Transfusion最新文献

{"title":"Characterization of a population with pregnancy potential and anti-K alloimmunization in the United States.","authors":"Emily Kelly, Marci Rosenberg, Juan Gonzalez-Velez, Sara Bakhtary, Gisela Marrero-Rivera","doi":"10.1111/trf.18333","DOIUrl":"https://doi.org/10.1111/trf.18333","url":null,"abstract":"<p><strong>Background: </strong>Maternal alloantibody formation against fetal blood cell antigens can lead to hemolytic disease of the fetus and newborn (HDFN), and anti-K alloimmunization has the potential to result in severe HDFN. Despite the benefits of prophylactic K-matched red blood cell transfusions demonstrated in other high-income countries, the United States lacks such a national policy for patients with pregnancy potential (PWPP). This study aims to characterize a population of PWPP impacted by anti-K alloimmunization in a large US academic medical system.</p><p><strong>Study design and methods: </strong>Retrospective review was undertaken to identify all cases of anti-K alloimmunization among PWPP between August 1, 2021, and July 31, 2024, in the University of California, San Francisco (UCSF) network. Demographic, clinical, and transfusion data were collected from electronic medical records and the blood bank information system and reviewed by an interdisciplinary physician team.</p><p><strong>Results: </strong>Over the 3-year study period, 150 anti-K results were reported for 69 unique PWPPs. The median age was 38 years (range: 11-50). Most PWPPs were not chronically transfused (32/39; 82% with ≤6 lifetime RBC units) and lacked identifiable alloimmunization-associated comorbidities (45/69; 65%). Thirty-seven (63%) of the PWPPs had red blood cell transfusions administered only at facilities outside of the UCSF network. Five of fifteen (33%) pregnancies following incident anti-K alloantibody identification resulted in healthy live births.</p><p><strong>Discussion: </strong>Our results support reconsideration of a national policy of prophylactic K-matching or K-negative transfusion for people with pregnancy potential as a way to prevent further alloimmunization and improve clinical care in this population.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":"65 9","pages":"1567-1573"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuing Medical Education.","authors":"","doi":"10.1111/trf.18371","DOIUrl":"https://doi.org/10.1111/trf.18371","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":"65 9","pages":"1620"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel method for autologous peripheral blood stem cell harvest using highly concentrated sodium citrate solution replacing acid citrate dextrose solution A.","authors":"Wataru Kitamura, Keiko Fujii, Masaya Abe, Kazuhiro Ikeuchi, Joji Shimono, Kana Washio, Fumio Otsuka, Yoshinobu Maeda, Nobuharu Fujii","doi":"10.1111/trf.18360","DOIUrl":"10.1111/trf.18360","url":null,"abstract":"<p><strong>Background: </strong>As the processed blood volume increases, a larger amount of anticoagulant (AC) is required, which leads to a serious issue of fluid dilution in large-volume leukocytapheresis (defined as ≥3-fold total blood volume). We previously reported a novel method for allogeneic peripheral blood stem cell harvest (PBSCH) using highly concentrated sodium citrate (HSC; 5.32%), which shortened the procedure time and reduced the need for an AC solution without heparin. In this study, we extended this novel method to autologous PBSCH (auto-PBSCH) and compared it with patients who received auto-PBSCH using normal concentrated sodium citrate (NSC; 2.2%).</p><p><strong>Study design and methods: </strong>We retrospectively analyzed consecutive auto-PBSCH data obtained using the Spectra Optia continuous mononuclear cell collection mode between May 2017 and May 2025 at our institution.</p><p><strong>Results: </strong>Leukocytapheresis was performed using NSC in 36 patients and HSC in 22. In the HSC group, patients tended to be younger, had significantly lower body weight, and had significantly fewer hematopoietic tumors as primary diseases compared to the NSC group. After propensity score-matched cohort adjusted for patient background, the total amount of AC solution was significantly lower (694 [range, 77-1648] vs. 298 mL [range, 64-797], p = .02), and procedure time was significantly shorter (224 [range, 117-395] vs. 181 min [range, 103-309], p = .048) in the HSC group. Furthermore, the loss rates of magnesium and potassium were lower in the HSC group.</p><p><strong>Conclusion: </strong>This novel leukocytapheresis method demonstrated the efficacy and safety in auto-PBSCH, while minimizing the patient burden.