Transfusion最新文献

{"title":"How does a national blood operator detect early infectious disease signals affecting blood and cellular therapy product safety and sufficiency?","authors":"Leisa Bruneau, Carmen L Charlton, Sandra Ramirez-Arcos, Dilini Kumaran, David Allan, Olivia Norman, Matthew Seftel, Evan M Bloch, Chantale Pambrun, Sheila F O'Brien, Cynthia Cranney, Steven J Drews","doi":"10.1111/trf.70388","DOIUrl":"10.1111/trf.70388","url":null,"abstract":"<p><strong>Background: </strong>Public access to up-to-date information on infectious diseases and outbreaks has grown rapidly with the advent of artificial intelligence platforms. While this information can improve patient care and support research, the sheer volume of available data coupled with the challenge of identifying misinformation and disinformation can be overwhelming. A key challenge is managing large information volumes and identifying early, subtle signals that may indicate risks or opportunities to prevent infection. The aim of this manuscript is to explain how a national blood operator identifies and evaluates subtle infectious disease signals generated by horizon scanning to proactively protect the blood supply, including biotherapy products.</p><p><strong>Methods: </strong>Horizon scanning protocols were developed to detect early signals of change (emerging/re-emerging pathogens, geopolitical/environmental changes, scientific and technological advances, new therapies/treatments for infectious diseases, and blood operator transfusion medicine changes). Communication strategies were created to alert national and international transfusion medicine decision makers of blood safety-related events.</p><p><strong>Results: </strong>Several key components of a horizon scanning approach are presented to illustrate how novel information can be identified, processed, and formulated into knowledge translation products. Efficient and cost-effective approaches are presented to enable horizon scanning activities with limited resources and time commitments.</p><p><strong>Discussion: </strong>Horizon scanning is an efficient and necessary activity to safeguard the blood supply. Here we present a collaborative group-based approach, which reduces operator bias and improves overall examination of multiple data sources. This approach does not require expensive technology, can focus on open-source information, and engages new scientists in learning about infectious diseases.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1902-1909"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13674131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The blood system in Ukraine: Experience in martial law conditions.","authors":"Yevgen Chornenkyy, Mark Jedrzejczak, Marium Malik, Oleksandr Serhiienko, Dmytro Koval, Ricardo Sumugod, Margaret Fink, Paul Lindholm, Glenn Ramsey","doi":"10.1111/trf.70372","DOIUrl":"10.1111/trf.70372","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background/case studies: &lt;/strong&gt;Efficient blood and blood components supply is key to the stable operation of a health care system, especially to a civilian population and military under martial law. The blood system is an important component of a state's defense capability and national security. Since 2022, Ukraine has advanced experience in self-sufficiency with whole blood and blood components in the conditions of a land war, without importing blood components.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design/methods: &lt;/strong&gt;In October 2022, a Ukrainian transfusion medicine delegation-headed by Specialized State Institution «Ukrainian Transplant Coordination Center» (SSI «UTCC»), the national coordinator of Ukraine's blood system-visited several Midwestern US blood banks, including Northwestern Memorial Hospital, to exchange information on blood system organization, transfusion practice, and disaster preparedness. During a daylong seminar and follow-up communications, delegation members described the Ukrainian blood system, wartime challenges, and plans to meet European Union standards, while also learning about US laboratory standards, transfusion practices, and emerging blood components such as cold-stored platelets. The approaches presented during this exchange have since demonstrated sustained effectiveness and systemic resilience across subsequent years of full-scale conflict, through to the present day.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results/findings: &lt;/strong&gt;In 2021, Ukraine had 24 regional blood establishments and 385 hospital blood banks collecting whole blood and blood components. The donor rate was 7.5 per 1000 inhabitants, and 44% of donors were first-time donors. Most donors (95%) were voluntary donors aged 18-45 years. The national blood system served both civilian and military needs. Since the invasion, some blood establishments and hospital blood banks have been damaged, destroyed, or occupied. These disruptions created urgent challenges, including coordination of blood system activities to maintain a continuous blood supply for civilian and military healthcare systems, management of the donor pool, development and management of national whole blood and blood component inventories, implementation of new transfusion practices and basic transfusion training for the security and defense forces, and traceability and hemovigilance during the prehospital stage of medical evacuation. In response, the Ministry of Health of Ukraine established the Operational Headquarters to coordinate the blood system under martial law. Blood establishments now report blood stocks daily, and some operate on a 24-h cycle to increase collection volumes. New approaches to donor recruitment and blood collection were developed to improve donor safety, and organizational partnerships and national donor campaigns were launched, including \"Your blood can fight. Become a donor.