Transfusion最新文献_第4页

Addressing platelet insecurity - A national call to action. 解决血小板不安全问题--全国行动呼吁。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-12 DOI: 10.1111/trf.17987

Eric A Gehrie, Pampee P Young, Sridhar V Basavaraju, Arthur W Bracey, Andrew P Cap, Liz Culler, Nancy M Dunbar, Mary Homer, Iris Isufi, Rob Macedo, Tanya Petraszko, Glenn Ramsey, Christopher A Tormey, Richard M Kaufman, Edward L Snyder

引用次数: 0

Cover 封面

IF 2.9 3区医学

Transfusion Pub Date : 2024-08-10 DOI: 10.1111/trf.17437

引用次数: 0

Implementing pathogen reduction technology while discontinuing blood donor deferral criteria for sexual risk behaviors: A simulation study. 在实施减少病原体技术的同时，取消献血者性危险行为的推迟标准：模拟研究。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-10 DOI: 10.1111/trf.17981

Marie-Pier Domingue, Sheila F O'Brien, Yves Grégoire, Marion C Lanteri, Susan L Stramer, Félix Camirand Lemyre, Antoine Lewin

{"title":"Implementing pathogen reduction technology while discontinuing blood donor deferral criteria for sexual risk behaviors: A simulation study.","authors":"Marie-Pier Domingue, Sheila F O'Brien, Yves Grégoire, Marion C Lanteri, Susan L Stramer, Félix Camirand Lemyre, Antoine Lewin","doi":"10.1111/trf.17981","DOIUrl":"https://doi.org/10.1111/trf.17981","url":null,"abstract":"Background: Combining pathogen reduction technology (PRT) with blood screening may alleviate concerns over the risk of transfusion-transmitted infections (TTI) and support changes in blood donor selection to potentially increase blood availability. This study aimed to estimate the residual risk of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) transfusion-transmission in Canada after implementing PRT, while eliminating deferrals for sexual risk behaviors.Study design and methods: A probabilistic approach that combined Bayesian networks with Monte Carlo simulations was used to estimate the risk of transfusing HIV-, HBV-, or HCV-contaminated blood components. Different scenarios were considered to compare the current residual risk after PRT implementation, with and without donor deferral criteria for sexual risk behaviors. Donor profiles and blood component outcomes were simulated based on a literature review including the prevalence and incidence of HIV, HBV, and HCV in the Canadian blood donor population; the use of current blood screening assays; and HIV, HBV, and HCV blood donor viral loads.Results: In the universal PRT scenario (i.e., with PRT/without deferral criteria), the estimated risks of HIV, HBV, and HCV transmission were significantly lower than those in the currently observed scenario (i.e., without PRT/with deferral criteria).Conclusions: This risk model suggests that PRT for platelets and plasma (and eventually for RBCs when available) significantly reduces the residual risks of HIV, HBV and HCV transfusion-transmission and could enable the removal of blood donor deferral criteria for sexual risk behaviors.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Masthead and Table of Contents 刊头和目录

IF 2.9 3区医学

Transfusion Pub Date : 2024-08-10 DOI: 10.1111/trf.17438

引用次数: 0

Efficacy and safety of novel freeze-dried plasma products in a porcine combat casualty model. 新型冻干血浆产品在猪战伤模型中的有效性和安全性。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-09 DOI: 10.1111/trf.17971

Frédérique Dufour-Gaume, Vénétia Cardona, Audrey Bordone, Florent Montespan, Philippe Vest, Anne-Margaux Legland, Nadira Frescaline, Nicolas Prat