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1662-1672"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel missense mutation c.359G>A in SLC14A1, associated with Jk(a-b-) phenotype in a Chinese blood donor.","authors":"Aijing Li, Chen Wang, Minghao Li, Ziyan Zhu, Luyi Ye","doi":"10.1111/trf.18363","DOIUrl":"https://doi.org/10.1111/trf.18363","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":"65 9","pages":"E55-E57"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Continuing Medical Education associated with \"Hemostatic function, immunomodulatory capacity and effects of lipemia in cold-stored whole blood\".","authors":"","doi":"10.1111/trf.18237","DOIUrl":"10.1111/trf.18237","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1764"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ABO-mismatched platelet and plasma transfusion practices and the potential for transfusion-related alpha-gal syndrome: The Biomedical Excellence for Safer Transfusion Collaborative Study.","authors":"Nancy M Dunbar, Richard M Kaufman, Karina S Bary, Gregory R M Bellairs, Claudia S Cohn, Fanny Delettre, Stephanie Ditcham, Gustavo C Duarte, Amanda Ellison, Roberta Fachini, Chloe E George, Catherine Humbrecht, Vernon Louw, Sascha Meier, Sarah Morley, Meridah Mwase, Nancy Robitaille, Kylie Rushford, Tomohiko Sato, Richard Schäfer, Julie Staves, Minoko Takanashi, Pierre Tiberghien, Silvano Wendel, Erica M Wood, Alyssa Ziman, Michael F Murphy","doi":"10.1111/trf.18338","DOIUrl":"10.1111/trf.18338","url":null,"abstract":"<p><strong>Background: </strong>Alpha-gal syndrome (AGS) is caused by IgE antibodies against the alpha-gal oligosaccharide, which is structurally similar to the Group B antigen. Recent case reports of severe allergic transfusion reactions (ATRs) in Group O patients receiving Group B plasma and platelets raise the possibility of a new adverse event, herein called transfusion-related AGS (TRAGS). The primary goal of this study was to assess the frequency of Groups B and AB plasma and platelet transfusions to Group O patients.</p><p><strong>Study design and methods: </strong>In this multi-site retrospective study, participating sites submitted the numbers of platelet and plasma transfusions administered during a 2-year period categorized by patient and product ABO group.</p><p><strong>Results: </strong>Fourteen sites from 10 countries participated. Group O patients received Group AB for an average of 9.9% (range 2.8%-29.2%) of plasma transfusions and Group B for 3.2% (0%-12.8%). AB plasma transfusion to Group O patients represented 4.5% (0.9%-14.6%) of the total plasma transfused; Group B 1.4% (0%-5.1%). Group O patients received Group AB for an average of 1.5% (range 0%-5.9%) of platelet transfusions and Group B for 4.1% (0%-14.2%). AB platelet transfusion to Group O patients represented 0.6% (0%-2.7%) of the total platelets transfused; Group B platelets were 1.8% (0%-6.7%).</p><p><strong>Discussion: </strong>Evidence supporting the possibility of a new adverse event, TRAGS, is accumulating. This study quantifies how often Group O patients may be exposed to Group B antigen in Group B or AB plasma and/or platelet transfusions, providing an estimate of the scope of potential risk for TRAGS.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1621-1629"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lead impregnation in blood donors in Algiers.","authors":"Smail Benbouabdellah, Salma Kaddour","doi":"10.1111/trf.18358","DOIUrl":"10.1111/trf.18358","url":null,"abstract":"<p><strong>Introduction: </strong>Lead exposure, even at low levels, can severely impact the neurological development of newborns, especially premature infants due to their low birth weight. Blood transfusion is an overlooked or unknown indirect exposure pathway.</p><p><strong>Objective: </strong>To quantify blood lead levels among blood donors in Algiers.</p><p><strong>Materials and methods: </strong>The study involved 484 donors from 16 transfusion centers in Algiers. A questionnaire assessed lead exposure sources, and blood samples were analyzed using inductively coupled plasma mass spectrometry (ICP/MS) to measure lead levels, with a decision threshold of 10 μg/L. The critical threshold for premature newborns has been set at 18 μg/L in the donor.</p><p><strong>Discussion: </strong>Thirty percent of donors had measurable blood lead levels, with 17.98% exceeding the critical threshold of 18 μg/L. No donors under 20 had measurable lead levels. Recent home renovations and kohl use were linked to higher lead levels. Occupational exposure, such as a car bodyworker with a lead level of 163.28 μg/L, poses a risk for low birth weight newborns receiving transfusions.</p><p><strong>Conclusion: </strong>Selection criteria for newborn transfusions should limit lead exposure, favoring young donors without recent lead exposure. Testing blood lead levels in donors could improve neonatal transfusion safety. Further research is required to refine critical thresholds and improve screening protocols.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1599-1608"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking twin chimerism.","authors":"Robert E Wenk, Kayla M Sheets","doi":"10.1111/trf.18341","DOIUrl":"10.1111/trf.18341","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1751-1755"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Comparative changes of pre-operative autologous transfusions and peri-operative cell salvage in the United States.","authors":"","doi":"10.1111/trf.18372","DOIUrl":"10.1111/trf.18372","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1765"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a novel B allele with a nucleotide change (c.826G>T) responsible for B_el phenotype.","authors":"Jue Hou, Hongli Guan, Meng Li","doi":"10.1111/trf.18362","DOIUrl":"https://doi.org/10.1111/trf.18362","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":"65 9","pages":"E58-E60"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}