Transfusion最新文献

{"title":"A novel RHD allele combining partial D (c.455A>C) and weak D (c.1154G>C) variants.","authors":"Glenn Ramsey, Kim Hue-Roye, Gorka Ochoa-Garay, Johnathon Pugh, Ricardo S Sumugod, Paul F Lindholm, Sunitha Vege","doi":"10.1111/trf.18433","DOIUrl":"https://doi.org/10.1111/trf.18433","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible NAT-negative transfusion-transmitted Babesia microti.","authors":"Courtney Hopkins, Christopher Gresens, Sara Bakhtary, Ralph Vassallo","doi":"10.1111/trf.18431","DOIUrl":"https://doi.org/10.1111/trf.18431","url":null,"abstract":"<p><strong>Background: </strong>The incidence of transfusion-transmitted babesiosis (TTB) has declined substantially in recent years following the introduction of geographically selective nucleic acid testing (NAT) by blood collectors. This approach has proven quite effective in interdicting parasite-infected units from US regions where Babesia is endemic and is complemented by donor screening questions about prior diagnosis (used in lieu of NAT in non-Babesia-endemic states). Despite these successes, however, breakthrough cases continue to occur due to limitations in the current geographically targeted testing strategy.</p><p><strong>Case report: </strong>Herein, we report a Minnesota donor reinstated almost 3.5 years after a Babesia NAT-positive donation whose first post-reinstatement donation tested NAT-negative. Three months later, a subsequent donation tested NAT-positive for Babesia microti. Notification of the hospital that transfused the NAT-negative red blood cell unit revealed a likely B. microti transmission.</p><p><strong>Discussion: </strong>This reverse-notification TTB case was unlikely to have been the result of either a product from an asymptomatic untested donor from a non-endemic state infected during travel to an endemic area or a tick-borne infection of the transfusion recipient. More likely, TTB resulted from transfusion of a NAT-negative unit donated 3 months prior to the involved donor's subsequent NAT-positive collection. To our knowledge, this is the first reported potential Babesia NAT failure.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with HIV infection in U.S. blood donors across evolving deferral policies.","authors":"Vivian I Avelino-Silva, Zhanna Kaidarova, Eduard Grebe, Daniel Hindes, Roberta L Bruhn, Edward Notari, Donna Burke, Debra A Kessler, Carlos Delvalle, Rita Reik, Vilson Ortiz, Sheri Fallon, Marion C Lanteri, Susan L Stramer, Benyam Hailu, Hong Yang, Barbee Whitaker, Brian Custer","doi":"10.1111/trf.18411","DOIUrl":"https://doi.org/10.1111/trf.18411","url":null,"abstract":"<p><strong>Background: </strong>The implementation of revised blood donor deferral policies may change factors associated with HIV infection in donors. Here, we assessed factors associated with HIV in the U.S. blood donor population between 2015 and 2023.</p><p><strong>Study design and methods: </strong>Using exposure data obtained from interviews of HIV cases and matched controls, we investigated sociodemographic and behavioral factors associated with any HIV infection or recently acquired HIV infection, overall and by strata of deferral policy period (lifetime, 12-month and 3-month), for men who have sex with men and other potential risk groups using conditional logistic regression.</p><p><strong>Results: </strong>Multivariable analyses showed that several sociodemographic and behavioral factors were significantly associated with HIV infection, but with no clear evidence of changes in these factors across deferral policy periods. Similarly, several factors were significantly associated with recent HIV infection, with odds ratios similar to those observed for any HIV infection. An association between non-heterosexual orientation and HIV infection remained stable across deferral periods included in the study after adjustment for potential confounders. We found no evidence that non-heterosexual orientation is more strongly associated with recent than with any HIV infection among blood donors.</p><p><strong>Discussion: </strong>Our findings suggest no major impact of revised deferral policies on HIV risk factors among blood donors, nor among risk factors for any HIV and recent HIV infection in this population. These findings should be reassessed after sufficient accrual of data from the individual donor assessment deferral policy period.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid thawing of fresh frozen plasma with a 45°C dry tempering system maintains critical coagulation activities.","authors":"Shunya Rikimaru, Kosaku Mimura, Nozomi Takano, Mitsuhiko Tadano, Keiji Minakawa, Koki Ueda, Kinuyo Kawabata, Hiroki Shimura, Kenneth E Nollet, Hitoshi Ohto, Kazuhiko Ikeda","doi":"10.1111/trf.18426","DOIUrl":"https://doi.org/10.1111/trf.18426","url":null,"abstract":"<p><strong>Background: </strong>The ability to rapidly transfuse similar volumes of fresh frozen plasma (FFP) and packed red blood cells can reduce mortality in patients with critical bleeding. This is a compelling reason to thaw FFP quickly in real-world clinical practice. A new dry tempering system thaws FFP between two aluminum panels that are maintained at a specific temperature. The FP-2000 (for two bags) and FP-4000 (for four bags) thaw FFP at 37°C (Dry NORMAL mode) and 45°C (Dry EXPRESS mode).