Transfusion最新文献_第6页

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 DOI: 10.1111/trf.18015

引用次数: 0

Characterization of blood bank and transfusion medicine practices for pregnant individuals with fetuses at risk of hemolytic disease in the United States. 美国针对有溶血病风险胎儿的孕妇的血库和输血医学实践特点。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-09-09 DOI: 10.1111/trf.18011

Jeremy W Jacobs, Garrett S Booth, Kenneth J Moise, Brian D Adkins, Sara Bakhtary, Ross M Fasano, Ruchika Goel, Hannah D Hinton, Sadia A Laghari, Laura D Stephens, Christopher A Tormey, Elizabeth P Crowe, Evan M Bloch, Elizabeth A Abels

{"title":"Characterization of blood bank and transfusion medicine practices for pregnant individuals with fetuses at risk of hemolytic disease in the United States.","authors":"Jeremy W Jacobs, Garrett S Booth, Kenneth J Moise, Brian D Adkins, Sara Bakhtary, Ross M Fasano, Ruchika Goel, Hannah D Hinton, Sadia A Laghari, Laura D Stephens, Christopher A Tormey, Elizabeth P Crowe, Evan M Bloch, Elizabeth A Abels","doi":"10.1111/trf.18011","DOIUrl":"10.1111/trf.18011","url":null,"abstract":"Background: Hemolytic disease of the fetus and newborn (HDFN) is caused by maternal alloantibody-mediated destruction of fetal/neonatal red blood cells (RBCs). While the pathophysiology has been well-characterized, the clinical and laboratory monitoring practices are inconsistent.Methods: We surveyed 103 US institutions to characterize laboratory testing practices for individuals with fetuses at risk of HDFN. Questions included antibody testing and titration methodologies, the use of critical titers, paternal and cell-free fetal DNA testing, and result reporting and documentation practices.Results: The response rate was 44% (45/103). Most respondents (96%, 43/45) assess maternal antibody titers, primarily using conventional tube-based methods only (79%, 34/43). Among respondents, 51% (23/45) rescreen all individuals for antibodies in the third trimester, and 60% (27/45) perform paternal RBC antigen testing. A minority (27%, 12/45) utilize cell-free fetal DNA (cffDNA) testing to predict fetal antigen status. Maternal antibody titers are performed even when the fetus is not considered to be at risk of HDFN based on cffDNA or paternal RBC antigen testing at 23% (10/43) of sites that assess titers.Discussion: There is heterogeneity across US institutions regarding the testing, monitoring, and reporting practices for pregnant individuals with fetuses at risk of HDFN, including the use of antibody titers in screening and monitoring programs, the use of paternal RBC antigen testing and cffDNA, and documentation of fetal antigen results. Standardization of laboratory testing protocols and closer collaboration between the blood bank and transfusion medicine service and the obstetric/maternal-fetal medicine service are needed.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142155040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simple formula for adjusted performance parameters in evaluation of diagnostic methods. 诊断方法评估中调整性能参数的简单公式。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-08-15 DOI: 10.1111/trf.17989

Frederik Banch Clausen, Alberte Aspaas Lundquist, Emil Urhammer, Leif Kofoed Nielsen, Klaus Rieneck

引用次数: 0

The effectiveness of telephone surveys on the return of first-time donors: A randomized controlled trial. 电话调查对首次捐献者回归的有效性：随机对照试验。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI: 10.1111/trf.17974

Vanessa C Marsano, Dirk Hasenclever, Reinhard Henschler

{"title":"The effectiveness of telephone surveys on the return of first-time donors: A randomized controlled trial.","authors":"Vanessa C Marsano, Dirk Hasenclever, Reinhard Henschler","doi":"10.1111/trf.17974","DOIUrl":"10.1111/trf.17974","url":null,"abstract":"Background: The management of blood supply depends, among other factors, on the effective remobilization of first-time donors (FTDs). This study investigates the efficacy of telephone calls to increase second donation rates.Study design and methods: A randomized controlled trial was conducted on 418 first-time blood donors. In the telephone group (TG, n = 206), men were contacted 9-10 and women 13-14 weeks after their first donation. They were asked about satisfaction and intention to return, and offered an appointment. The primary outcome was the return rate within 6 months after the first donation.Results: The mean age was 28.8 ± 10.0 years and 59.9% of FTDs were female. In the TG, 89.3% were reached. Approximately 50% of each group had donated a second time by 24.2 weeks for the control group (CG) and 14.8 weeks for the TG. The six-month return rate was 65.0% in the TG and 54.3% in the CG (95%-CI [0.9%; 20.6%]; p = .033). The restricted mean time to return within 6 months was 19.4 weeks in the CG compared to 17.2 weeks in the TG (95%-CI [0.7; 3.7]; p = .004). The intervention effect tended to be larger in men than in women.Discussion: Contacting FTDs by phone after their first donation increases the six-month return rate and reduces the interval to a second donation. Male donors appear to be more receptive to this intervention. Whether the effect of the intervention helps to establish a donor identity in the long term should be the subject of further studies.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Providing red blood cells to facilitate organ transplant via normothermic perfusion techniques: A single-center experience. 通过常温灌注技术提供红细胞以促进器官移植：单中心经验。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-08-24 DOI: 10.1111/trf.17994