{"title":"Efficacy and safety of novel freeze-dried plasma products in a porcine combat casualty model.","authors":"Frédérique Dufour-Gaume, Vénétia Cardona, Audrey Bordone, Florent Montespan, Philippe Vest, Anne-Margaux Legland, Nadira Frescaline, Nicolas Prat","doi":"10.1111/trf.17971","DOIUrl":"https://doi.org/10.1111/trf.17971","url":null,"abstract":"Background: Hemorrhagic shock is well documented as a leading cause of preventable fatalities among military casualties. During military operations plasma can be transfused while waiting for whole blood. This study was conducted to assess the safety and efficacy of two new freeze-dried plasma formulations in a porcine model of traumatic hemorrhagic shock.Study design and methods: In the face of species-specific transfusion, transfusible blood products were derived from porcine sources. The efficacy of three lyophilized plasma (LP) formulations was evaluated: lyophilized plasma (LP), concentrated lyophilized plasma (CLP), and platelet-rich concentrated lyophilized plasma (PCLP). Pigs were subjected to multi-trauma and hemorrhagic shock. Ninety minutes post-shock induction, the animals were treated with one of the three lyophilized products. Monitoring included systolic blood pressure and cardiac output. Point-of-care and laboratory diagnostic tests were used to assess renal function, real-time hemostasis (ROTEM), and coagulation. Histological examinations of kidney, lung, and muscle tissues were conducted 4 h after shock induction.Results: CLP and PCLP significantly improved systolic blood pressure and cardiac output and positively influenced base excess, creatinine, various ROTEM, and coagulation markers compared with standard LP without histologic modification. No adverse effect was associated with the transfusion of any of the plasma products throughout the experimental procedures.Conclusion: Both CLP and PCLP exhibit promising therapeutic potential for managing hemorrhagic shock in scenario where whole blood supplies are limited. However, the distinct physiological and coagulation characteristics of the swine model necessitate further investigation using humanized preclinical models to fully understand their clinical applicability and constraints.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141910134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Four novel ABO*B alleles associated with reduced B antigen expression. 四种与 B 抗原表达减少有关的新型 ABO*B 等位基因。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-08 DOI: 10.1111/trf.17969

Yan Li, Liling Zhou, Wei Han, Zhaoze Ma, Chenlong Wang

引用次数: 0

Correction to "Clinical data for intravenous iron - debunking the hype around hypersensitivity". 更正 "静脉注射铁剂的临床数据--揭穿关于超敏反应的炒作"。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-08 DOI: 10.1111/trf.17977

引用次数: 0

Alloimmunization in myelodysplastic syndrome is associated with higher healthcare costs, longer hospitalizations, and increased mortality. 骨髓增生异常综合症患者的同种免疫与较高的医疗费用、较长的住院时间和较高的死亡率有关。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-07 DOI: 10.1111/trf.17966

Elisabet Viayna, Eric A Gehrie, Christopher Blanchette

{"title":"Alloimmunization in myelodysplastic syndrome is associated with higher healthcare costs, longer hospitalizations, and increased mortality.","authors":"Elisabet Viayna, Eric A Gehrie, Christopher Blanchette","doi":"10.1111/trf.17966","DOIUrl":"https://doi.org/10.1111/trf.17966","url":null,"abstract":"Background: Transfusion of red blood cells (RBC) is an important component of treatment for myelodysplastic syndromes (MDS). Patients receiving frequent transfusions are more likely to develop alloimmunization, an immune reaction to minor RBC antigens that increases the risk of complications including delayed hemolysis. Phenotypic matching is believed to reduce alloimmunization although rigorous evidence is lacking. This study examines the association of alloimmunization with clinical and economic outcomes and may give insight into the potential benefit of phenotypic matching in MDS.Study design and methods: This study used data from 1054 hospitals included in the Premier hospital chargemaster dataset. Alloimmunized MDS patients (January 2015 to June 2019) were indirectly identified by ICD-10 codes (antiglobulin crossmatch and RBC antibody identification). The primary objective was assessment of the association between incremental cost per patient encounter and alloimmunization in MDS patients. Secondary objectives were assessment of the association of length of stay, intensive care unit (ICU) admission, and inpatient mortality for alloimmunized versus non-alloimmunized MDS patients.Results: Worse clinical and economic outcomes were observed for the alloimmunized group. Higher costs (14%), more ICU admissions (38%), longer hospital (21%) and ICU stays (55%), and greater mortality (30%) were observed among alloimmunized MDS patients compared to non-alloimmunized (p < .0001 for all comparisons).Discussion: Alloimmunization may be associated with higher costs and greater risk of ICU admission and death in patients with MDS. While further mechanistic research is needed, it seems that MDS patients may benefit substantially from practices that limit risk of alloimmunization, including providing prophylactic antigen matching.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Australian fresh frozen plasma audit: A National Blood Transfusion Committee and Blood Matters collaboration. 澳大利亚新鲜冷冻血浆审计：国家输血委员会与血液事务合作。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-05 DOI: 10.1111/trf.17978