</p><p><strong>Study design and methods: </strong>We compared FFP thawed in a conventional water bath with FFP thawed by dry tempering at 37°C and 45°C, with particular attention to thawing speed, subsequent coagulation factor activity, and evidence of precipitation or denaturation of proteins.</p><p><strong>Results: </strong>Dry tempering can thaw FFP without bag damage or risks associated with contaminated water. Dry EXPRESS mode at 45°C could thaw FFP as fast as a water bath and had significantly shorter thawing durations than Dry NORMAL mode at 37°C for 240 mL and 480 mL bags. Moreover, both Dry EXPRESS mode and Dry NORMAL mode maintained coagulation factor activities in thawed FFP, with no evidence of protein precipitation or denaturation.</p><p><strong>Discussion: </strong>Dry tempering is useful for thawing FFP in real-world clinical situations. In contrast to open water baths, dry tempering systems could be incorporated into ambulance and emergency response vehicles responding to traumatic bleeding events. Uniquely, the new dry tempering system at 45°C could save precious minutes in a massive transfusion protocol while preserving FFP coagulation activity.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postresuscitation platelet transfusion in major trauma patients.","authors":"Andrea Rossetto, Joseph Reynolds, Ella Ykema, Ross Davenport, Elaine Cole, Paul Vulliamy","doi":"10.1111/trf.18414","DOIUrl":"https://doi.org/10.1111/trf.18414","url":null,"abstract":"<p><strong>Background: </strong>Platelet transfusions (PLT-t) are a cornerstone of contemporary trauma resuscitation, but little is known about their use in the postresuscitation period. Our aims were to describe the utilization of PLT-t after resuscitation and examine their impact on platelet count and clinical outcomes.</p><p><strong>Study design and methods: </strong>Adult trauma patients admitted to critical care at a single major trauma center were included. We compared patients who received PLT-t postresuscitation (>24 h after injury) with those who did not and examined platelet increments before and after each individual PLT-t episode. Logistic regressions were constructed to examine the association between postresuscitation PLT-t and clinical outcomes.</p><p><strong>Results: </strong>This study included 803 injured patients, of whom 109 (14%) received at least one PLT-t after resuscitation. Overall, 30% (221/725) of all platelet units administered to the cohort were given in the postresuscitation phase, most in the first week of admission and to patients with moderate-severe thrombocytopenia. The median platelet count increment following transfusion was 19 × 10⁹/L (interquartile range 1-30), and 24% of transfusions failed to increase the platelet count within 24 h. Postresuscitation PLT-t in patients with moderate-severe thrombocytopenia was independently associated with reduced mortality (OR 0.42, p = .039) but a longer critical care length of stay among survivors (coefficient 0.35, p = .007).</p><p><strong>Conclusion: </strong>Postresuscitation PLT-t is frequently administered in trauma patients. The impact on platelet counts is variable, likely attributable to differences in timing and pretransfusion platelet count. After adjusting for relevant confounders, postresuscitation PLT-t was associated with reduced mortality in this cohort.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Provider uptake of the anemia protocol across different intensive care units over 5 years in urban medical center.","authors":"Khalid Almahmoud, Shannara Bauer, Christopher Sherry, Carey Mancuso, Erin Suydam","doi":"10.1111/trf.18415","DOIUrl":"https://doi.org/10.1111/trf.18415","url":null,"abstract":"<p><strong>Background: </strong>Anemia is a common condition among critically ill patients. To address this, patient blood management (PBM) programs have been introduced to enhance anemia treatment while reducing the need for transfusions. This study assesses the implementation and effectiveness of an anemia management protocol across multiple intensive care units (ICUs), with a particular emphasis on its impact within the trauma ICU (TICU).</p><p><strong>Methods: </strong>We retrospectively reviewed ICU patients at AGH from 2016 to 2020. Adult patients (≥18 years) with an admission hemoglobin <12 g/dL were included. Statistical analyses compared patients receiving the anemia protocol management (AP) versus those receiving standard of care (nonanemia protocol [N-AP]).</p><p><strong>Results: </strong>Out of 28,420 ICU admissions, 32% of TICU patients met the inclusion criteria, with 43% managed using the AP-significantly higher than in other ICUs (p < .001). Within the TICU, patients receiving the protocol had fewer daily blood draws (p = .04), lower transfusion rates (p = .001), and higher average hemoglobin levels (p = .03) compared to those not managed with the protocol. Over time, protocol use in the TICU increased from 15% in 2016 to 41% in 2020 (p < .001), which correlated with reductions in transfusions and blood draws.</p><p><strong>Conclusion: </strong>The adoption of a structured AP was linked to enhanced anemia management, decreased transfusion requirements, and fewer blood draws in ICU patients. The TICU showed the highest rate of protocol adoption and the most notable improvements. These results support the broader implementation of protocol-driven PBM approaches to optimize outcomes in ICU settings.