Elizabeth S Allen, Laura D Stephens, Nesinee Weber, Aleah L Brubaker, Ken Hudson, Victor Pretorius, Gabriel Schnickel, Patricia M Kopko

{"title":"Providing red blood cells to facilitate organ transplant via normothermic perfusion techniques: A single-center experience.","authors":"Elizabeth S Allen, Laura D Stephens, Nesinee Weber, Aleah L Brubaker, Ken Hudson, Victor Pretorius, Gabriel Schnickel, Patricia M Kopko","doi":"10.1111/trf.17994","DOIUrl":"10.1111/trf.17994","url":null,"abstract":"Background: Normothermic regional perfusion (NRP) and normothermic machine perfusion (NMP) are organ procurement and transport techniques that can improve organ quality, facilitate longer transport, and reduce postoperative complications, increasing organ availability and improving outcomes. NRP and NMP often require allogeneic red blood cells (RBCs). Our academic transfusion service began providing RBCs to support NRP and NMP for adult heart transplant (HT), orthotopic liver transplant (OLT), and multiorgan transplant (MOT) in August 2020.Methods: This single-center, retrospective study describes the implementation process and analyzes the characteristics of RBC support during the first 3 years of the perfusion programs. Timing and quantity of units issued and used, organ recipient demographics, and transplant outcomes were obtained from transfusion service and electronic medical records.Results: From 2020 to 2023, the transfusion service received 233 requests to support NRP and NMP perfusion cases. Of these, 105 cases resulted in RBC use, and units were returned or discarded in 112 cases. A total of 131 patients received perfusion-facilitated transplants (92 HT, 27 OLT, and 12 MOT). The majority of perfusion-facilitated HTs utilized NRP (81/92, 88%), whereas most perfusion-facilitated OLTs utilized NMP (21/27, 78%). Across all 233 requests, a total of 381 RBC units were used to facilitate 131 transplants, averaging 2.91 units/transplant.Discussion: Provision of RBCs for NRP and NMP techniques represents a novel method for transfusion services to support and facilitate life-saving organ transplants with only modest product use, about three RBC units per organ transplant in this single-center study.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Addressing platelet insecurity - A national call to action. 解决血小板不安全问题--全国行动呼吁。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-08-12 DOI: 10.1111/trf.17987

Eric A Gehrie, Pampee P Young, Sridhar V Basavaraju, Arthur W Bracey, Andrew P Cap, Liz Culler, Nancy M Dunbar, Mary Homer, Iris Isufi, Rob Macedo, Tanya Petraszko, Glenn Ramsey, Christopher A Tormey, Richard M Kaufman, Edward L Snyder

引用次数: 0

The incidence of donor white blood cell survival (transfusion-associated microchimerism) in Australian pediatric patients. 澳大利亚儿科患者捐献者白细胞存活率（输血相关微嵌合体）。

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-10-03 DOI: 10.1111/trf.18010

Rena Hirani, Bryony Ross, Yafeng Ma, Kathleen Irish, Janis Chamberlain, Therese Becker, Amy Smalley, Helen Irving, David O Irving

{"title":"The incidence of donor white blood cell survival (transfusion-associated microchimerism) in Australian pediatric patients.","authors":"Rena Hirani, Bryony Ross, Yafeng Ma, Kathleen Irish, Janis Chamberlain, Therese Becker, Amy Smalley, Helen Irving, David O Irving","doi":"10.1111/trf.18010","DOIUrl":"10.1111/trf.18010","url":null,"abstract":"Introduction: Donor leucocyte survival following red blood cell (RBC) transfusion, known as transfusion-associated microchimerism (TAM), can occur in some patients. In Australia, despite the introduction of leucocyte filtration (leucodepletion) during RBC manufacture, TAM has been detected in adult trauma patients. However, the incidence of TAM in Australian pediatric patients has not been analyzed.Methods: Patients aged 0-16 years were recruited across two cohorts. Retrospective participants had RBC transfusion between January 1, 2002 and November 15, 2017 and prospective participants received RBC transfusion between December 1, 2016 and November 25, 2020. Twelve bi-allelic insertion/deletion (InDel) polymorphisms were used to detect microchimerism amplification patterns using real-time PCR (RT-PCR) and droplet digital PCR (ddPCR).Results: Of the retrospective cohort (n = 40), six patients showed amplification of InDel sequences indicating potential microchimerism. For three patients, minor InDel sequences were detected using RT-PCR only, two patients had minor InDel amplification using ddPCR only, and one patient had minor InDel amplification that was confirmed using both techniques. Amplification of minor sequences occurred in three patients who had received a bone marrow transplant in addition to RBC transfusion. In the prospective cohort (n = 25), no InDel amplification indicating potential microchimerism was detected using RT-PCR.Discussion: Cell-based therapies had been administered in three patients where microchimerism amplification patterns were detected. Three patients have microchimerism that may be attributed to RBC transfusion. In prospective patients, who received leucodepleted and gamma-irradiated RBC units, no potential microchimerism amplification were detected. ddPCR may be a suitable technique for TAM analysis but requires further evaluation.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How do we manage hyperhemolysis syndrome. 如何处理高溶血综合征？

