressing reticulocytosis and to identify other potential red cell exchange (RCE) parameters predictive of reticulocytosis.Study design and methods: This retrospective analysis of 17 patients who underwent chronic RCE at a single institution between 2014 and 2022 examined both standard red cell exchanges (SRCE) and exchanges preceded by isovolemic hemodilution (IVH-RCE). Post-procedure parameters with biologic plausibility to influence the subsequent procedure's absolute reticulocyte count (sPre-ARC) were examined using regression modeling.Results: Neither post-hematocrit, nor post-hemoglobin (Hb), nor ΔHb/day was associated with sPre-ARC or the change in HbS% per day (ΔHbS%/day). Concurrent Hb was predictive for SRCE but not IVH-RCE, where ARC trended lower than with SRCE. Male gender and post-procedure neutrophil and white cell counts were predictors of sPre-ARC, consistent with their associations with SCD morbidity and mortality. IVH-RCE had a stronger correlation than standard RCE between pre-Hct and neutrophil or white cell depletion.Discussion: Although targeting a post-procedure Hct maintains a higher subsequent pre-procedure Hb and a lower sPre-HbS%, it does not lead to sustained suppression of reticulocytosis as measured by the sPre-ARC or the ΔHbS%/day. IVH-RCE or the addition of hydroxyurea could be considered in those patients with high reticulocyte, white blood cell, or neutrophil counts.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence, incidence, and residual risk for human immunodeficiency virus among blood donors from 2003 to 2022 in Guangzhou, China. 2003 年至 2022 年中国广州献血者中人类免疫缺陷病毒的流行率、发病率和残留风险。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-10 DOI: 10.1111/trf.18025

Junmou Xie, Zhongping Li, Haojian Liang, Zhijian Huang, Rongsong Du, Wenbo Gao, Boquan Huang, Fenfang Liao, Xia Rong, Yongshui Fu, Yongmei Nie, Huaqin Liang, Hao Wang

{"title":"Prevalence, incidence, and residual risk for human immunodeficiency virus among blood donors from 2003 to 2022 in Guangzhou, China.","authors":"Junmou Xie, Zhongping Li, Haojian Liang, Zhijian Huang, Rongsong Du, Wenbo Gao, Boquan Huang, Fenfang Liao, Xia Rong, Yongshui Fu, Yongmei Nie, Huaqin Liang, Hao Wang","doi":"10.1111/trf.18025","DOIUrl":"https://doi.org/10.1111/trf.18025","url":null,"abstract":"Background: China's significant population affected by HIV poses a substantial threat to blood transfusion safety. Despite advancements in blood testing techniques, a residual risk of HIV transmission persists. Accurately assessing HIV epidemic and the residual risk is vital for monitoring blood supply safety and evaluating the effectiveness of new screening tests.Methods: We conducted a retrospective analysis of HIV detection results among voluntary blood donors from 2003 to 2022. The study included data on HIV-confirmed positive donors, HIV prevalence, infection risk factors, and an incidence-window period mathematical model to estimate the residual risk of HIV.Results: Between 2003 and 2022, HIV prevalence among blood donors in Guangzhou showed a peak-shaped trend, initially increasing before declining. The overall HIV prevalence was 18.9 infections per 100,000 donations. Male donors had a significantly higher prevalence compared with female donors. Donors aged 26-35 years had the highest prevalence. Ethnic minority donors had a higher prevalence compared with Han donors. Repeat donors had a lower prevalence compared with first-time donors. Donors from other provinces had a higher prevalence compared with local donors. During the period of 2003 to 2022, the residual risk of HIV in Guangzhou steadily decreased, reaching a notable 1 in 526,316 donations in the past two years.Conclusion: The HIV epidemic among blood donors in Guangzhou remains severe, but the residual risk of HIV is decreasing. Novel detection methods have proven advantageous in reducing this residual risk. Implementing additional effective measures is imperative to ensure blood safety and curb the spread of HIV.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical application of centrifugal-membrane hybrid plasmapheresis in the treatment of hyperlipidemia. 离心-膜混合血浆置换术在治疗高脂血症中的临床应用。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-09 DOI: 10.1111/trf.18046