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Storage duration of platelet concentrates and clinical outcomes in cardiac surgery patients.","authors":"Fabienne M A van Hout, Camila Caram-Deelder, Aad Pors, Rutger A Middelburg, Robert J M Klautz, Peter M J Rosseel, Hendrik J F Helmerhorst, Leo M G van de Watering, Jean-Louis Kerkhoffs, Meindert Palmen, Johanna G van der Bom","doi":"10.1111/trf.18410","DOIUrl":"https://doi.org/10.1111/trf.18410","url":null,"abstract":"<p><strong>Background: </strong>The changes in platelet structure and function arising from its collection and storage are collectively called \"platelet storage lesion.\" In patients this might potentially be associated with impaired hemostasis and adverse events. We performed a hypothesis-generating retrospective study in cardiac surgery patients transfused with platelets in two hospitals between 2005 and 2017.</p><p><strong>Study design and methods: </strong>We explored whether longer storage duration of platelets is associated with changes in in-hospital mortality, blood loss after surgery, reoperation for bleeding, stroke, myocardial infarction, infection, systemic inflammatory response syndrome, shock, and multi-organ failure in cardiac surgery patients. Platelet concentrates were classified as platelets with shorter storage duration (PSSD; stored 1-3 days) or platelets with longer storage duration (PLSD; stored 4-7 days). Associations between storage duration and endpoints were quantified using logistic regression adjusted for potential confounders.</p><p><strong>Results: </strong>In patients transfused with PLSD, in-hospital mortality (212/2117; 10.0%) was significantly higher than in patients transfused with PSSD (109/1439; 7.6%) (adjusted odds ratio [aOR] 1.47, 95% confidence interval [CI] 1.13-1.91). Patients transfused with PLSD experienced postoperative blood loss ≥1000 mL (102/285; 35.8%) significantly more frequently than patients transfused with PSSD (87/326; 26.7%), aOR 1.74 (95% CI 1.19-2.52). In patients transfused with PLSD, the need for reoperation for bleeding (99/285; 34.7%) was significantly higher than in patients transfused with PSSD (87/326; 26.7%) (aOR 1.62, 95% CI 1.12-2.35). There was no notable association with other endpoints.</p><p><strong>Conclusion: </strong>In cardiac surgery patients, transfusion of PLSD was associated with higher in-hospital mortality, more blood loss, and reoperations for bleeding, compared to transfusion of PSSD.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case for improved transfusion history sharing through the Alloantibody Exchange.","authors":"Steve Holden, Jennifer M Jones, Sheri Hugan, Jensyn Cone Sullivan","doi":"10.1111/trf.18406","DOIUrl":"https://doi.org/10.1111/trf.18406","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-read DNA sequencing resolves a rare case of alloimmune hemolysis mimicking autoimmune hemolysis.","authors":"Hui Xiao Chao, Thomas Ma, Livia Hegerova, Theresa Nester, Nina Sen, LaySee Er, Samantha Harris, Tina Lockwood, Jillian G Buchan, Kerry W Lannert, Joseph Gasper, Joy Goffena, Miranda P G Zalusky, Sophie H R Storz, Celina Montemayor-Garcia, Monica B Pagano, Jill M Johnsen, Sandhya R Panch, Danny E Miller","doi":"10.1111/trf.18403","DOIUrl":"https://doi.org/10.1111/trf.18403","url":null,"abstract":"<p><strong>Background: </strong>Immune hemolytic anemia poses a significant challenge in transfusion medicine, as identification of underlying alloantibodies can be masked by warm and/or cold autoantibodies. This increases the risk of transfusing incompatible blood, which can precipitate or exacerbate hemolysis. Identifying alloantibodies in the presence of autoantibodies remains difficult with standard serologic and genotypic methods, often delaying accurate diagnosis and appropriate transfusion strategies.</p><p><strong>Case report: </strong>We describe a 63-year-old woman with autoimmune hemolytic anemia who suffered near-fatal hemolysis following transfusion. Despite extensive serologic and genotypic testing, the cause of her hemolytic transfusion reactions remained elusive. Given her clinical course and transfusion history, we hypothesized that her acute hemolytic transfusion reactions could be due to immune sensitization to a high-incidence RBC antigen. Research whole-genome long-read sequencing (LRS) revealed homozygosity for a rare KEL*02N.16 allele, consistent with a rare Ko phenotype, which was validated by Sanger sequencing. Retrospective serologic testing with Ko RBCs further confirmed alloimmunization within the Kell system.</p><p><strong>Conclusion: </strong>This case highlights the limitations of conventional serologic and genotypic methods in detecting rare blood group phenotypes, and emphasizes the diagnostic power of long-read sequencing in transfusion medicine. Early molecular testing in complex hemolytic cases can facilitate targeted transfusion strategies, reduce the risk of severe hemolysis, and improve patient outcomes. As sequencing technologies become more accessible, they have the potential to revolutionize blood group typing and alloimmunization risk assessment in clinical practice.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red blood cell alloimmunization: A new checkpoint inhibitor immune-related adverse event?","authors":"Lianne Rotin, Wenzie Ng, Bailie Jones, Brian Marsell, Christine Cserti-Gazdewich","doi":"10.1111/trf.18409","DOIUrl":"https://doi.org/10.1111/trf.18409","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}