IF 2.5 3区医学

Transfusion Pub Date : 2024-10-01 Epub Date: 2024-10-03 DOI: 10.1111/trf.17995

Brian D Adkins, Samer Z Kaylani, Alecia Nero, Ibrahim F Ibrahim, Yu-Min Shen, Ravindra Sarode

{"title":"How do we manage hyperhemolysis syndrome.","authors":"Brian D Adkins, Samer Z Kaylani, Alecia Nero, Ibrahim F Ibrahim, Yu-Min Shen, Ravindra Sarode","doi":"10.1111/trf.17995","DOIUrl":"10.1111/trf.17995","url":null,"abstract":"Background: Hyperhemolysis syndrome (HHS) is a catastrophic anemia characterized by destruction of both donor and patient red blood cells (RBC). HHS occurs after transfusion and can cause significant morbidity and mortality. Given the difficulty in diagnosing and managing this process, we provide a detailed overview of our treatment protocol.Study design and methods: Members of the Transfusion Medicine and Hematology faculty at our institution collaborated in an iterative process to produce a consensus approach to patients with HHS.Results: We present diagnostic criteria for HHS: recent transfusion within past 7 days (up to 21 days), rapid hemoglobin decline to below the pretransfusion level (usually hemoglobin drop >25% from pretransfusion), a significant decrease in HbA% (in patients with sickle cell disease or beta thalassemia), low or decreasing reticulocyte count in a patient with worsening anemia, and laboratory evidence of hemolysis. We also describe an in-depth approach to management focusing on optimizing hematopoiesis while dampening the immune response.Conclusion: We provide a comprehensive approach to the diagnosis and management of HHS based on contemporary literature and clinical experience designed to optimize outcomes for patients.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New and emerging technologies for pretransfusion blood quality assessment: A state-of-the-art review. 用于输血前血液质量评估的新兴技术：最新技术回顾。

IF 2.5 3区医学

Transfusion Pub Date : 2024-09-26 DOI: 10.1111/trf.18019

Melissa C Caughey, Richard O Francis, Matthew S Karafin

引用次数: 0

Impact of elevated direct factor Xa inhibitor plasma levels on perioperative blood loss in patients undergoing urgent surgery. 直接 Xa 因子抑制剂血浆水平升高对紧急手术患者围手术期失血量的影响。

IF 2.5 3区医学

Transfusion Pub Date : 2024-09-25 DOI: 10.1111/trf.18021

Alexander Mair, Sebastian D Sahli, Jan-Dirk Studt, Julia Braun, Justyna Lunkiewicz, Donat R Spahn, Alexander Kaserer

{"title":"Impact of elevated direct factor Xa inhibitor plasma levels on perioperative blood loss in patients undergoing urgent surgery.","authors":"Alexander Mair, Sebastian D Sahli, Jan-Dirk Studt, Julia Braun, Justyna Lunkiewicz, Donat R Spahn, Alexander Kaserer","doi":"10.1111/trf.18021","DOIUrl":"https://doi.org/10.1111/trf.18021","url":null,"abstract":"Introduction: Data on the perioperative bleeding risk associated with elevated plasma levels of direct factor Xa inhibitors (FXa inhibitors) are limited. This study examines perioperative red blood cell (RBC) loss in patients undergoing urgent surgery with a residual FXa inhibitor level exceeding 100 mcg/L and without preoperative FXa inhibitor reversal.Methods: This retrospective analysis includes data from 32 patients who underwent urgent noncardiac surgery between 2018 and 2022. This study aims to analyze perioperative RBC loss in patients undergoing urgent surgery with a residual FXa inhibitor level exceeding 100 mcg/L and without preoperative FXa inhibitor antidote-based reversal or unspecific treatment with 4-factor prothrombin complex concentrate (PCC). All patients were managed using a watch-and-wait strategy.Results: The last determination of FXa inhibitor plasma concentration prior to surgery showed a median of 245 mcg/L (IQR 144-345), with a median time interval of 3.8 h (IQR 2.4-7.2) before incision. Median RBC loss during surgery was 49 mL (IQR 0-253), 189 mL (IQR 104-217) until POD1 and 254 mL (IQR 58-265) until POD3. Only one patient required intraoperative treatment with 4-factor-PCC and none required reversal with andexanet alfa. Linear regression models found no significant influence of FXa inhibitor plasma levels on intraoperative RBC loss. Rivaroxaban was associated with higher RBC loss until postoperative Day 1 compared with apixaban. No thromboembolic events were observed.Conclusion: Despite markedly elevated plasma concentrations of residual direct FXa inhibitors, perioperative RBC loss was limited in patients undergoing urgent noncardiac surgery. The intraoperative watch-and-wait strategy with selective intraoperative FXa inhibitor reversal or treatment only when required appears to be an appropriate approach.","PeriodicalId":23266,"journal":{"name":"Transfusion","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0