Zhongmei Yi, Chunxi Wu, Yumeng Zhou, Bin Zhang

{"title":"Clinical application of centrifugal-membrane hybrid plasmapheresis in the treatment of hyperlipidemia.","authors":"Zhongmei Yi, Chunxi Wu, Yumeng Zhou, Bin Zhang","doi":"10.1111/trf.18046","DOIUrl":"https://doi.org/10.1111/trf.18046","url":null,"abstract":"Objective: This study aimed to clarify the clinical application of centrifugal-membrane hybrid plasmapheresis (CMHP) in the treatment of hyperlipidemia.Methods: A retrospective study was conducted on 48 patients who were diagnosed with hyperlipidemia and had received CMHP treatment. Serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were monitored, and adverse reactions to the treatment were observed.Results: Forty-eight patients with hyperlipidemia received CMHP over 59 sessions. The average age of the 48 patients with hyperlipidemia, including 32 males (66.67%) and 16 females (33.33%), was 44.23 ± 12.02 years. Twenty-nine outpatients (60.42%) and 19 inpatients (39.58%) were included. Hypertriglyceridemia was diagnosed in 16 cases (33.33%), mixed hyperlipidemia in 31 cases (64.58%), and hypercholesterolemia in one case (2.08%). The pretreatment blood lipid concentrations were significantly different after the 59 CMHP treatments (p < .001). The concentrations of TC, TG, HDL-C, and LDL-C decreased significantly after the treatment, and the median ratios of reduction were 67.06% (range: 58.97%-71.87%), 63.33% (range: 55.20%-74.86%), 45.87% (range: 35.86%-52.95%), and 66.09% (range: 44.37%-73.94%), respectively. Three adverse reactions (5.08%) were recorded. No differences were detected in therapeutic parameters, effects, or adverse reactions between the two blood cell separators, there was no difference in Lipoprotein apheresis efficacy.Conclusion: This preliminary study demonstrated the clinical application of CMHP in patients in the treatment of hyperlipidemia. However, further studies are needed applying CMHP with hyperlipidemia.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142393563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of a novel RHD allele with c.336T>G that causes weakened RhD antigen expression. 鉴定出一个新的 RHD 等位基因 c.336T>G，该等位基因会导致 RhD 抗原表达减弱。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-09 DOI: 10.1111/trf.18042

Minghao Li, Ziyan Zhu, Luyi Ye

引用次数: 0

A novel variant c.505C>T based on the ABO*B.01 allele associated with a B_el phenotype. 基于 ABO*B.01 等位基因的新型 c.505C>T 变异与 Bel 表型有关。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-09 DOI: 10.1111/trf.18043

Hua Wang, Yanling Ying, Ruiqing Guo, Xiaozhen Hong, Fei Wang, Yi Xu, Yunxiang Wu, Demei Zhang

引用次数: 0

Racial-ethnicity group distributions of blood product use in acute trauma care transfusion. 急性创伤救护输血中血液制品使用的种族-族裔群体分布。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-09 DOI: 10.1111/trf.18030

Tristan Wisont, Zhinan Liu, Zaher Kmail, Lynn G Stansbury, M Angele Theard, Monica S Vavilala, John R Hess

{"title":"Racial-ethnicity group distributions of blood product use in acute trauma care transfusion.","authors":"Tristan Wisont, Zhinan Liu, Zaher Kmail, Lynn G Stansbury, M Angele Theard, Monica S Vavilala, John R Hess","doi":"10.1111/trf.18030","DOIUrl":"https://doi.org/10.1111/trf.18030","url":null,"abstract":"Background: Recent studies suggest Black patients are transfused less often and at lower hemoglobin levels than White patients. In elective surgery, Black and Non-White patients have greater estimated blood loss and transfusion frequency. We asked whether similar transfusion disparities are observable in acute trauma resuscitation.Methods: In a single-center retrospective analysis of trauma registry/blood-bank-linked data from a large US trauma center, we identified all acute trauma patients 2011-2022. Our data sources permitted distinction of Race and Ethnicity and therefor binning as Non-White-race/not Hispanic plus any-race/Hispanic or White/not Hispanic. We tallied Injury Severity Scores mild through profound (ISS 1-9, 9-15, 16-25, >25), type (blunt vs. penetrating) and mechanism (firearms, etc.), and associated blood use overall and in the first, first four, and first 24 h, comparing results with chi square, p < .01.Results: Overall, 50,394 (68.41%) acute trauma patients were classified as White and 23,251 (31.7%) as Other than White. White patients were more likely to receive any blood products (17.8% vs. 11.9%), but, for all measures of urgency/quantity, Non-White patients were transfused more often (respectively, first 4 h, 51.9% vs. 42.1%; ≥3u/first hour, 18.5% vs. 11.0%; ≥10u/24 h, 8.1% vs. 3.8%) (all p < .001). White patients were far more likely to have blunt injury than Non-White patients, (77.2% vs. 42.6%), less likely to have penetrating injury (10.1% vs. 14%) and far less likely to be injured by firearms (30.6% vs. 56.9%) (all p < .001).Conclusions: At our center, blood use in acute trauma resuscitation was associated with injury severity and mechanism, not race/ethnicity.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142393565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0