\" The production, supply, logistics, and redistribution of whole blood and blood components to areas of need","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1884-1890"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13674120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis B virus infection with high HBsAg and undetectable DNA levels in untreated blood donors: Viral mechanisms and transfusion safety implications.","authors":"Maelenn Païline Delcourt, Marion Vermeulen, Aneta Kopacz, Manuela Miletic, Andrew Saville, Christoph Niederhauser, Jean-Michel Pawlotsky, Syria Laperche, Daniel Candotti","doi":"10.1111/trf.70334","DOIUrl":"10.1111/trf.70334","url":null,"abstract":"<p><strong>Background: </strong>Blood donor screening occasionally identifies individuals with high HBV surface antigen (HBsAg) levels despite undetectable or extremely low HBV DNA. Molecular basis and transfusion risk of this discordant profile remain unclear.</p><p><strong>Study design and methods: </strong>Seventy-five blood donors with HBsAg >100 IU/mL and undetectable or very low HBV DNA (<6 IU/mL), including 39 ID-NAT-nonreactive, were investigated. HBV DNA was further assessed using a second ID-NAT assay, confirmatory PCR following virion concentration, and sequencing. Sequences were compared with those from genotype-matched high-viremia controls. Selected basic core promoter (BCP) and core mutations were introduced into 1.18-mer replication-competent Hepatitis B virus (HBV) plasmids to assess effects on extracellular virion-associated DNA production.</p><p><strong>Results: </strong>Four (5%) samples were nonreactive by the two ID-NAT assays. HBV DNA was confirmed in all donors, often at unquantifiable levels, and all were anti-HBc positive. No consistent molecular signature was identified. Heterogeneous, case-specific mutations were detected in BCP, core, and PreS1, including variants predicted to affect pregenomic RNA transcription, encapsidation, or virion assembly, with no evidence of impaired polymerase activity. In vitro, selected BCP mutations significantly reduced extracellular HBV DNA without affecting HBsAg production. Most core mutations had minimal impact, although two strains carrying cN92T/cM93T or cS170F showed reduced virion-associated DNA. Some constructs exhibited impaired virion secretion or increased naked capsid production.</p><p><strong>Conclusion: </strong>HBsAg-positive/low-DNA profile largely reflects chronic inactive infection with minimal viremia. Diverse regulatory and structural mutations may contribute in a multifactorial manner. Persistent viral genomes and residual replication support continued HBsAg screening where NAT sensitivity is suboptimal and anti-HBc testing cannot be implemented.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1993-2006"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13674214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148537014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel homozygous ABCB6 variant causing the Lan null phenotype and anti-Lan-mediated hemolytic disease of the fetus and newborn: A case report and a review of anti-Lan in pregnancy.","authors":"Jing Feng, Li Tian, Yan Zhang, Kai Zhu, Haijuan Wang, Hong Zhao, Luyi Ye, Jian Chen","doi":"10.1111/trf.70319","DOIUrl":"10.1111/trf.70319","url":null,"abstract":"<p><strong>Background: </strong>The Lan antigen is a high-prevalence red blood cell antigen encoded by the ATP binding cassette subfamily B member 6 (ABCB6) gene. Variants in this gene are responsible for Lan null and variant phenotypes. Individuals lacking the Lan antigen may develop anti-Lan antibodies following sensitizing events such as transfusion or pregnancy. Hemolytic disease of the fetus and newborn (HDFN) caused by anti-Lan antibodies is extremely rare.</p><p><strong>Case presentation: </strong>We report a case of a Chinese pregnant woman carrying a novel homozygous variant in exon 17 of the ABCB6 gene (NM_005689.4:c.2312_2313del), resulting in a Lan null phenotype. Anti-Lan antibodies were detected in maternal plasma, neonatal plasma, and cord blood eluate. The newborn developed mild HDFN, which resolved spontaneously without intervention, leading to a favorable outcome.</p><p><strong>Conclusion: </strong>This represents the first documented case of anti-Lan-mediated HDFN in an Asian population and the fifth case worldwide. Our findings expand the genetic diversity and geographic spectrum of this rare condition and provide important insights for clinical management.