Lisa Clarke, Ellen Maxwell, Trish Roberts, Linley Bielby

{"title":"Australian fresh frozen plasma audit: A National Blood Transfusion Committee and Blood Matters collaboration.","authors":"Lisa Clarke, Ellen Maxwell, Trish Roberts, Linley Bielby","doi":"10.1111/trf.17978","DOIUrl":"https://doi.org/10.1111/trf.17978","url":null,"abstract":"Background: There is a paucity of high-quality data to guide appropriate fresh frozen plasma transfusion with current recommendations based on consensus opinion. The limitations of the product and testing modalities are poorly understood with the rare but potentially serious side effects underappreciated. Combined this has resulted in the widespread misuse of FFP.Study design and methods: Retrospective data capturing FFP transfusion within the 12-month period of April 1, 2022 and March 31, 2023 was entered by Australian health care providers. Appropriate transfusion was assessed by the adjudicators and defined as one in keeping with current recommendations. Descriptive and comparative analyses were performed using SAS Studio version 9.4.Results: During the study period, 935 FFP transfusion episodes were captured. The most frequent indications for FFP were massive hemorrhage 344 (37%), bleeding 141 (15%), and preoperative use 90 (10%). Males received 534 (60%) transfusions. Critical care specialists were the largest users of FFP, prescribing 568 (63%) of transfusions. FFP was used appropriately in 546 (61%) transfusions. However, when massive hemorrhage was excluded only 202 (37%) transfusions were appropriate. Patients with an INR <1.5 received 37% of transfusions. Transfusion associated adverse events were reported in 2% (15) of transfusions including two non-fatal anaphylactic reactions.Discussion: This audit assesses the appropriate use of FFP across all major clinical indications and provides the largest body of evidence of Australian plasma transfusion practices. It highlights the widespread misuse of FFP, which is predominantly guided by consensus recommendations due to a lack of high-quality data.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of half red blood cell units in oncology patients during severe shortages to extend hospital supply. 在红细胞严重短缺的情况下，为肿瘤患者使用半红细胞单位，以延长医院的供应量。

IF 2.5 3区医学

Transfusion Pub Date : 2024-08-05 DOI: 10.1111/trf.17972

Lefan Zhuang, Haoyue Shan, Dongyun Yang, Jennifer Woo, Shirong Wang, Alexander Garcia, Ryan Jackson, Shan Yuan

{"title":"Use of half red blood cell units in oncology patients during severe shortages to extend hospital supply.","authors":"Lefan Zhuang, Haoyue Shan, Dongyun Yang, Jennifer Woo, Shirong Wang, Alexander Garcia, Ryan Jackson, Shan Yuan","doi":"10.1111/trf.17972","DOIUrl":"https://doi.org/10.1111/trf.17972","url":null,"abstract":"Background: The COVID-19 pandemic exerted an unprecedented impact on the blood supply from 2020 through 2022. As a result, throughout 2021 there were months our hospital had less than one-day supply of type O RBCs. To meet transfusion needs, whole RBC units were split into half units and issued to stable, non-bleeding patients. This single-institution, retrospective study examines time intervals to subsequent transfusion and total numbers of RBC units subsequently transfused after the first half or whole RBC unit.Study design and methods: Patients who were transfused RBC between May 21, 2021 and November 1, 2021 were divided into in- and outpatient groups, then based on whether they received at least 1 half RBC unit or only whole RBC units during the study period. The time interval between this first half unit transfusion, or first whole unit transfusion in those who did not receive half units, and the subsequent RBC transfusion within 90 days was calculated and compared, as well as the total number of RBC units transfused 30 days after the first unit.Results: In general, patients transfused with half units received a subsequent transfusion significantly earlier than those transfused with whole units. Additionally, receiving an index half unit was associated with more RBC transfusions in the following 30 days (p = .001).Conclusion: Transfusion of half RBC units during a severe RBC blood shortage can temporarily decrease RBC usage but will result in a shorter interval to the next transfusion and greater total number of RBC units transfused in subsequent days.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0