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"2025-2030"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency whole-tank transfer of cord blood units after cryogenic failure: A safe rescue strategy.","authors":"Jesus Fernandez-Sojo, Carmen Azqueta, Nerea Castillo-Flores, Mònica Linares, Elena Valdivia, Laura Medina-Boronat, Sergio Arteaga, Nuria Rubio, Sonia Poyatos, Alexander Guterres, Ana Garcia-Buendia, Sergi Querol, Joan R Grifols","doi":"10.1111/trf.70330","DOIUrl":"10.1111/trf.70330","url":null,"abstract":"<p><strong>Background: </strong>Cryogenic storage of cord blood units (CBUs) is critical to ensure long-term viability and safety. Loss of vacuum in liquid nitrogen (LN₂) tanks is an exceptionally rare but high-risk event that may lead to accelerated LN₂ evaporation and potential warming of stored units.</p><p><strong>Case report: </strong>We describe an emergency rescue transfer following suspected vacuum loss in a BioArchive cryogenic tank at a public cord blood bank. The tank contained 2880 CBUs, including 14 directed units. Progressive LN₂ consumption suggested structural failure, and in situ repair was not feasible. A rapid transfer procedure using a backup BioArchive-compatible tank was performed with the assistance of the manufacturer. The maneuver involved crane-assisted repositioning of the tank under the robotic system and was completed in 40 s. Continuous temperature monitoring confirmed stable vapor-phase conditions throughout the procedure. Six CBUs stored in upper tank positions (worst-case exposure) were evaluated post-thaw. Cell recovery, viability, and clonogenic capacity were preserved and met release criteria for transplantation.</p><p><strong>Conclusion: </strong>Emergency transfer of CBUs during cryogenic tank malfunction is feasible and can be performed safely without compromising product quality when executed under controlled conditions. This report provides practical guidance for managing rare but critical storage failures in cord blood banking using BioArchive system.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"2037-2041"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfusion intensity in the ICU: Reasons and triggers.","authors":"Merijn C Reuland, Senta J Raasveld, Jimmy Schenk, Claudia van den Oord, Sanne de Bruin, Caroline M Schaap, Andrew W J Flint, Jan Bakker, Maurizio Cecconi, Aarne Feldheiser, Jens Meier, Thomas W L Scheeren, Tarikul Hamid, Michaël Piagnerelli, Tina Tomić Mahečić, Jan Benes, Lene Russell, Hernan Aguirre-Bermeo, Konstantina Triantafyllopoulou, Vasiliki Chantziara, Mohan Gurjar, Sheila Nainan Myatra, Vincenzo Pota, Muhammed Elhadi, Ryszard Gawda, Mafalda Mourisco, Marcus Lance, Vojislava Neskovic, Matej Podbregar, Juan V Llau, Manuel Quintana-Diaz, Maria Cronhjort, Carmen A Pfortmueller, Nihan Yapici, Nathan D Nielsen, Akshay Shah, Harm-Jan de Grooth, Zoe McQuilten, Cécile Aubron, Alexander P J Vlaar, Marcella C A Müller","doi":"10.1111/trf.70350","DOIUrl":"10.1111/trf.70350","url":null,"abstract":"<p><strong>Background: </strong>The reasons and physiological triggers for blood transfusion in critically ill patients are not well characterized. Beyond hemoglobin levels, hemodynamic instability is frequently cited, but its role across clinical contexts remains unclear.</p><p><strong>Aims: </strong>(1) To determine whether reasons and triggers for RBC transfusion differ across intensive care unit (ICU) days with varying transfusion intensity. (2) To describe reasons for non-RBC transfusions across these intensity groups.</p><p><strong>Methods: </strong>This sub-study of the prospective International Point Prevalence Study of Intensive Care Unit Transfusion Practices (InPUT) classified ICU days by transfusion intensity: nonmajor (1 RBC unit), major (≥2 units), and massive (≥6 units in a single event, ≥10 per day, or Massive Transfusion Protocol activation). ICU days without transfusion for active bleeding were classified as no bleeding.</p><p><strong>Results: </strong>Significant differences in the multivariate composition of reasons for RBC transfusion were observed across intensity groups on permutational analysis of variance (PERMANOVA). Hypotension was the most frequently cited physiological trigger in nonmajor (54%, n = 80/148) and major transfusions (68%, n = 196/288), but less frequent in massive transfusions (30%, n = 14/64). Tachycardia was the second most common trigger in nonmajor (37%, n = 80/148), major (40%, n = 116/288), and massive transfusions (22%, n = 19/64).</p><p><strong>Conclusion: </strong>RBC transfusions are administered for distinct, intensity-dependent combinations of reasons and triggers. Transfusion intensity and clinical context are therefore key factors in evaluating transfusion practices. Among bleeding critically ill patients, hypotension and tachycardia are the most frequently cited physiological triggers.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1963-1973"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13674203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization patterns of low-titer group O whole blood in a level 1 trauma center.","authors":"Maryam Asif, Alisha D Berry, Shafaq Zahid, Erin Tuott, Lynn G Stansbury, John R Hess","doi":"10.1111/trf.70332","DOIUrl":"10.1111/trf.70332","url":null,"abstract":"<p><strong>Background: </strong>Whole blood (WB) is an easy-to-use resuscitation fluid. As more low-titer group O WB has become available at our hospital, it is being used in an increasingly diverse range of situations, both pre-hospital and in-hospital.</p><p><strong>Study design and methods: </strong>We conducted a retrospective analysis of all WB units issued by our transfusion service during calendar year 2024. Data were obtained from the transfusion service database and linked to patient medical records to characterize indications, location of transfusion, and patient outcomes. Results are descriptive.</p><p><strong>Results: </strong>A total of 1915 WB units were issued. 1879 units (98.1%) were transfused to 524 patients, of which 237 units (12.6%) were prehospital. Of these, 1817 units (96.7%) were transfused to patients ultimately treated at HMC. Trauma accounted for the majority of in-hospital utilization (87.6%), with motor vehicle collisions (MVCs) and penetrating trauma the most common indications. Non-trauma indications accounted for 12.4% of transfused units and included gastrointestinal bleeding, vascular surgery, cardiac emergencies, necrotizing soft tissue infections, and other shock states. Among 477 admitted patients who received WB, in-hospital mortality was 29.6%. Operational strategies, including extended cooler validation and retention of inventory ownership until use, supported high utilization with minimal waste.</p><p><strong>Conclusions: </strong>Whole blood utilization was primarily driven by traumatic hemorrhage but extended across diverse acute care settings. Utilization patterns were shaped by supply limitations and operational considerations rather than clinical demand alone, underscoring the importance of incorporating logistics and utilization data into future whole blood research and implementation efforts.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1910-1915"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13674113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do I transition oncology patients from intravenous immunoglobulin to subcutaneous immunoglobulin in an outpatient clinic?","authors":"Dior Caruso, Hilary Weatherby, Schenell Rosario, Graham Dozois, Lani Lieberman","doi":"10.1111/trf.70353","DOIUrl":"10.1111/trf.70353","url":null,"abstract":"<p><strong>Background: </strong>Intravenous immunoglobulin (IVIG) treating secondary immunodeficiency (SID) for oncology patients causes strain for outpatient clinic capacity. Home-based subcutaneous immunoglobulin (SCIG) offers equivalent efficacy and improves patient convenience and resource utilization. Transition to home-based SCIG remains infrequent due to fragmented referral pathways, limited clinician awareness, and inconsistent patient education. The project objective was to increase the number of patients transitioning from IVIG to SCIG.</p><p><strong>Methods: </strong>A quality improvement initiative was established following a baseline assessment of the SCIG transition process and IVIG utilization patterns. A driver diagram informed change ideas tested across seven Plan-Do-Study-Act (PDSA) cycles. The outcome measure was the monthly SCIG referral rate. The process measures were the median monthly number of chronic, new start, and total IVIG users in the outpatient clinic. The balancing measures assessed if SCIG referrals had an effect on chair time and operational costs. Electronic referral process was developed, clinician education enhanced, nurse champion role created, and clinician and patient education materials were standardized.</p><p><strong>Results: </strong>Following the intervention, the number of patients transitioning from IVIG to SCIG increased from 3.7% to 8.5%. The number of monthly new start IVIG users remained the same while the number of monthly chronic IVIG users increased. The balancing measures indicate that SCIG referrals did not reduce chair time but generated significant cost avoidance.</p><p><strong>Discussion: </strong>Transitions from IVIG to SCIG have shifted care into the home, reducing outpatient pressure and costs. Long-term sustainability requires improved referral of chronic IVIG users and strategies to support patient engagement.</p>","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"1893-1901"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148631777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apparent reduction of anti-FXa activity after 4F-PCC Administration: True reversal or PCC-related analytical effect?","authors":"Gabor Erdoes, Andreas Koster, Ingvild Birschmann","doi":"10.1111/trf.70351","DOIUrl":"10.1111/trf.70351","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"2045-2046"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RBC depletion with Gelofusine in allogeneic hematopoietic stem cell transplantation.","authors":"Antonio Bruno, Gianpaolo Del Proposto, Gaspare Adorno, Michele Abignente, Paolo De Vita, Giulio Puleri, Aleandra Ferrantini, Raffaella Cerretti, Francesco Buccisano, Adriano Venditti","doi":"10.1111/trf.70356","DOIUrl":"10.1111/trf.70356","url":null,"abstract":"","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":" ","pages":"2047-2048"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148593320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}